{"id":"https://openalex.org/W7225748902","doi":"https://doi.org/10.64898/2026.11.08.765151","title":"Preclinical Evaluation of a Novel BOC-Modified Triazoloacridinone (TRA-01AR) in Combination with 5-Fluorouracil in Colorectal Cancer","display_name":"Preclinical Evaluation of a Novel BOC-Modified Triazoloacridinone (TRA-01AR) in Combination with 5-Fluorouracil in Colorectal Cancer","publication_year":2026,"publication_date":"2026-11-10","ids":{"openalex":"https://openalex.org/W7225748902","doi":"https://doi.org/10.64898/2026.11.08.765151"},"language":"en","primary_location":{"id":"doi:10.64898/2026.11.08.765151","doi":"https://doi.org/10.64898/2026.11.08.765151","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.11.08.765151","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nd","license_id":"https://openalex.org/licenses/cc-by-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.64898/2026.11.08.765151","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054211044","display_name":"Marta \u015awitalska","orcid":"https://orcid.org/0000-0001-7920-2251","observed_orcids":["https://orcid.org/0000-0001-7920-2251"]},"institutions":[{"id":"https://openalex.org/I4210163977","display_name":"Ludwik Hirszfeld Institute of Immunology and Experimental Therapy","ror":"https://ror.org/05b7p8k90","country_code":"PL","type":"facility","lineage":["https://openalex.org/I4210163977","https://openalex.org/I99542240"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Marta Switalska","raw_affiliation_strings":["Hirszfeld Institute of Immunology and Experimental Therapy Polish Academy of Science, Wroclaw, Poland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hirszfeld Institute of Immunology and Experimental Therapy Polish Academy of Science, Wroclaw, Poland;","institution_ids":["https://openalex.org/I4210163977"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053657963","display_name":"Paulina Czechowicz","orcid":"https://orcid.org/0000-0002-1693-484X","observed_orcids":["https://orcid.org/0000-0002-1693-484X"]},"institutions":[{"id":"https://openalex.org/I219388962","display_name":"University of Wroc\u0142aw","ror":"https://ror.org/00yae6e25","country_code":"PL","type":"education","lineage":["https://openalex.org/I219388962"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Paulina Czechowicz","raw_affiliation_strings":["Department of Biophysics, Faculty of Biotechnology, University of Wroclaw, Wroclaw, Poland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biophysics, Faculty of Biotechnology, University of Wroclaw, Wroclaw, Poland;","institution_ids":["https://openalex.org/I219388962"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044807382","display_name":"Magdalena Milczarek","orcid":"https://orcid.org/0000-0001-6696-5305","observed_orcids":["https://orcid.org/0000-0001-6696-5305"]},"institutions":[{"id":"https://openalex.org/I4210163977","display_name":"Ludwik Hirszfeld Institute of Immunology and Experimental Therapy","ror":"https://ror.org/05b7p8k90","country_code":"PL","type":"facility","lineage":["https://openalex.org/I4210163977","https://openalex.org/I99542240"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Magdalena Milczarek","raw_affiliation_strings":["Hirszfeld Institute of Immunology and Experimental Therapy Polish Academy of Science, Wroclaw, Poland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hirszfeld Institute of Immunology and Experimental Therapy Polish Academy of Science, Wroclaw, Poland;","institution_ids":["https://openalex.org/I4210163977"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024006453","display_name":"Sylwia Bartoszewska","orcid":"https://orcid.org/0000-0001-8063-1272","observed_orcids":["https://orcid.org/0000-0001-8063-1272"]},"institutions":[{"id":"https://openalex.org/I75124487","display_name":"Gda\u0144sk Medical University","ror":"https://ror.org/019sbgd69","country_code":"PL","type":"education","lineage":["https://openalex.org/I75124487"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Sylwia Bartoszewska","raw_affiliation_strings":["Department of Inorganic Chemistry, Medical University of Gdansk, Gdansk, Poland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Inorganic Chemistry, Medical University of Gdansk, Gdansk, Poland;","institution_ids":["https://openalex.org/I75124487"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000580616","display_name":"Beata Filip\u2010Psurska","orcid":"https://orcid.org/0000-0003-2910-5642","observed_orcids":["https://orcid.org/0000-0003-2910-5642"]},"institutions":[{"id":"https://openalex.org/I4210163977","display_name":"Ludwik Hirszfeld Institute of Immunology and Experimental Therapy","ror":"https://ror.org/05b7p8k90","country_code":"PL","type":"facility","lineage":["https://openalex.org/I4210163977","https://openalex.org/I99542240"]},{"id":"https://openalex.org/I99542240","display_name":"Polish Academy of Sciences","ror":"https://ror.org/01dr6c206","country_code":"PL","type":"government","lineage":["https://openalex.org/I99542240"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Beata Filip-Psurska","raw_affiliation_strings":["Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences;"],"raw_orcid":"https://orcid.org/0000-0003-2910-5642","affiliations":[{"raw_affiliation_string":"Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences;","institution_ids":["https://openalex.org/I4210163977","https://openalex.org/I99542240"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161405862","display_name":"Katarzyna Wierzbicka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I219388962","display_name":"University of Wroc\u0142aw","ror":"https://ror.org/00yae6e25","country_code":"PL","type":"education","lineage":["https://openalex.org/I219388962"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Katarzyna Wierzbicka","raw_affiliation_strings":["Department of Biophysics, Faculty of Biotechnology, University of Wroclaw, Wroclaw, Poland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biophysics, Faculty of Biotechnology, University of Wroclaw, Wroclaw, Poland;","institution_ids":["https://openalex.org/I219388962"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068400357","display_name":"Mateusz Psurski","orcid":"https://orcid.org/0000-0001-8866-7149","observed_orcids":["https://orcid.org/0000-0001-8866-7149"]},"institutions":[{"id":"https://openalex.org/I4210163977","display_name":"Ludwik Hirszfeld Institute of Immunology and Experimental Therapy","ror":"https://ror.org/05b7p8k90","country_code":"PL","type":"facility","lineage":["https://openalex.org/I4210163977","https://openalex.org/I99542240"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Mateusz Psurski","raw_affiliation_strings":["Hirszfeld Institute of Immunology and Experimental Therapy Polish Academy of Science, Wroclaw, Poland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hirszfeld Institute of Immunology and Experimental Therapy Polish Academy of Science, Wroclaw, Poland;","institution_ids":["https://openalex.org/I4210163977"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082309267","display_name":"Damian Szczesny","orcid":"https://orcid.org/0000-0002-6914-6206","observed_orcids":["https://orcid.org/0000-0002-6914-6206"]},"institutions":[{"id":"https://openalex.org/I75124487","display_name":"Gda\u0144sk Medical University","ror":"https://ror.org/019sbgd69","country_code":"PL","type":"education","lineage":["https://openalex.org/I75124487"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Damian Szczesny","raw_affiliation_strings":["Department of Biopharmaceutics and Pharmacodynamics, Medical University of Gdansk, Gdansk, Poland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biopharmaceutics and Pharmacodynamics, Medical University of Gdansk, Gdansk, Poland;","institution_ids":["https://openalex.org/I75124487"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053931786","display_name":"Eliza Turlej","orcid":"https://orcid.org/0000-0002-0555-0736","observed_orcids":["https://orcid.org/0000-0002-0555-0736"]},"institutions":[{"id":"https://openalex.org/I4210163977","display_name":"Ludwik Hirszfeld Institute of Immunology and Experimental Therapy","ror":"https://ror.org/05b7p8k90","country_code":"PL","type":"facility","lineage":["https://openalex.org/I4210163977","https://openalex.org/I99542240"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Eliza Turlej","raw_affiliation_strings":["Hirszfeld Institute of Immunology and Experimental Therapy Polish Academy of Science, Wroclaw, Poland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hirszfeld Institute of Immunology and Experimental Therapy Polish Academy of Science, Wroclaw, Poland;","institution_ids":["https://openalex.org/I4210163977"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161399618","display_name":"Karol Krzyminski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40413290","display_name":"University of Gda\u0144sk","ror":"https://ror.org/011dv8m48","country_code":"PL","type":"education","lineage":["https://openalex.org/I40413290"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Karol Krzyminski","raw_affiliation_strings":["Faculty of Chemistry, University of Gdansk, Gdansk, Poland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Chemistry, University of Gdansk, Gdansk, Poland;","institution_ids":["https://openalex.org/I40413290"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112445201","display_name":"Ma\u0142gorzata Gawro\u0144ska","orcid":"https://orcid.org/0000-0001-6918-2197","observed_orcids":["https://orcid.org/0000-0001-6918-2197"]},"institutions":[{"id":"https://openalex.org/I219388962","display_name":"University of Wroc\u0142aw","ror":"https://ror.org/00yae6e25","country_code":"PL","type":"education","lineage":["https://openalex.org/I219388962"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Malgorzata Gawronska","raw_affiliation_strings":["Department of Biophysics, Faculty of Biotechnology, University of Wroclaw, Wroclaw, Poland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biophysics, Faculty of Biotechnology, University of Wroclaw, Wroclaw, Poland;","institution_ids":["https://openalex.org/I219388962"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074012331","display_name":"Magdalena Gebert","orcid":"https://orcid.org/0000-0003-4989-516X","observed_orcids":["https://orcid.org/0000-0003-4989-516X"]},"institutions":[{"id":"https://openalex.org/I4210120768","display_name":"Maj Institute of Pharmacology","ror":"https://ror.org/0288swk05","country_code":"PL","type":"facility","lineage":["https://openalex.org/I4210120768","https://openalex.org/I99542240"]},{"id":"https://openalex.org/I99542240","display_name":"Polish Academy of Sciences","ror":"https://ror.org/01dr6c206","country_code":"PL","type":"government","lineage":["https://openalex.org/I99542240"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Magdalena Gebert","raw_affiliation_strings":["nstitute of Pharmacology, Polish Academy of Sciences, Krakow, Poland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"nstitute of Pharmacology, Polish Academy of Sciences, Krakow, Poland;","institution_ids":["https://openalex.org/I4210120768","https://openalex.org/I99542240"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065923375","display_name":"Leszek Kalinowski","orcid":"https://orcid.org/0000-0001-7270-1592","observed_orcids":["https://orcid.org/0000-0001-7270-1592"]},"institutions":[{"id":"https://openalex.org/I75124487","display_name":"Gda\u0144sk Medical University","ror":"https://ror.org/019sbgd69","country_code":"PL","type":"education","lineage":["https://openalex.org/I75124487"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Leszek Kalinowski","raw_affiliation_strings":["Department of Medical Laboratory Diagnostics-Fahrenheit Biobank BBMRI.pl, Medical University of Gdansk, Gdansk, Poland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Laboratory Diagnostics-Fahrenheit Biobank BBMRI.pl, Medical University of Gdansk, Gdansk, Poland;","institution_ids":["https://openalex.org/I75124487"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058615793","display_name":"David K. Crossman","orcid":"https://orcid.org/0000-0002-0981-169X","observed_orcids":["https://orcid.org/0000-0002-0981-169X"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David K Crossman","raw_affiliation_strings":["Department of Genetics, The UAB Genomics Core Facility, University of Alabama at Birmingham, Birmingham, AL, USA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, The UAB Genomics Core Facility, University of Alabama at Birmingham, Birmingham, AL, USA;","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075050584","display_name":"Maciej Bagi\u0144ski","orcid":"https://orcid.org/0000-0002-6795-7515","observed_orcids":["https://orcid.org/0000-0002-6795-7515"]},"institutions":[{"id":"https://openalex.org/I169333911","display_name":"Gda\u0144sk University of Technology","ror":"https://ror.org/006x4sc24","country_code":"PL","type":"education","lineage":["https://openalex.org/I169333911"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Maciej Baginski","raw_affiliation_strings":["Department of Pharmaceutical Technology and Biochemistry, Faculty of Chemistry, Gdansk University of Technology, Gdansk, Poland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Technology and Biochemistry, Faculty of Chemistry, Gdansk University of Technology, Gdansk, Poland;","institution_ids":["https://openalex.org/I169333911"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161364304","display_name":"Michal Markuszewski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I75124487","display_name":"Gda\u0144sk Medical University","ror":"https://ror.org/019sbgd69","country_code":"PL","type":"education","lineage":["https://openalex.org/I75124487"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Michal Markuszewski","raw_affiliation_strings":["Department of Biopharmaceutics and Pharmacodynamics, Medical University of Gdansk, Gdansk, Poland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biopharmaceutics and Pharmacodynamics, Medical University of Gdansk, Gdansk, Poland;","institution_ids":["https://openalex.org/I75124487"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039708431","display_name":"James F. Collawn","orcid":"https://orcid.org/0000-0002-2528-2759","observed_orcids":["https://orcid.org/0000-0002-2528-2759"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James F Collawn","raw_affiliation_strings":["Department of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, USA, Birmingham, AL 35233;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, USA, Birmingham, AL 35233;","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002720012","display_name":"Liliana Schaefer","orcid":"https://orcid.org/0000-0002-3318-3005","observed_orcids":["https://orcid.org/0000-0002-3318-3005"]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Liliana Schaefer","raw_affiliation_strings":["Institute of Pharmacology and Toxicology, Goethe University Frankfurt, Frankfurt, Germany;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pharmacology and Toxicology, Goethe University Frankfurt, Frankfurt, Germany;","institution_ids":["https://openalex.org/I114090438"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036813232","display_name":"Rafa\u0142 Bartoszewski","orcid":"https://orcid.org/0000-0002-2864-6757","observed_orcids":["https://orcid.org/0000-0002-2864-6757"]},"institutions":[{"id":"https://openalex.org/I219388962","display_name":"University of Wroc\u0142aw","ror":"https://ror.org/00yae6e25","country_code":"PL","type":"education","lineage":["https://openalex.org/I219388962"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Rafal Bartoszewski","raw_affiliation_strings":["Uniwersity of Wroclaw"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Uniwersity of Wroclaw","institution_ids":["https://openalex.org/I219388962"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022446752","display_name":"Joanna Wietrzyk","orcid":"https://orcid.org/0000-0003-4980-6606","observed_orcids":["https://orcid.org/0000-0003-4980-6606"]},"institutions":[{"id":"https://openalex.org/I4210163977","display_name":"Ludwik Hirszfeld Institute of Immunology and Experimental Therapy","ror":"https://ror.org/05b7p8k90","country_code":"PL","type":"facility","lineage":["https://openalex.org/I4210163977","https://openalex.org/I99542240"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Joanna Wietrzyk","raw_affiliation_strings":["Hirszfeld Institute of Immunology and Experimental Therapy Polish Academy of Science, Wroclaw, Poland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hirszfeld Institute of Immunology and Experimental Therapy Polish Academy of Science, Wroclaw, Poland;","institution_ids":["https://openalex.org/I4210163977"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":9,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.9351000189781189,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.9351000189781189,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.019300000742077827,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.01080000028014183,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C2778375690","wikidata":"https://www.wikidata.org/wiki/Q7814214","display_name":"Tolerability","level":3,"score":0.7893999814987183},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.713699996471405},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5716000199317932},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5314000248908997},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4986000061035156},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.46369999647140503},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.42910000681877136},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.42590001225471497},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4133000075817108},{"id":"https://openalex.org/C2776120743","wikidata":"https://www.wikidata.org/wiki/Q3271540","display_name":"Mechanism of action","level":3,"score":0.41019999980926514},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.3813999891281128},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.37070000171661377},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.3700000047683716},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3626999855041504},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.34769999980926514},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.33169999718666077},{"id":"https://openalex.org/C172268261","wikidata":"https://www.wikidata.org/wiki/Q4764988","display_name":"Animal studies","level":2,"score":0.32739999890327454},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.32280001044273376},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.3199000060558319},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.2939000129699707},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.29339998960494995},{"id":"https://openalex.org/C57600042","wikidata":"https://www.wikidata.org/wiki/Q227564","display_name":"Oxidative phosphorylation","level":2,"score":0.27489998936653137},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.274399995803833},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.2736999988555908},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.2685999870300293},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.26499998569488525},{"id":"https://openalex.org/C2780962732","wikidata":"https://www.wikidata.org/wiki/Q422327","display_name":"Oxaliplatin","level":4,"score":0.2563000023365021},{"id":"https://openalex.org/C73573662","wikidata":"https://www.wikidata.org/wiki/Q130996","display_name":"DNA replication","level":3,"score":0.2558000087738037},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.25429999828338623},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.2515000104904175}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.11.08.765151","doi":"https://doi.org/10.64898/2026.11.08.765151","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.11.08.765151","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nd","license_id":"https://openalex.org/licenses/cc-by-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.11.08.765151","doi":"https://doi.org/10.64898/2026.11.08.765151","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.11.08.765151","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nd","license_id":"https://openalex.org/licenses/cc-by-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"5-Fluorouracil":[0],"(5-FU)":[1],"remains":[2,118],"a":[3,47,88,146,158],"cornerstone":[4],"of":[5,33,99,126,216],"colorectal":[6],"cancer":[7,67],"(CRC)":[8],"therapy,":[9],"yet":[10],"its":[11,220],"clinical":[12],"efficacy":[13],"is":[14],"limited":[15],"by":[16,94],"resistance,":[17],"systemic":[18,161],"toxicity,":[19],"and":[20,46,57,70,81,163,179,205,218],"unfavorable":[21],"pharmacokinetics.":[22],"Strategies":[23],"that":[24,175],"enhance":[25],"tumor":[26,132],"sensitivity":[27],"while":[28],"maintaining":[29],"tolerability":[30,204],"are":[31,210],"therefore":[32],"considerable":[34],"interest.":[35],"Here,":[36],"we":[37],"evaluated":[38],"5-FU":[39,127,138,152,185],"in":[40,58,134,145,223],"combination":[41,125],"with":[42,128,140,157,169],"two":[43],"triazoloacridinones,":[44],"C-1305":[45,129,188],"novel":[48],"BOC-modified":[49],"derivative,":[50],"TRA-01AR,":[51],"using":[52],"integrated":[53],"cellular,":[54],"transcriptomic,":[55],"bioenergetic,":[56],"vivo":[59],"approaches.":[60],"Both":[61],"compounds":[62],"induced":[63],"cytotoxic":[64],"effects":[65],"across":[66],"cell":[68,82],"models":[69],"produced":[71],"overlapping":[72],"but":[73],"distinct":[74,199],"transcriptional":[75,178],"responses,":[76],"primarily":[77],"affecting":[78],"DNA":[79],"replication":[80],"cycle":[83],"pathways.":[84],"Bioenergetic":[85],"profiling":[86],"revealed":[87],"shift":[89],"toward":[90],"oxidative":[91],"phosphorylation":[92],"accompanied":[93],"reduced":[95,131],"glycolysis,":[96],"indicating":[97],"modulation":[98],"cellular":[100],"metabolism":[101],"relevant":[102,182],"to":[103,112,119,151,183,212],"chemotherapy":[104],"response.":[105,186],"Interestingly,":[106],"TRA-01AR":[107,141,154,197],"exhibited":[108,198],"delayed":[109],"cytotoxicity":[110],"relative":[111],"C-1305,":[113],"although":[114],"the":[115,124,184,194],"underlying":[116],"mechanism":[117,215],"be":[120],"defined.":[121],"In":[122],"vivo,":[123],"significantly":[130],"weight":[133],"HT-29":[135],"xenografts,":[136],"whereas":[137],"combined":[139],"did":[142],"not":[143],"result":[144],"statistically":[147],"significant":[148],"reduction":[149],"compared":[150,168],"alone.":[153],"was":[155],"associated":[156],"more":[159],"favorable":[160],"profile":[162],"increased":[164],"intratumoral":[165],"blood":[166],"flow":[167],"C-1305.":[170],"Collectively,":[171],"these":[172],"findings":[173],"indicate":[174],"triazoloacridinones":[176],"modulate":[177],"metabolic":[180],"programs":[181],"While":[187],"demonstrated":[189],"greater":[190],"antitumor":[191],"activity":[192],"under":[193],"tested":[195],"conditions,":[196],"biological":[200],"effects,":[201],"including":[202],"improved":[203],"vascular":[206],"modulation.":[207],"Further":[208],"studies":[209],"required":[211],"clarify":[213],"TRA-01AR's":[214],"action":[217],"assess":[219],"potential":[221],"relevance":[222],"CRC-specific":[224],"therapies.":[225]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-11T00:00:00"}