{"id":"https://openalex.org/W7225740135","doi":"https://doi.org/10.1186/s12865-026-00927-4","title":"The prognostic evaluation value of lung ultrasound score combined with serum miR-224-5p in acute respiratory distress syndrome","display_name":"The prognostic evaluation value of lung ultrasound score combined with serum miR-224-5p in acute respiratory distress syndrome","publication_year":2026,"publication_date":"2026-11-10","ids":{"openalex":"https://openalex.org/W7225740135","doi":"https://doi.org/10.1186/s12865-026-00927-4"},"language":"en","primary_location":{"id":"doi:10.1186/s12865-026-00927-4","doi":"https://doi.org/10.1186/s12865-026-00927-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12865-026-00927-4","pdf_url":null,"source":{"id":"https://openalex.org/S127311448","display_name":"BMC Immunology","issn_l":"1471-2172","issn":["1471-2172"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1186/s12865-026-00927-4","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5161374707","display_name":"Wenying Xu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210153612","display_name":"Chongqing Public Health Medical Center","ror":"https://ror.org/04dcmpg83","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153612"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenying Xu","raw_affiliation_strings":["Department of Sonography and Electrocardiography, CHONGQING PUBLIC HEALTH MEDICAL CENTER, Chongqing, 400036, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Sonography and Electrocardiography, CHONGQING PUBLIC HEALTH MEDICAL CENTER, Chongqing, 400036, China","institution_ids":["https://openalex.org/I4210153612"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100412177","display_name":"Fei Zhang","orcid":"https://orcid.org/0000-0002-4445-3023","observed_orcids":["https://orcid.org/0000-0002-4445-3023"]},"institutions":[{"id":"https://openalex.org/I4210103346","display_name":"Nanfang Hospital","ror":"https://ror.org/01eq10738","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103346"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fei Zhang","raw_affiliation_strings":["Department of Medical Imaging, Zengcheng Campus, Nanfang Hospital, Southern Medical University, Guangzhou, 511358, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Imaging, Zengcheng Campus, Nanfang Hospital, Southern Medical University, Guangzhou, 511358, China","institution_ids":["https://openalex.org/I4210103346","https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100294970","display_name":"Gang Zhou","orcid":"https://orcid.org/0000-0002-7448-6635","observed_orcids":["https://orcid.org/0000-0002-7448-6635"]},"institutions":[{"id":"https://openalex.org/I4210153612","display_name":"Chongqing Public Health Medical Center","ror":"https://ror.org/04dcmpg83","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153612"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Gang Zhou","raw_affiliation_strings":["Clinical Laboratory, CHONGQING PUBLIC HEALTH MEDICAL CENTER, Chongqing, 400036, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Laboratory, CHONGQING PUBLIC HEALTH MEDICAL CENTER, Chongqing, 400036, China","institution_ids":["https://openalex.org/I4210153612"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5152140038","display_name":"Jinjin Tian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210132906","display_name":"Xuzhou Central Hospital","ror":"https://ror.org/048q23a93","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210132906"]},{"id":"https://openalex.org/I76569877","display_name":"Southeast University","ror":"https://ror.org/04ct4d772","country_code":"CN","type":"education","lineage":["https://openalex.org/I76569877"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jinjin Tian","raw_affiliation_strings":["Department of Ultrasound, Xuzhou Central Hospital (Southeast University Affiliated Hospital), Xuzhou, 221009, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ultrasound, Xuzhou Central Hospital (Southeast University Affiliated Hospital), Xuzhou, 221009, China","institution_ids":["https://openalex.org/I4210132906","https://openalex.org/I76569877"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161416895","display_name":"Haijing Song","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Haijing Song","raw_affiliation_strings":["Department of Ultrasound, The First People\u2019s Hospital of Yongkang, Zhejiang, 321300, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ultrasound, The First People\u2019s Hospital of Yongkang, Zhejiang, 321300, China","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5161396931","display_name":"Ran Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I78978612","display_name":"Yangzhou University","ror":"https://ror.org/03tqb8s11","country_code":"CN","type":"education","lineage":["https://openalex.org/I78978612"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ran Zhang","raw_affiliation_strings":["Department of Respiratory and Critical Care Medicine, Huai\u2019an Fifth Hospital Affiliated to Yangzhou University, Yangzhou, 223300, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory and Critical Care Medicine, Huai\u2019an Fifth Hospital Affiliated to Yangzhou University, Yangzhou, 223300, China","institution_ids":["https://openalex.org/I78978612"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5161396931"],"corresponding_institution_ids":["https://openalex.org/I78978612"],"apc_list":{"value":3090,"currency":"USD","value_usd":3090},"apc_paid":{"value":3090,"currency":"USD","value_usd":3090},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.7031000256538391,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.7031000256538391,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.12049999833106995,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11738","display_name":"Ultrasound in Clinical Applications","score":0.10180000215768814,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.800000011920929},{"id":"https://openalex.org/C2776348555","wikidata":"https://www.wikidata.org/wiki/Q344873","display_name":"ARDS","level":3,"score":0.7174999713897705},{"id":"https://openalex.org/C58471807","wikidata":"https://www.wikidata.org/wiki/Q327120","display_name":"Receiver operating characteristic","level":2,"score":0.6718999743461609},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5666000247001648},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.54339998960495},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5027999877929688},{"id":"https://openalex.org/C76318530","wikidata":"https://www.wikidata.org/wiki/Q16833590","display_name":"Area under the curve","level":2,"score":0.4871000051498413},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.4864000082015991},{"id":"https://openalex.org/C2909621147","wikidata":"https://www.wikidata.org/wiki/Q344873","display_name":"Acute respiratory distress","level":3,"score":0.4779999852180481},{"id":"https://openalex.org/C2781090800","wikidata":"https://www.wikidata.org/wiki/Q776030","display_name":"Systemic inflammatory response syndrome","level":3,"score":0.39559999108314514},{"id":"https://openalex.org/C198433322","wikidata":"https://www.wikidata.org/wiki/Q3910099","display_name":"Predictive value of tests","level":2,"score":0.3781999945640564},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.365200012922287},{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.3490999937057495},{"id":"https://openalex.org/C143753070","wikidata":"https://www.wikidata.org/wiki/Q162564","display_name":"Ultrasound","level":2,"score":0.34880000352859497},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.336899995803833},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3240000009536743},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.31700000166893005},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.3052000105381012},{"id":"https://openalex.org/C3019719930","wikidata":"https://www.wikidata.org/wiki/Q3910099","display_name":"Predictive value","level":2,"score":0.3034999966621399},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.299699991941452},{"id":"https://openalex.org/C141983124","wikidata":"https://www.wikidata.org/wiki/Q188008","display_name":"Respiratory distress","level":2,"score":0.2924000024795532},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.28940001130104065},{"id":"https://openalex.org/C48023723","wikidata":"https://www.wikidata.org/wiki/Q856198","display_name":"Real-time polymerase chain reaction","level":3,"score":0.2892000079154968},{"id":"https://openalex.org/C2778488018","wikidata":"https://www.wikidata.org/wiki/Q42395","display_name":"White blood cell","level":2,"score":0.289000004529953},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.2797999978065491},{"id":"https://openalex.org/C11783203","wikidata":"https://www.wikidata.org/wiki/Q5478027","display_name":"Framingham Risk Score","level":3,"score":0.27970001101493835},{"id":"https://openalex.org/C9418649","wikidata":"https://www.wikidata.org/wiki/Q5275407","display_name":"Diffuse alveolar damage","level":4,"score":0.2784999907016754},{"id":"https://openalex.org/C2777914695","wikidata":"https://www.wikidata.org/wiki/Q12192","display_name":"Pneumonia","level":2,"score":0.27799999713897705},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.27129998803138733},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.2703000009059906},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2702000141143799},{"id":"https://openalex.org/C2776252253","wikidata":"https://www.wikidata.org/wiki/Q7663815","display_name":"Systemic inflammation","level":3,"score":0.26649999618530273},{"id":"https://openalex.org/C534529494","wikidata":"https://www.wikidata.org/wiki/Q7891","display_name":"Respiratory system","level":2,"score":0.266400009393692},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.26570001244544983},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2563000023365021},{"id":"https://openalex.org/C74172505","wikidata":"https://www.wikidata.org/wiki/Q194908","display_name":"Interleukin","level":3,"score":0.2542000114917755},{"id":"https://openalex.org/C503630168","wikidata":"https://www.wikidata.org/wiki/Q178069","display_name":"Necrosis","level":2,"score":0.2515999972820282}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1186/s12865-026-00927-4","doi":"https://doi.org/10.1186/s12865-026-00927-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12865-026-00927-4","pdf_url":null,"source":{"id":"https://openalex.org/S127311448","display_name":"BMC Immunology","issn_l":"1471-2172","issn":["1471-2172"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Immunology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1186/s12865-026-00927-4","doi":"https://doi.org/10.1186/s12865-026-00927-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12865-026-00927-4","pdf_url":null,"source":{"id":"https://openalex.org/S127311448","display_name":"BMC Immunology","issn_l":"1471-2172","issn":["1471-2172"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Immunology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"This":[0],"study":[1],"investigated":[2],"whether":[3],"the":[4,8,18,36,67,92,152,189,195,203,214,229,259],"combined":[5,72,164],"application":[6],"of":[7,70,119,169,191,197,205,217,221,231,248],"lung":[9],"ultrasound":[10],"score":[11,75,133,154,223],"(LUS":[12,74],"score)":[13],"and":[14,38,101,111,116,127,175,193,199,224],"serum":[15,77],"miR-224-5p":[16,144,156,183,225,238],"enhances":[17],"prognostic":[19,55,159,232,260],"prediction":[20],"accuracy":[21,230],"in":[22,234,264],"patients":[23,235],"with":[24,31,85,155,166,236],"acute":[25],"respiratory":[26],"distress":[27],"syndrome":[28],"(ARDS).":[29],"Patients":[30],"ARDS":[32],"were":[33,83,105,123],"stratified":[34],"into":[35],"survivor":[37],"non-survivor":[39],"groups":[40],"according":[41],"to":[42,53,65,107],"their":[43],"28-day":[44],"survival":[45],"status":[46],"post-diagnosis.":[47],"Logistic":[48],"regression":[49],"analysis":[50],"was":[51,63,89,134,254],"performed":[52],"identify":[54],"risk":[56,138],"factors.":[57,201],"Receiver":[58],"operating":[59],"characteristic":[60],"(ROC)":[61],"curve":[62],"applied":[64],"evaluate":[66,108],"predictive":[68,160],"efficacy":[69],"two-variable":[71],"model":[73,165,261],"+":[76],"miR-224-5p).":[78],"In":[79,178],"vitro,":[80],"BEAS-2B":[81],"cells":[82,179],"treated":[84],"LPS.":[86],"Cell":[87],"viability":[88],"evaluated":[90],"by":[91,125,181],"CCK-8":[93],"assay.":[94],"Caspase-3":[95],"activity":[96,103,190],"assay,":[97],"MDA":[98,198],"content":[99],"measurement,":[100],"SOD":[102],"assay":[104],"conducted":[106],"cell":[109,186,243],"apoptosis":[110],"oxidative":[112],"stress.":[113],"The":[114,219],"transcriptional":[115],"secretory":[117],"levels":[118],"inflammatory":[120,200],"cytokines":[121],"(IL-6/IL-8/IL-1\u03b2)":[122],"determined":[124],"RT-qPCR":[126],"ELISA,":[128],"respectively.":[129],"An":[130],"elevated":[131],"LUS":[132,153,222],"identified":[135],"as":[136,146],"a":[137,163,255],"factor":[139],"for":[140],"unfavorable":[141],"prognosis,":[142],"while":[143],"served":[145],"an":[147,167],"independent":[148],"protective":[149,215],"factor.":[150],"Integrating":[151],"markedly":[157],"improved":[158],"accuracy,":[161],"yielding":[162],"AUC":[168],"0.8924":[170],"(95%CI:":[171],"0.8370\u20130.9479),":[172],"83.33%":[173],"sensitivity":[174],"84.78%":[176],"specificity.":[177],"induced":[180],"LPS,":[182],"significantly":[184],"enhanced":[185],"viability,":[187],"increased":[188],"SOD,":[192],"reduced":[194],"synthesis":[196],"As":[202],"target":[204],"miR-224-5p,":[206],"SETD7":[207],"(SET":[208],"domain-containing":[209],"lysine":[210],"methyltransferase":[211],"7)":[212],"weakened":[213],"effect":[216],"miR-224-5p.":[218],"combination":[220],"can":[226],"effectively":[227],"improve":[228],"assessment":[233],"ARDS.":[237],"mitigates":[239],"LPS-induced":[240],"bronchial":[241],"epithelial":[242],"injury":[244],"via":[245],"targeted":[246],"regulation":[247],"SETD7.":[249],"However,":[250],"given":[251],"that":[252],"this":[253],"single-center":[256],"retrospective":[257],"study,":[258],"requires":[262],"validation":[263],"multicenter":[265],"cohorts.":[266]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-11T00:00:00"}