{"id":"https://openalex.org/W7225740873","doi":"https://doi.org/10.1371/journal.ppat.1014795","title":"Modulation of Fe3+ homeostasis by African Swine Fever virus facilitates its efficient replication in Ornithodoros lahorensis and pigs","display_name":"Modulation of Fe3+ homeostasis by African Swine Fever virus facilitates its efficient replication in Ornithodoros lahorensis and pigs","publication_year":2026,"publication_date":"2026-11-10","ids":{"openalex":"https://openalex.org/W7225740873","doi":"https://doi.org/10.1371/journal.ppat.1014795"},"language":"en","primary_location":{"id":"doi:10.1371/journal.ppat.1014795","doi":"https://doi.org/10.1371/journal.ppat.1014795","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.ppat.1014795","pdf_url":null,"source":{"id":"https://openalex.org/S2004986","display_name":"PLoS Pathogens","issn_l":"1553-7366","issn":["1553-7366","1553-7374"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Pathogens","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1371/journal.ppat.1014795","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5161372671","display_name":"Hua-Lin Sun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210090981","display_name":"Lanzhou Veterinary Research Institute","ror":"https://ror.org/00dg3j745","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210090981","https://openalex.org/I4210127390","https://openalex.org/I4210138501","https://openalex.org/I4210151987"]},{"id":"https://openalex.org/I4210138501","display_name":"Chinese Academy of Agricultural Sciences","ror":"https://ror.org/0313jb750","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210127390","https://openalex.org/I4210138501","https://openalex.org/I4210151987"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hua-Lin Sun","raw_affiliation_strings":["Gansu Province Research Center for Basic Disciplines of Pathogen Biology","Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gansu Province Research Center for Basic Disciplines of Pathogen Biology","institution_ids":[]},{"raw_affiliation_string":"Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences","institution_ids":["https://openalex.org/I4210090981","https://openalex.org/I4210138501"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100414348","display_name":"Ying Liu","orcid":"https://orcid.org/0000-0002-8997-2257","observed_orcids":["https://orcid.org/0000-0002-8997-2257"]},"institutions":[{"id":"https://openalex.org/I4210090981","display_name":"Lanzhou Veterinary Research Institute","ror":"https://ror.org/00dg3j745","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210090981","https://openalex.org/I4210127390","https://openalex.org/I4210138501","https://openalex.org/I4210151987"]},{"id":"https://openalex.org/I4210138501","display_name":"Chinese Academy of Agricultural Sciences","ror":"https://ror.org/0313jb750","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210127390","https://openalex.org/I4210138501","https://openalex.org/I4210151987"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ying Liu","raw_affiliation_strings":["Gansu Province Research Center for Basic Disciplines of Pathogen Biology","Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gansu Province Research Center for Basic Disciplines of Pathogen Biology","institution_ids":[]},{"raw_affiliation_string":"Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences","institution_ids":["https://openalex.org/I4210090981","https://openalex.org/I4210138501"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030745827","display_name":"Rongzeng Hao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210090981","display_name":"Lanzhou Veterinary Research Institute","ror":"https://ror.org/00dg3j745","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210090981","https://openalex.org/I4210127390","https://openalex.org/I4210138501","https://openalex.org/I4210151987"]},{"id":"https://openalex.org/I4210138501","display_name":"Chinese Academy of Agricultural Sciences","ror":"https://ror.org/0313jb750","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210127390","https://openalex.org/I4210138501","https://openalex.org/I4210151987"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rong-Zeng Hao","raw_affiliation_strings":["Gansu Province Research Center for Basic Disciplines of Pathogen Biology","Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gansu Province Research Center for Basic Disciplines of Pathogen Biology","institution_ids":[]},{"raw_affiliation_string":"Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences","institution_ids":["https://openalex.org/I4210090981","https://openalex.org/I4210138501"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100886897","display_name":"Zhao Zi-min","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210090981","display_name":"Lanzhou Veterinary Research Institute","ror":"https://ror.org/00dg3j745","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210090981","https://openalex.org/I4210127390","https://openalex.org/I4210138501","https://openalex.org/I4210151987"]},{"id":"https://openalex.org/I4210138501","display_name":"Chinese Academy of Agricultural Sciences","ror":"https://ror.org/0313jb750","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210127390","https://openalex.org/I4210138501","https://openalex.org/I4210151987"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zi-Min Zhao","raw_affiliation_strings":["Gansu Province Research Center for Basic Disciplines of Pathogen Biology","Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gansu Province Research Center for Basic Disciplines of Pathogen Biology","institution_ids":[]},{"raw_affiliation_string":"Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences","institution_ids":["https://openalex.org/I4210090981","https://openalex.org/I4210138501"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161365548","display_name":"Ji-Fei Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210090981","display_name":"Lanzhou Veterinary Research Institute","ror":"https://ror.org/00dg3j745","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210090981","https://openalex.org/I4210127390","https://openalex.org/I4210138501","https://openalex.org/I4210151987"]},{"id":"https://openalex.org/I4210138501","display_name":"Chinese Academy of Agricultural Sciences","ror":"https://ror.org/0313jb750","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210127390","https://openalex.org/I4210138501","https://openalex.org/I4210151987"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ji-Fei Yang","raw_affiliation_strings":["Gansu Province Research Center for Basic Disciplines of Pathogen Biology","Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gansu Province Research Center for Basic Disciplines of Pathogen Biology","institution_ids":[]},{"raw_affiliation_string":"Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences","institution_ids":["https://openalex.org/I4210090981","https://openalex.org/I4210138501"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161373990","display_name":"Xin-Ting Lan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210090981","display_name":"Lanzhou Veterinary Research Institute","ror":"https://ror.org/00dg3j745","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210090981","https://openalex.org/I4210127390","https://openalex.org/I4210138501","https://openalex.org/I4210151987"]},{"id":"https://openalex.org/I4210138501","display_name":"Chinese Academy of Agricultural Sciences","ror":"https://ror.org/0313jb750","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210127390","https://openalex.org/I4210138501","https://openalex.org/I4210151987"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xin-Ting Lan","raw_affiliation_strings":["Gansu Province Research Center for Basic Disciplines of Pathogen Biology","Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gansu Province Research Center for Basic Disciplines of Pathogen Biology","institution_ids":[]},{"raw_affiliation_string":"Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences","institution_ids":["https://openalex.org/I4210090981","https://openalex.org/I4210138501"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067727975","display_name":"Zhan-Cheng Tian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210090981","display_name":"Lanzhou Veterinary Research Institute","ror":"https://ror.org/00dg3j745","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210090981","https://openalex.org/I4210127390","https://openalex.org/I4210138501","https://openalex.org/I4210151987"]},{"id":"https://openalex.org/I4210138501","display_name":"Chinese Academy of Agricultural Sciences","ror":"https://ror.org/0313jb750","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210127390","https://openalex.org/I4210138501","https://openalex.org/I4210151987"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhan-Cheng Tian","raw_affiliation_strings":["Gansu Province Research Center for Basic Disciplines of Pathogen Biology","Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gansu Province Research Center for Basic Disciplines of Pathogen Biology","institution_ids":[]},{"raw_affiliation_string":"Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences","institution_ids":["https://openalex.org/I4210090981","https://openalex.org/I4210138501"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161384436","display_name":"Bell-Sakyi Lesley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146655781","display_name":"University of Liverpool","ror":"https://ror.org/04xs57h96","country_code":"GB","type":"education","lineage":["https://openalex.org/I146655781"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Bell-Sakyi Lesley","raw_affiliation_strings":["Institute of Infection, University of Liverpool"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Infection, University of Liverpool","institution_ids":["https://openalex.org/I146655781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161364047","display_name":"Gui-Quan Guan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210090981","display_name":"Lanzhou Veterinary Research Institute","ror":"https://ror.org/00dg3j745","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210090981","https://openalex.org/I4210127390","https://openalex.org/I4210138501","https://openalex.org/I4210151987"]},{"id":"https://openalex.org/I4210138501","display_name":"Chinese Academy of Agricultural Sciences","ror":"https://ror.org/0313jb750","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210127390","https://openalex.org/I4210138501","https://openalex.org/I4210151987"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Gui-Quan Guan","raw_affiliation_strings":["Gansu Province Research Center for Basic Disciplines of Pathogen Biology","Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gansu Province Research Center for Basic Disciplines of Pathogen Biology","institution_ids":[]},{"raw_affiliation_string":"Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences","institution_ids":["https://openalex.org/I4210090981","https://openalex.org/I4210138501"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161370647","display_name":"Hong Yin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210090981","display_name":"Lanzhou Veterinary Research Institute","ror":"https://ror.org/00dg3j745","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210090981","https://openalex.org/I4210127390","https://openalex.org/I4210138501","https://openalex.org/I4210151987"]},{"id":"https://openalex.org/I4210138501","display_name":"Chinese Academy of Agricultural Sciences","ror":"https://ror.org/0313jb750","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210127390","https://openalex.org/I4210138501","https://openalex.org/I4210151987"]},{"id":"https://openalex.org/I78978612","display_name":"Yangzhou University","ror":"https://ror.org/03tqb8s11","country_code":"CN","type":"education","lineage":["https://openalex.org/I78978612"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hong Yin","raw_affiliation_strings":["Gansu Province Research Center for Basic Disciplines of Pathogen Biology","Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences","Yangzhou University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gansu Province Research Center for Basic Disciplines of Pathogen Biology","institution_ids":[]},{"raw_affiliation_string":"Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences","institution_ids":["https://openalex.org/I4210090981","https://openalex.org/I4210138501"]},{"raw_affiliation_string":"Yangzhou University","institution_ids":["https://openalex.org/I78978612"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102772674","display_name":"Qingli Niu","orcid":"https://orcid.org/0000-0002-4782-5611","observed_orcids":["https://orcid.org/0000-0002-4782-5611","https://orcid.org/0000-0002-0318-295X"]},"institutions":[{"id":"https://openalex.org/I4210090981","display_name":"Lanzhou Veterinary Research Institute","ror":"https://ror.org/00dg3j745","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210090981","https://openalex.org/I4210127390","https://openalex.org/I4210138501","https://openalex.org/I4210151987"]},{"id":"https://openalex.org/I4210138501","display_name":"Chinese Academy of Agricultural Sciences","ror":"https://ror.org/0313jb750","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210127390","https://openalex.org/I4210138501","https://openalex.org/I4210151987"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qing-Li Niu","raw_affiliation_strings":["Gansu Province Research Center for Basic Disciplines of Pathogen Biology","Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences"],"raw_orcid":"https://orcid.org/0000-0002-4782-5611","affiliations":[{"raw_affiliation_string":"Gansu Province Research Center for Basic Disciplines of Pathogen Biology","institution_ids":[]},{"raw_affiliation_string":"Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences","institution_ids":["https://openalex.org/I4210090981","https://openalex.org/I4210138501"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3043,"currency":"USD","value_usd":3043},"apc_paid":{"value":3043,"currency":"USD","value_usd":3043},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"22","issue":"11","first_page":"e1014795","last_page":"e1014795"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11560","display_name":"Animal Disease Management and Epidemiology","score":0.9110999703407288,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11560","display_name":"Animal Disease Management and Epidemiology","score":0.9110999703407288,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.02239999920129776,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.0035000001080334187,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C2778359420","wikidata":"https://www.wikidata.org/wiki/Q195760","display_name":"African swine fever virus","level":3,"score":0.9879999756813049},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7663999795913696},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.6762999892234802},{"id":"https://openalex.org/C2776665880","wikidata":"https://www.wikidata.org/wiki/Q640158","display_name":"Ornithodoros","level":3,"score":0.6313999891281128},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.6123999953269958},{"id":"https://openalex.org/C2781140337","wikidata":"https://www.wikidata.org/wiki/Q640684","display_name":"Argasidae","level":4,"score":0.5580999851226807},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.5432000160217285},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.4999000132083893},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.49079999327659607},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.35760000348091125},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3411000072956085},{"id":"https://openalex.org/C153726182","wikidata":"https://www.wikidata.org/wiki/Q3720909","display_name":"Intracellular parasite","level":3,"score":0.3352999985218048},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.3147999942302704},{"id":"https://openalex.org/C12914427","wikidata":"https://www.wikidata.org/wiki/Q7933612","display_name":"Viral shedding","level":3,"score":0.299699991941452},{"id":"https://openalex.org/C2776672577","wikidata":"https://www.wikidata.org/wiki/Q419618","display_name":"Deferoxamine","level":2,"score":0.29030001163482666},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.28049999475479126},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.27869999408721924},{"id":"https://openalex.org/C2779758228","wikidata":"https://www.wikidata.org/wiki/Q858790","display_name":"DNA virus","level":4,"score":0.2687999904155731},{"id":"https://openalex.org/C92087593","wikidata":"https://www.wikidata.org/wiki/Q427389","display_name":"Vector (molecular biology)","level":4,"score":0.2653999924659729}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1371/journal.ppat.1014795","doi":"https://doi.org/10.1371/journal.ppat.1014795","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.ppat.1014795","pdf_url":null,"source":{"id":"https://openalex.org/S2004986","display_name":"PLoS Pathogens","issn_l":"1553-7366","issn":["1553-7366","1553-7374"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Pathogens","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1371/journal.ppat.1014795","doi":"https://doi.org/10.1371/journal.ppat.1014795","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.ppat.1014795","pdf_url":null,"source":{"id":"https://openalex.org/S2004986","display_name":"PLoS Pathogens","issn_l":"1553-7366","issn":["1553-7366","1553-7374"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Pathogens","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":57,"referenced_works":["https://openalex.org/W79310625","https://openalex.org/W1546720152","https://openalex.org/W1965100677","https://openalex.org/W1966619786","https://openalex.org/W1987311941","https://openalex.org/W1996152690","https://openalex.org/W1997183854","https://openalex.org/W2001070158","https://openalex.org/W2024826805","https://openalex.org/W2025067359","https://openalex.org/W2049741486","https://openalex.org/W2051233094","https://openalex.org/W2053476949","https://openalex.org/W2069178581","https://openalex.org/W2081388900","https://openalex.org/W2086891449","https://openalex.org/W2107090468","https://openalex.org/W2124253765","https://openalex.org/W2143881989","https://openalex.org/W2146773981","https://openalex.org/W2156356581","https://openalex.org/W2165268250","https://openalex.org/W2171306839","https://openalex.org/W2256756668","https://openalex.org/W2759112714","https://openalex.org/W2789695849","https://openalex.org/W2887996898","https://openalex.org/W2904820355","https://openalex.org/W2944611036","https://openalex.org/W2974548560","https://openalex.org/W2974880087","https://openalex.org/W2981124349","https://openalex.org/W2989385987","https://openalex.org/W2994795770","https://openalex.org/W3011248616","https://openalex.org/W3011868091","https://openalex.org/W3069213303","https://openalex.org/W3092348514","https://openalex.org/W3094319646","https://openalex.org/W3112876017","https://openalex.org/W3177407679","https://openalex.org/W3213157858","https://openalex.org/W4283013100","https://openalex.org/W4292575157","https://openalex.org/W4309284776","https://openalex.org/W4376226522","https://openalex.org/W4385754775","https://openalex.org/W4387903042","https://openalex.org/W4392001708","https://openalex.org/W4407956319","https://openalex.org/W4408244283","https://openalex.org/W4409250713","https://openalex.org/W4411284868","https://openalex.org/W4411452630","https://openalex.org/W4411744591","https://openalex.org/W4415005159","https://openalex.org/W7139959181"],"related_works":[],"abstract_inverted_index":{"African":[0],"swine":[1],"fever":[2],"virus":[3],"(ASFV)":[4],"can":[5,53],"be":[6],"transmitted":[7],"through":[8,306],"direct":[9],"contact":[10],"and,":[11],"in":[12,30,61,102,150,183,215,260,269,272,283,287,313],"specific":[13],"ecological":[14],"settings,":[15],"by":[16],"Ornithodoros":[17,94],"spp":[18],".":[19,274,295],"soft":[20],"ticks.":[21],"However,":[22],"the":[23,129,202,240,288],"cellular":[24,44],"mechanisms":[25],"that":[26,106,118,190,300],"support":[27,311],"ASFV":[28,66,107,119,132,156,181,243,254,301,324,342],"replication":[29,75,182,312,343],"both":[31,184],"porcine":[32,185],"host":[33,314],"and":[34,46,57,64,90,113,146,186,209,232,249,262,267,278,315,327,331,344],"tick":[35],"vector":[36,316],"remain":[37],"poorly":[38],"understood.":[39],"Iron":[40],"is":[41,195],"essential":[42],"for":[43,197,337],"metabolism":[45],"viral":[47,169,199,252],"replication,":[48],"but":[49],"excessive":[50,158],"labile":[51,122,138,174],"iron":[52,111,175,258,265,276,329],"induce":[54],"oxidative":[55],"stress":[56],"ferroptosis-like":[58,148,280],"morphological":[59,281],"changes":[60,149,282],"mitochondria.":[62],"Whether":[63],"how":[65],"exploits":[67,302],"intracellular":[68,110,164],"Fe":[69,123,139,192,246,303],"3+":[70,124,140,193,247,304],"homeostasis":[71,248,305,330],"to":[72,244,310],"sustain":[73],"its":[74,220],"has":[76],"not":[77],"been":[78],"fully":[79],"defined.":[80],"In":[81],"this":[82],"study,":[83],"proteomic":[84],"analysis":[85],"of":[86,173,213,237,242,291],"ASFV-infected":[87,292],"PAM":[88],"(pig)":[89],"OME/CTVM24":[91],"(derived":[92],"from":[93],"moubata":[95],")":[96],"cells":[97],"revealed":[98],"a":[99,216,307],"marked":[100],"reduction":[101],"ferritin/FTH1":[103],"abundance,":[104],"suggesting":[105],"infection":[108,255],"alters":[109],"storage":[112],"availability.":[114],"Further":[115],"analyses":[116],"showed":[117],"dynamically":[120],"regulated":[121],"levels":[125,259],"during":[126],"infection.":[127],"At":[128,153],"early":[130],"stage,":[131],"promoted":[133,210],"NCOA4-associated":[134],"ferritin":[135],"turnover,":[136],"increased":[137,256],"release,":[141],"enhanced":[142],"mitochondria-endoplasmic":[143],"reticulum":[144],"contact,":[145],"induced":[147],"mitochondrial":[151,228],"morphology.":[152],"later":[154],"stages,":[155],"restrained":[157],"iron-associated":[159],"damage,":[160],"thereby":[161],"maintaining":[162],"an":[163],"environment":[165],"compatible":[166],"with":[167,176,207],"continued":[168],"replication.":[170,253],"Pharmacological":[171],"depletion":[172,268,277],"deferoxamine":[177],"mesylate":[178],"markedly":[179],"suppressed":[180],"tick-derived":[187],"cells,":[188],"indicating":[189],"controlled":[191],"availability":[194],"required":[196],"efficient":[198],"propagation.":[200],"Mechanistically,":[201],"ASFV-encoded":[203],"protein":[204],"pA151R":[205,225],"interacted":[206],"NCOA4":[208],"autophagic":[211],"degradation":[212],"FTH1":[214],"manner":[217],"dependent":[218],"on":[219],"intact":[221],"LC3-interacting":[222],"region":[223],"motif.":[224],"also":[226],"impaired":[227,239],"outer":[229],"membrane":[230],"integrity":[231],"disrupted":[233],"MDA5-MAVS/VISA":[234],"signaling.":[235],"Deletion":[236],"A151R":[238],"ability":[241],"modulate":[245],"significantly":[250],"reduced":[251],"serum":[257],"pigs":[261],"caused":[263],"abnormal":[264],"redistribution":[266],"splenic":[270],"tissues":[271],"vivo":[273],"Similar":[275],"transient":[279],"mitochondria":[284],"were":[285],"observed":[286],"salivary":[289],"glands":[290],"O.":[293],"lahorensis":[294],"Collectively,":[296],"these":[297],"findings":[298],"demonstrate":[299],"pA151R-NCOA4-FTH1-dependent":[308],"mechanism":[309],"cells.":[317],"This":[318],"study":[319],"provides":[320],"new":[321],"insights":[322],"into":[323],"metabolic":[325],"regulation":[326],"identifies":[328],"pA151R-mediated":[332],"ferritinophagy":[333],"as":[334],"potential":[335],"targets":[336],"strategies":[338],"aimed":[339],"at":[340],"limiting":[341],"tick-associated":[345],"transmission.":[346]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-11T00:00:00"}