{"id":"https://openalex.org/W7225753104","doi":"https://doi.org/10.64898/2026.11.07.765085","title":"Systemic TLR7 agonism moderates disease severity in acute DSS-induced colitis in mice","display_name":"Systemic TLR7 agonism moderates disease severity in acute DSS-induced colitis in mice","publication_year":2026,"publication_date":"2026-11-10","ids":{"openalex":"https://openalex.org/W7225753104","doi":"https://doi.org/10.64898/2026.11.07.765085"},"language":"en","primary_location":{"id":"doi:10.64898/2026.11.07.765085","doi":"https://doi.org/10.64898/2026.11.07.765085","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.11.07.765085","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.64898/2026.11.07.765085","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5115994996","display_name":"Daniel Kazimierczyk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel Kazimierczyk","raw_affiliation_strings":["Mass General Hospital;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mass General Hospital;","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090399098","display_name":"Brian Seed","orcid":"https://orcid.org/0000-0002-9279-1940","observed_orcids":["https://orcid.org/0000-0002-9279-1940"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian Seed","raw_affiliation_strings":["Mass General Hospital;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mass General Hospital;","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070078256","display_name":"Nitya Jain","orcid":"https://orcid.org/0000-0002-6423-4485","observed_orcids":["https://orcid.org/0000-0002-6423-4485"]},"institutions":[{"id":"https://openalex.org/I48633490","display_name":"Mass General Brigham","ror":"https://ror.org/04py2rh25","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Nitya Jain","raw_affiliation_strings":["Mass General Brigham"],"raw_orcid":"https://orcid.org/0000-0002-6423-4485","affiliations":[{"raw_affiliation_string":"Mass General Brigham","institution_ids":["https://openalex.org/I48633490"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5070078256"],"corresponding_institution_ids":["https://openalex.org/I48633490"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9775000214576721,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9775000214576721,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.018200000748038292,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7785999774932861},{"id":"https://openalex.org/C2779836521","wikidata":"https://www.wikidata.org/wiki/Q14914081","display_name":"TLR7","level":5,"score":0.7537000179290771},{"id":"https://openalex.org/C2778260677","wikidata":"https://www.wikidata.org/wiki/Q917447","display_name":"Inflammatory bowel disease","level":3,"score":0.6388999819755554},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6208999752998352},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.5938000082969666},{"id":"https://openalex.org/C2775862500","wikidata":"https://www.wikidata.org/wiki/Q2453464","display_name":"Colitis","level":2,"score":0.590499997138977},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5602999925613403},{"id":"https://openalex.org/C14527384","wikidata":"https://www.wikidata.org/wiki/Q4693403","display_name":"Agonism","level":3,"score":0.4699999988079071},{"id":"https://openalex.org/C2776252253","wikidata":"https://www.wikidata.org/wiki/Q7663815","display_name":"Systemic inflammation","level":3,"score":0.4471000134944916},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4357999861240387},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4221000075340271},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.38040000200271606},{"id":"https://openalex.org/C2780931953","wikidata":"https://www.wikidata.org/wiki/Q9371","display_name":"Spleen","level":2,"score":0.37880000472068787},{"id":"https://openalex.org/C2779075594","wikidata":"https://www.wikidata.org/wiki/Q8084905","display_name":"Autoimmune disease","level":3,"score":0.31470000743865967},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3046000003814697},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.28949999809265137},{"id":"https://openalex.org/C2779280984","wikidata":"https://www.wikidata.org/wiki/Q1472","display_name":"Crohn's disease","level":3,"score":0.2858999967575073},{"id":"https://openalex.org/C25938499","wikidata":"https://www.wikidata.org/wiki/Q7663812","display_name":"Systemic administration","level":3,"score":0.2793999910354614},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.27399998903274536},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.2727999985218048},{"id":"https://openalex.org/C31179232","wikidata":"https://www.wikidata.org/wiki/Q14911549","display_name":"CX3CR1","level":5,"score":0.26030001044273376},{"id":"https://openalex.org/C196166836","wikidata":"https://www.wikidata.org/wiki/Q902926","display_name":"Immunophenotyping","level":3,"score":0.25679999589920044}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.11.07.765085","doi":"https://doi.org/10.64898/2026.11.07.765085","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.11.07.765085","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.11.07.765085","doi":"https://doi.org/10.64898/2026.11.07.765085","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.11.07.765085","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Toll-like":[0],"receptor":[1],"7":[2],"(TLR7)":[3],"is":[4,23,107,116],"an":[5,93],"endosomal":[6],"sensor":[7],"of":[8,45,83,96,121,145],"single-stranded":[9],"RNA,":[10],"studied":[11],"for":[12,31],"its":[13],"antiviral":[14],"and":[15,25,75,89,92,141,148],"pro-inflammatory":[16],"functions.":[17],"Its":[18],"role":[19],"in":[20,55,62,111,139],"intestinal":[21],"inflammation":[22],"undefined,":[24],"no":[26],"approved":[27],"or":[28],"clinical-stage":[29],"therapy":[30],"inflammatory":[32],"bowel":[33],"disease":[34,53],"(IBD)":[35],"engages":[36],"this":[37],"pathway.":[38],"Here":[39],"we":[40],"report":[41],"that":[42,103],"systemic":[43,123],"administration":[44],"the":[46,84,112,122],"reference":[47],"TLR7":[48,105,133],"agonist":[49],"GS-9620":[50],"(vesatolimod)":[51],"moderates":[52],"severity":[54],"acute":[56],"dextran":[57],"sodium":[58],"sulfate":[59],"(DSS)-induced":[60],"colitis":[61],"mice.":[63],"GS-9620-treated":[64],"mice":[65],"lost":[66],"less":[67],"weight,":[68],"had":[69],"lower":[70],"Disease":[71],"Activity":[72],"Index":[73],"scores,":[74],"were":[76],"protected":[77],"from":[78],"DSS-induced":[79],"colon":[80],"shortening.":[81],"Immunophenotyping":[82],"spleen":[85],"showed":[86],"reduced":[87],"Th17":[88],"Tr17":[90],"populations":[91],"increased":[94],"proportion":[95],"regulatory":[97,128],"T":[98],"cells.":[99],"These":[100],"findings":[101],"indicate":[102],"pharmacological":[104],"agonism":[106],"not":[108],"merely":[109],"tolerated":[110],"inflamed":[113],"intestine":[114],"but":[115],"associated":[117],"with":[118],"a":[119,127,135],"shift":[120],"immune":[124],"compartment":[125],"toward":[126],"phenotype.":[129],"The":[130],"results":[131],"identify":[132],"as":[134],"candidate":[136],"disease-moderating":[137],"target":[138],"IBD":[140],"motivate":[142],"direct":[143],"tests":[144],"causality,":[146],"route":[147],"chronic-disease":[149],"relevance.":[150]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-11T00:00:00"}