{"id":"https://openalex.org/W7225748677","doi":"https://doi.org/10.1186/s13048-026-02340-2","title":"Follicular development dynamics, ovarian response, and reproductive outcomes among three recombinant FSH preparations: a single-center retrospective cohort study","display_name":"Follicular development dynamics, ovarian response, and reproductive outcomes among three recombinant FSH preparations: a single-center retrospective cohort study","publication_year":2026,"publication_date":"2026-11-10","ids":{"openalex":"https://openalex.org/W7225748677","doi":"https://doi.org/10.1186/s13048-026-02340-2"},"language":"en","primary_location":{"id":"doi:10.1186/s13048-026-02340-2","doi":"https://doi.org/10.1186/s13048-026-02340-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13048-026-02340-2","pdf_url":null,"source":{"id":"https://openalex.org/S15947008","display_name":"Journal of Ovarian Research","issn_l":"1757-2215","issn":["1757-2215"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Ovarian Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1186/s13048-026-02340-2","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015756939","display_name":"Masato Kobanawa","orcid":"https://orcid.org/0000-0002-5545-0477","observed_orcids":["https://orcid.org/0000-0002-5545-0477"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Masato Kobanawa","raw_affiliation_strings":["Kobanawa Clinic, 169-3 Tagiya, Omitama-shi, Ibarak-ken, Japan"],"raw_orcid":"https://orcid.org/0000-0002-5545-0477","affiliations":[{"raw_affiliation_string":"Kobanawa Clinic, 169-3 Tagiya, Omitama-shi, Ibarak-ken, Japan","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5161397379","display_name":"Kenji Sato","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kenji Sato","raw_affiliation_strings":["Kobanawa Clinic, 169-3 Tagiya, Omitama-shi, Ibarak-ken, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kobanawa Clinic, 169-3 Tagiya, Omitama-shi, Ibarak-ken, Japan","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5015756939"],"corresponding_institution_ids":[],"apc_list":{"value":3290,"currency":"USD","value_usd":3290},"apc_paid":{"value":3290,"currency":"USD","value_usd":3290},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.9286999702453613,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.9286999702453613,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10390","display_name":"Ovarian function and disorders","score":0.0364999994635582,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11156","display_name":"Reproductive Health and Technologies","score":0.022299999371170998,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.635200023651123},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.6079000234603882},{"id":"https://openalex.org/C187785154","wikidata":"https://www.wikidata.org/wiki/Q5464664","display_name":"Follicular phase","level":2,"score":0.5949000120162964},{"id":"https://openalex.org/C2778478619","wikidata":"https://www.wikidata.org/wiki/Q7113249","display_name":"Controlled ovarian hyperstimulation","level":4,"score":0.5568000078201294},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.4855000078678131},{"id":"https://openalex.org/C2781230225","wikidata":"https://www.wikidata.org/wiki/Q3150564","display_name":"Ovulation induction","level":4,"score":0.4772999882698059},{"id":"https://openalex.org/C2776600139","wikidata":"https://www.wikidata.org/wiki/Q7113253","display_name":"Ovarian reserve","level":4,"score":0.47099998593330383},{"id":"https://openalex.org/C512716672","wikidata":"https://www.wikidata.org/wiki/Q200117","display_name":"In vitro fertilisation","level":3,"score":0.4471000134944916},{"id":"https://openalex.org/C2776690073","wikidata":"https://www.wikidata.org/wiki/Q3246226","display_name":"Oocyte","level":3,"score":0.4377000033855438},{"id":"https://openalex.org/C2778279030","wikidata":"https://www.wikidata.org/wiki/Q1543380","display_name":"Live birth","level":3,"score":0.4162999987602234},{"id":"https://openalex.org/C2779279165","wikidata":"https://www.wikidata.org/wiki/Q200774","display_name":"Follicle-stimulating hormone","level":4,"score":0.4113999903202057},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.4050000011920929},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3939000070095062},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.38940000534057617},{"id":"https://openalex.org/C142773365","wikidata":"https://www.wikidata.org/wiki/Q3499793","display_name":"Antral follicle","level":3,"score":0.36880001425743103},{"id":"https://openalex.org/C2780536345","wikidata":"https://www.wikidata.org/wiki/Q953556","display_name":"Ovarian follicle","level":3,"score":0.36469998955726624},{"id":"https://openalex.org/C2781065240","wikidata":"https://www.wikidata.org/wiki/Q1760461","display_name":"Ovarian hyperstimulation syndrome","level":4,"score":0.34279999136924744},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.3400000035762787},{"id":"https://openalex.org/C2778324911","wikidata":"https://www.wikidata.org/wiki/Q9631","display_name":"Ovary","level":2,"score":0.33090001344680786},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.32839998602867126},{"id":"https://openalex.org/C500014431","wikidata":"https://www.wikidata.org/wiki/Q25862","display_name":"Assisted reproductive technology","level":4,"score":0.3176000118255615},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.3163999915122986},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.31470000743865967},{"id":"https://openalex.org/C2776210078","wikidata":"https://www.wikidata.org/wiki/Q351870","display_name":"Reproductive medicine","level":3,"score":0.31029999256134033},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.3100999891757965},{"id":"https://openalex.org/C2909827854","wikidata":"https://www.wikidata.org/wiki/Q416821","display_name":"Menotropins","level":5,"score":0.30320000648498535},{"id":"https://openalex.org/C46699223","wikidata":"https://www.wikidata.org/wiki/Q11078","display_name":"Endocrine system","level":3,"score":0.29409998655319214},{"id":"https://openalex.org/C2778575703","wikidata":"https://www.wikidata.org/wiki/Q50265477","display_name":"Luteinizing hormone","level":3,"score":0.2858999967575073},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.27379998564720154},{"id":"https://openalex.org/C131872663","wikidata":"https://www.wikidata.org/wiki/Q5284418","display_name":"Obstetrics","level":1,"score":0.2718999981880188},{"id":"https://openalex.org/C2778782382","wikidata":"https://www.wikidata.org/wiki/Q409770","display_name":"Gonadotropin","level":3,"score":0.26489999890327454},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.25940001010894775},{"id":"https://openalex.org/C2778780466","wikidata":"https://www.wikidata.org/wiki/Q21108939","display_name":"Anti-M\u00fcllerian hormone","level":3,"score":0.2572999894618988}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1186/s13048-026-02340-2","doi":"https://doi.org/10.1186/s13048-026-02340-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13048-026-02340-2","pdf_url":null,"source":{"id":"https://openalex.org/S15947008","display_name":"Journal of Ovarian Research","issn_l":"1757-2215","issn":["1757-2215"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Ovarian Research","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1186/s13048-026-02340-2","doi":"https://doi.org/10.1186/s13048-026-02340-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13048-026-02340-2","pdf_url":null,"source":{"id":"https://openalex.org/S15947008","display_name":"Journal of Ovarian Research","issn_l":"1757-2215","issn":["1757-2215"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Ovarian Research","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Recombinant":[2],"follicle-stimulating":[3],"hormone":[4],"(rFSH)":[5],"preparations":[6],"differ":[7],"in":[8,151,210,252],"their":[9,55],"glycosylation":[10],"profiles":[11],"and":[12,37,44,90,110,131,137,144,166,168,226,234],"pharmacological":[13],"properties.":[14],"However,":[15],"whether":[16],"these":[17,179,242],"molecular":[18],"differences":[19,148,180,209],"influence":[20],"follicular":[21,33,98,249],"growth":[22,250],"dynamics":[23,251],"during":[24],"controlled":[25,57],"ovarian":[26,35,58,104,142,211,224,254],"stimulation":[27,59,145,170,228],"(COS)":[28],"remains":[29],"unclear.":[30],"We":[31],"compared":[32,117],"development,":[34,99],"response,":[36],"reproductive":[38,191,201],"outcomes":[39,80,96,192,202],"among":[40,195,205],"follitropin":[41,62,154,173,216],"alfa,":[42,177],"beta,":[43],"delta.":[45,155],"Methods":[46],"This":[47],"retrospective":[48,232],"cohort":[49],"study":[50],"included":[51,97],"329":[52],"women":[53],"undergoing":[54],"first":[56],"cycle":[60],"with":[61,172,176,215],"alfa":[63,136],"(":[64,69,75],"n":[65,70,76],"=":[66,71,77],"151),":[67],"beta":[68,138,174,217],"111),":[72],"or":[73,122],"delta":[74],"67).":[78],"Primary":[79],"were":[81,116,149,181,193,203,213],"oocyte":[82,85,92,164],"yield,":[83,86],"mature":[84],"follicle-to-oocyte":[87],"index":[88,93],"(FOI)":[89],"follicle-to-mature":[91],"(FmOI).":[94],"Secondary":[95],"endocrine":[100],"profiles,":[101],"embryological":[102],"outcomes,":[103],"hyperstimulation":[105],"syndrome,":[106],"cumulative":[107,111],"pregnancy":[108],"rate,":[109],"live":[112],"birth":[113],"rate.":[114],"Outcomes":[115],"using":[118],"multivariable":[119],"regression":[120,124],"analyses":[121,157],"logistic":[123],"analysis":[125],"adjusted":[126],"for":[127,187],"age,":[128],"anti-M\u00fcllerian":[129],"hormone,":[130],"body":[132],"weight.":[133],"Results":[134],"Follitropin":[135],"showed":[139],"broadly":[140],"comparable":[141,194,204],"responses":[143],"durations,":[146],"whereas":[147],"observed":[150],"comparisons":[152],"involving":[153],"Exploratory":[156],"revealed":[158],"modest":[159,219],"numerical":[160],"trends":[161,221],"toward":[162,222],"higher":[163],"yield":[165],"FOI":[167],"shorter":[169,227],"duration":[171],"than":[175],"although":[178],"not":[182],"statistically":[183],"significant":[184],"after":[185],"adjustment":[186],"multiple":[188],"comparisons.":[189],"Cumulative":[190],"the":[196,231,245],"three":[197],"groups.":[198],"Conclusions":[199],"Although":[200],"recombinant":[206],"FSH":[207],"preparations,":[208],"responsiveness":[212],"observed,":[214],"showing":[218],"exploratory":[220],"greater":[223],"response":[225],"duration.":[229],"Despite":[230],"design":[233],"lack":[235],"of":[236,248],"an":[237],"a":[238],"priori":[239],"power":[240],"calculation,":[241],"findings":[243],"highlight":[244],"potential":[246],"value":[247],"individualized":[253],"stimulation.":[255]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-11T00:00:00"}