{"id":"https://openalex.org/W7225745672","doi":"https://doi.org/10.3389/fcimb.2026.1996565","title":"Distinct plasma proteomic trajectories during PD-1 blockade and PEG-IFN\u03b1 therapy are associated with HBsAg response in chronic hepatitis B","display_name":"Distinct plasma proteomic trajectories during PD-1 blockade and PEG-IFN\u03b1 therapy are associated with HBsAg response in chronic hepatitis B","publication_year":2026,"publication_date":"2026-11-10","ids":{"openalex":"https://openalex.org/W7225745672","doi":"https://doi.org/10.3389/fcimb.2026.1996565"},"language":"en","primary_location":{"id":"doi:10.3389/fcimb.2026.1996565","doi":"https://doi.org/10.3389/fcimb.2026.1996565","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcimb.2026.1996565","pdf_url":"https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2026.1996565/pdf","source":{"id":"https://openalex.org/S2506667490","display_name":"Frontiers in Cellular and Infection Microbiology","issn_l":"2235-2988","issn":["2235-2988"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cellular and Infection Microbiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2026.1996565/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113540599","display_name":"Hongmin Wang","orcid":"https://orcid.org/0009-0003-2424-6398","observed_orcids":["https://orcid.org/0009-0003-2424-6398"]},"institutions":[{"id":"https://openalex.org/I126520041","display_name":"University of Science and Technology of China","ror":"https://ror.org/04c4dkn09","country_code":"CN","type":"education","lineage":["https://openalex.org/I126520041","https://openalex.org/I19820366"]},{"id":"https://openalex.org/I2802939634","display_name":"Chinese PLA General Hospital","ror":"https://ror.org/04gw3ra78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802939634"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hongmin Wang","raw_affiliation_strings":["Senior Department of Infectious Diseases, Chinese PLA General Hospital, National Clinical Research Center for Infectious Diseases","The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Senior Department of Infectious Diseases, Chinese PLA General Hospital, National Clinical Research Center for Infectious Diseases","institution_ids":["https://openalex.org/I2802939634"]},{"raw_affiliation_string":"The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China","institution_ids":["https://openalex.org/I126520041"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070126631","display_name":"Yaping Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210131893","display_name":"Second Affiliated Hospital of Xi'an Jiaotong University","ror":"https://ror.org/03aq7kf18","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210131893"]},{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yaping Li","raw_affiliation_strings":["Department of Hepatology and Infectious Diseases, Second Affiliated Hospital of Xi\u2019an Jiaotong University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatology and Infectious Diseases, Second Affiliated Hospital of Xi\u2019an Jiaotong University","institution_ids":["https://openalex.org/I4210131893","https://openalex.org/I87445476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161370330","display_name":"Xiaoying Li","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiaoying Li","raw_affiliation_strings":["Centre for Hepatology, Shandong Public Health Clinical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Hepatology, Shandong Public Health Clinical Center","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161366082","display_name":"Xin Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802939634","display_name":"Chinese PLA General Hospital","ror":"https://ror.org/04gw3ra78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802939634"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xin Zhang","raw_affiliation_strings":["Senior Department of Infectious Diseases, Chinese PLA General Hospital, National Clinical Research Center for Infectious Diseases"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Senior Department of Infectious Diseases, Chinese PLA General Hospital, National Clinical Research Center for Infectious Diseases","institution_ids":["https://openalex.org/I2802939634"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100434811","display_name":"Qing Wang","orcid":"https://orcid.org/0000-0002-3067-5522","observed_orcids":["https://orcid.org/0000-0002-3067-5522"]},"institutions":[{"id":"https://openalex.org/I2802939634","display_name":"Chinese PLA General Hospital","ror":"https://ror.org/04gw3ra78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802939634"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qing Wang","raw_affiliation_strings":["Senior Department of Infectious Diseases, Chinese PLA General Hospital, National Clinical Research Center for Infectious Diseases"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Senior Department of Infectious Diseases, Chinese PLA General Hospital, National Clinical Research Center for Infectious Diseases","institution_ids":["https://openalex.org/I2802939634"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5152941186","display_name":"Shanquan Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shanquan Liu","raw_affiliation_strings":["The Second School of Clinical Medicine, Southern Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Second School of Clinical Medicine, Southern Medical University","institution_ids":["https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161384931","display_name":"Shengxian Yang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shengxian Yang","raw_affiliation_strings":["Medical School of Chinese PLA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical School of Chinese PLA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5121921150","display_name":"Xiaoning Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802939634","display_name":"Chinese PLA General Hospital","ror":"https://ror.org/04gw3ra78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802939634"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoning Zhang","raw_affiliation_strings":["Senior Department of Infectious Diseases, Chinese PLA General Hospital, National Clinical Research Center for Infectious Diseases"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Senior Department of Infectious Diseases, Chinese PLA General Hospital, National Clinical Research Center for Infectious Diseases","institution_ids":["https://openalex.org/I2802939634"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161382643","display_name":"Xueshan Qiao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xueshan Qiao","raw_affiliation_strings":["Medical School of Chinese PLA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical School of Chinese PLA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103126076","display_name":"Shuangsuo Dang","orcid":"https://orcid.org/0000-0003-0918-9535","observed_orcids":["https://orcid.org/0000-0003-0918-9535","https://orcid.org/0000-0002-9257-5711","https://orcid.org/0000-0002-3231-6531"]},"institutions":[{"id":"https://openalex.org/I4210131893","display_name":"Second Affiliated Hospital of Xi'an Jiaotong University","ror":"https://ror.org/03aq7kf18","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210131893"]},{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shuangsuo Dang","raw_affiliation_strings":["Department of Hepatology and Infectious Diseases, Second Affiliated Hospital of Xi\u2019an Jiaotong University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatology and Infectious Diseases, Second Affiliated Hospital of Xi\u2019an Jiaotong University","institution_ids":["https://openalex.org/I4210131893","https://openalex.org/I87445476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161409349","display_name":"Fu-Sheng Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126520041","display_name":"University of Science and Technology of China","ror":"https://ror.org/04c4dkn09","country_code":"CN","type":"education","lineage":["https://openalex.org/I126520041","https://openalex.org/I19820366"]},{"id":"https://openalex.org/I2802939634","display_name":"Chinese PLA General Hospital","ror":"https://ror.org/04gw3ra78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802939634"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Fu-Sheng Wang","raw_affiliation_strings":["Medical School of Chinese PLA","Senior Department of Infectious Diseases, Chinese PLA General Hospital, National Clinical Research Center for Infectious Diseases","The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical School of Chinese PLA","institution_ids":[]},{"raw_affiliation_string":"Senior Department of Infectious Diseases, Chinese PLA General Hospital, National Clinical Research Center for Infectious Diseases","institution_ids":["https://openalex.org/I2802939634"]},{"raw_affiliation_string":"The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China","institution_ids":["https://openalex.org/I126520041"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5152786528","display_name":"Junliang Fu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802939634","display_name":"Chinese PLA General Hospital","ror":"https://ror.org/04gw3ra78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802939634"]},{"id":"https://openalex.org/I4210149412","display_name":"Second Affiliated Hospital of Anhui Medical University","ror":"https://ror.org/047aw1y82","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210149412"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Junliang Fu","raw_affiliation_strings":["Medical School of Chinese PLA","Senior Department of Infectious Diseases, Chinese PLA General Hospital, National Clinical Research Center for Infectious Diseases","The Second Affiliated Hospital of Anhui Medical University","The Second School of Clinical Medicine, Southern Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical School of Chinese PLA","institution_ids":[]},{"raw_affiliation_string":"Senior Department of Infectious Diseases, Chinese PLA General Hospital, National Clinical Research Center for Infectious Diseases","institution_ids":["https://openalex.org/I2802939634"]},{"raw_affiliation_string":"The Second Affiliated Hospital of Anhui Medical University","institution_ids":["https://openalex.org/I4210149412"]},{"raw_affiliation_string":"The Second School of Clinical Medicine, Southern Medical University","institution_ids":["https://openalex.org/I58200834"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5152786528","https://openalex.org/A5161409349"],"corresponding_institution_ids":["https://openalex.org/I126520041","https://openalex.org/I2802939634","https://openalex.org/I4210149412","https://openalex.org/I58200834"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"16","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.003700000001117587,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C2778468042","wikidata":"https://www.wikidata.org/wiki/Q273976","display_name":"Blockade","level":3,"score":0.7448999881744385},{"id":"https://openalex.org/C2777410769","wikidata":"https://www.wikidata.org/wiki/Q2282887","display_name":"HBsAg","level":4,"score":0.66839998960495},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5971999764442444},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5914000272750854},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5641999840736389},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.5509999990463257},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.5230000019073486},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5148000121116638},{"id":"https://openalex.org/C3020491458","wikidata":"https://www.wikidata.org/wiki/Q131742","display_name":"Chronic hepatitis","level":3,"score":0.4584999978542328},{"id":"https://openalex.org/C80311884","wikidata":"https://www.wikidata.org/wiki/Q7268939","display_name":"Quantitative proteomics","level":4,"score":0.4253000020980835},{"id":"https://openalex.org/C2777382497","wikidata":"https://www.wikidata.org/wiki/Q6853","display_name":"Hepatitis B","level":2,"score":0.3747999966144562},{"id":"https://openalex.org/C124535831","wikidata":"https://www.wikidata.org/wiki/Q4915074","display_name":"Biomarker discovery","level":4,"score":0.3569999933242798},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.3450999855995178},{"id":"https://openalex.org/C146543888","wikidata":"https://www.wikidata.org/wiki/Q425056","display_name":"Blood proteins","level":2,"score":0.31779998540878296},{"id":"https://openalex.org/C104397665","wikidata":"https://www.wikidata.org/wiki/Q860947","display_name":"Proteome","level":2,"score":0.3125},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.311599999666214},{"id":"https://openalex.org/C2777895361","wikidata":"https://www.wikidata.org/wiki/Q1758614","display_name":"Longitudinal study","level":2,"score":0.2994999885559082},{"id":"https://openalex.org/C136935669","wikidata":"https://www.wikidata.org/wiki/Q14912150","display_name":"GDF15","level":2,"score":0.2653999924659729},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2639999985694885},{"id":"https://openalex.org/C186836561","wikidata":"https://www.wikidata.org/wiki/Q1931516","display_name":"Microarray","level":4,"score":0.2565000057220459},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2531999945640564},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.25270000100135803},{"id":"https://openalex.org/C2776455275","wikidata":"https://www.wikidata.org/wiki/Q154869","display_name":"Hepatitis C","level":2,"score":0.2526000142097473},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.25209999084472656},{"id":"https://openalex.org/C2776029263","wikidata":"https://www.wikidata.org/wiki/Q131742","display_name":"Hepatitis","level":2,"score":0.25110000371932983}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3389/fcimb.2026.1996565","doi":"https://doi.org/10.3389/fcimb.2026.1996565","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcimb.2026.1996565","pdf_url":"https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2026.1996565/pdf","source":{"id":"https://openalex.org/S2506667490","display_name":"Frontiers in Cellular and Infection Microbiology","issn_l":"2235-2988","issn":["2235-2988"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cellular and Infection Microbiology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.3389/fcimb.2026.1996565","doi":"https://doi.org/10.3389/fcimb.2026.1996565","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcimb.2026.1996565","pdf_url":"https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2026.1996565/pdf","source":{"id":"https://openalex.org/S2506667490","display_name":"Frontiers in Cellular and Infection Microbiology","issn_l":"2235-2988","issn":["2235-2988"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cellular and Infection Microbiology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225745672.pdf","grobid_xml":"https://content.openalex.org/works/W7225745672.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W1534756886","https://openalex.org/W1618424270","https://openalex.org/W1983251878","https://openalex.org/W2008583523","https://openalex.org/W2042635330","https://openalex.org/W2044963057","https://openalex.org/W2064823659","https://openalex.org/W2094736478","https://openalex.org/W2140430530","https://openalex.org/W2151918606","https://openalex.org/W2152095262","https://openalex.org/W2337204897","https://openalex.org/W2885273410","https://openalex.org/W2898214436","https://openalex.org/W2962219096","https://openalex.org/W2984221112","https://openalex.org/W3031206422","https://openalex.org/W3144344661","https://openalex.org/W3160938771","https://openalex.org/W3164930583","https://openalex.org/W3165103004","https://openalex.org/W4315753997","https://openalex.org/W4317722168","https://openalex.org/W4319660733","https://openalex.org/W4384382829","https://openalex.org/W4388127680","https://openalex.org/W4389839231","https://openalex.org/W4400406254","https://openalex.org/W4401073376","https://openalex.org/W4414404206","https://openalex.org/W4416099817","https://openalex.org/W7117106125","https://openalex.org/W7119504859","https://openalex.org/W7129360837","https://openalex.org/W7154445574","https://openalex.org/W7155619948"],"related_works":[],"abstract_inverted_index":{"Background":[0],"PD-1":[1,50,120,161,193],"blockade":[2,51,194],"and":[3,21,64,76,87,146,166,187,195,227],"pegylated":[4],"interferon-\u03b1":[5],"(PEG-IFN\u03b1)":[6],"are":[7],"promising":[8],"immunomodulatory":[9],"strategies":[10],"for":[11,225],"chronic":[12],"hepatitis":[13],"B":[14],"(CHB),":[15],"but":[16],"their":[17],"systemic":[18],"immune":[19],"effects":[20],"response-associated":[22],"proteomic":[23,33,117,202,216],"patterns":[24],"remain":[25,180],"poorly":[26],"defined.":[27],"Methods":[28],"We":[29],"performed":[30],"longitudinal":[31,116,199,223],"plasma":[32],"profiling":[34],"using":[35,72,84],"the":[36,127,155,160,172,219],"Olink":[37],"Target":[38],"96":[39],"Inflammation":[40],"panel":[41],"in":[42,141,159,171,204],"25":[43],"nucleos(t)ide":[44],"analogue-suppressed":[45],"patients":[46],"with":[47,78,122],"CHB":[48],"receiving":[49],"(n=10)":[52],"or":[53],"PEG-IFN\u03b1":[54,112,173,196],"(n=15).":[55],"Plasma":[56],"samples":[57],"were":[58,70,82,92,168,188],"collected":[59],"at":[60,103],"baseline,":[61],"week":[62,65,104],"12,":[63],"24.":[66,105],"Longitudinal":[67],"protein":[68],"changes":[69,124,140],"analyzed":[71],"linear":[73],"mixed-effects":[74],"models,":[75],"associations":[77,177],"week-24":[79],"HBsAg":[80,96,207],"decline":[81,97,208],"evaluated":[83],"responder\u2013non-responder":[85],"comparisons":[86],"Spearman\u2019s":[88],"rank":[89],"correlation.":[90],"Responders":[91],"defined":[93],"by":[94,211],"an":[95],"of":[98,222,230],"\u22651":[99],"log":[100],"10":[101],"IU/mL":[102],"Results":[106],"Seventy-seven":[107],"proteins":[108],"passed":[109],"quality-control":[110],"criteria.":[111],"induced":[113],"substantially":[114],"broader":[115],"remodeling":[118],"than":[119,214],"blockade,":[121],"most":[123],"occurring":[125],"within":[126],"first":[128],"12":[129],"weeks.":[130],"Treatment-by-time":[131],"analyses":[132,149],"identified":[133],"distinct":[134,198],"trajectories":[135],"between":[136],"therapies,":[137],"including":[138],"differential":[139],"IL-18R1,":[142],"TNF,":[143],"CX3CL1,":[144],"CXCL9,":[145],"CXCL10.":[147],"Response-associated":[148],"suggested":[150],"treatment-specific":[151,212],"patterns:":[152],"IL-10":[153],"was":[154,209],"leading":[156],"exploratory":[157],"signal":[158],"cohort,":[162],"whereas":[163],"IL-12B,":[164],"CDCP1,":[165],"FGF-21":[167],"more":[169],"prominent":[170],"cohort.":[174],"These":[175],"response-related":[176],"did":[178],"not":[179],"significant":[181],"after":[182],"false":[183],"discovery":[184],"rate":[185],"correction":[186],"therefore":[189],"considered":[190],"exploratory.":[191],"Conclusions":[192],"induce":[197],"circulating":[200],"inflammatory":[201],"programs":[203],"CHB.":[205],"Favorable":[206],"accompanied":[210],"rather":[213],"universal":[215],"signatures,":[217],"supporting":[218],"potential":[220],"value":[221],"proteomics":[224],"mechanistic":[226],"biomarker":[228],"studies":[229],"HBV":[231],"functional-cure":[232],"strategies.":[233]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-11T00:00:00"}