{"id":"https://openalex.org/W7225751891","doi":"https://doi.org/10.3390/nutraceuticals6040073","title":"The Coffee\u2013Gut\u2013Redox Axis in Healthy Aging: Microbial Metabolism, Redox Signaling, and Implications for Coffee-Derived Nutraceuticals","display_name":"The Coffee\u2013Gut\u2013Redox Axis in Healthy Aging: Microbial Metabolism, Redox Signaling, and Implications for Coffee-Derived Nutraceuticals","publication_year":2026,"publication_date":"2026-11-10","ids":{"openalex":"https://openalex.org/W7225751891","doi":"https://doi.org/10.3390/nutraceuticals6040073"},"language":"en","primary_location":{"id":"doi:10.3390/nutraceuticals6040073","doi":"https://doi.org/10.3390/nutraceuticals6040073","is_oa":true,"landing_page_url":"https://doi.org/10.3390/nutraceuticals6040073","pdf_url":null,"source":{"id":"https://openalex.org/S4210197188","display_name":"Nutraceuticals","issn_l":"1661-3821","issn":["1661-3821"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutraceuticals","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/nutraceuticals6040073","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100744986","display_name":"Shahidul Islam","orcid":"https://orcid.org/0000-0003-3131-6692","observed_orcids":["https://orcid.org/0000-0003-3131-6692"]},"institutions":[{"id":"https://openalex.org/I1336096307","display_name":"United States Department of Agriculture","ror":"https://ror.org/01na82s61","country_code":"US","type":"government","lineage":["https://openalex.org/I1336096307"]},{"id":"https://openalex.org/I94525581","display_name":"University of Arkansas at Pine Bluff","ror":"https://ror.org/03zsjhd07","country_code":"US","type":"education","lineage":["https://openalex.org/I94525581"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Shahidul Islam","raw_affiliation_strings":["Horticulture & Nutraceuticals (Regulatory Science) Laboratory, United States Department of Agriculture Regulatory Science Center of Excellence, School of Agriculture, Fisheries and Human Sciences, University of Arkansas at Pine Bluff, 1200 North University Drive, Mail Slot 4913, Pine Bluff, AR 71601, USA"],"raw_orcid":"https://orcid.org/0000-0003-3131-6692","affiliations":[{"raw_affiliation_string":"Horticulture & Nutraceuticals (Regulatory Science) Laboratory, United States Department of Agriculture Regulatory Science Center of Excellence, School of Agriculture, Fisheries and Human Sciences, University of Arkansas at Pine Bluff, 1200 North University Drive, Mail Slot 4913, Pine Bluff, AR 71601, USA","institution_ids":["https://openalex.org/I1336096307","https://openalex.org/I94525581"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5100744986"],"corresponding_institution_ids":["https://openalex.org/I1336096307","https://openalex.org/I94525581"],"apc_list":{"value":1000,"currency":"CHF","value_usd":1207},"apc_paid":{"value":1000,"currency":"CHF","value_usd":1207},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"6","issue":"4","first_page":"73","last_page":"73"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11264","display_name":"Coffee research and impacts","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11264","display_name":"Coffee research and impacts","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.011099999770522118,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10035","display_name":"Phytochemicals and Antioxidant Activities","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C2777389649","wikidata":"https://www.wikidata.org/wiki/Q928965","display_name":"Trigonelline","level":2,"score":0.6037999987602234},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.586899995803833},{"id":"https://openalex.org/C96942376","wikidata":"https://www.wikidata.org/wiki/Q21130714","display_name":"Catabolism","level":3,"score":0.5461999773979187},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5117999911308289},{"id":"https://openalex.org/C17857428","wikidata":"https://www.wikidata.org/wiki/Q533025","display_name":"Nutraceutical","level":2,"score":0.4839000105857849},{"id":"https://openalex.org/C2780117898","wikidata":"https://www.wikidata.org/wiki/Q421964","display_name":"Chlorogenic acid","level":2,"score":0.4388999938964844},{"id":"https://openalex.org/C2776901170","wikidata":"https://www.wikidata.org/wiki/Q12499775","display_name":"Nicotinamide adenine dinucleotide","level":4,"score":0.38850000500679016},{"id":"https://openalex.org/C2779728014","wikidata":"https://www.wikidata.org/wiki/Q192423","display_name":"Nicotinamide","level":3,"score":0.3659000098705292},{"id":"https://openalex.org/C197957613","wikidata":"https://www.wikidata.org/wiki/Q407280","display_name":"Cofactor","level":3,"score":0.35530000925064087},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.35420000553131104},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.3476000130176544},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3418999910354614},{"id":"https://openalex.org/C55904794","wikidata":"https://www.wikidata.org/wiki/Q82682","display_name":"Redox","level":2,"score":0.3122999966144562},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.2992999851703644},{"id":"https://openalex.org/C2987857752","wikidata":"https://www.wikidata.org/wiki/Q12147","display_name":"Human health","level":2,"score":0.29820001125335693},{"id":"https://openalex.org/C75520062","wikidata":"https://www.wikidata.org/wiki/Q15321392","display_name":"NAD+ kinase","level":3,"score":0.29319998621940613},{"id":"https://openalex.org/C3020471959","wikidata":"https://www.wikidata.org/wiki/Q183206","display_name":"B vitamins","level":2,"score":0.28839999437332153},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2784999907016754},{"id":"https://openalex.org/C101014631","wikidata":"https://www.wikidata.org/wiki/Q4889568","display_name":"Microbial metabolism","level":3,"score":0.2759999930858612},{"id":"https://openalex.org/C2778312467","wikidata":"https://www.wikidata.org/wiki/Q132809","display_name":"Clostridia","level":3,"score":0.26910001039505005},{"id":"https://openalex.org/C2776335861","wikidata":"https://www.wikidata.org/wiki/Q412611","display_name":"Metaphosphate","level":3,"score":0.26899999380111694},{"id":"https://openalex.org/C192989942","wikidata":"https://www.wikidata.org/wiki/Q68685","display_name":"Metabolic pathway","level":3,"score":0.26840001344680786},{"id":"https://openalex.org/C2780561631","wikidata":"https://www.wikidata.org/wiki/Q421331","display_name":"Sirtuin","level":4,"score":0.267300009727478},{"id":"https://openalex.org/C2778500429","wikidata":"https://www.wikidata.org/wiki/Q60235","display_name":"Caffeine","level":2,"score":0.26600000262260437},{"id":"https://openalex.org/C9927688","wikidata":"https://www.wikidata.org/wiki/Q4915012","display_name":"Biological pathway","level":4,"score":0.26330000162124634},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.26260000467300415},{"id":"https://openalex.org/C2775881703","wikidata":"https://www.wikidata.org/wiki/Q744577","display_name":"Hydroxytyrosol","level":4,"score":0.26010000705718994}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3390/nutraceuticals6040073","doi":"https://doi.org/10.3390/nutraceuticals6040073","is_oa":true,"landing_page_url":"https://doi.org/10.3390/nutraceuticals6040073","pdf_url":null,"source":{"id":"https://openalex.org/S4210197188","display_name":"Nutraceuticals","issn_l":"1661-3821","issn":["1661-3821"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutraceuticals","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.3390/nutraceuticals6040073","doi":"https://doi.org/10.3390/nutraceuticals6040073","is_oa":true,"landing_page_url":"https://doi.org/10.3390/nutraceuticals6040073","pdf_url":null,"source":{"id":"https://openalex.org/S4210197188","display_name":"Nutraceuticals","issn_l":"1661-3821","issn":["1661-3821"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutraceuticals","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":116,"referenced_works":["https://openalex.org/W1963960348","https://openalex.org/W1972508135","https://openalex.org/W1975076117","https://openalex.org/W1977922285","https://openalex.org/W1978729916","https://openalex.org/W1979815711","https://openalex.org/W1982664338","https://openalex.org/W1983028591","https://openalex.org/W2017253183","https://openalex.org/W2026221670","https://openalex.org/W2026346483","https://openalex.org/W2040637037","https://openalex.org/W2042503457","https://openalex.org/W2047446226","https://openalex.org/W2053969387","https://openalex.org/W2064248211","https://openalex.org/W2065402709","https://openalex.org/W2065424390","https://openalex.org/W2068050349","https://openalex.org/W2073714219","https://openalex.org/W2074401669","https://openalex.org/W2075795211","https://openalex.org/W2077627098","https://openalex.org/W2092189052","https://openalex.org/W2092576407","https://openalex.org/W2099130114","https://openalex.org/W2099456560","https://openalex.org/W2100121015","https://openalex.org/W2100404723","https://openalex.org/W2110936821","https://openalex.org/W2117800935","https://openalex.org/W2119802120","https://openalex.org/W2120180949","https://openalex.org/W2126525177","https://openalex.org/W2127507974","https://openalex.org/W2131220626","https://openalex.org/W2137201442","https://openalex.org/W2139399563","https://openalex.org/W2140065939","https://openalex.org/W2146546535","https://openalex.org/W2150406923","https://openalex.org/W2151356634","https://openalex.org/W2160293048","https://openalex.org/W2168377537","https://openalex.org/W2170416289","https://openalex.org/W2175944226","https://openalex.org/W2218478385","https://openalex.org/W2248702106","https://openalex.org/W2371807656","https://openalex.org/W2418901284","https://openalex.org/W2507252693","https://openalex.org/W2529485316","https://openalex.org/W2550679725","https://openalex.org/W2556574846","https://openalex.org/W2581443065","https://openalex.org/W2605131570","https://openalex.org/W2607434574","https://openalex.org/W2617957470","https://openalex.org/W2735828659","https://openalex.org/W2767209834","https://openalex.org/W2771044916","https://openalex.org/W2793021392","https://openalex.org/W2800093478","https://openalex.org/W2802216404","https://openalex.org/W2803593477","https://openalex.org/W2809745740","https://openalex.org/W2885093728","https://openalex.org/W2897397781","https://openalex.org/W2903292083","https://openalex.org/W2918418281","https://openalex.org/W2934490979","https://openalex.org/W2942278269","https://openalex.org/W2944634367","https://openalex.org/W2954124338","https://openalex.org/W2963531283","https://openalex.org/W2973093541","https://openalex.org/W3005884664","https://openalex.org/W3008334529","https://openalex.org/W3017276068","https://openalex.org/W3022382574","https://openalex.org/W3031907375","https://openalex.org/W3036363797","https://openalex.org/W3044428548","https://openalex.org/W3045056638","https://openalex.org/W3049519705","https://openalex.org/W3080351627","https://openalex.org/W3118909662","https://openalex.org/W3120218865","https://openalex.org/W3132024224","https://openalex.org/W3161404642","https://openalex.org/W3179744329","https://openalex.org/W3196097976","https://openalex.org/W3197332688","https://openalex.org/W3202710049","https://openalex.org/W3206349742","https://openalex.org/W3207200577","https://openalex.org/W3211471395","https://openalex.org/W3217299719","https://openalex.org/W4210580871","https://openalex.org/W4281773109","https://openalex.org/W4281797937","https://openalex.org/W4296741338","https://openalex.org/W4297691593","https://openalex.org/W4313531093","https://openalex.org/W4362715619","https://openalex.org/W4388857728","https://openalex.org/W4392956639","https://openalex.org/W4404436573","https://openalex.org/W4404487676","https://openalex.org/W4409737484","https://openalex.org/W4410808156","https://openalex.org/W4413309655","https://openalex.org/W4416624813","https://openalex.org/W7128716658","https://openalex.org/W7130711262","https://openalex.org/W7155099732"],"related_works":[],"abstract_inverted_index":{"Coffee":[0],"is":[1,12,92,121],"a":[2,27,56,176],"chemically":[3],"heterogeneous":[4],"dietary":[5],"exposure":[6],"whose":[7],"association":[8],"with":[9,109,143],"healthy":[10],"aging":[11],"epidemiologically":[13],"consistent":[14],"but":[15,133],"mechanistically":[16],"unresolved.":[17],"This":[18],"critical":[19],"hypothesis":[20],"review":[21],"proposes":[22],"the":[23],"Coffee\u2013Gut\u2013Redox":[24],"Axis":[25],"(CGRA),":[26],"branched,":[28],"falsifiable":[29],"model":[30],"that":[31],"has":[32],"not":[33,135],"yet":[34],"been":[35],"causally":[36],"validated":[37],"in":[38],"humans.":[39],"In":[40],"this":[41],"model,":[42],"roast-,":[43],"brew-,":[44],"and":[45,53,62,67,76,87,102,104,152,168,175],"processing-dependent":[46],"delivery":[47],"of":[48,123],"chlorogenic":[49,71],"acids,":[50],"melanoidins/fiber,":[51],"caffeine":[52],"trigonelline":[54],"engages":[55],"microbiome-dependent":[57],"arm":[58],"(colonic":[59],"phenolic":[60],"catabolism":[61],"short-chain":[63],"fatty":[64],"acid":[65,72],"production)":[66],"microbiome-independent":[68],"arms":[69],"(proximal":[70],"absorption,":[73],"caffeine\u2013adenosine":[74],"signaling":[75],"trigonelline-supported":[77],"nicotinamide":[78],"adenine":[79],"dinucleotide":[80],"synthesis),":[81],"which":[82,154],"converge":[83],"on":[84],"context-dependent":[85],"redox":[86],"inflammatory":[88],"signaling.":[89],"Each":[90],"linkage":[91],"graded":[93],"separately":[94],"for":[95,172],"association,":[96],"human":[97,118],"target":[98],"engagement,":[99],"preclinical":[100],"plausibility":[101],"mediation,":[103],"experimental":[105],"concentrations":[106],"are":[107,155],"compared":[108],"exposures":[110],"achievable":[111],"from":[112],"brewed":[113],"coffee.":[114],"The":[115],"most":[116],"reproducible":[117],"microbial":[119,131],"signal":[120],"enrichment":[122],"Lawsonibacter":[124],"asaccharolyticus;":[125],"small":[126],"interventions":[127],"show":[128],"partly":[129],"caffeine-independent":[130],"remodeling":[132],"have":[134],"tested":[136],"mediation.":[137],"Prospective":[138],"cohorts":[139],"report":[140],"concordant":[141],"associations":[142],"mortality,":[144],"type":[145],"2":[146],"diabetes,":[147],"liver":[148],"fibrosis,":[149],"Parkinson":[150],"disease,":[151],"frailty,":[153],"treated":[156],"as":[157],"concordance":[158],"rather":[159],"than":[160],"validation.":[161],"We":[162],"specify":[163],"refutation":[164],"criteria,":[165],"safety,":[166],"intolerance":[167],"allergen":[169],"considerations,":[170],"requirements":[171],"coffee-derived":[173],"nutraceuticals,":[174],"standardized,":[177],"multi-arm,":[178],"multi-omic":[179],"trial":[180],"architecture.":[181]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-11T00:00:00"}
