{"id":"https://openalex.org/W7225739914","doi":"https://doi.org/10.3389/fgene.2026.1989287","title":"Integrated transcriptomic and functional analysis identifies an SLC7A11-associated lncRNA program in papillary thyroid carcinoma","display_name":"Integrated transcriptomic and functional analysis identifies an SLC7A11-associated lncRNA program in papillary thyroid carcinoma","publication_year":2026,"publication_date":"2026-11-10","ids":{"openalex":"https://openalex.org/W7225739914","doi":"https://doi.org/10.3389/fgene.2026.1989287"},"language":"en","primary_location":{"id":"doi:10.3389/fgene.2026.1989287","doi":"https://doi.org/10.3389/fgene.2026.1989287","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fgene.2026.1989287","pdf_url":null,"source":{"id":"https://openalex.org/S2597340651","display_name":"Frontiers in Genetics","issn_l":"1664-8021","issn":["1664-8021"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Genetics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3389/fgene.2026.1989287","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5161404046","display_name":"Yu Xiang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yu Xiang","raw_affiliation_strings":["Department of Laboratory Medicine, Suining Central Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, Suining Central Hospital","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100707283","display_name":"Lin Wu","orcid":"https://orcid.org/0000-0001-7169-3519","observed_orcids":["https://orcid.org/0000-0001-7169-3519"]},"institutions":[{"id":"https://openalex.org/I158842170","display_name":"Chongqing University","ror":"https://ror.org/023rhb549","country_code":"CN","type":"education","lineage":["https://openalex.org/I158842170"]},{"id":"https://openalex.org/I87780372","display_name":"Chongqing Medical University","ror":"https://ror.org/017z00e58","country_code":"CN","type":"education","lineage":["https://openalex.org/I87780372"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Lin Wu","raw_affiliation_strings":["Department of Hepatological Surgery, Chongqing University Central Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatological Surgery, Chongqing University Central Hospital","institution_ids":["https://openalex.org/I158842170","https://openalex.org/I87780372"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5161415764","display_name":"Piyun Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I158842170","display_name":"Chongqing University","ror":"https://ror.org/023rhb549","country_code":"CN","type":"education","lineage":["https://openalex.org/I158842170"]},{"id":"https://openalex.org/I4210135470","display_name":"Chongqing Emergency Medical Center","ror":"https://ror.org/03xhwyc44","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210135470"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Piyun Zhang","raw_affiliation_strings":["Department of Gastroenterology, Chongqing University Central Hospital, Chongqing Emergency Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Chongqing University Central Hospital, Chongqing Emergency Medical Center","institution_ids":["https://openalex.org/I158842170","https://openalex.org/I4210135470"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5100707283","https://openalex.org/A5161415764"],"corresponding_institution_ids":["https://openalex.org/I158842170","https://openalex.org/I4210135470","https://openalex.org/I87780372"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.8955000042915344,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.8955000042915344,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":0.08089999854564667,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.7384999990463257},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6830000281333923},{"id":"https://openalex.org/C2993294228","wikidata":"https://www.wikidata.org/wiki/Q13632630","display_name":"Thyroid carcinoma","level":3,"score":0.5564000010490417},{"id":"https://openalex.org/C2779761222","wikidata":"https://www.wikidata.org/wiki/Q826522","display_name":"Thyroid cancer","level":3,"score":0.510699987411499},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5080000162124634},{"id":"https://openalex.org/C134305767","wikidata":"https://www.wikidata.org/wiki/Q725508","display_name":"Somatic cell","level":3,"score":0.4593999981880188},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.44699999690055847},{"id":"https://openalex.org/C2780851360","wikidata":"https://www.wikidata.org/wiki/Q21686041","display_name":"Immune checkpoint","level":4,"score":0.445499986410141},{"id":"https://openalex.org/C2781461381","wikidata":"https://www.wikidata.org/wiki/Q2292945","display_name":"Papillary thyroid cancer","level":4,"score":0.4341000020503998},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.4099999964237213},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4016999900341034},{"id":"https://openalex.org/C27153228","wikidata":"https://www.wikidata.org/wiki/Q3787274","display_name":"Transcriptional regulation","level":4,"score":0.3779999911785126},{"id":"https://openalex.org/C2779419633","wikidata":"https://www.wikidata.org/wiki/Q7322423","display_name":"Ribosome biogenesis","level":5,"score":0.3569999933242798},{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.33899998664855957},{"id":"https://openalex.org/C2779727006","wikidata":"https://www.wikidata.org/wiki/Q426188","display_name":"FOXP3","level":3,"score":0.33820000290870667},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.334199994802475},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.32030001282691956},{"id":"https://openalex.org/C2779256057","wikidata":"https://www.wikidata.org/wiki/Q16909647","display_name":"Tumor progression","level":3,"score":0.314300000667572},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.3140000104904175},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.29600000381469727},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.2953000068664551},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2915000021457672},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.2865000069141388},{"id":"https://openalex.org/C104397665","wikidata":"https://www.wikidata.org/wiki/Q860947","display_name":"Proteome","level":2,"score":0.2815999984741211},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.28049999475479126},{"id":"https://openalex.org/C13514818","wikidata":"https://www.wikidata.org/wiki/Q5552256","display_name":"Germline mutation","level":4,"score":0.2743000090122223},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.27300000190734863},{"id":"https://openalex.org/C161078062","wikidata":"https://www.wikidata.org/wiki/Q1068690","display_name":"Functional genomics","level":5,"score":0.26969999074935913},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.2551000118255615}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3389/fgene.2026.1989287","doi":"https://doi.org/10.3389/fgene.2026.1989287","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fgene.2026.1989287","pdf_url":null,"source":{"id":"https://openalex.org/S2597340651","display_name":"Frontiers in Genetics","issn_l":"1664-8021","issn":["1664-8021"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Genetics","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.3389/fgene.2026.1989287","doi":"https://doi.org/10.3389/fgene.2026.1989287","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fgene.2026.1989287","pdf_url":null,"source":{"id":"https://openalex.org/S2597340651","display_name":"Frontiers in Genetics","issn_l":"1664-8021","issn":["1664-8021"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Genetics","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W1848939527","https://openalex.org/W1869029218","https://openalex.org/W1985213868","https://openalex.org/W2159707944","https://openalex.org/W2163294546","https://openalex.org/W2640064441","https://openalex.org/W2793869566","https://openalex.org/W2886498337","https://openalex.org/W2943793201","https://openalex.org/W3014091199","https://openalex.org/W3090693089","https://openalex.org/W3094159415","https://openalex.org/W3159024074","https://openalex.org/W4308834893","https://openalex.org/W4319310752","https://openalex.org/W4391317426","https://openalex.org/W4391843556","https://openalex.org/W4392194187","https://openalex.org/W4402175368","https://openalex.org/W4413972333"],"related_works":[],"abstract_inverted_index":{"Background":[0],"Tumor":[1],"progression":[2],"is":[3,22,34],"shaped":[4],"by":[5,141,149],"coordinated":[6],"transcriptional":[7,93,165,307],"programs":[8,49],"that":[9],"support":[10],"metabolic":[11],"stress":[12,53,333,356],"adaptation":[13,357],"and":[14,30,33,65,102,121,152,182,201,211,237,248,256,267,273,289,305,332,358],"remodel":[15],"interactions":[16],"with":[17,51,89,168,178,189,220,302],"the":[18,44,169,196,243,275,352],"immune":[19,119,208,359],"microenvironment.":[20],"SLC7A11":[21],"a":[23,105,163,311,340,348],"major":[24],"regulator":[25],"of":[26,104,125,135,206,269,310,322],"cellular":[27,287,330],"cystine":[28],"metabolism":[29],"redox":[31],"homeostasis":[32],"also":[35,231,325],"closely":[36],"linked":[37,195],"to":[38,40,85,114,199,328],"susceptibility":[39],"disulfide":[41],"stress.":[42],"However,":[43],"long":[45],"non-coding":[46],"RNA":[47],"(lncRNA)":[48],"associated":[50,88,167,177,301],"SLC7A11-dependent":[52],"states":[54],"in":[55,112,130,144,187,253,278,285,316,361],"papillary":[56,80,317],"thyroid":[57,74,81,145,270,318,362],"carcinoma":[58,75],"remain":[59],"poorly":[60],"characterized.":[61],"Methods":[62],"Transcriptomic,":[63],"clinicopathological,":[64],"somatic":[66,234],"mutation":[67,235],"data":[68],"from":[69],"The":[70],"Cancer":[71],"Genome":[72],"Atlas":[73],"cohort":[76],"(TCGA-THCA),":[77],"comprising":[78],"primarily":[79],"carcinoma,":[82],"were":[83,250,257],"integrated":[84],"identify":[86,296],"lncRNAs":[87,127,137,264],"an":[90,221,297],"SLC7A11-centered":[91,170],"stress-related":[92],"network.":[94,171],"Penalized":[95],"regression":[96],"was":[97,109,128,138,176],"used":[98],"for":[99,259,350],"feature":[100],"reduction":[101,277],"generation":[103],"seven-lncRNA":[106,164],"score,":[107],"which":[108],"subsequently":[110],"examined":[111],"relation":[113],"clinical":[115,131,180],"outcome,":[116],"tumor-associated":[117],"pathways,":[118,203],"programs,":[120],"genomic":[122],"features.":[123],"Expression":[124],"candidate":[126],"evaluated":[129],"specimens.":[132],"Functional":[133],"relevance":[134],"selected":[136,258],"further":[139],"assessed":[140],"siRNA-mediated":[142],"silencing":[143],"cancer":[146,271],"cells":[147,272],"followed":[148],"proliferation,":[150],"migration,":[151],"drug-response":[153],"assays":[154],"based":[155],"on":[156],"cell":[157,279],"viability":[158],"measurements.":[159],"Results":[160],"We":[161],"identified":[162],"program":[166,174,300,324,345],"A":[172],"higher":[173],"score":[175],"unfavorable":[179],"outcome":[181],"showed":[183],"stronger":[184],"discriminatory":[185],"value":[186],"patients":[188],"more":[190],"advanced":[191],"disease.":[192],"Transcriptomic":[193],"analyses":[194],"high-score":[197],"state":[198,315],"immune-":[200],"cytokine-related":[202],"increased":[204],"expression":[205],"multiple":[207],"checkpoint":[209],"molecules,":[210],"altered":[212],"estimated":[213],"immune-cell":[214],"infiltration,":[215],"collectively":[216],"revealing":[217],"features":[218,308],"consistent":[219],"immune-recognizable":[222],"but":[223],"potentially":[224],"functionally":[225,312,327],"constrained":[226,313],"tumor":[227,239,254,314,355],"phenotype.":[228],"High-score":[229],"tumors":[230],"displayed":[232],"distinct":[233],"patterns":[236],"lower":[238],"mutational":[240],"burden.":[241],"Among":[242],"seven":[244],"lncRNAs,":[245],"AC107071.1,":[246],"AC073957.3,":[247],"PRKAR1B-AS1":[249],"consistently":[251],"overexpressed":[252],"tissues":[255],"functional":[260,283],"interrogation.":[261],"Silencing":[262],"these":[263],"reduced":[265],"proliferation":[266],"migration":[268],"enhanced":[274],"ML210-associated":[276],"viability,":[280],"supporting":[281],"their":[282],"involvement":[284],"malignant":[286,329],"behavior":[288,331],"stress-associated":[290],"drug":[291],"responses.":[292],"Conclusion":[293],"These":[294],"findings":[295],"SLC7A11-linked":[298],"lncRNA":[299,344],"aggressive":[303],"disease":[304],"immune-related":[306],"suggestive":[309],"carcinoma.":[319,363],"Selected":[320],"components":[321],"this":[323,343],"contribute":[326],"sensitivity.":[334],"Rather":[335],"than":[336],"serving":[337],"solely":[338],"as":[339],"prognostic":[341],"classifier,":[342],"may":[346],"provide":[347],"framework":[349],"understanding":[351],"interplay":[353],"between":[354],"remodeling":[360]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-11T00:00:00"}