{"id":"https://openalex.org/W7225751133","doi":"https://doi.org/10.54254/2753-8818/2026.hz38838","title":"M echanisms of R esistance to A tezolizumab C ombined with B evacizumab ( a +T) T herapy in A dvanced H epatocellular C arcinoma","display_name":"M echanisms of R esistance to A tezolizumab C ombined with B evacizumab ( a +T) T herapy in A dvanced H epatocellular C arcinoma","publication_year":2026,"publication_date":"2026-11-10","ids":{"openalex":"https://openalex.org/W7225751133","doi":"https://doi.org/10.54254/2753-8818/2026.hz38838"},"language":"en","primary_location":{"id":"doi:10.54254/2753-8818/2026.hz38838","doi":"https://doi.org/10.54254/2753-8818/2026.hz38838","is_oa":true,"landing_page_url":"https://doi.org/10.54254/2753-8818/2026.hz38838","pdf_url":"https://tns.ewapub.com/article/view/38838.pdf","source":{"id":"https://openalex.org/S4387283303","display_name":"Theoretical and Natural Science","issn_l":"2753-8818","issn":["2753-8818","2753-8826"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Theoretical and Natural Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://tns.ewapub.com/article/view/38838.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5161378150","display_name":"Xiru Huang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I21741975","display_name":"Suzhou University of Technology","ror":"https://ror.org/05g6ben79","country_code":"CN","type":"education","lineage":["https://openalex.org/I21741975"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiru Huang","raw_affiliation_strings":["Suzhou University of Technology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Suzhou University of Technology","institution_ids":["https://openalex.org/I21741975"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5161378150"],"corresponding_institution_ids":["https://openalex.org/I21741975"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"191","issue":"1","first_page":"None","last_page":"None"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.9307000041007996,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.9307000041007996,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.0658000037074089,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.5746999979019165},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5526000261306763},{"id":"https://openalex.org/C2775949291","wikidata":"https://www.wikidata.org/wiki/Q20707748","display_name":"Atezolizumab","level":5,"score":0.4611999988555908},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.43459999561309814},{"id":"https://openalex.org/C2777977315","wikidata":"https://www.wikidata.org/wiki/Q7243056","display_name":"Primary (astronomy)","level":2,"score":0.4115999937057495},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.39969998598098755},{"id":"https://openalex.org/C2777802072","wikidata":"https://www.wikidata.org/wiki/Q413299","display_name":"Bevacizumab","level":3,"score":0.37779998779296875},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.3668000102043152},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.3652999997138977},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.36149999499320984},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.36070001125335693},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.35760000348091125},{"id":"https://openalex.org/C64903051","wikidata":"https://www.wikidata.org/wiki/Q2198549","display_name":"Drug development","level":3,"score":0.32440000772476196},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3190000057220459},{"id":"https://openalex.org/C2994294914","wikidata":"https://www.wikidata.org/wiki/Q1645075","display_name":"Acquired resistance","level":3,"score":0.31279999017715454},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.29339998960494995},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2881999909877777},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.2752000093460083},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.2644999921321869},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.2644999921321869},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.2637999951839447},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2637999951839447},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.25209999084472656}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.54254/2753-8818/2026.hz38838","doi":"https://doi.org/10.54254/2753-8818/2026.hz38838","is_oa":true,"landing_page_url":"https://doi.org/10.54254/2753-8818/2026.hz38838","pdf_url":"https://tns.ewapub.com/article/view/38838.pdf","source":{"id":"https://openalex.org/S4387283303","display_name":"Theoretical and Natural Science","issn_l":"2753-8818","issn":["2753-8818","2753-8826"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Theoretical and Natural Science","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.54254/2753-8818/2026.hz38838","doi":"https://doi.org/10.54254/2753-8818/2026.hz38838","is_oa":true,"landing_page_url":"https://doi.org/10.54254/2753-8818/2026.hz38838","pdf_url":"https://tns.ewapub.com/article/view/38838.pdf","source":{"id":"https://openalex.org/S4387283303","display_name":"Theoretical and Natural Science","issn_l":"2753-8818","issn":["2753-8818","2753-8826"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Theoretical and Natural Science","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225751133.pdf","grobid_xml":"https://content.openalex.org/works/W7225751133.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Hepatocellular":[0],"carcinoma":[1],"has":[2],"a":[3,32,55,134,173,182],"high":[4],"degree":[5],"of":[6,9,68,85,92,100,137],"malignancy,":[7],"most":[8],"which":[10,44],"have":[11],"been":[12],"diagnosed":[13],"in":[14,111,149,160],"the":[15,24,47,65,83,90,98,112,146,161],"middle":[16],"and":[17,20,38,64,72,88,94,108,128,140,154,157,164,180],"late":[18],"stages,":[19],"systematic":[21,62],"treatment":[22],"is":[23,31,133],"main":[25],"treatment.":[26],"Atezolizumab":[27],"combined":[28],"with":[29,82],"bevacizumab":[30],"first-line":[33],"standard":[34],"regimen,":[35],"but":[36],"primary":[37,69,93,152],"secondary":[39,95],"drug":[40,70,86,96,121],"resistance":[41,71,122,132],"occurs":[42],"frequently,":[43],"seriously":[45],"affects":[46],"long-term":[48],"efficacy.":[49],"The":[50,116],"existing":[51],"research":[52],"focuses":[53],"on":[54],"single":[56],"pathway":[57],"or":[58],"cell":[59,102],"subsets,":[60],"lacks":[61],"integration,":[63,151],"core":[66],"factors":[67],"clinical":[73,155],"classification":[74,84,175],"system":[75],"are":[76,114],"still":[77],"unclear.":[78],"This":[79,142],"article":[80],"starts":[81],"resistance,":[87],"compares":[89],"characteristics":[91],"resistance;":[97],"mechanisms":[99],"myeloid":[101],"remodeling,":[103],"adaptive":[104],"immunity,":[105],"immune":[106],"rejection":[107],"tumor":[109],"dedifferentiation":[110],"microenvironment":[113],"described.":[115],"three":[117],"signal":[118],"axes":[119],"drive":[120],"through":[123],"metabolic":[124],"reprogramming,":[125],"oxidative":[126],"stress":[127],"macrophage":[129],"polarization.":[130],"Drug":[131],"dynamic":[135],"process":[136],"molecular":[138],"abnormalities":[139],"immunosuppression.":[141],"paper":[143],"points":[144],"out":[145],"current":[147],"deficiencies":[148],"mechanism":[150],"initiation":[153],"classification,":[156],"proposes":[158],"that":[159],"future,":[162],"multi-omics":[163],"spatial":[165],"transcriptome":[166],"technology":[167],"should":[168],"be":[169],"used":[170],"to":[171],"construct":[172],"multi-dimensional":[174],"system,":[176],"explore":[177],"intervention":[178],"targets,":[179],"provide":[181],"theoretical":[183],"reference":[184],"for":[185],"individualized":[186],"reversal":[187],"strategies.":[188]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-11T00:00:00"}
