{"id":"https://openalex.org/W7225748765","doi":"https://doi.org/10.61373/pp026w.0009","title":"Exploring cancer neuroscience with psychedelics: Brain-body crosstalk, neuroimmune modulation, and implications from tumor biology to end-of-life support","display_name":"Exploring cancer neuroscience with psychedelics: Brain-body crosstalk, neuroimmune modulation, and implications from tumor biology to end-of-life support","publication_year":2026,"publication_date":"2026-11-10","ids":{"openalex":"https://openalex.org/W7225748765","doi":"https://doi.org/10.61373/pp026w.0009"},"language":"en","primary_location":{"id":"doi:10.61373/pp026w.0009","doi":"https://doi.org/10.61373/pp026w.0009","is_oa":true,"landing_page_url":"https://doi.org/10.61373/pp026w.0009","pdf_url":null,"source":{"id":"https://openalex.org/S4404675698","display_name":"Psychedelics.","issn_l":"2997-2671","issn":["2997-2671","2997-268X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["ki-jl-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Psychedelics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.61373/pp026w.0009","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5161379097","display_name":"Feilong Cheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126520041","display_name":"University of Science and Technology of China","ror":"https://ror.org/04c4dkn09","country_code":"CN","type":"education","lineage":["https://openalex.org/I126520041","https://openalex.org/I19820366"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210092888","display_name":"Changchun Institute of Applied Chemistry","ror":"https://ror.org/00h52n341","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210092888"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Feilong Cheng","raw_affiliation_strings":["Interdisciplinary Laboratory for Frontier Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, China","School of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei, 230026, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Interdisciplinary Laboratory for Frontier Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210092888"]},{"raw_affiliation_string":"School of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei, 230026, China","institution_ids":["https://openalex.org/I126520041"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161379115","display_name":"Cong Lin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210092888","display_name":"Changchun Institute of Applied Chemistry","ror":"https://ror.org/00h52n341","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210092888"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Cong Lin","raw_affiliation_strings":["Interdisciplinary Laboratory for Frontier Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Interdisciplinary Laboratory for Frontier Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210092888"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161377138","display_name":"Shanwen Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130930","display_name":"Peking University First Hospital","ror":"https://ror.org/02z1vqm45","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210130930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shanwen Chen","raw_affiliation_strings":["Department of Gastrointestinal Surgery, Peking University First Hospital, Beijing, 100034, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastrointestinal Surgery, Peking University First Hospital, Beijing, 100034, China","institution_ids":["https://openalex.org/I4210130930"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5127654822","display_name":"Xiaohui Wang","orcid":"https://orcid.org/0000-0002-3415-5612","observed_orcids":["https://orcid.org/0000-0002-3415-5612"]},"institutions":[{"id":"https://openalex.org/I126520041","display_name":"University of Science and Technology of China","ror":"https://ror.org/04c4dkn09","country_code":"CN","type":"education","lineage":["https://openalex.org/I126520041","https://openalex.org/I19820366"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210092888","display_name":"Changchun Institute of Applied Chemistry","ror":"https://ror.org/00h52n341","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210092888"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaohui Wang","raw_affiliation_strings":["Interdisciplinary Laboratory for Frontier Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, China","School of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei, 230026, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Interdisciplinary Laboratory for Frontier Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210092888"]},{"raw_affiliation_string":"School of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei, 230026, China","institution_ids":["https://openalex.org/I126520041"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"12"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12553","display_name":"Psychedelics and Drug Studies","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T12553","display_name":"Psychedelics and Drug Studies","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T12626","display_name":"Cancer, Stress, Anesthesia, and Immune Response","score":0.0032999999821186066,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.7670999765396118},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4814999997615814},{"id":"https://openalex.org/C38042653","wikidata":"https://www.wikidata.org/wiki/Q1500332","display_name":"Psychoneuroimmunology","level":3,"score":0.41940000653266907},{"id":"https://openalex.org/C37000724","wikidata":"https://www.wikidata.org/wiki/Q50430226","display_name":"Serotonergic","level":4,"score":0.4129999876022339},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3970000147819519},{"id":"https://openalex.org/C2780375056","wikidata":"https://www.wikidata.org/wiki/Q905905","display_name":"Neuromodulation","level":3,"score":0.3896999955177307},{"id":"https://openalex.org/C201934248","wikidata":"https://www.wikidata.org/wiki/Q2492999","display_name":"Neuroimmunology","level":3,"score":0.38089999556541443},{"id":"https://openalex.org/C188147891","wikidata":"https://www.wikidata.org/wiki/Q147638","display_name":"Cognitive science","level":1,"score":0.36390000581741333},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3553999960422516},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3447999954223633},{"id":"https://openalex.org/C22467394","wikidata":"https://www.wikidata.org/wiki/Q849359","display_name":"Multidisciplinary approach","level":2,"score":0.3409000039100647},{"id":"https://openalex.org/C2994186709","wikidata":"https://www.wikidata.org/wiki/Q29483","display_name":"Palliative care","level":2,"score":0.33719998598098755},{"id":"https://openalex.org/C2780087125","wikidata":"https://www.wikidata.org/wiki/Q2062293","display_name":"Vagus nerve stimulation","level":4,"score":0.33629998564720154},{"id":"https://openalex.org/C127882523","wikidata":"https://www.wikidata.org/wiki/Q38066","display_name":"Existentialism","level":2,"score":0.33469998836517334},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.334199994802475},{"id":"https://openalex.org/C27415008","wikidata":"https://www.wikidata.org/wiki/Q7256382","display_name":"Psychological intervention","level":2,"score":0.33180001378059387},{"id":"https://openalex.org/C50738837","wikidata":"https://www.wikidata.org/wiki/Q781492","display_name":"Optogenetics","level":2,"score":0.3100000023841858},{"id":"https://openalex.org/C26760741","wikidata":"https://www.wikidata.org/wiki/Q160402","display_name":"Perception","level":2,"score":0.3098999857902527},{"id":"https://openalex.org/C128544194","wikidata":"https://www.wikidata.org/wiki/Q474859","display_name":"Translational research","level":2,"score":0.30480000376701355},{"id":"https://openalex.org/C139265228","wikidata":"https://www.wikidata.org/wiki/Q5283089","display_name":"Distress","level":2,"score":0.29980000853538513},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.298799991607666},{"id":"https://openalex.org/C2780674031","wikidata":"https://www.wikidata.org/wiki/Q2012719","display_name":"Cancer immunotherapy","level":4,"score":0.295199990272522},{"id":"https://openalex.org/C47611674","wikidata":"https://www.wikidata.org/wiki/Q849491","display_name":"Neuroplasticity","level":2,"score":0.2847000062465668},{"id":"https://openalex.org/C2776885095","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immunosurveillance","level":3,"score":0.28049999475479126},{"id":"https://openalex.org/C96526673","wikidata":"https://www.wikidata.org/wiki/Q4867047","display_name":"Basic science","level":2,"score":0.2773999869823456},{"id":"https://openalex.org/C542102704","wikidata":"https://www.wikidata.org/wiki/Q183257","display_name":"Psychotherapist","level":1,"score":0.2606000006198883},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.25929999351501465}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.61373/pp026w.0009","doi":"https://doi.org/10.61373/pp026w.0009","is_oa":true,"landing_page_url":"https://doi.org/10.61373/pp026w.0009","pdf_url":null,"source":{"id":"https://openalex.org/S4404675698","display_name":"Psychedelics.","issn_l":"2997-2671","issn":["2997-2671","2997-268X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["ki-jl-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Psychedelics","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.61373/pp026w.0009","doi":"https://doi.org/10.61373/pp026w.0009","is_oa":true,"landing_page_url":"https://doi.org/10.61373/pp026w.0009","pdf_url":null,"source":{"id":"https://openalex.org/S4404675698","display_name":"Psychedelics.","issn_l":"2997-2671","issn":["2997-2671","2997-268X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["ki-jl-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Psychedelics","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":68,"referenced_works":["https://openalex.org/W1522923028","https://openalex.org/W1601681275","https://openalex.org/W1698044858","https://openalex.org/W1965037168","https://openalex.org/W1969794861","https://openalex.org/W1976693202","https://openalex.org/W2028691981","https://openalex.org/W2088396693","https://openalex.org/W2093828252","https://openalex.org/W2111553780","https://openalex.org/W2111940175","https://openalex.org/W2141382054","https://openalex.org/W2146578632","https://openalex.org/W2149233218","https://openalex.org/W2160119698","https://openalex.org/W2170596036","https://openalex.org/W2209554327","https://openalex.org/W2264494318","https://openalex.org/W2291931403","https://openalex.org/W2329316201","https://openalex.org/W2465360896","https://openalex.org/W2558412547","https://openalex.org/W2559739670","https://openalex.org/W2587948429","https://openalex.org/W2802172273","https://openalex.org/W2808301300","https://openalex.org/W2809651259","https://openalex.org/W2872347999","https://openalex.org/W2883680686","https://openalex.org/W2886249511","https://openalex.org/W2974724557","https://openalex.org/W3000429196","https://openalex.org/W3005441929","https://openalex.org/W3020839129","https://openalex.org/W3023228010","https://openalex.org/W3039116382","https://openalex.org/W3081126678","https://openalex.org/W3085556079","https://openalex.org/W3094714065","https://openalex.org/W3097571542","https://openalex.org/W3127181543","https://openalex.org/W3179469168","https://openalex.org/W3200757480","https://openalex.org/W3201325011","https://openalex.org/W3214079493","https://openalex.org/W4200362142","https://openalex.org/W4206759226","https://openalex.org/W4292187617","https://openalex.org/W4306164229","https://openalex.org/W4307093712","https://openalex.org/W4365810952","https://openalex.org/W4367857311","https://openalex.org/W4385319219","https://openalex.org/W4386504040","https://openalex.org/W4386620675","https://openalex.org/W4387602070","https://openalex.org/W4388142090","https://openalex.org/W4389794307","https://openalex.org/W4391037724","https://openalex.org/W4391774309","https://openalex.org/W4400729513","https://openalex.org/W4403351423","https://openalex.org/W4406120474","https://openalex.org/W4407958909","https://openalex.org/W4408040475","https://openalex.org/W4408540649","https://openalex.org/W4411451381","https://openalex.org/W4412827025"],"related_works":[],"abstract_inverted_index":{"Recent":[0],"advancements":[1],"in":[2,53,84,106,166,172,179,255],"cancer":[3,167,256],"neuroscience":[4],"highlight":[5,155],"the":[6,12,156,224,243],"intricate":[7],"bidirectional":[8],"interactions":[9],"among":[10],"tumors,":[11,120],"nervous":[13],"system,":[14],"and":[15,42,45,61,71,80,115,121,130,142,146,176,191,209,215,234,241],"immune":[16,75],"mechanisms,":[17],"revealing":[18],"new":[19],"conceptual":[20,62],"avenues":[21],"for":[22,28,163,185,202,226],"investigation.":[23],"Serotonergic":[24],"psychedelics,":[25],"historically":[26],"explored":[27],"their":[29],"profound":[30],"effects":[31,208],"on":[32,134],"consciousness,":[33],"are":[34],"increasingly":[35],"recognized":[36],"as":[37,46],"modulators":[38],"of":[39,118,137,247],"neural":[40,70],"circuits":[41],"neuroimmune":[43,72,123],"pathways,":[44],"interventions":[47],"that":[48,65,90],"can":[49],"alleviate":[50],"existential":[51,177],"distress":[52,178],"cancer-related":[54,69,173],"contexts.":[55],"This":[56],"review":[57,222],"synthesizes":[58],"current":[59],"evidence":[60,160,184,199],"frameworks":[63],"suggesting":[64],"psychedelics":[66,104],"may":[67],"engage":[68],"processes,":[73],"influence":[74,108],"signaling":[76],"within":[77],"tumor":[78],"microenvironments,":[79],"provide":[81],"psychological":[82],"relief":[83],"palliative":[85],"care":[86],"settings,":[87,182],"while":[88,183],"emphasizing":[89],"most":[91,157],"oncology-relevant":[92],"mechanisms":[93],"remain":[94,212],"preclinical":[95,129],"or":[96],"theoretical.":[97],"We":[98],"explore":[99],"potential":[100],"pathways":[101],"through":[102],"which":[103,169],"could,":[105],"principle,":[107],"tumor-host":[109],"interactions,":[110],"including":[111],"neuron-glioma":[112],"synapses,":[113],"autonomic":[114],"sensory":[116],"innervation":[117],"peripheral":[119],"systemic":[122],"communication.":[124],"Additionally,":[125],"we":[126,154],"critically":[127],"examine":[128],"emerging":[131],"clinical":[132,159,198],"data":[133],"psychedelic-associated":[135],"modulation":[136],"serotonin":[138],"receptor":[139],"signaling,":[140],"vagal":[141],"sympathetic":[143],"nerve":[144],"activity,":[145],"anti-inflammatory":[147],"processes":[148],"with":[149],"relevance":[150],"to":[151,161,237],"oncology.":[152],"Moreover,":[153],"robust":[158],"date":[162],"psychedelic-assisted":[164,248],"therapy":[165],"populations,":[168],"supports":[170],"improvements":[171],"anxiety,":[174],"depression,":[175],"carefully":[180],"supported":[181],"pain-related":[186],"outcomes":[187,254],"is":[188,200],"more":[189],"heterogeneous":[190],"remains":[192],"less":[193],"well":[194],"established.":[195],"Across":[196],"domains,":[197],"strongest":[201],"distress-related":[203],"outcomes,":[204],"whereas":[205],"oncology-specific":[206],"biological":[207],"tumor-related":[210],"endpoints":[211],"largely":[213],"untested":[214],"should":[216],"be":[217],"considered":[218],"hypothesis-generating.":[219],"Finally,":[220],"this":[221],"underscores":[223],"need":[225],"rigorous,":[227],"multidisciplinary":[228],"research":[229],"integrating":[230],"oncology,":[231],"neuroscience,":[232],"immunology,":[233],"psychedelic":[235],"pharmacology":[236],"clarify":[238],"mechanistic":[239],"boundaries":[240],"inform":[242],"cautious":[244],"future":[245],"integration":[246],"approaches":[249],"aimed":[250],"at":[251],"improving":[252],"patient-centered":[253],"care.":[257]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-11T00:00:00"}