{"id":"https://openalex.org/W7225753158","doi":"https://doi.org/10.64898/2026.11.09.26367657","title":"PNEUMOCOCCAL CONJUGATE VACCINE SCHEDULES SHAPE SEROTYPE-SPECIFIC MEMORY B-CELL RESPONSES","display_name":"PNEUMOCOCCAL CONJUGATE VACCINE SCHEDULES SHAPE SEROTYPE-SPECIFIC MEMORY B-CELL RESPONSES","publication_year":2026,"publication_date":"2026-11-10","ids":{"openalex":"https://openalex.org/W7225753158","doi":"https://doi.org/10.64898/2026.11.09.26367657"},"language":"en","primary_location":{"id":"doi:10.64898/2026.11.09.26367657","doi":"https://doi.org/10.64898/2026.11.09.26367657","is_oa":false,"landing_page_url":"https://doi.org/10.64898/2026.11.09.26367657","pdf_url":null,"source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5161398145","display_name":"Hugh Brown","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210150290","display_name":"Murdoch Children's Research Institute","ror":"https://ror.org/048fyec77","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I4210150290"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Hugh Brown","raw_affiliation_strings":["Murdoch Children's Research Institute;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Murdoch Children's Research Institute;","institution_ids":["https://openalex.org/I4210150290"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037819557","display_name":"Thanh Van Phan","orcid":"https://orcid.org/0009-0006-5056-7285","observed_orcids":["https://orcid.org/0009-0006-5056-7285"]},"institutions":[{"id":"https://openalex.org/I2802701112","display_name":"Institut Pasteur in Ho Chi Minh City","ror":"https://ror.org/00g2j5111","country_code":"VN","type":"nonprofit","lineage":["https://openalex.org/I2802701112"]}],"countries":["VN"],"is_corresponding":false,"raw_author_name":"Thanh V Phan","raw_affiliation_strings":["Pasteur Institute of Ho Chi Minh City;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pasteur Institute of Ho Chi Minh City;","institution_ids":["https://openalex.org/I2802701112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091849647","display_name":"Zheng Quan Toh","orcid":"https://orcid.org/0000-0002-0282-5837","observed_orcids":["https://orcid.org/0000-0002-0282-5837"]},"institutions":[{"id":"https://openalex.org/I4210150290","display_name":"Murdoch Children's Research Institute","ror":"https://ror.org/048fyec77","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I4210150290"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Zheng Quan Toh","raw_affiliation_strings":["Murdoch Children's Research Institute;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Murdoch Children's Research Institute;","institution_ids":["https://openalex.org/I4210150290"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061621892","display_name":"Beth Temple","orcid":"https://orcid.org/0000-0002-4885-9848","observed_orcids":["https://orcid.org/0000-0002-4885-9848"]},"institutions":[{"id":"https://openalex.org/I4210085939","display_name":"Menzies School of Health Research","ror":"https://ror.org/006mbby82","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I29894533","https://openalex.org/I4210085939"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Beth Temple","raw_affiliation_strings":["Menzies School of Health Research;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Menzies School of Health Research;","institution_ids":["https://openalex.org/I4210085939"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048489056","display_name":"Cattram Duong Nguyen","orcid":"https://orcid.org/0000-0002-0599-8645","observed_orcids":["https://orcid.org/0000-0002-0599-8645"]},"institutions":[{"id":"https://openalex.org/I4210150290","display_name":"Murdoch Children's Research Institute","ror":"https://ror.org/048fyec77","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I4210150290"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Cattram Nguyen","raw_affiliation_strings":["Murdoch Children's Research Institute;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Murdoch Children's Research Institute;","institution_ids":["https://openalex.org/I4210150290"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5099035400","display_name":"Kien Vientrung","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802701112","display_name":"Institut Pasteur in Ho Chi Minh City","ror":"https://ror.org/00g2j5111","country_code":"VN","type":"nonprofit","lineage":["https://openalex.org/I2802701112"]}],"countries":["VN"],"is_corresponding":false,"raw_author_name":"Kien Vientrung","raw_affiliation_strings":["Pasteur Institute of Ho Chi Minh City;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pasteur Institute of Ho Chi Minh City;","institution_ids":["https://openalex.org/I2802701112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100595329","display_name":"Hoang Van Anh Nguyen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802701112","display_name":"Institut Pasteur in Ho Chi Minh City","ror":"https://ror.org/00g2j5111","country_code":"VN","type":"nonprofit","lineage":["https://openalex.org/I2802701112"]}],"countries":["VN"],"is_corresponding":false,"raw_author_name":"Hoang Van Anh Nguyen","raw_affiliation_strings":["Pasteur Institute of Ho Chi Minh City;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pasteur Institute of Ho Chi Minh City;","institution_ids":["https://openalex.org/I2802701112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5128983230","display_name":"Nhung Vu Pham Hong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802701112","display_name":"Institut Pasteur in Ho Chi Minh City","ror":"https://ror.org/00g2j5111","country_code":"VN","type":"nonprofit","lineage":["https://openalex.org/I2802701112"]}],"countries":["VN"],"is_corresponding":false,"raw_author_name":"Nhung Vu Pham Hong","raw_affiliation_strings":["Pasteur Institute of Ho Chi Minh City;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pasteur Institute of Ho Chi Minh City;","institution_ids":["https://openalex.org/I2802701112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027122698","display_name":"Vo Thi Trang Dai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802701112","display_name":"Institut Pasteur in Ho Chi Minh City","ror":"https://ror.org/00g2j5111","country_code":"VN","type":"nonprofit","lineage":["https://openalex.org/I2802701112"]}],"countries":["VN"],"is_corresponding":false,"raw_author_name":"Vo Thi Trang Dai","raw_affiliation_strings":["Pasteur Institute of Ho Chi Minh City;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pasteur Institute of Ho Chi Minh City;","institution_ids":["https://openalex.org/I2802701112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090740500","display_name":"Kathryn Bright","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210150290","display_name":"Murdoch Children's Research Institute","ror":"https://ror.org/048fyec77","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I4210150290"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Kathryn Bright","raw_affiliation_strings":["Murdoch Children's Research Institute;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Murdoch Children's Research Institute;","institution_ids":["https://openalex.org/I4210150290"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159113172","display_name":"Hau Phuc Tran","orcid":"https://orcid.org/0009-0009-5072-0237","observed_orcids":["https://orcid.org/0009-0009-5072-0237"]},"institutions":[{"id":"https://openalex.org/I2802701112","display_name":"Institut Pasteur in Ho Chi Minh City","ror":"https://ror.org/00g2j5111","country_code":"VN","type":"nonprofit","lineage":["https://openalex.org/I2802701112"]}],"countries":["VN"],"is_corresponding":false,"raw_author_name":"Hau Phuc Tran","raw_affiliation_strings":["Pasteur Institute of Ho Chi Minh City;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pasteur Institute of Ho Chi Minh City;","institution_ids":["https://openalex.org/I2802701112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028622059","display_name":"Rachel A. Higgins","orcid":"https://orcid.org/0000-0002-2750-7261","observed_orcids":["https://orcid.org/0000-0002-2750-7261"]},"institutions":[{"id":"https://openalex.org/I4210150290","display_name":"Murdoch Children's Research Institute","ror":"https://ror.org/048fyec77","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I4210150290"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Rachel A Higgins","raw_affiliation_strings":["Murdoch Children's Research Institute;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Murdoch Children's Research Institute;","institution_ids":["https://openalex.org/I4210150290"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051820864","display_name":"Nadia Mazarakis","orcid":"https://orcid.org/0000-0001-7681-2775","observed_orcids":["https://orcid.org/0000-0001-7681-2775"]},"institutions":[{"id":"https://openalex.org/I4210150290","display_name":"Murdoch Children's Research Institute","ror":"https://ror.org/048fyec77","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I4210150290"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Nadia Mazarakis","raw_affiliation_strings":["Murdoch Children's Research Institute;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Murdoch Children's Research Institute;","institution_ids":["https://openalex.org/I4210150290"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113414352","display_name":"Skyy Luu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210150290","display_name":"Murdoch Children's Research Institute","ror":"https://ror.org/048fyec77","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I4210150290"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Skyy Luu","raw_affiliation_strings":["Murdoch Children's Research Institute;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Murdoch Children's Research Institute;","institution_ids":["https://openalex.org/I4210150290"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100282879","display_name":"Leanne Quah","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210150290","display_name":"Murdoch Children's Research Institute","ror":"https://ror.org/048fyec77","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I4210150290"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Leanne Quah","raw_affiliation_strings":["Murdoch Children's Research institute;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Murdoch Children's Research institute;","institution_ids":["https://openalex.org/I4210150290"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076683873","display_name":"Daniel Grant Pellicci","orcid":"https://orcid.org/0000-0001-5305-2398","observed_orcids":["https://orcid.org/0000-0001-5305-2398"]},"institutions":[{"id":"https://openalex.org/I4210150290","display_name":"Murdoch Children's Research Institute","ror":"https://ror.org/048fyec77","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I4210150290"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Daniel G Pellicci","raw_affiliation_strings":["Murdoch Children's Research Institute;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Murdoch Children's Research Institute;","institution_ids":["https://openalex.org/I4210150290"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104185217","display_name":"TT Nguyen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802701112","display_name":"Institut Pasteur in Ho Chi Minh City","ror":"https://ror.org/00g2j5111","country_code":"VN","type":"nonprofit","lineage":["https://openalex.org/I2802701112"]}],"countries":["VN"],"is_corresponding":false,"raw_author_name":"Thuong Vu Nguyen","raw_affiliation_strings":["Pasteur Institute of Ho Chi Minh City;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pasteur Institute of Ho Chi Minh City;","institution_ids":["https://openalex.org/I2802701112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023106012","display_name":"Jeremy Anderson","orcid":"https://orcid.org/0000-0003-2150-7399","observed_orcids":["https://orcid.org/0000-0003-2150-7399"]},"institutions":[{"id":"https://openalex.org/I4210150290","display_name":"Murdoch Children's Research Institute","ror":"https://ror.org/048fyec77","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I4210150290"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Jeremy Anderson","raw_affiliation_strings":["Murdoch Children's Research Institute;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Murdoch Children's Research Institute;","institution_ids":["https://openalex.org/I4210150290"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016242677","display_name":"Kim Mulholland","orcid":"https://orcid.org/0000-0001-7947-680X","observed_orcids":["https://orcid.org/0000-0001-7947-680X"]},"institutions":[{"id":"https://openalex.org/I4210089966","display_name":"London School of Hygiene & Tropical Medicine","ror":"https://ror.org/00a0jsq62","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I4210089966"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Kim Mulholland","raw_affiliation_strings":["London School of Hygiene and Tropical Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"London School of Hygiene and Tropical Medicine","institution_ids":["https://openalex.org/I4210089966"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016217164","display_name":"Paul Vincent Licciardi","orcid":"https://orcid.org/0000-0001-6086-6285","observed_orcids":["https://orcid.org/0000-0001-6086-6285"]},"institutions":[{"id":"https://openalex.org/I4210150290","display_name":"Murdoch Children's Research Institute","ror":"https://ror.org/048fyec77","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I4210150290"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Paul Licciardi","raw_affiliation_strings":["Murdoch Children's Research Institute;"],"raw_orcid":"https://orcid.org/0000-0001-6086-6285","affiliations":[{"raw_affiliation_string":"Murdoch Children's Research Institute;","institution_ids":["https://openalex.org/I4210150290"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10654","display_name":"Pneumonia and Respiratory Infections","score":0.9404000043869019,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10654","display_name":"Pneumonia and Respiratory Infections","score":0.9404000043869019,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10873","display_name":"Bacterial Infections and Vaccines","score":0.03689999878406525,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13410","display_name":"Immune responses and vaccinations","score":0.01269999984651804,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C2778866548","wikidata":"https://www.wikidata.org/wiki/Q7205991","display_name":"Pneumococcal conjugate vaccine","level":4,"score":0.8664000034332275},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7045999765396118},{"id":"https://openalex.org/C10389963","wikidata":"https://www.wikidata.org/wiki/Q848328","display_name":"Serotype","level":2,"score":0.5530999898910522},{"id":"https://openalex.org/C68387754","wikidata":"https://www.wikidata.org/wiki/Q7271585","display_name":"Schedule","level":2,"score":0.48739999532699585},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.42730000615119934},{"id":"https://openalex.org/C2779301066","wikidata":"https://www.wikidata.org/wiki/Q14538008","display_name":"Pneumococcal vaccine","level":4,"score":0.38989999890327454},{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.3853999972343445},{"id":"https://openalex.org/C103621254","wikidata":"https://www.wikidata.org/wiki/Q9199","display_name":"Vietnamese","level":2,"score":0.38269999623298645},{"id":"https://openalex.org/C2776152631","wikidata":"https://www.wikidata.org/wiki/Q4366062","display_name":"Pneumococcal infections","level":4,"score":0.3483999967575073},{"id":"https://openalex.org/C2779359726","wikidata":"https://www.wikidata.org/wiki/Q1195394","display_name":"Memory B cell","level":4,"score":0.34389999508857727},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.33250001072883606},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.33239999413490295},{"id":"https://openalex.org/C3020803494","wikidata":"https://www.wikidata.org/wiki/Q2712836","display_name":"Pneumococcal disease","level":4,"score":0.32670000195503235},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.3246999979019165},{"id":"https://openalex.org/C3018913218","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody response","level":3,"score":0.32330000400543213},{"id":"https://openalex.org/C197336794","wikidata":"https://www.wikidata.org/wiki/Q5161150","display_name":"Conjugate","level":2,"score":0.3188999891281128},{"id":"https://openalex.org/C2780791431","wikidata":"https://www.wikidata.org/wiki/Q1644301","display_name":"Vaccination schedule","level":4,"score":0.30329999327659607},{"id":"https://openalex.org/C2991763054","wikidata":"https://www.wikidata.org/wiki/Q38103695","display_name":"Immunological memory","level":4,"score":0.2720000147819519},{"id":"https://openalex.org/C99476002","wikidata":"https://www.wikidata.org/wiki/Q42297","display_name":"Analysis of variance","level":2,"score":0.26910001039505005},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.26809999346733093},{"id":"https://openalex.org/C2781253189","wikidata":"https://www.wikidata.org/wiki/Q221179","display_name":"Streptococcus pneumoniae","level":3,"score":0.26579999923706055},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.26269999146461487},{"id":"https://openalex.org/C2984752397","wikidata":"https://www.wikidata.org/wiki/Q3259956","display_name":"Primary care","level":2,"score":0.25760000944137573},{"id":"https://openalex.org/C2780655333","wikidata":"https://www.wikidata.org/wiki/Q333203","display_name":"Weaning","level":2,"score":0.25619998574256897},{"id":"https://openalex.org/C2779583294","wikidata":"https://www.wikidata.org/wiki/Q5161160","display_name":"Conjugate vaccine","level":4,"score":0.2531999945640564},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.25290000438690186}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.11.09.26367657","doi":"https://doi.org/10.64898/2026.11.09.26367657","is_oa":false,"landing_page_url":"https://doi.org/10.64898/2026.11.09.26367657","pdf_url":null,"source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Reduced-dose":[0],"pneumococcal":[1],"conjugate":[2],"vaccine":[3,62],"(PCV)":[4],"schedules":[5,81,145,156,170,229],"(1+1;":[6],"one":[7,10,112],"primary":[8],"and":[9,76,103,107,128,137,168,181,207,214,246],"booster)":[11],"are":[12,28],"now":[13],"endorsed":[14],"by":[15,211,218],"the":[16,154,166,242],"World":[17],"Health":[18],"Organisation":[19],"under":[20],"specific":[21],"circumstances.":[22],"Serotype-specific":[23],"memory":[24],"B":[25],"cells":[26],"(BMEM)":[27],"a":[29,45,87],"marker":[30],"of":[31,44,71,79,82,100,117,194,230,244],"long-term":[32,248],"protection":[33],"but":[34],"data":[35],"from":[36],"infant":[37],"reduced-dose":[38],"trials":[39],"remain":[40],"limited.":[41],"As":[42],"part":[43],"randomised":[46,58],"controlled":[47],"trial":[48],"in":[49,57,186],"Vietnamese":[50],"infants,":[51],"we":[52],"characterised":[53],"serotype-specific":[54,122,195],"BMEM":[55,123,139,151,176,236],"responses":[56,124,140,152,177,210,217],"subsets":[59],"(N=50":[60],"per":[61,64],"group":[63],"timepoint)":[65],"following":[66],"0+1":[67,155,167],"(at":[68],"12":[69,77,98],"months":[70,78,99],"age)":[72,80],"or":[73,84,113,198,232],"1+1":[74,144,169,228],"(2":[75],"PCV10":[83,231],"PCV13,":[85],"using":[86],"multimer":[88],"spectral":[89],"flow":[90],"cytometry":[91],"approach.":[92],"Blood":[93],"samples":[94],"were":[95,171,183],"collected":[96],"at":[97,104,125,157],"age":[101],"(baseline)":[102],"day":[105,108,126,129,158,161,212,219],"7":[106,127],"28":[109,130],"post-vaccination.":[110],"A":[111],"two":[114],"dose":[115],"schedule":[116],"either":[118,147],"PCV":[119,148],"induced":[120],"robust":[121,235],"for":[131,146,178,241],"most":[132],"serotypes.":[133],"PCV13":[134,203,233],"generated":[135,204],"earlier":[136],"higher":[138,150,205,215],"than":[141,153],"PCV10,":[142],"while":[143],"produced":[149],"7.":[159],"By":[160],"28,":[162,220],"these":[163],"differences":[164],"between":[165],"no":[172],"longer":[173],"apparent.":[174],"Notably,":[175],"serotypes":[179],"6B":[180],"23F":[182],"detectable":[184],"even":[185],"infants":[187],"who":[188],"did":[189],"not":[190],"achieve":[191],"protective":[192],"levels":[193],"IgG":[196],"greater":[197],"equal":[199],"to":[200,222],"0.35":[201],"ug/mL.":[202],"plasmablast":[206],"plasma":[208],"cell":[209],"7,":[213],"cTfh":[216],"compared":[221],"PCV10.":[223],"These":[224],"findings":[225],"show":[226],"that":[227],"induce":[234],"responses,":[237],"with":[238],"important":[239],"implications":[240],"evaluation":[243],"PCVs":[245],"understanding":[247],"protection.":[249]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-11T00:00:00"}
