{"id":"https://openalex.org/W7225747006","doi":"https://doi.org/10.21203/rs.3.rs-11638370/v1","title":"Evaluation of 24-Hour D-Dimer Stability at Room Temperature","display_name":"Evaluation of 24-Hour D-Dimer Stability at Room Temperature","publication_year":2026,"publication_date":"2026-11-10","ids":{"openalex":"https://openalex.org/W7225747006","doi":"https://doi.org/10.21203/rs.3.rs-11638370/v1"},"language":"en","primary_location":{"id":"doi:10.21203/rs.3.rs-11638370/v1","doi":"https://doi.org/10.21203/rs.3.rs-11638370/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-11638370/v1","pdf_url":"https://www.researchsquare.com/article/rs-11638370/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.researchsquare.com/article/rs-11638370/latest.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5117422031","display_name":"Gustav Valentino","orcid":"https://orcid.org/0000-0002-9320-4656","observed_orcids":["https://orcid.org/0000-0002-9320-4656"]},"institutions":[{"id":"https://openalex.org/I190243414","display_name":"President University","ror":"https://ror.org/04w4pwd42","country_code":"ID","type":"education","lineage":["https://openalex.org/I190243414"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Gustav Valentino","raw_affiliation_strings":["Universitas Presiden: President University"],"raw_orcid":"https://orcid.org/0000-0002-9320-4656","affiliations":[{"raw_affiliation_string":"Universitas Presiden: President University","institution_ids":["https://openalex.org/I190243414"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034381860","display_name":"Usi Sukorini","orcid":"https://orcid.org/0000-0001-6928-6957","observed_orcids":["https://orcid.org/0000-0001-6928-6957"]},"institutions":[{"id":"https://openalex.org/I165230279","display_name":"Universitas Gadjah Mada","ror":"https://ror.org/03ke6d638","country_code":"ID","type":"education","lineage":["https://openalex.org/I165230279"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Usi Sukorini","raw_affiliation_strings":["Gadjah Mada University"],"raw_orcid":"https://orcid.org/0000-0001-6928-6957","affiliations":[{"raw_affiliation_string":"Gadjah Mada University","institution_ids":["https://openalex.org/I165230279"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11314","display_name":"Clinical Laboratory Practices and Quality Control","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/3607","display_name":"Medical Laboratory Technology"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11314","display_name":"Clinical Laboratory Practices and Quality Control","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/3607","display_name":"Medical Laboratory Technology"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11721","display_name":"Blood properties and coagulation","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10292","display_name":"Acute Myocardial Infarction Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C160798450","wikidata":"https://www.wikidata.org/wiki/Q4230870","display_name":"Concordance","level":2,"score":0.7949000000953674},{"id":"https://openalex.org/C206041023","wikidata":"https://www.wikidata.org/wiki/Q1751970","display_name":"Wilcoxon signed-rank test","level":3,"score":0.6370999813079834},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.597000002861023},{"id":"https://openalex.org/C112972136","wikidata":"https://www.wikidata.org/wiki/Q7595718","display_name":"Stability (learning theory)","level":2,"score":0.48840001225471497},{"id":"https://openalex.org/C48921125","wikidata":"https://www.wikidata.org/wiki/Q10861030","display_name":"Linear regression","level":2,"score":0.42750000953674316},{"id":"https://openalex.org/C3018577593","wikidata":"https://www.wikidata.org/wiki/Q470749","display_name":"Limits of agreement","level":2,"score":0.3700000047683716},{"id":"https://openalex.org/C2779036427","wikidata":"https://www.wikidata.org/wiki/Q381899","display_name":"Fibrinogen","level":2,"score":0.35510000586509705},{"id":"https://openalex.org/C3020079912","wikidata":"https://www.wikidata.org/wiki/Q3918988","display_name":"Plasma concentration","level":2,"score":0.35190001130104065},{"id":"https://openalex.org/C105054674","wikidata":"https://www.wikidata.org/wiki/Q3707381","display_name":"Mean difference","level":3,"score":0.31369999051094055},{"id":"https://openalex.org/C2781059462","wikidata":"https://www.wikidata.org/wiki/Q5158906","display_name":"Concordance correlation coefficient","level":2,"score":0.3075999915599823},{"id":"https://openalex.org/C2777027219","wikidata":"https://www.wikidata.org/wiki/Q1284190","display_name":"Constant (computer programming)","level":2,"score":0.29910001158714294},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2847999930381775},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.28380000591278076},{"id":"https://openalex.org/C152877465","wikidata":"https://www.wikidata.org/wiki/Q208042","display_name":"Regression analysis","level":2,"score":0.2809000015258789},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.27799999713897705},{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.2621000111103058},{"id":"https://openalex.org/C82706917","wikidata":"https://www.wikidata.org/wiki/Q10251","display_name":"Plasma","level":2,"score":0.2596000134944916},{"id":"https://openalex.org/C102959455","wikidata":"https://www.wikidata.org/wiki/Q7313954","display_name":"Repeated measures design","level":2,"score":0.25440001487731934}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.21203/rs.3.rs-11638370/v1","doi":"https://doi.org/10.21203/rs.3.rs-11638370/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-11638370/v1","pdf_url":"https://www.researchsquare.com/article/rs-11638370/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.21203/rs.3.rs-11638370/v1","doi":"https://doi.org/10.21203/rs.3.rs-11638370/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-11638370/v1","pdf_url":"https://www.researchsquare.com/article/rs-11638370/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225747006.pdf","grobid_xml":"https://content.openalex.org/works/W7225747006.grobid-xml"},"referenced_works_count":11,"referenced_works":["https://openalex.org/W2016499071","https://openalex.org/W2052492883","https://openalex.org/W2076034098","https://openalex.org/W2127294394","https://openalex.org/W2164223312","https://openalex.org/W2567601689","https://openalex.org/W2793860733","https://openalex.org/W2891970774","https://openalex.org/W2909148082","https://openalex.org/W2947416534","https://openalex.org/W4200067197"],"related_works":[],"abstract_inverted_index":{"Abstract":[0],"Objective":[1],"To":[2],"determine":[3],"the":[4,59,125],"stability":[5,156],"of":[6,12,49,118,141,177,181],"plasma":[7,26],"D-dimer":[8,83,152],"after":[9,46,148,157],"24":[10,47,95,158],"hours":[11,48,96,159],"storage":[13,51],"at":[14,33,71,88,94,128,160],"room":[15,161],"temperature":[16],"(23\u201325\u00b0C).":[17],"Methods":[18],"In":[19],"this":[20],"paired":[21],"ex":[22],"vivo":[23],"study,":[24],"citrated":[25],"from":[27],"365":[28],"oncology":[29],"patients":[30],"was":[31,56,84,113,133],"analyzed":[32],"baseline":[34,89],"(HemosIL":[35],"D-Dimer":[36],"HS":[37],"500":[38,72],"on":[39],"an":[40],"ACL":[41],"TOP":[42],"550)":[43],"and":[44,68,90],"again":[45],"room-temperature":[50],"in":[52],"capped":[53],"microtubes.":[54],"Agreement":[55],"assessed":[57],"with":[58,124],"Wilcoxon":[60],"signed-rank":[61],"test,":[62],"Passing\u2013Bablok":[63,101],"regression,":[64],"percentage-difference":[65],"Bland\u2013Altman":[66],"analysis,":[67],"diagnostic":[69],"concordance":[70,132],"ng/mL":[73,86,92],"fibrinogen":[74],"equivalent":[75],"units":[76],"(FEU)":[77],"(0.50":[78],"mg/L":[79],"FEU).":[80],"Results":[81],"Median":[82],"292":[85],"FEU":[87,93],"294":[91],"(":[97],"P":[98],"=":[99,137],".70).":[100],"regression":[102],"showed":[103,153],"no":[104],"constant":[105],"or":[106],"proportional":[107],"bias.":[108],"The":[109],"mean":[110],"relative":[111],"bias":[112],"\u2212":[114,120],"1.6%":[115],"(95%":[116],"limits":[117],"agreement,":[119],"45.4%":[121],"to":[122],"42.3%),":[123],"largest":[126],"differences":[127],"low":[129],"concentrations.":[130],"Diagnostic":[131],"95.9%":[134],"(350/365;":[135],"\u03ba":[136],"0.90),":[138],"but":[139],"12":[140],"108":[142],"baseline-positive":[143],"samples":[144],"(11.1%)":[145],"became":[146],"negative":[147],"storage.":[149],"Conclusions":[150],"Plasma":[151],"high":[154],"overall":[155],"temperature,":[162],"suggesting":[163],"that":[164],"laboratories":[165],"can":[166],"process":[167],"delayed":[168],"samples.":[169],"Borderline-positive":[170],"results":[171],"should":[172],"be":[173],"interpreted":[174],"cautiously":[175],"because":[176],"a":[178],"small":[179],"risk":[180],"false-negative":[182],"classification.":[183]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-11T00:00:00"}