{"id":"https://openalex.org/W7225740396","doi":"https://doi.org/10.64898/2026.11.09.765360","title":"HMGB1/CXCL12 heterocomplex activates CXCR4 to suppress the ability of Muller glia to become proliferating progenitor-like cells in the chick retina","display_name":"HMGB1/CXCL12 heterocomplex activates CXCR4 to suppress the ability of Muller glia to become proliferating progenitor-like cells in the chick retina","publication_year":2026,"publication_date":"2026-11-10","ids":{"openalex":"https://openalex.org/W7225740396","doi":"https://doi.org/10.64898/2026.11.09.765360"},"language":"en","primary_location":{"id":"doi:10.64898/2026.11.09.765360","doi":"https://doi.org/10.64898/2026.11.09.765360","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.11.09.765360","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.64898/2026.11.09.765360","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012936799","display_name":"Lisa E. Kelly","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lisa Kelly","raw_affiliation_strings":["Department of Neuroscience, College of Medicine, The Ohio State University;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, College of Medicine, The Ohio State University;","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043883257","display_name":"Olivia Taylor","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Olivia Taylor","raw_affiliation_strings":["Department of Neuroscience, College of Medicine, The Ohio State University,;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, College of Medicine, The Ohio State University,;","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041383601","display_name":"Heithem M. El\u2010Hodiri","orcid":"https://orcid.org/0000-0002-5847-4298","observed_orcids":["https://orcid.org/0000-0002-5847-4298"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Heithem El-Hodiri","raw_affiliation_strings":["Department of Neuroscience, College of Medicine, The Ohio State University,;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, College of Medicine, The Ohio State University,;","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5126754309","display_name":"Samantha Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Samantha Lee","raw_affiliation_strings":["Department of Neuroscience, College of Medicine, The Ohio State University,;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, College of Medicine, The Ohio State University,;","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161406906","display_name":"Elina Parekh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elina Parekh","raw_affiliation_strings":["Department of Neuroscience, College of Medicine, The Ohio State University,;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, College of Medicine, The Ohio State University,;","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161394091","display_name":"Evan Hawthorn","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Evan Hawthorn","raw_affiliation_strings":["Kentucky College of Osteopathic Medicine;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kentucky College of Osteopathic Medicine;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161363699","display_name":"Joshua Wright","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joshua Wright","raw_affiliation_strings":["Neuroscience Graduate Program, The Ohio State University,;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroscience Graduate Program, The Ohio State University,;","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012746794","display_name":"Mary Guest","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mary Guest","raw_affiliation_strings":["Neuroscience Graduate Program, The Ohio State University,;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroscience Graduate Program, The Ohio State University,;","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161400806","display_name":"Allen Tangemen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I95240055","display_name":"Northeast Ohio Medical University","ror":"https://ror.org/04q9qf557","country_code":"US","type":"education","lineage":["https://openalex.org/I95240055"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Allen Tangemen","raw_affiliation_strings":["Northeast Ohio Medical University, Rootstown"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northeast Ohio Medical University, Rootstown","institution_ids":["https://openalex.org/I95240055"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063139808","display_name":"Andy J. Fischer","orcid":"https://orcid.org/0000-0001-6123-7405","observed_orcids":["https://orcid.org/0000-0001-6123-7405"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andy Fischer","raw_affiliation_strings":["Department of Neuroscience, College of Medicine, The Ohio State University,;"],"raw_orcid":"https://orcid.org/0000-0001-6123-7405","affiliations":[{"raw_affiliation_string":"Department of Neuroscience, College of Medicine, The Ohio State University,;","institution_ids":["https://openalex.org/I52357470"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.9301999807357788,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.9301999807357788,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.010700000450015068,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.0066999997943639755,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7750999927520752},{"id":"https://openalex.org/C2777102633","wikidata":"https://www.wikidata.org/wiki/Q735343","display_name":"Muller glia","level":4,"score":0.7249000072479248},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6182000041007996},{"id":"https://openalex.org/C2779830541","wikidata":"https://www.wikidata.org/wiki/Q1622829","display_name":"Microglia","level":3,"score":0.524399995803833},{"id":"https://openalex.org/C2780545709","wikidata":"https://www.wikidata.org/wiki/Q21130552","display_name":"HMGB1","level":3,"score":0.5238999724388123},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4997999966144562},{"id":"https://openalex.org/C77255625","wikidata":"https://www.wikidata.org/wiki/Q402093","display_name":"Reprogramming","level":3,"score":0.49160000681877136},{"id":"https://openalex.org/C12823836","wikidata":"https://www.wikidata.org/wiki/Q24720618","display_name":"Chemokine receptor","level":4,"score":0.4731000065803528},{"id":"https://openalex.org/C2777093970","wikidata":"https://www.wikidata.org/wiki/Q169342","display_name":"Retina","level":2,"score":0.4708000123500824},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.4625000059604645},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.414900004863739},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.4027000069618225},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.39489999413490295},{"id":"https://openalex.org/C2780884517","wikidata":"https://www.wikidata.org/wiki/Q177105","display_name":"Neuroglia","level":3,"score":0.36320000886917114},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.36079999804496765},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3407000005245209},{"id":"https://openalex.org/C129470790","wikidata":"https://www.wikidata.org/wiki/Q415718","display_name":"CXCR4","level":4,"score":0.32249999046325684},{"id":"https://openalex.org/C2780827179","wikidata":"https://www.wikidata.org/wiki/Q422001","display_name":"Retinal","level":2,"score":0.311599999666214},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.30649998784065247},{"id":"https://openalex.org/C84913492","wikidata":"https://www.wikidata.org/wiki/Q5014892","display_name":"CXC chemokine receptors","level":5,"score":0.2881999909877777},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.27630001306533813},{"id":"https://openalex.org/C5858377","wikidata":"https://www.wikidata.org/wiki/Q986112","display_name":"CXCL10","level":4,"score":0.2529999911785126},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.25}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.11.09.765360","doi":"https://doi.org/10.64898/2026.11.09.765360","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.11.09.765360","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.11.09.765360","doi":"https://doi.org/10.64898/2026.11.09.765360","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.11.09.765360","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"We":[0,181],"investigated":[1],"how":[2],"High":[3],"Mobility":[4],"Group":[5],"Box":[6],"1":[7],"(HMGB1)":[8],"signaling":[9,121,199,213],"regulates":[10],"glial":[11],"reactivity":[12],"and":[13,55,57,94,104,119,155,172,195,223],"Muller":[14,102,123,193,220],"glia-derived":[15],"progenitor":[16],"cell":[17],"(MGPC)":[18],"formation":[19,138,225],"in":[20,52,122,125,192,205,226],"the":[21,62],"chick":[22],"retina.":[23],"HMGB1":[24,48,132,164,175],"released":[25],"from":[26,61],"stressed":[27,65],"cells":[28,80],"is":[29,49,58,89,99,105,170],"known":[30],"to":[31,41,157,167,188],"form":[32],"a":[33,71],"heterocomplex":[34],"with":[35,153],"C-X-C":[36,43],"chemokine":[37,44],"ligand":[38],"12":[39],"(CXCL12)":[40],"activate":[42],"receptor":[45],"4":[46],"(CXCR4).":[47],"broadly":[50],"expressed":[51,90,100],"retinal":[53,67],"neurons":[54,68],"glia":[56,103,124,221],"rapidly":[59,106],"exported":[60,82],"nuclei":[63],"of":[64,129,162,174,197],"inner":[66],"after":[69],"damage,":[70],"process":[72],"blocked":[73],"by":[74,91,101],"inflachromene.":[75],"Stressed":[76],"or":[77,112,135,147,176],"damaged":[78,227],"amacrine":[79],"also":[81],"different":[83],"transcription":[84],"factors":[85],"out":[86],"nuclei.":[87],"CXCL12":[88],"amacrine,":[92],"horizontal,":[93],"bipolar":[95],"cells,":[96],"whereas":[97],"CXCR4":[98,110,130,169,177,190],"upregulated":[107],"following":[108],"damage.":[109],"agonist":[111],"recombinant":[113],"HMGB1/CXCL12":[114,136],"treatment":[115],"selectively":[116],"stimulates":[117],"mTOR":[118],"Jak/Stat":[120],"undamaged":[126],"retinas.":[127,207,228],"Inhibition":[128],"signaling,":[131],"nuclear":[133],"export,":[134],"complex":[137],"potently":[139],"stimulated":[140],"MGPC":[141,159,203,224],"proliferation":[142,160,204],"without":[143],"affecting":[144],"neuronal":[145],"death":[146],"microglial":[148],"activation.":[149],"In":[150],"retinas":[151],"treated":[152],"insulin":[154],"FGF2,":[156],"induce":[158],"independent":[161],"injury,":[163],"remains":[165],"confined":[166],"nuclei,":[168],"downregulated,":[171],"inhibition":[173],"has":[178],"no":[179],"effect.":[180],"further":[182],"demonstrate":[183],"that":[184,218],"microglia":[185],"are":[186],"required":[187],"maintain":[189],"expression":[191],"glia,":[194],"blockade":[196],"HMGB1/CXCL12-CXCR4":[198,212],"does":[200],"not":[201],"restore":[202],"microglia-depleted":[206],"Together,":[208],"these":[209],"findings":[210],"identify":[211],"as":[214],"an":[215],"injury-induced":[216],"pathway":[217],"limits":[219],"reprogramming":[222]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-11T00:00:00"}