{"id":"https://openalex.org/W7225739867","doi":"https://doi.org/10.21203/rs.3.rs-11369829/v1","title":"Baseline and Time-Dependent Laboratory Prognostic Factors for In-Hospital Mortality After Acute Diquat Poisoning: A Retrospective Cohort Study","display_name":"Baseline and Time-Dependent Laboratory Prognostic Factors for In-Hospital Mortality After Acute Diquat Poisoning: A Retrospective Cohort Study","publication_year":2026,"publication_date":"2026-11-10","ids":{"openalex":"https://openalex.org/W7225739867","doi":"https://doi.org/10.21203/rs.3.rs-11369829/v1"},"language":"en","primary_location":{"id":"doi:10.21203/rs.3.rs-11369829/v1","doi":"https://doi.org/10.21203/rs.3.rs-11369829/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-11369829/v1","pdf_url":null,"source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.21203/rs.3.rs-11369829/v1","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102006933","display_name":"Na Meng","orcid":"https://orcid.org/0000-0002-5234-8872","observed_orcids":["https://orcid.org/0000-0002-5234-8872"]},"institutions":[{"id":"https://openalex.org/I4210099373","display_name":"Second Hospital of Hebei Medical University","ror":"https://ror.org/015ycqv20","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099373"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Na Meng","raw_affiliation_strings":["The Second Hospital of Hebei Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Second Hospital of Hebei Medical University","institution_ids":["https://openalex.org/I4210099373"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161381677","display_name":"Yongkai Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210099373","display_name":"Second Hospital of Hebei Medical University","ror":"https://ror.org/015ycqv20","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099373"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yongkai Li","raw_affiliation_strings":["The Second Hospital of Hebei Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Second Hospital of Hebei Medical University","institution_ids":["https://openalex.org/I4210099373"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124202773","display_name":"Yiqing Sun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210099373","display_name":"Second Hospital of Hebei Medical University","ror":"https://ror.org/015ycqv20","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099373"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yiqing Sun","raw_affiliation_strings":["The Second Hospital of Hebei Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Second Hospital of Hebei Medical University","institution_ids":["https://openalex.org/I4210099373"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002411454","display_name":"Hengbo Gao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210099373","display_name":"Second Hospital of Hebei Medical University","ror":"https://ror.org/015ycqv20","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099373"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hengbo Gao","raw_affiliation_strings":["The Second Hospital of Hebei Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Second Hospital of Hebei Medical University","institution_ids":["https://openalex.org/I4210099373"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036424090","display_name":"Dongqi Yao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210099373","display_name":"Second Hospital of Hebei Medical University","ror":"https://ror.org/015ycqv20","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099373"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dongqi Yao","raw_affiliation_strings":["The Second Hospital of Hebei Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Second Hospital of Hebei Medical University","institution_ids":["https://openalex.org/I4210099373"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102218366","display_name":"Yingping Tian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210099373","display_name":"Second Hospital of Hebei Medical University","ror":"https://ror.org/015ycqv20","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099373"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yingping Tian","raw_affiliation_strings":["The Second Hospital of Hebei Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Second Hospital of Hebei Medical University","institution_ids":["https://openalex.org/I4210099373"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210099373"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13639","display_name":"Paraquat toxicity studies and treatments","score":0.8281000256538391,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13639","display_name":"Paraquat toxicity studies and treatments","score":0.8281000256538391,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11635","display_name":"Poisoning and overdose treatments","score":0.16609999537467957,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10875","display_name":"Pesticide Exposure and Toxicity","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.847000002861023},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.7240999937057495},{"id":"https://openalex.org/C2780306776","wikidata":"https://www.wikidata.org/wiki/Q426660","display_name":"Creatinine","level":2,"score":0.6299999952316284},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.5455999970436096},{"id":"https://openalex.org/C2777163875","wikidata":"https://www.wikidata.org/wiki/Q910903","display_name":"Diquat","level":3,"score":0.5370000004768372},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4902999997138977},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.48089998960494995},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.47510001063346863},{"id":"https://openalex.org/C122048520","wikidata":"https://www.wikidata.org/wiki/Q2913954","display_name":"Percentile","level":2,"score":0.34619998931884766},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.3336000144481659},{"id":"https://openalex.org/C2778176769","wikidata":"https://www.wikidata.org/wiki/Q764079","display_name":"Blood urea nitrogen","level":3,"score":0.3327000141143799},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.3271999955177307},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.32280001044273376},{"id":"https://openalex.org/C194828623","wikidata":"https://www.wikidata.org/wiki/Q2861470","display_name":"Emergency medicine","level":1,"score":0.32089999318122864},{"id":"https://openalex.org/C10515644","wikidata":"https://www.wikidata.org/wiki/Q543310","display_name":"Survival analysis","level":2,"score":0.29980000853538513},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.29919999837875366},{"id":"https://openalex.org/C2778143274","wikidata":"https://www.wikidata.org/wiki/Q1626599","display_name":"Reference range","level":2,"score":0.2651999890804291},{"id":"https://openalex.org/C164465091","wikidata":"https://www.wikidata.org/wiki/Q7248371","display_name":"Prognostic variable","level":3,"score":0.263700008392334},{"id":"https://openalex.org/C179755657","wikidata":"https://www.wikidata.org/wiki/Q58702","display_name":"Mortality rate","level":2,"score":0.2547000050544739},{"id":"https://openalex.org/C2994390833","wikidata":"https://www.wikidata.org/wiki/Q764079","display_name":"Urea nitrogen","level":3,"score":0.25049999356269836}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.21203/rs.3.rs-11369829/v1","doi":"https://doi.org/10.21203/rs.3.rs-11369829/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-11369829/v1","pdf_url":null,"source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.21203/rs.3.rs-11369829/v1","doi":"https://doi.org/10.21203/rs.3.rs-11369829/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-11369829/v1","pdf_url":null,"source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W2024886564","https://openalex.org/W2100962265","https://openalex.org/W2115692333","https://openalex.org/W2161831980","https://openalex.org/W2275737843","https://openalex.org/W2791757297","https://openalex.org/W2793750436","https://openalex.org/W2982693598","https://openalex.org/W3032046824","https://openalex.org/W3112180238","https://openalex.org/W4206051734","https://openalex.org/W4280654477","https://openalex.org/W4291015419","https://openalex.org/W4293242440","https://openalex.org/W4389047413","https://openalex.org/W4389490625","https://openalex.org/W4391411334","https://openalex.org/W4394792561","https://openalex.org/W4398168421","https://openalex.org/W4399322215","https://openalex.org/W4402127852","https://openalex.org/W4405500583","https://openalex.org/W4409309415"],"related_works":[],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Acute":[2,106],"diquat":[3,64,98,159],"poisoning":[4,65],"can":[5],"progress":[6],"rapidly":[7],"from":[8,67],"gastrointestinal":[9],"injury":[10,180],"to":[11],"renal,":[12],"neurologic,":[13],"circulatory,":[14],"and":[15,27,43,50,84,105,108,124,186,208,259,274,292,300,313],"multiorgan":[16],"failure.":[17],"Most":[18],"prognostic":[19,41],"studies":[20],"rely":[21],"on":[22],"measurements":[23,49],"obtained":[24],"at":[25,88,279],"presentation":[26],"therefore":[28],"do":[29],"not":[30,214,315],"capture":[31],"how":[32],"laboratory":[33,48,115,146,223],"abnormalities":[34,284],"evolve":[35],"during":[36],"hospitalization.":[37],"We":[38],"evaluated":[39],"baseline":[40,91],"factors":[42],"explored":[44],"associations":[45,235,309],"between":[46],"serial":[47],"in-hospital":[51,79],"mortality.":[52,202],"Methods":[53],"This":[54],"single-center":[55],"retrospective":[56],"cohort":[57],"included":[58,94],"patients":[59,278],"with":[60,135,201,227],"analytically":[61],"confirmed":[62],"acute":[63],"treated":[66],"January":[68],"2019":[69],"through":[70],"June":[71],"2024.":[72],"Admission":[73,157,268],"was":[74,81,142,206,213],"defined":[75],"as":[76,127,318],"time":[77],"zero;":[78],"death":[80],"the":[82,145,209,296],"event,":[83],"survivors":[85],"were":[86,117,198,236],"censored":[87],"discharge.":[89],"The":[90,203,232],"Cox":[92,133],"model":[93,204],"log10-transformed":[95],"admission":[96],"plasma":[97,158],"concentration,":[99],"anuria,":[100,271],"central":[101,177],"nervous":[102,178],"system":[103,179],"injury,":[104,273,290],"Physiology":[107],"Chronic":[109],"Health":[110],"Evaluation":[111],"II":[112,188],"score.":[113],"Serial":[114,283],"results":[116],"structured":[118],"in":[119,131,155,285],"a":[120],"start-stop":[121],"data":[122],"set":[123],"assessed":[125],"individually":[126],"internal":[128],"time-dependent":[129,222],"covariates":[130],"adjusted":[132],"models":[134],"patient-clustered":[136],"robust":[137],"standard":[138],"errors.":[139],"False-discovery-rate":[140],"adjustment":[141],"applied":[143],"across":[144],"analyses.":[147],"Results":[148],"Among":[149],"201":[150],"patients,":[151],"60":[152],"(29.9%)":[153],"died":[154],"hospital.":[156],"concentration":[160],"(hazard":[161],"ratio":[162],"[HR]":[163],"per":[164,191],"10-fold":[165],"increase,":[166,193],"2.72;":[167],"95%":[168,174,183,195,244,250,256,264],"CI,":[169,175,184,196,245,251,257,265],"1.63\u20134.53),":[170],"anuria":[171],"(HR,":[172,181,242,248,254,262],"7.43;":[173],"2.52\u201321.91),":[176],"4.78;":[182],"1.55\u201314.74),":[185],"APACHE":[187],"score":[189],"(HR":[190],"5-point":[192],"1.23;":[194],"1.07\u20131.41)":[197],"independently":[199],"associated":[200,226],"C-index":[205],"0.937,":[207],"global":[210],"proportional-hazards":[211],"test":[212],"significant":[215],"(P":[216],"=":[217],"0.067).":[218],"Ten":[219],"of":[220],"24":[221],"variables":[224],"remained":[225],"mortality":[228,298],"after":[229],"false-discovery-rate":[230],"correction.":[231],"largest":[233],"standardized":[234],"observed":[237],"for":[238],"blood":[239],"urea":[240],"nitrogen":[241],"2.18;":[243],"1.54\u20133.10),":[246],"hemoglobin":[247],"1.77;":[249],"1.15\u20132.74),":[252],"creatinine":[253],"1.76;":[255],"1.27\u20132.43),":[258],"creatine":[260],"kinase":[261],"1.60;":[263],"1.29\u20131.99).":[266],"Conclusions":[267],"toxin":[269],"burden,":[270],"neurologic":[272],"physiologic":[275],"severity":[276],"identified":[277],"high":[280],"early":[281],"risk.":[282],"coagulation,":[286],"renal":[287],"function,":[288],"tissue":[289],"inflammation,":[291],"hepatic":[293],"function":[294],"tracked":[295],"evolving":[297],"hazard":[299],"may":[301],"support":[302],"repeated":[303],"bedside":[304],"reassessment.":[305],"These":[306],"exploratory":[307],"dynamic":[308],"require":[310],"external":[311],"validation":[312],"should":[314],"be":[316],"interpreted":[317],"causal":[319],"treatment":[320],"targets.":[321]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-11T00:00:00"}
