{"id":"https://openalex.org/W7225748896","doi":"https://doi.org/10.3389/fphys.2026.1979880","title":"IL-1\u03b2-associated inflammation, lipid metabolic alterations and epithelial barrier injury in necrotizing enterocolitis: partial protection by fenofibrate","display_name":"IL-1\u03b2-associated inflammation, lipid metabolic alterations and epithelial barrier injury in necrotizing enterocolitis: partial protection by fenofibrate","publication_year":2026,"publication_date":"2026-11-10","ids":{"openalex":"https://openalex.org/W7225748896","doi":"https://doi.org/10.3389/fphys.2026.1979880"},"language":"en","primary_location":{"id":"doi:10.3389/fphys.2026.1979880","doi":"https://doi.org/10.3389/fphys.2026.1979880","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphys.2026.1979880","pdf_url":"https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2026.1979880/pdf","source":{"id":"https://openalex.org/S52732750","display_name":"Frontiers in Physiology","issn_l":"1664-042X","issn":["1664-042X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Physiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2026.1979880/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5161409936","display_name":"Yinghui Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111599522","display_name":"Jiangnan University","ror":"https://ror.org/04mkzax54","country_code":"CN","type":"education","lineage":["https://openalex.org/I111599522"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yinghui Zhang","raw_affiliation_strings":["Department of Neonatology, Wuxi Maternity and Child Health Care Hospital, Affiliated Women\u2019s Hospital of Jiangnan University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neonatology, Wuxi Maternity and Child Health Care Hospital, Affiliated Women\u2019s Hospital of Jiangnan University","institution_ids":["https://openalex.org/I111599522"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083720436","display_name":"\u5468\u4e9a\u6167","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111599522","display_name":"Jiangnan University","ror":"https://ror.org/04mkzax54","country_code":"CN","type":"education","lineage":["https://openalex.org/I111599522"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yahui Zhou","raw_affiliation_strings":["Department of Neonatology, Affiliated Children\u2019s Hospital of Jiangnan University, Wuxi Children\u2019s Hospital, Wuxi Key Laboratory of Genetic and Metabolic Diseases in Children"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neonatology, Affiliated Children\u2019s Hospital of Jiangnan University, Wuxi Children\u2019s Hospital, Wuxi Key Laboratory of Genetic and Metabolic Diseases in Children","institution_ids":["https://openalex.org/I111599522"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038220151","display_name":"Renqiang Yu","orcid":"https://orcid.org/0000-0001-6529-0158","observed_orcids":["https://orcid.org/0000-0001-6529-0158"]},"institutions":[{"id":"https://openalex.org/I111599522","display_name":"Jiangnan University","ror":"https://ror.org/04mkzax54","country_code":"CN","type":"education","lineage":["https://openalex.org/I111599522"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Renqiang Yu","raw_affiliation_strings":["Department of Neonatology, Wuxi Maternity and Child Health Care Hospital, Affiliated Women\u2019s Hospital of Jiangnan University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neonatology, Wuxi Maternity and Child Health Care Hospital, Affiliated Women\u2019s Hospital of Jiangnan University","institution_ids":["https://openalex.org/I111599522"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040775278","display_name":"Yingzi Mei","orcid":"https://orcid.org/0000-0002-8593-4114","observed_orcids":["https://orcid.org/0000-0002-8593-4114"]},"institutions":[{"id":"https://openalex.org/I111599522","display_name":"Jiangnan University","ror":"https://ror.org/04mkzax54","country_code":"CN","type":"education","lineage":["https://openalex.org/I111599522"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yingzi Mei","raw_affiliation_strings":["Department of Neonatology, Wuxi Maternity and Child Health Care Hospital, Affiliated Women\u2019s Hospital of Jiangnan University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neonatology, Wuxi Maternity and Child Health Care Hospital, Affiliated Women\u2019s Hospital of Jiangnan University","institution_ids":["https://openalex.org/I111599522"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5040775278"],"corresponding_institution_ids":["https://openalex.org/I111599522"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11294","display_name":"Infant Nutrition and Health","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11294","display_name":"Infant Nutrition and Health","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10858","display_name":"Clinical Nutrition and Gastroenterology","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C2778110834","wikidata":"https://www.wikidata.org/wiki/Q419724","display_name":"Fenofibrate","level":2,"score":0.7138000130653381},{"id":"https://openalex.org/C2779303187","wikidata":"https://www.wikidata.org/wiki/Q10859678","display_name":"Necrotizing enterocolitis","level":2,"score":0.7087000012397766},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6600000262260437},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.6230999827384949},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.5408999919891357},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5400000214576721},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4262000024318695},{"id":"https://openalex.org/C177779419","wikidata":"https://www.wikidata.org/wiki/Q1053832","display_name":"Tight junction","level":2,"score":0.40529999136924744},{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.3984000086784363},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3806999921798706},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.38029998540878296},{"id":"https://openalex.org/C4733338","wikidata":"https://www.wikidata.org/wiki/Q2792936","display_name":"Lipid metabolism","level":2,"score":0.3790000081062317},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3634999990463257},{"id":"https://openalex.org/C20299238","wikidata":"https://www.wikidata.org/wiki/Q363928","display_name":"Lipocalin","level":2,"score":0.3562999963760376},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.33550000190734863},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.3176000118255615},{"id":"https://openalex.org/C96525457","wikidata":"https://www.wikidata.org/wiki/Q5014879","display_name":"CXCL1","level":4,"score":0.31700000166893005},{"id":"https://openalex.org/C3019368612","wikidata":"https://www.wikidata.org/wiki/Q17154506","display_name":"Intestinal mucosa","level":2,"score":0.30959999561309814},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.304500013589859},{"id":"https://openalex.org/C2776637226","wikidata":"https://www.wikidata.org/wiki/Q6658207","display_name":"Liver injury","level":2,"score":0.289900004863739},{"id":"https://openalex.org/C529295009","wikidata":"https://www.wikidata.org/wiki/Q41301","display_name":"Epithelium","level":2,"score":0.2856000065803528},{"id":"https://openalex.org/C503630168","wikidata":"https://www.wikidata.org/wiki/Q178069","display_name":"Necrosis","level":2,"score":0.28220000863075256},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2782000005245209},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27799999713897705},{"id":"https://openalex.org/C2775862500","wikidata":"https://www.wikidata.org/wiki/Q2453464","display_name":"Colitis","level":2,"score":0.2759999930858612},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.26820001006126404},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.26589998602867126},{"id":"https://openalex.org/C2776465410","wikidata":"https://www.wikidata.org/wiki/Q14911599","display_name":"Retinol binding protein 4","level":5,"score":0.2612999975681305},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.2581000030040741},{"id":"https://openalex.org/C2776200302","wikidata":"https://www.wikidata.org/wiki/Q827450","display_name":"Hepatocyte","level":3,"score":0.2531999945640564},{"id":"https://openalex.org/C2776258884","wikidata":"https://www.wikidata.org/wiki/Q3055368","display_name":"Enterocolitis","level":2,"score":0.2524000108242035}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3389/fphys.2026.1979880","doi":"https://doi.org/10.3389/fphys.2026.1979880","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphys.2026.1979880","pdf_url":"https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2026.1979880/pdf","source":{"id":"https://openalex.org/S52732750","display_name":"Frontiers in Physiology","issn_l":"1664-042X","issn":["1664-042X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Physiology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.3389/fphys.2026.1979880","doi":"https://doi.org/10.3389/fphys.2026.1979880","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphys.2026.1979880","pdf_url":"https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2026.1979880/pdf","source":{"id":"https://openalex.org/S52732750","display_name":"Frontiers in Physiology","issn_l":"1664-042X","issn":["1664-042X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Physiology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225748896.pdf","grobid_xml":"https://content.openalex.org/works/W7225748896.grobid-xml"},"referenced_works_count":24,"referenced_works":["https://openalex.org/W1618627661","https://openalex.org/W1964986858","https://openalex.org/W1984180564","https://openalex.org/W2057604945","https://openalex.org/W2072852259","https://openalex.org/W2074448653","https://openalex.org/W2145189896","https://openalex.org/W2512327724","https://openalex.org/W2795552079","https://openalex.org/W2890723100","https://openalex.org/W2990693650","https://openalex.org/W3036762817","https://openalex.org/W3173155334","https://openalex.org/W3180002942","https://openalex.org/W3213927789","https://openalex.org/W4200536940","https://openalex.org/W4205198200","https://openalex.org/W4220989233","https://openalex.org/W4235469056","https://openalex.org/W4280529994","https://openalex.org/W4282964700","https://openalex.org/W4309607314","https://openalex.org/W4393039525","https://openalex.org/W4411655372"],"related_works":[],"abstract_inverted_index":{"Introduction":[0],"Necrotizing":[1],"enterocolitis":[2],"(NEC)":[3],"is":[4],"characterized":[5],"by":[6,134],"exaggerated":[7],"inflammation":[8],"and":[9,19,43,58,69,106,118,125,137,140,146,153,173,184],"epithelial":[10,174],"barrier":[11,175],"injury,":[12],"but":[13],"the":[14,31,119,190],"relationship":[15],"between":[16,115],"inflammatory":[17,104,128],"signaling":[18],"intestinal":[20,33],"lipid-metabolic":[21],"dysfunction":[22],"remains":[23],"incompletely":[24],"defined.":[25],"Methods":[26],"We":[27],"integrated":[28],"analysis":[29],"of":[30],"human":[32],"transcriptomic":[34],"dataset":[35],"GSE46619":[36],"with":[37,53,60,111],"experiments":[38],"in":[39,157,177],"rat":[40],"IEC-6":[41,49,123],"cells":[42,50,124],"a":[44,92,164,195],"neonatal":[45,72],"mouse":[46,126],"NEC":[47,94,100],"model.":[48],"were":[51,187],"challenged":[52],"LPS":[54],"or":[55,63,85,129,200],"recombinant":[56],"IL-1\u03b2":[57],"treated":[59],"Il1b":[61,144],"siRNA":[62],"fenofibrate.":[64,97],"In":[65,122],"vivo":[66,158],",":[67],"male":[68],"female":[70],"C57BL/6":[71],"mice":[73],"underwent":[74],"formula-feeding/hypoxia":[75],"exposure":[76],"from":[77],"postnatal":[78,89],"day":[79,90],"7":[80],"to":[81],"10":[82],"after":[83],"AAV9-shIl1b":[84],"control-vector":[86],"administration":[87],"on":[88],"2;":[91],"separate":[93],"group":[95],"received":[96],"Results":[98],"Human":[99],"samples":[101],"showed":[102],"increased":[103,141],"signatures":[105],"lower":[107],"fatty-acid-metabolism":[108,120],"GSVA":[109],"scores,":[110],"an":[112],"inverse":[113],"association":[114],"IL1B":[116],"expression":[117],"score.":[121],"ileum,":[127],"NEC-like":[130],"injury":[131,156,176],"was":[132],"accompanied":[133],"reduced":[135],"tight-junction":[136],"PPAR\u03b1/CPT1A-associated":[138],"markers":[139],"lipid-peroxidation/lipid-content":[142],"indices.":[143],"knockdown":[145],"fenofibrate":[147],"each":[148],"partially":[149],"attenuated":[150],"these":[151],"abnormalities":[152],"improved":[154],"histological":[155],".":[159],"Discussion":[160],"These":[161],"findings":[162],"support":[163],"working":[165],"model":[166],"linking":[167],"IL-1\u03b2-associated":[168],"inflammation,":[169],"lipid":[170],"metabolic":[171],"alterations,":[172],"experimental":[178],"NEC.":[179],"Because":[180],"fatty-acid":[181],"oxidation":[182],"flux":[183],"PPAR\u03b1":[185,202],"loss-of-function":[186],"not":[188,193],"tested,":[189],"data":[191],"do":[192],"establish":[194],"direct":[196],"IL-1\u03b2-PPAR\u03b1":[197],"causal":[198],"pathway":[199],"strict":[201],"dependency.":[203]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-11T00:00:00"}