{"id":"https://openalex.org/W7225744818","doi":"https://doi.org/10.1182/blood.2026034088","title":"Nuclear Receptor Nur77 Orchestrates Hematopoietic Lineage Commitment to Avert Anemia in Diabetes","display_name":"Nuclear Receptor Nur77 Orchestrates Hematopoietic Lineage Commitment to Avert Anemia in Diabetes","publication_year":2026,"publication_date":"2026-11-10","ids":{"openalex":"https://openalex.org/W7225744818","doi":"https://doi.org/10.1182/blood.2026034088"},"language":"en","primary_location":{"id":"doi:10.1182/blood.2026034088","doi":"https://doi.org/10.1182/blood.2026034088","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood.2026034088","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1182/blood.2026034088","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022080590","display_name":"Qiao\u2010ling Huang","orcid":"https://orcid.org/0009-0001-0253-5071","observed_orcids":["https://orcid.org/0009-0001-0253-5071"]},"institutions":[{"id":"https://openalex.org/I191208505","display_name":"Xiamen University","ror":"https://ror.org/00mcjh785","country_code":"CN","type":"education","lineage":["https://openalex.org/I191208505"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qiao-ling Huang","raw_affiliation_strings":["Xiamen University, Xiamen, China"],"raw_orcid":"https://orcid.org/0009-0001-0253-5071","affiliations":[{"raw_affiliation_string":"Xiamen University, Xiamen, China","institution_ids":["https://openalex.org/I191208505"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101334477","display_name":"Deyi Feng","orcid":"https://orcid.org/0000-0003-1837-1320","observed_orcids":["https://orcid.org/0000-0003-1837-1320","https://orcid.org/0009-0009-3253-4078"]},"institutions":[{"id":"https://openalex.org/I191208505","display_name":"Xiamen University","ror":"https://ror.org/00mcjh785","country_code":"CN","type":"education","lineage":["https://openalex.org/I191208505"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"De-yi Feng","raw_affiliation_strings":["Xiamen University, Xiamen, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Xiamen University, Xiamen, China","institution_ids":["https://openalex.org/I191208505"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070138303","display_name":"Y. Huang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I191208505","display_name":"Xiamen University","ror":"https://ror.org/00mcjh785","country_code":"CN","type":"education","lineage":["https://openalex.org/I191208505"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yinxiang Huang","raw_affiliation_strings":["Xiamen University, Xiamen, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Xiamen University, Xiamen, China","institution_ids":["https://openalex.org/I191208505"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069965407","display_name":"Qi-Tao Chen","orcid":"https://orcid.org/0009-0001-8118-4520","observed_orcids":["https://orcid.org/0009-0001-8118-4520"]},"institutions":[{"id":"https://openalex.org/I191208505","display_name":"Xiamen University","ror":"https://ror.org/00mcjh785","country_code":"CN","type":"education","lineage":["https://openalex.org/I191208505"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qi-tao Chen","raw_affiliation_strings":["Xiamen University, Xiamen, China"],"raw_orcid":"https://orcid.org/0009-0001-8118-4520","affiliations":[{"raw_affiliation_string":"Xiamen University, Xiamen, China","institution_ids":["https://openalex.org/I191208505"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102845068","display_name":"Wenxiu Zhao","orcid":"https://orcid.org/0000-0002-1236-4173","observed_orcids":["https://orcid.org/0000-0002-1236-4173"]},"institutions":[{"id":"https://openalex.org/I191208505","display_name":"Xiamen University","ror":"https://ror.org/00mcjh785","country_code":"CN","type":"education","lineage":["https://openalex.org/I191208505"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wen-xiu Zhao","raw_affiliation_strings":["Xiamen University, Xiamen, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Xiamen University, Xiamen, China","institution_ids":["https://openalex.org/I191208505"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161415991","display_name":"Xiao-xue Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I191208505","display_name":"Xiamen University","ror":"https://ror.org/00mcjh785","country_code":"CN","type":"education","lineage":["https://openalex.org/I191208505"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiao-xue Li","raw_affiliation_strings":["Xiamen University, Xiamen, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Xiamen University, Xiamen, China","institution_ids":["https://openalex.org/I191208505"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104993224","display_name":"Qian Xiao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I191208505","display_name":"Xiamen University","ror":"https://ror.org/00mcjh785","country_code":"CN","type":"education","lineage":["https://openalex.org/I191208505"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qian Xiao","raw_affiliation_strings":["Xiamen University, Xiamen, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Xiamen University, Xiamen, China","institution_ids":["https://openalex.org/I191208505"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161391207","display_name":"Heng-hui Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I191208505","display_name":"Xiamen University","ror":"https://ror.org/00mcjh785","country_code":"CN","type":"education","lineage":["https://openalex.org/I191208505"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Heng-hui Li","raw_affiliation_strings":["Xiamen University, Xiamen, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Xiamen University, Xiamen, China","institution_ids":["https://openalex.org/I191208505"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113847178","display_name":"Wu Rong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I191208505","display_name":"Xiamen University","ror":"https://ror.org/00mcjh785","country_code":"CN","type":"education","lineage":["https://openalex.org/I191208505"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rong Wu","raw_affiliation_strings":["Xiamen University, Xiamen, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Xiamen University, Xiamen, China","institution_ids":["https://openalex.org/I191208505"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161385357","display_name":"Yi Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I191208505","display_name":"Xiamen University","ror":"https://ror.org/00mcjh785","country_code":"CN","type":"education","lineage":["https://openalex.org/I191208505"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yi Zhang","raw_affiliation_strings":["Xiamen University, Xiamen, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Xiamen University, Xiamen, China","institution_ids":["https://openalex.org/I191208505"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161367594","display_name":"Yue Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I191208505","display_name":"Xiamen University","ror":"https://ror.org/00mcjh785","country_code":"CN","type":"education","lineage":["https://openalex.org/I191208505"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yue Chen","raw_affiliation_strings":["Xiamen University, Xiamen, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Xiamen University, Xiamen, China","institution_ids":["https://openalex.org/I191208505"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007875989","display_name":"\u674e\u5b66\u5747","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I191208505","display_name":"Xiamen University","ror":"https://ror.org/00mcjh785","country_code":"CN","type":"education","lineage":["https://openalex.org/I191208505"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xuejun Li","raw_affiliation_strings":["Xiamen University, Xiamen, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Xiamen University, Xiamen, China","institution_ids":["https://openalex.org/I191208505"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042477637","display_name":"Qiao Wu","orcid":"https://orcid.org/0000-0002-2928-142X","observed_orcids":["https://orcid.org/0000-0002-2928-142X"]},"institutions":[{"id":"https://openalex.org/I191208505","display_name":"Xiamen University","ror":"https://ror.org/00mcjh785","country_code":"CN","type":"education","lineage":["https://openalex.org/I191208505"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qiao Wu","raw_affiliation_strings":["Xiamen University, Xiamen, China"],"raw_orcid":"https://orcid.org/0000-0002-2928-142X","affiliations":[{"raw_affiliation_string":"Xiamen University, Xiamen, China","institution_ids":["https://openalex.org/I191208505"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5158405271","display_name":"Caoxin Huang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I191208505","display_name":"Xiamen University","ror":"https://ror.org/00mcjh785","country_code":"CN","type":"education","lineage":["https://openalex.org/I191208505"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Caoxin Huang","raw_affiliation_strings":["Xiamen University, Xiamen, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Xiamen University, Xiamen, China","institution_ids":["https://openalex.org/I191208505"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032802010","display_name":"Hang\u2010zi Chen","orcid":"https://orcid.org/0000-0002-4827-2182","observed_orcids":["https://orcid.org/0000-0002-4827-2182"]},"institutions":[{"id":"https://openalex.org/I191208505","display_name":"Xiamen University","ror":"https://ror.org/00mcjh785","country_code":"CN","type":"education","lineage":["https://openalex.org/I191208505"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hang-zi Chen","raw_affiliation_strings":["Xiamen University, Xiamen, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Xiamen University, Xiamen, China","institution_ids":["https://openalex.org/I191208505"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I191208505"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":{"value":5500,"currency":"USD","value_usd":5500},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13991","display_name":"Nuclear Receptors and Signaling","score":0.9721999764442444,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13991","display_name":"Nuclear Receptors and Signaling","score":0.9721999764442444,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.010099999606609344,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12919","display_name":"Blood disorders and treatments","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C35552991","wikidata":"https://www.wikidata.org/wiki/Q12063746","display_name":"Nerve growth factor IB","level":5,"score":0.6693999767303467},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.5845999717712402},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.5264999866485596},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5239999890327454},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5120999813079834},{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.4666000008583069},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.46549999713897705},{"id":"https://openalex.org/C63932345","wikidata":"https://www.wikidata.org/wiki/Q422500","display_name":"Nuclear receptor","level":4,"score":0.4632999897003174},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.45590001344680786},{"id":"https://openalex.org/C2778248108","wikidata":"https://www.wikidata.org/wiki/Q5445","display_name":"Anemia","level":2,"score":0.3718000054359436},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.34869998693466187},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.31690001487731934},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.29319998621940613},{"id":"https://openalex.org/C2779703530","wikidata":"https://www.wikidata.org/wiki/Q837174","display_name":"Erythropoiesis","level":3,"score":0.29089999198913574},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2881999909877777},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.27970001101493835},{"id":"https://openalex.org/C2778086970","wikidata":"https://www.wikidata.org/wiki/Q514525","display_name":"Hematopoietic stem cell","level":4,"score":0.2791000008583069},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.27869999408721924},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.27410000562667847},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.27070000767707825},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.262800008058548},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2619999945163727}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood.2026034088","doi":"https://doi.org/10.1182/blood.2026034088","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood.2026034088","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood Journal","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1182/blood.2026034088","doi":"https://doi.org/10.1182/blood.2026034088","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood.2026034088","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood Journal","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Anemia":[0],"is":[1],"a":[2,19,51,62,134,146],"prevalent":[3],"but":[4],"poorly":[5],"understood":[6],"complication":[7],"of":[8,22,47,79,93,98,103,122],"diabetes":[9],"mellitus.":[10],"Here,":[11],"we":[12],"identify":[13],"orphan":[14],"nuclear":[15],"receptor":[16],"Nur77":[17,25,48,59,104,118,144],"as":[18,61,145],"critical":[20],"suppressor":[21],"diabetic":[23,37,43,115,123,139],"anemia.":[24,40],"expression":[26,78],"was":[27],"downregulated":[28],"in":[29,65,82,114,120,138],"hematopoietic":[30],"stem":[31],"and":[32,77,142],"progenitor":[33],"cells":[34],"(HSPCs)":[35],"from":[36],"patients":[38],"with":[39,70,105,127],"In":[41],"multiple":[42],"mouse":[44],"models,":[45],"knockout":[46],"induced":[49],"anemia,":[50],"phenotype":[52],"recapitulated":[53],"by":[54],"bone":[55],"marrow":[56],"transplantation.":[57],"Mechanistically,":[58],"functioned":[60],"transcriptional":[63],"repressor":[64],"HSPCs,":[66],"whose":[67],"deficiency,":[68],"together":[69],"diabetes-associated":[71],"epigenetic":[72],"modifications,":[73],"enhanced":[74],"chromatin":[75],"accessibility":[76],"genes":[80],"involved":[81],"myeloid":[83,90],"leukocyte":[84],"differentiation.":[85],"Consequently,":[86],"this":[87],"led":[88],"to":[89],"leukocyte-biased":[91],"differentiation":[92],"HSPCs":[94,121],"at":[95],"the":[96],"expense":[97],"erythroid":[99],"lineage.":[100],"Pharmacological":[101],"upregulation":[102],"its":[106],"agonist":[107],"cytosporone":[108],"B":[109],"(Csn-B)":[110],"effectively":[111],"prevented":[112],"anemia":[113,128,140],"mice.":[116],"Clinically,":[117],"levels":[119],"patient":[124],"negatively":[125],"correlated":[126],"occurrence.":[129],"Collectively,":[130],"our":[131],"findings":[132],"reveal":[133],"novel":[135],"Nur77-mediated":[136],"pathway":[137],"pathogenesis":[141],"propose":[143],"new":[147],"therapeutic":[148],"target.":[149]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-11T00:00:00"}