{"id":"https://openalex.org/W7225751464","doi":"https://doi.org/10.64898/2026.11.08.763706","title":"Bacterial-Mimetic Membranes Reveal Hopanoid-Associated Domain-Like Lateral Heterogeneity","display_name":"Bacterial-Mimetic Membranes Reveal Hopanoid-Associated Domain-Like Lateral Heterogeneity","publication_year":2026,"publication_date":"2026-11-10","ids":{"openalex":"https://openalex.org/W7225751464","doi":"https://doi.org/10.64898/2026.11.08.763706"},"language":"en","primary_location":{"id":"doi:10.64898/2026.11.08.763706","doi":"https://doi.org/10.64898/2026.11.08.763706","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.11.08.763706","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.64898/2026.11.08.763706","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049854583","display_name":"Mateusz Rzycki","orcid":"https://orcid.org/0000-0003-3655-3048","observed_orcids":["https://orcid.org/0000-0003-3655-3048"]},"institutions":[{"id":"https://openalex.org/I11923345","display_name":"Wroc\u0142aw University of Science and Technology","ror":"https://ror.org/008fyn775","country_code":"PL","type":"education","lineage":["https://openalex.org/I11923345"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Mateusz Rzycki","raw_affiliation_strings":["Wroclaw University of Science and Technology;"],"raw_orcid":"https://orcid.org/0000-0003-3655-3048","affiliations":[{"raw_affiliation_string":"Wroclaw University of Science and Technology;","institution_ids":["https://openalex.org/I11923345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5134620646","display_name":"Maxime Kucharski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I11923345","display_name":"Wroc\u0142aw University of Science and Technology","ror":"https://ror.org/008fyn775","country_code":"PL","type":"education","lineage":["https://openalex.org/I11923345"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Maxime Kucharski","raw_affiliation_strings":["Department of Biomedical Engineering, Wroclaw University of Science and Technology;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Wroclaw University of Science and Technology;","institution_ids":["https://openalex.org/I11923345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045659226","display_name":"Natalia Szulc","orcid":"https://orcid.org/0000-0003-2951-1827","observed_orcids":["https://orcid.org/0000-0003-2951-1827"]},"institutions":[{"id":"https://openalex.org/I27912750","display_name":"Wroc\u0142aw University of Environmental and Life Sciences","ror":"https://ror.org/05cs8k179","country_code":"PL","type":"education","lineage":["https://openalex.org/I27912750"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Natalia Szulc","raw_affiliation_strings":["Department of Physics and Biophysics, Wroclaw University of Environmental and Life Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physics and Biophysics, Wroclaw University of Environmental and Life Sciences","institution_ids":["https://openalex.org/I27912750"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011248729","display_name":"Dominik Drabik","orcid":"https://orcid.org/0000-0003-4568-4066","observed_orcids":["https://orcid.org/0000-0003-4568-4066"]},"institutions":[{"id":"https://openalex.org/I11923345","display_name":"Wroc\u0142aw University of Science and Technology","ror":"https://ror.org/008fyn775","country_code":"PL","type":"education","lineage":["https://openalex.org/I11923345"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Dominik Drabik","raw_affiliation_strings":["Wroclaw University of Science and Technology;"],"raw_orcid":"https://orcid.org/0000-0003-4568-4066","affiliations":[{"raw_affiliation_string":"Wroclaw University of Science and Technology;","institution_ids":["https://openalex.org/I11923345"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12793","display_name":"Caveolin-1 and cellular processes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.8727999925613403},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.630299985408783},{"id":"https://openalex.org/C130316041","wikidata":"https://www.wikidata.org/wiki/Q189206","display_name":"Vesicle","level":3,"score":0.5985999703407288},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.49950000643730164},{"id":"https://openalex.org/C2776330855","wikidata":"https://www.wikidata.org/wiki/Q650187","display_name":"Phosphatidylcholine","level":4,"score":0.4607999920845032},{"id":"https://openalex.org/C96347405","wikidata":"https://www.wikidata.org/wiki/Q16863771","display_name":"Membrane biophysics","level":4,"score":0.45260000228881836},{"id":"https://openalex.org/C125501631","wikidata":"https://www.wikidata.org/wiki/Q1587185","display_name":"Biological membrane","level":3,"score":0.4260999858379364},{"id":"https://openalex.org/C39944091","wikidata":"https://www.wikidata.org/wiki/Q423279","display_name":"Lipid bilayer","level":3,"score":0.42399999499320984},{"id":"https://openalex.org/C59593255","wikidata":"https://www.wikidata.org/wiki/Q901663","display_name":"Molecular dynamics","level":2,"score":0.3628000020980835},{"id":"https://openalex.org/C159467904","wikidata":"https://www.wikidata.org/wiki/Q2001702","display_name":"Chemical physics","level":1,"score":0.3549000024795532},{"id":"https://openalex.org/C73099012","wikidata":"https://www.wikidata.org/wiki/Q5459050","display_name":"Flexural rigidity","level":2,"score":0.34279999136924744},{"id":"https://openalex.org/C122398194","wikidata":"https://www.wikidata.org/wiki/Q6815129","display_name":"Membrane fluidity","level":3,"score":0.33809998631477356},{"id":"https://openalex.org/C142874826","wikidata":"https://www.wikidata.org/wiki/Q5353574","display_name":"Elasticity of cell membranes","level":5,"score":0.3239000141620636},{"id":"https://openalex.org/C107565407","wikidata":"https://www.wikidata.org/wiki/Q6815134","display_name":"Membrane lipids","level":3,"score":0.32019999623298645},{"id":"https://openalex.org/C2778106830","wikidata":"https://www.wikidata.org/wiki/Q29548","display_name":"Cell membrane","level":3,"score":0.31450000405311584},{"id":"https://openalex.org/C160343418","wikidata":"https://www.wikidata.org/wiki/Q185256","display_name":"Rigidity (electromagnetism)","level":2,"score":0.3093000054359436},{"id":"https://openalex.org/C144647389","wikidata":"https://www.wikidata.org/wiki/Q423042","display_name":"Membrane protein","level":3,"score":0.30630001425743103},{"id":"https://openalex.org/C2780841128","wikidata":"https://www.wikidata.org/wiki/Q5073781","display_name":"Characterization (materials science)","level":2,"score":0.29660001397132874},{"id":"https://openalex.org/C2780727160","wikidata":"https://www.wikidata.org/wiki/Q1500907","display_name":"Membrane structure","level":3,"score":0.2784000039100647},{"id":"https://openalex.org/C87210426","wikidata":"https://www.wikidata.org/wiki/Q1072476","display_name":"Bending","level":2,"score":0.2721000015735626},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.2669999897480011},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.25110000371932983}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.11.08.763706","doi":"https://doi.org/10.64898/2026.11.08.763706","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.11.08.763706","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.11.08.763706","doi":"https://doi.org/10.64898/2026.11.08.763706","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.11.08.763706","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Bacterial":[0],"membranes":[1,187],"are":[2,53,72,131],"increasingly":[3],"recognized":[4],"as":[5],"laterally":[6,67,145],"heterogeneous":[7],"assemblies":[8],"whose":[9,194],"local":[10,196,218],"organization":[11],"can":[12,188],"regulate":[13],"transport,":[14],"stress":[15],"adaptation,":[16],"and":[17,49,77,125,136,147,176,216,221],"interactions":[18],"with":[19],"membrane-active":[20],"compounds.":[21],"However,":[22],"the":[23,153,156],"physical":[24,69,192],"principles":[25],"by":[26,89],"which":[27,104],"bacterial":[28],"lipid":[29,86,90,150],"composition":[30],"generates":[31],"spatially":[32],"distinct":[33,68,195],"membrane":[34,63,117,158,178,201,214],"environments":[35,70,118,193],"remain":[36,143],"poorly":[37],"understood,":[38],"partly":[39],"because":[40],"experimentally":[41],"tractable":[42],"models":[43],"that":[44,58,71,184],"reproducibly":[45],"exhibit":[46,99,148],"lateral":[47,102],"segregation":[48],"permit":[50],"quantitative":[51,209],"characterization":[52],"limited.":[54],"Here,":[55],"we":[56],"show":[57],"a":[59,85,164,208],"multicomponent,":[60],"hopanoid-containing":[61,185],"bacterial-inspired":[62,157,186],"spontaneously":[64,189],"self-organizes":[65],"into":[66],"consistently":[73],"resolved":[74],"in":[75,93,108,120],"experiments":[76],"molecular":[78,112],"simulations.":[79,114],"Giant":[80],"unilamellar":[81],"vesicles":[82],"prepared":[83],"from":[84],"mixture":[87],"inspired":[88],"classes":[91],"found":[92],"hopanoid-producing":[94],"bacteria,":[95],"including":[96],"Methylorubrum":[97],"extorquens,":[98],"stable":[100],"micron-scale":[101],"segregation,":[103],"is":[105],"independently":[106,171],"reproduced":[107],"compositionally":[109],"matched":[110],"coarse-grained":[111],"dynamics":[113],"The":[115,203],"resulting":[116,204],"differ":[119],"composition,":[121,219],"packing,":[122],"order,":[123],"mobility,":[124],"mechanical":[126],"properties.":[127],"Hopanoid-associated":[128],"domain-like":[129],"regions":[130,142],"more":[132,134,144],"condensed,":[133],"ordered,":[135],"less":[137],"mobile,":[138],"whereas":[139],"PE-rich":[140],"non-domain":[141],"expanded":[146],"faster":[149],"diffusion.":[151],"At":[152],"global":[154,200],"level,":[155],"displays":[159],"greater":[160],"bending":[161],"rigidity":[162],"than":[163],"fluid":[165],"phosphatidylcholine":[166],"reference,":[167],"while":[168],"ATR-FTIR":[169],"measurements":[170],"support":[172],"increased":[173],"lipid-chain":[174],"ordering":[175],"denser":[177],"packing.":[179],"Together,":[180],"these":[181],"findings":[182],"establish":[183],"generate":[190],"coexisting":[191],"properties":[197],"collectively":[198],"determine":[199],"behavior.":[202],"experimental-computational":[205],"framework":[206],"provides":[207],"basis":[210],"for":[211],"investigating":[212],"bacterial-like":[213],"heterogeneity":[215],"how":[217],"dynamics,":[220],"mechanics":[222],"govern":[223],"responses":[224],"to":[225],"membrane-targeting":[226],"perturbations.":[227]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-11T00:00:00"}
