{"id":"https://openalex.org/W7225750151","doi":"https://doi.org/10.5281/zenodo.24102873","title":"Dihydroartemisinin-Piperaquine Based Post Discharge Malaria Chemoprevention Improved Parasite Clearance and Haemoglobin Recovery in Children","display_name":"Dihydroartemisinin-Piperaquine Based Post Discharge Malaria Chemoprevention Improved Parasite Clearance and Haemoglobin Recovery in Children","publication_year":2026,"publication_date":"2026-11-10","ids":{"openalex":"https://openalex.org/W7225750151","doi":"https://doi.org/10.5281/zenodo.24102873"},"language":"en","primary_location":{"id":"doi:10.5281/zenodo.24102873","doi":"https://doi.org/10.5281/zenodo.24102873","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.24102873","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.5281/zenodo.24102873","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5117511603","display_name":"Preye David Ogbe","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ogbe, Preye D.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5059536840","display_name":"Peter Erigbali","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Erigbali, Peter P.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12402","display_name":"Travel-related health issues","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8712000250816345},{"id":"https://openalex.org/C2778048844","wikidata":"https://www.wikidata.org/wiki/Q12156","display_name":"Malaria","level":2,"score":0.5805000066757202},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.5687000155448914},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.5450999736785889},{"id":"https://openalex.org/C2778059366","wikidata":"https://www.wikidata.org/wiki/Q707939","display_name":"Artesunate","level":4,"score":0.5184000134468079},{"id":"https://openalex.org/C2777288759","wikidata":"https://www.wikidata.org/wiki/Q4164182","display_name":"Dosing","level":2,"score":0.4959999918937683},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.413100004196167},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.3986000120639801},{"id":"https://openalex.org/C2775867548","wikidata":"https://www.wikidata.org/wiki/Q1897162","display_name":"Parasitemia","level":4,"score":0.3490000069141388},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.34470000863075256},{"id":"https://openalex.org/C2778534260","wikidata":"https://www.wikidata.org/wiki/Q218706","display_name":"Erythropoietin","level":2,"score":0.3264000117778778},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.3086000084877014},{"id":"https://openalex.org/C2778248108","wikidata":"https://www.wikidata.org/wiki/Q5445","display_name":"Anemia","level":2,"score":0.29350000619888306},{"id":"https://openalex.org/C71928629","wikidata":"https://www.wikidata.org/wiki/Q804206","display_name":"Parasite hosting","level":2,"score":0.2867000102996826},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2700999975204468},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.25679999589920044},{"id":"https://openalex.org/C2776793103","wikidata":"https://www.wikidata.org/wiki/Q419834","display_name":"Primaquine","level":4,"score":0.25290000438690186},{"id":"https://openalex.org/C500440147","wikidata":"https://www.wikidata.org/wiki/Q701216","display_name":"Pharmacotherapy","level":2,"score":0.250900000333786}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.5281/zenodo.24102873","doi":"https://doi.org/10.5281/zenodo.24102873","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.24102873","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},{"id":"doi:10.5281/zenodo.24102874","doi":"https://doi.org/10.5281/zenodo.24102874","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.24102874","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"}],"best_oa_location":{"id":"doi:10.5281/zenodo.24102873","doi":"https://doi.org/10.5281/zenodo.24102873","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.24102873","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Severe":[0],"malarial":[1,39],"anaemia":[2,172],"(SMA)":[3],"remains":[4],"a":[5,140,317],"leading":[6],"cause":[7],"of":[8,32,100,134,143,208,284,321],"paediatric":[9],"hospitalisation":[10],"and":[11,45,71,109,116,132,145,163,186,266,304,328,335],"mortality":[12],"in":[13,17,35,122,219,231],"sub-Saharan":[14],"Africa,":[15],"particularly":[16],"high-transmission":[18],"settings":[19],"such":[20],"as":[21,148],"Nigeria's":[22],"Niger":[23,66],"Delta":[24,67],"region.":[25],"This":[26],"study":[27,53],"evaluated":[28],"the":[29,103,129,149,153,205,220,232,281,296,305],"clinical":[30],"efficacy":[31],"dihydroartemisinin\u2013piperaquine":[33],"(DHAPQ)":[34],"children":[36,58,289],"with":[37,62,102,195,288,331],"severe":[38],"anaemia;,":[40],"by":[41,83],"assessing":[42],"parasite":[43,161,180,193,196,258,333],"clearance":[44,162],"haemoglobin":[46,164,174,267,337],"recovery.":[47,165,338],"A":[48],"prospective,":[49],"randomized,":[50],"open-label":[51],"comparative":[52],"was":[54,228,307,315,325,329],"conducted":[55],"involving":[56],"108":[57],"aged":[59],"6\u201359":[60],"months":[61],"SMA":[63],"recruited":[64],"from":[65],"University":[68],"Teaching":[69],"Hospital":[70],"Bayelsa":[72],"State":[73],"Specialist":[74],"Hospital.":[75],"After":[76],"completing":[77],"standard":[78],"treatment":[79,251,285,314,322],"intravenous":[80],"artesunate":[81],"followed":[82],"an":[84],"oral":[85],"artemisinin-based":[86],"combination":[87],"therapy":[88],"(ACT)],":[89],"participants":[90],"were":[91],"randomly":[92],"allocated":[93],"to":[94,199,214],"receive":[95,293],"either":[96],"four":[97],"3-day":[98],"courses":[99,111],"DHA-PQ,":[101],"first":[104],"course":[105,212],"administered":[106],"at":[107],"discharge":[108,119],"subsequent":[110],"during":[112],"weeks":[113],"2\u20133,":[114],"6\u20137":[115],"10\u201311":[117],"after":[118,204],"(12":[120],"doses":[121,135],"total":[123],"over":[124],"approximately":[125],"3":[126],"months;":[127],"verify":[128],"dosing":[130],"schedule":[131,155],"number":[133],"per":[136],"course)":[137],"(n=71),":[138],"or":[139],"placebo":[141],"comparator":[142],"paracetamol":[144],"vitamin":[146],"C":[147],"control":[150,221],"regimen":[151],"on":[152],"same":[154],"(control,":[156],"n=37).":[157],"Outcomes":[158],"measured":[159],"included":[160],"Baseline":[166,168],"characteristics":[167,169],"showed":[170],"profound":[171],"(mean":[173],"3.8":[175],"\u00b1":[176,183,201,216,236,241],"0.5":[177],"g/dL),":[178],"high":[179],"density":[181,197,259],"(60,864":[182],"8,096":[184],"parasites/\u03bcL),":[185],"significant":[187,309,318],"nutritional":[188],"heterogeneity.":[189],"DHA-PQ":[190,233,250,277,313,324],"demonstrated":[191],"superior":[192],"clearance,":[194,334],"falling":[198],"113":[200],"93":[202],"parasites/\u03bcL":[203,218],"third":[206,211],"dose":[207],"week":[209],"6-7,":[210],"(compared":[213],"1,245":[215],"866":[217],"group":[222,234],"(p":[223,310],"<":[224,245,264],"0.001).":[225,246],"Haemoglobin":[226],"recovery":[227],"significantly":[229],"greater":[230,336],"(7.1":[235],"0.8":[237],"g/dL":[238],"vs":[239],"6.2":[240],"0.9":[242],"g/dL;":[243],"p":[244,255,263,271],"Logistic":[247],"regression":[248],"identified":[249],"(AOR":[252,260,268],"=":[253,256,261,269,272,311],"3.84,":[254],"0.008),":[257,312],"0.62,":[262],"0.001),":[265],"1.56,":[270],"0.002).":[273],"Children":[274],"who":[275,290],"received":[276],"had":[278],"3.84":[279],"times":[280],"adjusted":[282],"odds":[283],"success":[286],"compared":[287],"did":[291],"not":[292,301],"DHAPQ.":[294],"Since":[295],"95%":[297],"CI":[298],"(1.42-10.37)":[299],"does":[300],"include":[302],"1":[303],"association":[306],"statistically":[308],"therefore":[316],"positive":[319],"predictor":[320],"success.":[323],"well":[326],"tolerated,":[327],"associated":[330],"faster":[332]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-11T00:00:00"}
