{"id":"https://openalex.org/W7225750262","doi":"https://doi.org/10.3389/fneur.2026.1834725","title":"Blood transcriptome change after deep brain stimulation in Parkinson\u2019s disease","display_name":"Blood transcriptome change after deep brain stimulation in Parkinson\u2019s disease","publication_year":2026,"publication_date":"2026-11-10","ids":{"openalex":"https://openalex.org/W7225750262","doi":"https://doi.org/10.3389/fneur.2026.1834725"},"language":"en","primary_location":{"id":"doi:10.3389/fneur.2026.1834725","doi":"https://doi.org/10.3389/fneur.2026.1834725","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fneur.2026.1834725","pdf_url":"https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2026.1834725/pdf","source":{"id":"https://openalex.org/S96975567","display_name":"Frontiers in Neurology","issn_l":"1664-2295","issn":["1664-2295"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Neurology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2026.1834725/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011510430","display_name":"Jong Hyeon Ahn","orcid":"https://orcid.org/0000-0002-6415-2316","observed_orcids":["https://orcid.org/0000-0002-6415-2316"]},"institutions":[{"id":"https://openalex.org/I2802194831","display_name":"Samsung Medical Center","ror":"https://ror.org/05a15z872","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2250650973","https://openalex.org/I2802194831"]},{"id":"https://openalex.org/I848706","display_name":"Sungkyunkwan University","ror":"https://ror.org/04q78tk20","country_code":"KR","type":"education","lineage":["https://openalex.org/I848706"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jong Hyeon Ahn","raw_affiliation_strings":["Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine","Neuroscience Center, Samsung Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine","institution_ids":["https://openalex.org/I2802194831","https://openalex.org/I848706"]},{"raw_affiliation_string":"Neuroscience Center, Samsung Medical Center","institution_ids":["https://openalex.org/I2802194831"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100783483","display_name":"Jong-Ho Park","orcid":"https://orcid.org/0000-0001-5883-8322","observed_orcids":["https://orcid.org/0000-0001-5883-8322"]},"institutions":[{"id":"https://openalex.org/I2802194831","display_name":"Samsung Medical Center","ror":"https://ror.org/05a15z872","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2250650973","https://openalex.org/I2802194831"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jong-Ho Park","raw_affiliation_strings":["Clinical Genomics Center, Samsung Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Genomics Center, Samsung Medical Center","institution_ids":["https://openalex.org/I2802194831"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161383329","display_name":"Ja-Hyun Jang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802194831","display_name":"Samsung Medical Center","ror":"https://ror.org/05a15z872","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2250650973","https://openalex.org/I2802194831"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Ja-Hyun Jang","raw_affiliation_strings":["Department of Laboratory Medicine and Genetics, Samsung Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine and Genetics, Samsung Medical Center","institution_ids":["https://openalex.org/I2802194831"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068806174","display_name":"Jin Whan Cho","orcid":"https://orcid.org/0000-0002-9145-6729","observed_orcids":["https://orcid.org/0000-0002-9145-6729"]},"institutions":[{"id":"https://openalex.org/I2802194831","display_name":"Samsung Medical Center","ror":"https://ror.org/05a15z872","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2250650973","https://openalex.org/I2802194831"]},{"id":"https://openalex.org/I848706","display_name":"Sungkyunkwan University","ror":"https://ror.org/04q78tk20","country_code":"KR","type":"education","lineage":["https://openalex.org/I848706"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jin Whan Cho","raw_affiliation_strings":["Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine","Neuroscience Center, Samsung Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine","institution_ids":["https://openalex.org/I2802194831","https://openalex.org/I848706"]},{"raw_affiliation_string":"Neuroscience Center, Samsung Medical Center","institution_ids":["https://openalex.org/I2802194831"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5146593582","display_name":"Jung Il Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802194831","display_name":"Samsung Medical Center","ror":"https://ror.org/05a15z872","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2250650973","https://openalex.org/I2802194831"]},{"id":"https://openalex.org/I848706","display_name":"Sungkyunkwan University","ror":"https://ror.org/04q78tk20","country_code":"KR","type":"education","lineage":["https://openalex.org/I848706"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jung Il Lee","raw_affiliation_strings":["Department of Neurosurgery, Samsung Medical Center, Sungkyunkwan University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Samsung Medical Center, Sungkyunkwan University School of Medicine","institution_ids":["https://openalex.org/I2802194831","https://openalex.org/I848706"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052627702","display_name":"Alfonso A. Fasano","orcid":"https://orcid.org/0000-0001-5346-0180","observed_orcids":["https://orcid.org/0000-0001-5346-0180"]},"institutions":[{"id":"https://openalex.org/I1339471597","display_name":"Humanitas University","ror":"https://ror.org/020dggs04","country_code":"IT","type":"education","lineage":["https://openalex.org/I1339471597"]},{"id":"https://openalex.org/I4210163047","display_name":"IRCCS Humanitas Research Hospital","ror":"https://ror.org/05d538656","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210163047"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alfonso Fasano","raw_affiliation_strings":["Department of Biomedical Sciences, Humanitas University","IRCCS Humanitas Research Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, Humanitas University","institution_ids":["https://openalex.org/I1339471597"]},{"raw_affiliation_string":"IRCCS Humanitas Research Hospital","institution_ids":["https://openalex.org/I4210163047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010345069","display_name":"Wooyoung Jang","orcid":"https://orcid.org/0000-0002-4808-7083","observed_orcids":["https://orcid.org/0000-0002-4808-7083"]},"institutions":[{"id":"https://openalex.org/I40542001","display_name":"University of Ulsan","ror":"https://ror.org/02c2f8975","country_code":"KR","type":"education","lineage":["https://openalex.org/I40542001"]},{"id":"https://openalex.org/I4210139505","display_name":"Gangneung Asan Hospital","ror":"https://ror.org/03pw3x387","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210139505","https://openalex.org/I4210167194"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Wooyoung Jang","raw_affiliation_strings":["Department of Neurology, Gangneung Asan Hospital, University of Ulsan College of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Gangneung Asan Hospital, University of Ulsan College of Medicine","institution_ids":["https://openalex.org/I40542001","https://openalex.org/I4210139505"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090093954","display_name":"Jinyoung Youn","orcid":"https://orcid.org/0000-0003-3350-5032","observed_orcids":["https://orcid.org/0000-0003-3350-5032"]},"institutions":[{"id":"https://openalex.org/I2802194831","display_name":"Samsung Medical Center","ror":"https://ror.org/05a15z872","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2250650973","https://openalex.org/I2802194831"]},{"id":"https://openalex.org/I848706","display_name":"Sungkyunkwan University","ror":"https://ror.org/04q78tk20","country_code":"KR","type":"education","lineage":["https://openalex.org/I848706"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Jinyoung Youn","raw_affiliation_strings":["Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine","Neuroscience Center, Samsung Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine","institution_ids":["https://openalex.org/I2802194831","https://openalex.org/I848706"]},{"raw_affiliation_string":"Neuroscience Center, Samsung Medical Center","institution_ids":["https://openalex.org/I2802194831"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5010345069","https://openalex.org/A5090093954"],"corresponding_institution_ids":["https://openalex.org/I2802194831","https://openalex.org/I40542001","https://openalex.org/I4210139505","https://openalex.org/I848706"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10919","display_name":"Deep Brain Stimulation and Movement Disorders","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10919","display_name":"Deep Brain Stimulation and Movement Disorders","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10614","display_name":"Transcranial Magnetic Stimulation Studies","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C2778542668","wikidata":"https://www.wikidata.org/wiki/Q618076","display_name":"Deep brain stimulation","level":4,"score":0.8413000106811523},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.7505999803543091},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.6553999781608582},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.589900016784668},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.5554999709129333},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.5454000234603882},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.4740000069141388},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4607999920845032},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.45570001006126404},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4302000105381012},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.41830000281333923},{"id":"https://openalex.org/C149364088","wikidata":"https://www.wikidata.org/wiki/Q185917","display_name":"Translation (biology)","level":4,"score":0.41690000891685486},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.40880000591278076},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.39890000224113464},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.3587999939918518},{"id":"https://openalex.org/C107397762","wikidata":"https://www.wikidata.org/wiki/Q2542347","display_name":"RNA-Seq","level":5,"score":0.33719998598098755},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.33379998803138733},{"id":"https://openalex.org/C2777427615","wikidata":"https://www.wikidata.org/wiki/Q954257","display_name":"Degenerative disease","level":3,"score":0.3296999931335449},{"id":"https://openalex.org/C132917006","wikidata":"https://www.wikidata.org/wiki/Q5250436","display_name":"Deep sequencing","level":4,"score":0.32260000705718994},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.2930999994277954},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.2842000126838684},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.27959999442100525},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.27709999680519104},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.2630999982357025},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.26269999146461487},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.251800000667572}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3389/fneur.2026.1834725","doi":"https://doi.org/10.3389/fneur.2026.1834725","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fneur.2026.1834725","pdf_url":"https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2026.1834725/pdf","source":{"id":"https://openalex.org/S96975567","display_name":"Frontiers in Neurology","issn_l":"1664-2295","issn":["1664-2295"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Neurology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.3389/fneur.2026.1834725","doi":"https://doi.org/10.3389/fneur.2026.1834725","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fneur.2026.1834725","pdf_url":"https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2026.1834725/pdf","source":{"id":"https://openalex.org/S96975567","display_name":"Frontiers in Neurology","issn_l":"1664-2295","issn":["1664-2295"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Neurology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225750262.pdf","grobid_xml":"https://content.openalex.org/works/W7225750262.grobid-xml"},"referenced_works_count":15,"referenced_works":["https://openalex.org/W1829183563","https://openalex.org/W1968235279","https://openalex.org/W2066398961","https://openalex.org/W2087829493","https://openalex.org/W2099300133","https://openalex.org/W2135729923","https://openalex.org/W2136645272","https://openalex.org/W2137005364","https://openalex.org/W2584874653","https://openalex.org/W2899566368","https://openalex.org/W3042523037","https://openalex.org/W3042580583","https://openalex.org/W3201532832","https://openalex.org/W3208933594","https://openalex.org/W4391144074"],"related_works":[],"abstract_inverted_index":{"Although":[0],"deep":[1],"brain":[2],"stimulation":[3],"(DBS)":[4],"has":[5],"been":[6],"shown":[7],"to":[8,31,44,53,121,174],"improve":[9],"both":[10],"motor":[11],"and":[12,69,74,100,124,129,133,150,158,178],"non-motor":[13],"symptoms":[14],"in":[15,34,38,117,153],"Parkinson\u2019s":[16],"disease":[17],"(PD)":[18],"patients,":[19],"the":[20,125,130,181],"exact":[21],"mechanism":[22],"of":[23,148,167,185],"action":[24],"remains":[25],"unclear.":[26],"Therefore,":[27],"this":[28],"study":[29,140],"aimed":[30],"investigate":[32],"changes":[33,110],"mRNA":[35,75],"expression":[36],"levels":[37,76],"PD":[39,48],"patients":[40,49],"after":[41,72,96,137],"DBS":[42,55,68,97,143],"compared":[43],"those":[45],"before":[46,67],"DBS.":[47,138,186],"who":[50],"were":[51,56,65,77,111],"scheduled":[52],"undergo":[54],"recruited":[57],"from":[58],"a":[59,114,146],"single":[60],"university":[61],"hospital.":[62],"Blood":[63],"samples":[64],"collected":[66],"3":[70,94],"months":[71,95],"DBS,":[73],"analyzed":[78],"using":[79],"RNA":[80,86],"sequencing.":[81],"Across":[82],"eight":[83],"patient":[84],"pairs,":[85],"sequencing":[87],"identified":[88],"18":[89],"differentially":[90],"expressed":[91],"genes":[92],"at":[93],"(17":[98],"downregulated":[99],"1":[101],"upregulated).":[102],"Gene":[103],"set":[104],"enrichment":[105],"analysis":[106],"showed":[107],"that":[108,142],"these":[109,176],"dominated":[112],"by":[113],"coordinated":[115],"reduction":[116],"gene":[118],"sets":[119],"related":[120],"cytoplasmic":[122],"translation":[123],"ribosome,":[126],"oxidative":[127],"phosphorylation":[128],"respiratory":[131],"chain,":[132],"neutrophil-associated":[134],"inflammatory":[135,159],"functions":[136],"This":[139],"suggests":[141],"could":[144],"influence":[145],"variety":[147],"molecular":[149],"cellular":[151],"processes":[152],"PD,":[154],"including":[155],"translational,":[156],"mitochondrial-bioenergetic,":[157],"programs,":[160],"providing":[161],"insights":[162],"into":[163],"its":[164],"potential":[165,182],"mechanisms":[166],"action.":[168],"Further":[169],"larger-scale":[170],"studies":[171],"are":[172],"needed":[173],"confirm":[175],"findings":[177],"fully":[179],"elucidate":[180],"neuroprotective":[183],"effect":[184]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-11T00:00:00"}
