{"id":"https://openalex.org/W7225740952","doi":"https://doi.org/10.3390/chemistry8110159","title":"Computational Design and In Silico Evaluation of Resveratrol Analogues as Potential Hemagglutinin Fusion Inhibitors of Influenza A (H1N1)","display_name":"Computational Design and In Silico Evaluation of Resveratrol Analogues as Potential Hemagglutinin Fusion Inhibitors of Influenza A (H1N1)","publication_year":2026,"publication_date":"2026-11-10","ids":{"openalex":"https://openalex.org/W7225740952","doi":"https://doi.org/10.3390/chemistry8110159"},"language":"en","primary_location":{"id":"doi:10.3390/chemistry8110159","doi":"https://doi.org/10.3390/chemistry8110159","is_oa":true,"landing_page_url":"https://doi.org/10.3390/chemistry8110159","pdf_url":null,"source":{"id":"https://openalex.org/S4210231268","display_name":"Chemistry","issn_l":"2624-8549","issn":["2624-8549"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/chemistry8110159","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075364152","display_name":"Norah F. Alqahtani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210099699","display_name":"University of Jeddah","ror":"https://ror.org/015ya8798","country_code":"SA","type":"education","lineage":["https://openalex.org/I4210099699"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Norah F. Alqahtani","raw_affiliation_strings":["Department of Chemistry, College of Science, University of Jeddah, Jeddah 21589, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, College of Science, University of Jeddah, Jeddah 21589, Saudi Arabia","institution_ids":["https://openalex.org/I4210099699"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007476538","display_name":"Faisal Mohammed Aqlan","orcid":"https://orcid.org/0000-0001-9424-3262","observed_orcids":["https://orcid.org/0000-0001-9424-3262"]},"institutions":[{"id":"https://openalex.org/I4210099699","display_name":"University of Jeddah","ror":"https://ror.org/015ya8798","country_code":"SA","type":"education","lineage":["https://openalex.org/I4210099699"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Faisal Mohammad Aqlan","raw_affiliation_strings":["Department of Chemistry, College of Science, University of Jeddah, Jeddah 21589, Saudi Arabia"],"raw_orcid":"https://orcid.org/0000-0001-9424-3262","affiliations":[{"raw_affiliation_string":"Department of Chemistry, College of Science, University of Jeddah, Jeddah 21589, Saudi Arabia","institution_ids":["https://openalex.org/I4210099699"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161364868","display_name":"Aijaz Ahmed","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I192619145","display_name":"University of the Witwatersrand","ror":"https://ror.org/03rp50x72","country_code":"ZA","type":"education","lineage":["https://openalex.org/I192619145"]},{"id":"https://openalex.org/I4210134769","display_name":"University of Pittsburgh Medical Center","ror":"https://ror.org/04ehecz88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210134769"]}],"countries":["US","ZA"],"is_corresponding":false,"raw_author_name":"Aijaz Ahmed","raw_affiliation_strings":["Department of Clinical Microbiology and Infectious Diseases, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg 2193, South Africa","Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Microbiology and Infectious Diseases, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg 2193, South Africa","institution_ids":["https://openalex.org/I192619145"]},{"raw_affiliation_string":"Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA","institution_ids":["https://openalex.org/I4210134769"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031846865","display_name":"Irfan Ahmed Rather","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185163786","display_name":"King Abdulaziz University","ror":"https://ror.org/02ma4wv74","country_code":"SA","type":"education","lineage":["https://openalex.org/I185163786"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Irfan Ahmed Rather","raw_affiliation_strings":["Department of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia","institution_ids":["https://openalex.org/I185163786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045726149","display_name":"Abdullah S. Al\u2010Bogami","orcid":"https://orcid.org/0000-0002-8670-2729","observed_orcids":["https://orcid.org/0000-0002-8670-2729"]},"institutions":[{"id":"https://openalex.org/I4210099699","display_name":"University of Jeddah","ror":"https://ror.org/015ya8798","country_code":"SA","type":"education","lineage":["https://openalex.org/I4210099699"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Abdullah Saad Al-Bogami","raw_affiliation_strings":["Department of Chemistry, College of Science, University of Jeddah, Jeddah 21589, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, College of Science, University of Jeddah, Jeddah 21589, Saudi Arabia","institution_ids":["https://openalex.org/I4210099699"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108746178","display_name":"Ammar M. AL-Farga","orcid":"https://orcid.org/0000-0002-0233-5539","observed_orcids":["https://orcid.org/0000-0002-0233-5539"]},"institutions":[{"id":"https://openalex.org/I185163786","display_name":"King Abdulaziz University","ror":"https://ror.org/02ma4wv74","country_code":"SA","type":"education","lineage":["https://openalex.org/I185163786"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Ammar Al-Farga","raw_affiliation_strings":["Department of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia","institution_ids":["https://openalex.org/I185163786"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003644513","display_name":"Mohmmad Younus Wani","orcid":"https://orcid.org/0000-0002-1838-1337","observed_orcids":["https://orcid.org/0000-0002-1838-1337"]},"institutions":[{"id":"https://openalex.org/I4210099699","display_name":"University of Jeddah","ror":"https://ror.org/015ya8798","country_code":"SA","type":"education","lineage":["https://openalex.org/I4210099699"]}],"countries":["SA"],"is_corresponding":true,"raw_author_name":"Mohmmad Younus Wani","raw_affiliation_strings":["Department of Chemistry, College of Science, University of Jeddah, Jeddah 21589, Saudi Arabia"],"raw_orcid":"https://orcid.org/0000-0002-1838-1337","affiliations":[{"raw_affiliation_string":"Department of Chemistry, College of Science, University of Jeddah, Jeddah 21589, Saudi Arabia","institution_ids":["https://openalex.org/I4210099699"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5003644513"],"corresponding_institution_ids":["https://openalex.org/I4210099699"],"apc_list":{"value":1800,"currency":"CHF","value_usd":2172},"apc_paid":{"value":1800,"currency":"CHF","value_usd":2172},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"8","issue":"11","first_page":"159","last_page":"159"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9502000212669373,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9502000212669373,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":0.040300000458955765,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.7473999857902527},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6549999713897705},{"id":"https://openalex.org/C41685203","wikidata":"https://www.wikidata.org/wiki/Q1974042","display_name":"Docking (animal)","level":2,"score":0.6355999708175659},{"id":"https://openalex.org/C134164806","wikidata":"https://www.wikidata.org/wiki/Q409485","display_name":"Neuraminidase","level":3,"score":0.5715000033378601},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5471000075340271},{"id":"https://openalex.org/C10679952","wikidata":"https://www.wikidata.org/wiki/Q5308937","display_name":"Druggability","level":3,"score":0.5159000158309937},{"id":"https://openalex.org/C2776816829","wikidata":"https://www.wikidata.org/wiki/Q407329","display_name":"Resveratrol","level":2,"score":0.5027999877929688},{"id":"https://openalex.org/C2777538117","wikidata":"https://www.wikidata.org/wiki/Q425196","display_name":"Neuraminidase inhibitor","level":5,"score":0.4724000096321106},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.4106000065803528},{"id":"https://openalex.org/C103038307","wikidata":"https://www.wikidata.org/wiki/Q6556360","display_name":"Lipid bilayer fusion","level":3,"score":0.41040000319480896},{"id":"https://openalex.org/C158525013","wikidata":"https://www.wikidata.org/wiki/Q2593739","display_name":"Fusion","level":2,"score":0.40400001406669617},{"id":"https://openalex.org/C116569031","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Ligand (biochemistry)","level":3,"score":0.3986999988555908},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.38850000500679016},{"id":"https://openalex.org/C53105671","wikidata":"https://www.wikidata.org/wiki/Q14777816","display_name":"Rational design","level":2,"score":0.37869998812675476},{"id":"https://openalex.org/C193042331","wikidata":"https://www.wikidata.org/wiki/Q1772003","display_name":"Structure\u2013activity relationship","level":3,"score":0.3702000081539154},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.365200012922287},{"id":"https://openalex.org/C178910836","wikidata":"https://www.wikidata.org/wiki/Q2196961","display_name":"Molecular model","level":2,"score":0.352400004863739},{"id":"https://openalex.org/C51639874","wikidata":"https://www.wikidata.org/wiki/Q167149","display_name":"Plasma protein binding","level":2,"score":0.328000009059906},{"id":"https://openalex.org/C2778692840","wikidata":"https://www.wikidata.org/wiki/Q9136673","display_name":"Hemagglutinin (influenza)","level":3,"score":0.3221000134944916},{"id":"https://openalex.org/C103697762","wikidata":"https://www.wikidata.org/wiki/Q4112105","display_name":"Virtual screening","level":3,"score":0.31679999828338623},{"id":"https://openalex.org/C105302883","wikidata":"https://www.wikidata.org/wiki/Q5477685","display_name":"Fragment molecular orbital","level":4,"score":0.3124000132083893},{"id":"https://openalex.org/C123894998","wikidata":"https://www.wikidata.org/wiki/Q425158","display_name":"Fusion protein","level":4,"score":0.30880001187324524},{"id":"https://openalex.org/C2777752112","wikidata":"https://www.wikidata.org/wiki/Q903238","display_name":"Lead compound","level":3,"score":0.30140000581741333},{"id":"https://openalex.org/C59593255","wikidata":"https://www.wikidata.org/wiki/Q901663","display_name":"Molecular dynamics","level":2,"score":0.2842999994754791},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.2793000042438507},{"id":"https://openalex.org/C164923092","wikidata":"https://www.wikidata.org/wiki/Q3705921","display_name":"Molecular descriptor","level":3,"score":0.27250000834465027},{"id":"https://openalex.org/C2780374985","wikidata":"https://www.wikidata.org/wiki/Q211509","display_name":"Oseltamivir","level":5,"score":0.2667999863624573},{"id":"https://openalex.org/C161624437","wikidata":"https://www.wikidata.org/wiki/Q1988322","display_name":"Small molecule","level":2,"score":0.25920000672340393},{"id":"https://openalex.org/C2777546802","wikidata":"https://www.wikidata.org/wiki/Q834390","display_name":"Influenza A virus","level":3,"score":0.2590999901294708},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.2563000023365021},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.2540999948978424}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3390/chemistry8110159","doi":"https://doi.org/10.3390/chemistry8110159","is_oa":true,"landing_page_url":"https://doi.org/10.3390/chemistry8110159","pdf_url":null,"source":{"id":"https://openalex.org/S4210231268","display_name":"Chemistry","issn_l":"2624-8549","issn":["2624-8549"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemistry","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.3390/chemistry8110159","doi":"https://doi.org/10.3390/chemistry8110159","is_oa":true,"landing_page_url":"https://doi.org/10.3390/chemistry8110159","pdf_url":null,"source":{"id":"https://openalex.org/S4210231268","display_name":"Chemistry","issn_l":"2624-8549","issn":["2624-8549"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W184073726","https://openalex.org/W285749399","https://openalex.org/W1887624773","https://openalex.org/W1917380911","https://openalex.org/W1967606591","https://openalex.org/W1981737096","https://openalex.org/W1982694126","https://openalex.org/W1997872815","https://openalex.org/W2006056421","https://openalex.org/W2009867031","https://openalex.org/W2025190578","https://openalex.org/W2071922898","https://openalex.org/W2092157292","https://openalex.org/W2096091144","https://openalex.org/W2096495877","https://openalex.org/W2096747776","https://openalex.org/W2106622743","https://openalex.org/W2112411768","https://openalex.org/W2144857097","https://openalex.org/W2145825913","https://openalex.org/W2171580171","https://openalex.org/W2174636944","https://openalex.org/W2176461640","https://openalex.org/W2203366477","https://openalex.org/W2313081270","https://openalex.org/W2396930286","https://openalex.org/W2593436234","https://openalex.org/W2597096740","https://openalex.org/W2775569101","https://openalex.org/W2782638015","https://openalex.org/W2810023675","https://openalex.org/W2898293688","https://openalex.org/W2918813360","https://openalex.org/W2985636042","https://openalex.org/W2996375962","https://openalex.org/W3043559273","https://openalex.org/W3047643736","https://openalex.org/W3083406432","https://openalex.org/W3096347613","https://openalex.org/W3141121523","https://openalex.org/W3175318380","https://openalex.org/W4221035250","https://openalex.org/W4313414335","https://openalex.org/W4362475920","https://openalex.org/W4389547140","https://openalex.org/W4390114224","https://openalex.org/W4395010444","https://openalex.org/W4397001794","https://openalex.org/W4405274844"],"related_works":[],"abstract_inverted_index":{"Influenza":[0],"A":[1],"hemagglutinin":[2],"(HA)":[3],"is":[4,39,213],"a":[5,19,205],"target":[6],"of":[7,42],"interest":[8],"for":[9,35,100,120,199,237],"viral":[10],"entry":[11],"inhibitors.":[12],"The":[13],"group":[14],"1":[15],"HA":[16,61],"stem":[17],"harbours":[18],"druggable":[20],"pocket,":[21],"occupied":[22],"by":[23,112],"the":[24,30,43,83,89,101,106,140,200,217],"fusion":[25,37],"inhibitor":[26],"F0045(S),":[27],"which":[28,109],"blocks":[29],"low-pH":[31],"conformational":[32],"change":[33],"required":[34],"membrane":[36],"and":[38,72,80,93,135,192,204,230,241],"mechanistically":[40],"independent":[41],"neuraminidase":[44],"inhibitors":[45],"in":[46,130],"clinical":[47],"use.":[48],"This":[49],"study":[50],"computationally":[51],"evaluated":[52],"eight":[53,125],"resveratrol":[54],"derivatives":[55,126],"using":[56],"molecular":[57,121],"docking":[58,86],"against":[59,97],"H1/PR8":[60],"(PDB":[62],"ID":[63],"6WCR),":[64],"density":[65],"functional":[66],"theory":[67],"calculations,":[68],"predicted":[69,196],"ADMET":[70,186],"properties,":[71,177],"internal-coordinate":[73],"normal":[74,179],"mode":[75,180],"analysis":[76,181],"with":[77],"iMODS.":[78],"L4":[79,136,231],"L2":[81,134,202,229],"yielded":[82],"most":[84],"favourable":[85,190],"scores":[87,159],"among":[88],"derivatives,":[90],"at":[91],"\u22128.8":[92],"\u22128.6":[94],"kcal/mol":[95,99],"respectively,":[96],"\u22125.2":[98],"co-crystallised":[102],"ligand":[103,131],"TU7":[104,114],"under":[105],"same":[107],"protocol,":[108],"was":[110,227],"validated":[111,247],"redocking":[113],"to":[115,216,220],"0.99":[116],"\u00c5":[117],"RMSD.":[118],"Normalised":[119],"size,":[122],"however,":[123],"all":[124],"exceeded":[127],"both":[128,189],"comparators":[129],"efficiency":[132],"while":[133,178],"ranked":[137],"lowest":[138],"within":[139],"series,":[141],"indicating":[142],"that":[143,212],"their":[144],"raw-score":[145],"advantage":[146],"derives":[147],"substantially":[148],"from":[149,155],"added":[150],"heavy-atom":[151],"count":[152],"rather":[153,244],"than":[154,245],"superior":[156],"complementarity.":[157],"These":[158],"support":[160],"experimental":[161,225],"prioritisation":[162],"but":[163],"do":[164],"not":[165],"establish":[166],"binding":[167],"affinity":[168],"or":[169],"antiviral":[170,248],"efficacy.":[171],"Electronic-structure":[172],"calculations":[173],"characterised":[174],"frontier":[175],"orbital":[176],"explored":[182],"collective":[183],"structural":[184],"flexibility.":[185],"predictions":[187],"identified":[188],"features":[191],"liabilities,":[193],"notably":[194],"poor":[195],"intestinal":[197],"absorption":[198],"glucuronide":[201],"(28.5%)":[203],"borderline":[206],"immunotoxicity":[207],"alert":[208],"(p":[209],"=":[210],"0.52)":[211],"too":[214],"close":[215],"decision":[218],"boundary":[219],"be":[221],"relied":[222],"upon.":[223],"No":[224],"validation":[226],"performed.":[228],"are":[232],"therefore":[233],"proposed":[234],"as":[235,246],"candidates":[236],"HA-binding,":[238],"fusion-inhibition,":[239],"antiviral,":[240],"cytotoxicity":[242],"testing":[243],"leads.":[249]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-11T00:00:00"}