{"id":"https://openalex.org/W7225752453","doi":"https://doi.org/10.53859/02352451_2026_40_8_59","title":"The effect of an experimental biological immunostimulant on the cytokine profile and complement system in rats","display_name":"The effect of an experimental biological immunostimulant on the cytokine profile and complement system in rats","publication_year":2026,"publication_date":"2026-11-10","ids":{"openalex":"https://openalex.org/W7225752453","doi":"https://doi.org/10.53859/02352451_2026_40_8_59"},"language":"en","primary_location":{"id":"doi:10.53859/02352451_2026_40_8_59","doi":"https://doi.org/10.53859/02352451_2026_40_8_59","is_oa":false,"landing_page_url":"https://doi.org/10.53859/02352451_2026_40_8_59","pdf_url":null,"source":{"id":"https://openalex.org/S4210233339","display_name":"Achievements of Science and Technology in Agro-Industrial Complex","issn_l":"0235-2451","issn":["0235-2451"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["russia-white-list-2"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Achievements of Science and Technology in Agro-Industrial Complex","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023067235","display_name":"Alexander Sergeevich Tishchenko","orcid":"https://orcid.org/0000-0003-0942-120X","observed_orcids":["https://orcid.org/0000-0003-0942-120X"]},"institutions":[{"id":"https://openalex.org/I2426469","display_name":"Kuban State Agrarian University","ror":"https://ror.org/058jafb94","country_code":"RU","type":"education","lineage":["https://openalex.org/I2426469"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"A. S. Tishchenko","raw_affiliation_strings":["Trubilin Kuban State Agrarian University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Trubilin Kuban State Agrarian University","institution_ids":["https://openalex.org/I2426469"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091469547","display_name":"Andrey Georgievich Koshchaev","orcid":"https://orcid.org/0000-0002-3904-2860","observed_orcids":["https://orcid.org/0000-0002-3904-2860"]},"institutions":[{"id":"https://openalex.org/I2426469","display_name":"Kuban State Agrarian University","ror":"https://ror.org/058jafb94","country_code":"RU","type":"education","lineage":["https://openalex.org/I2426469"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"A. G. Koshchaev","raw_affiliation_strings":["Trubilin Kuban State Agrarian University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Trubilin Kuban State Agrarian University","institution_ids":["https://openalex.org/I2426469"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161410980","display_name":"A. Kh. Shantyz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2426469","display_name":"Kuban State Agrarian University","ror":"https://ror.org/058jafb94","country_code":"RU","type":"education","lineage":["https://openalex.org/I2426469"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"A. Kh. Shantyz","raw_affiliation_strings":["Trubilin Kuban State Agrarian University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Trubilin Kuban State Agrarian University","institution_ids":["https://openalex.org/I2426469"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161388519","display_name":"M. G. Konovalov","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2426469","display_name":"Kuban State Agrarian University","ror":"https://ror.org/058jafb94","country_code":"RU","type":"education","lineage":["https://openalex.org/I2426469"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"M. G. Konovalov","raw_affiliation_strings":["Trubilin Kuban State Agrarian University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Trubilin Kuban State Agrarian University","institution_ids":["https://openalex.org/I2426469"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106881758","display_name":"Dmitry Alferov","orcid":"https://orcid.org/0009-0000-3587-3408","observed_orcids":["https://orcid.org/0009-0000-3587-3408"]},"institutions":[{"id":"https://openalex.org/I2426469","display_name":"Kuban State Agrarian University","ror":"https://ror.org/058jafb94","country_code":"RU","type":"education","lineage":["https://openalex.org/I2426469"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"D. O. Alferov","raw_affiliation_strings":["Trubilin Kuban State Agrarian University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Trubilin Kuban State Agrarian University","institution_ids":["https://openalex.org/I2426469"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028250937","display_name":"V.A. Belyak","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2426469","display_name":"Kuban State Agrarian University","ror":"https://ror.org/058jafb94","country_code":"RU","type":"education","lineage":["https://openalex.org/I2426469"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"V. A. Belyak","raw_affiliation_strings":["Trubilin Kuban State Agrarian University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Trubilin Kuban State Agrarian University","institution_ids":["https://openalex.org/I2426469"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I2426469"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"40","issue":"8","first_page":"59","last_page":"64"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.5814999938011169,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.5814999938011169,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.1670999974012375,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12322","display_name":"Animal health and immunology","score":0.1386999934911728,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C2781264782","wikidata":"https://www.wikidata.org/wiki/Q901656","display_name":"Immunostimulant","level":3,"score":0.8669999837875366},{"id":"https://openalex.org/C111684460","wikidata":"https://www.wikidata.org/wiki/Q334848","display_name":"Complement system","level":3,"score":0.6309999823570251},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6151999831199646},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.550000011920929},{"id":"https://openalex.org/C112313634","wikidata":"https://www.wikidata.org/wiki/Q7886648","display_name":"Complement (music)","level":5,"score":0.529699981212616},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5224000215530396},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.5020999908447266},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.46630001068115234},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3671000003814697},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.34119999408721924},{"id":"https://openalex.org/C2780420688","wikidata":"https://www.wikidata.org/wiki/Q759183","display_name":"Immunoassay","level":3,"score":0.3319000005722046},{"id":"https://openalex.org/C116073593","wikidata":"https://www.wikidata.org/wiki/Q864491","display_name":"Biological activity","level":3,"score":0.30000001192092896},{"id":"https://openalex.org/C189446657","wikidata":"https://www.wikidata.org/wiki/Q4736500","display_name":"Alternative complement pathway","level":4,"score":0.29840001463890076},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.29010000824928284},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.28540000319480896},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.28209999203681946},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2770000100135803},{"id":"https://openalex.org/C2908738225","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunopharmacology","level":3,"score":0.27639999985694885},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.27000001072883606},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.2667999863624573}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.53859/02352451_2026_40_8_59","doi":"https://doi.org/10.53859/02352451_2026_40_8_59","is_oa":false,"landing_page_url":"https://doi.org/10.53859/02352451_2026_40_8_59","pdf_url":null,"source":{"id":"https://openalex.org/S4210233339","display_name":"Achievements of Science and Technology in Agro-Industrial Complex","issn_l":"0235-2451","issn":["0235-2451"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["russia-white-list-2"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Achievements of Science and Technology in Agro-Industrial Complex","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W2038752330","https://openalex.org/W2089885332","https://openalex.org/W2106248075","https://openalex.org/W2970640684","https://openalex.org/W2984866506","https://openalex.org/W2991379773","https://openalex.org/W3001827567","https://openalex.org/W3002457465","https://openalex.org/W3005228132","https://openalex.org/W3139129400","https://openalex.org/W4389386158","https://openalex.org/W4402199264","https://openalex.org/W4402521271"],"related_works":[],"abstract_inverted_index":{"The":[0,43,64,89,243],"studies":[1],"were":[2,45,91],"conducted":[3],"to":[4,153,161,180,185,226,240],"substantiate":[5],"the":[6,18,29,36,40,69,114,143,189,194,219,232,247,252,262,268,278,287,305,310,320],"safety":[7],"and":[8,22,25,87,102,111,131,175,183,211,237,258,293,314],"immunoregulatory":[9,285],"efficacy":[10],"of":[11,17,20,31,39,55,84,121,171,191,234,289,304,309,316,322],"Immunocol-vet":[12,81,139,223,250,283],"through":[13],"a":[14,169,176,206,275],"quantitative":[15],"assessment":[16],"dynamics":[19],"proinflammatory":[21],"anti-inflammatory":[23],"cytokines":[24],"complement":[26,132],"components,":[27],"confirming":[28],"absence":[30],"hyperinflammatory":[32],"potential":[33],"while":[34,266],"maintaining":[35],"functional":[37,207],"activity":[38],"immune":[41,298],"response.":[42],"experiments":[44],"performed":[46],"in":[47,159,178,246,267],"2025-2026":[48],"on":[49,107,193],"5":[50],"groups":[51],"(15":[52],"animals":[53],"each)":[54],"Wistar":[56],"albino":[57],"rats":[58],"(weight":[59],"200":[60],"\u00b1":[61],"10":[62,112,220],"g).":[63],"experimental":[65],"design":[66],"included":[67],"studying":[68],"following":[70],"options:":[71],"intact":[72],"control,":[73],"pyrogenal,":[74,85,271],"polyacrylic":[75],"acid":[76],"(PAC),":[77],"Escherichia":[78],"coli":[79],"anatoxin,":[80],"(a":[82],"combination":[83,288],"PAC,":[86],"anatoxin).":[88],"drugs":[90],"administered":[92],"intramuscularly":[93],"at":[94,142,205],"0.2":[95],"ml":[96],"three":[97],"times":[98],"(days":[99],"1,":[100],"3,":[101,109,138],"7).":[103],"Blood":[104],"was":[105,213,255,259],"collected":[106],"days":[108],"7":[110,195],"(before":[113],"next":[115],"administration)":[116],"with":[117,156],"subsequent":[118],"enzyme":[119],"immunoassay":[120],"immunological":[122],"markers":[123],"(cytokines":[124],"IL-2,":[125],"IL-4,":[126],"IL-6,":[127],"IL-10,":[128],"IL-1\u03b2,":[129],"TNF-\u03b1":[130,244],"components":[133,290],"C3,":[134],"C5).":[135],"On":[136,218],"day":[137,165,254],"maintained":[140],"IL-4":[141,179,203,225],"control":[144,227,233,263,315],"level":[145,208],"(16.71":[146],"vs.":[147],"18.18":[148],"pg/ml),":[149,202,210,265],"pyrogenal":[150,167],"reduced":[151],"it":[152],"1.5":[154],"pg/ml":[155,182,230,257],"an":[157,296],"increase":[158],"IL-10":[160],"27.4":[162],"pg/ml.":[163,242],"By":[164],"7,":[166],"induced":[168],"peak":[170],"IL-6":[172,198],"(14.35":[173],"pg/ml)":[174,236],"decrease":[177],"0.17":[181],"C5":[184],"0.27":[186],"ng/ml.":[187],"In":[188],"presence":[190],"Immunocol-vet,":[192],"th":[196,221],"day,":[197,222],"remained":[199,204],"minimal":[200],"(0.05":[201],"(4.37":[209],"IL-1\u03b2":[212,318],"effectively":[214],"suppressed":[215],"(0.83":[216],"pg/ml).":[217,282],"restored":[224],"values":[228],"(9.66":[229],"versus":[231],"9.47":[235],"increased":[238],"IL-2":[239],"13.42":[241],"indicator":[245],"group":[248,269],"receiving":[249,270],"by":[251,301],"10th":[253],"120.18":[256],"lower":[260],"than":[261],"(145.61":[264],"its":[272],"value":[273],"reached":[274],"maximum":[276],"for":[277],"entire":[279],"experiment":[280],"(196.55":[281],"exhibits":[284],"properties:":[286],"(pyrogenal,":[291],"PAK,":[292],"toxoid)":[294],"ensures":[295],"early":[297,326],"response":[299],"followed":[300],"physiological":[302],"inhibition":[303],"inflammatory":[306],"cascade,":[307],"preservation":[308],"Th2":[311],"component":[312],"(IL-4),":[313],"pyrogenic":[317],"without":[319],"risk":[321],"developing":[323],"hyperinflammation":[324],"or":[325],"immunosuppression.":[327]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-11T00:00:00"}