{"id":"https://openalex.org/W7225738773","doi":"https://doi.org/10.3389/fmicb.2026.1980811","title":"Protection against lethal pneumonic plague by intramuscular F1V vaccine incorporating a colloidal TLR4-TLR7 dual adjuvant","display_name":"Protection against lethal pneumonic plague by intramuscular F1V vaccine incorporating a colloidal TLR4-TLR7 dual adjuvant","publication_year":2026,"publication_date":"2026-11-10","ids":{"openalex":"https://openalex.org/W7225738773","doi":"https://doi.org/10.3389/fmicb.2026.1980811"},"language":"en","primary_location":{"id":"doi:10.3389/fmicb.2026.1980811","doi":"https://doi.org/10.3389/fmicb.2026.1980811","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fmicb.2026.1980811","pdf_url":null,"source":{"id":"https://openalex.org/S2484704948","display_name":"Frontiers in Microbiology","issn_l":"1664-302X","issn":["1664-302X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Microbiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3389/fmicb.2026.1980811","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025424183","display_name":"Michael L. Davies","orcid":"https://orcid.org/0000-0003-4431-6448","observed_orcids":["https://orcid.org/0000-0003-4431-6448"]},"institutions":[{"id":"https://openalex.org/I2801122164","display_name":"United States Army Medical Research Institute of Infectious Diseases","ror":"https://ror.org/01pveve47","country_code":"US","type":"facility","lineage":["https://openalex.org/I106965489","https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I2801122164","https://openalex.org/I2802581893"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael L. Davies","raw_affiliation_strings":["Bacteriology Division, United States Army Medical Research Institute of Infectious Diseases"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bacteriology Division, United States Army Medical Research Institute of Infectious Diseases","institution_ids":["https://openalex.org/I2801122164"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022963938","display_name":"Jennifer L. Dankmeyer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801122164","display_name":"United States Army Medical Research Institute of Infectious Diseases","ror":"https://ror.org/01pveve47","country_code":"US","type":"facility","lineage":["https://openalex.org/I106965489","https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I2801122164","https://openalex.org/I2802581893"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer L. Dankmeyer","raw_affiliation_strings":["Bacteriology Division, United States Army Medical Research Institute of Infectious Diseases"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bacteriology Division, United States Army Medical Research Institute of Infectious Diseases","institution_ids":["https://openalex.org/I2801122164"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029585447","display_name":"Nathaniel O. Rill","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801122164","display_name":"United States Army Medical Research Institute of Infectious Diseases","ror":"https://ror.org/01pveve47","country_code":"US","type":"facility","lineage":["https://openalex.org/I106965489","https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I2801122164","https://openalex.org/I2802581893"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nathaniel O. Rill","raw_affiliation_strings":["Bacteriology Division, United States Army Medical Research Institute of Infectious Diseases"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bacteriology Division, United States Army Medical Research Institute of Infectious Diseases","institution_ids":["https://openalex.org/I2801122164"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087134602","display_name":"Christopher P. Klimko","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801122164","display_name":"United States Army Medical Research Institute of Infectious Diseases","ror":"https://ror.org/01pveve47","country_code":"US","type":"facility","lineage":["https://openalex.org/I106965489","https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I2801122164","https://openalex.org/I2802581893"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher P. Klimko","raw_affiliation_strings":["Bacteriology Division, United States Army Medical Research Institute of Infectious Diseases"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bacteriology Division, United States Army Medical Research Institute of Infectious Diseases","institution_ids":["https://openalex.org/I2801122164"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103166384","display_name":"Carlos I. Rodriguez","orcid":"https://orcid.org/0000-0001-9383-8168","observed_orcids":["https://orcid.org/0000-0001-9383-8168"]},"institutions":[{"id":"https://openalex.org/I2801122164","display_name":"United States Army Medical Research Institute of Infectious Diseases","ror":"https://ror.org/01pveve47","country_code":"US","type":"facility","lineage":["https://openalex.org/I106965489","https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I2801122164","https://openalex.org/I2802581893"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carlos I. Rodriguez","raw_affiliation_strings":["Bacteriology Division, United States Army Medical Research Institute of Infectious Diseases"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bacteriology Division, United States Army Medical Research Institute of Infectious Diseases","institution_ids":["https://openalex.org/I2801122164"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5143850826","display_name":"Taloria K. Wheeler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801122164","display_name":"United States Army Medical Research Institute of Infectious Diseases","ror":"https://ror.org/01pveve47","country_code":"US","type":"facility","lineage":["https://openalex.org/I106965489","https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I2801122164","https://openalex.org/I2802581893"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Taloria K. Wheeler","raw_affiliation_strings":["Bacteriology Division, United States Army Medical Research Institute of Infectious Diseases"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bacteriology Division, United States Army Medical Research Institute of Infectious Diseases","institution_ids":["https://openalex.org/I2801122164"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5143774338","display_name":"Wendy Webster-Zahnow","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801122164","display_name":"United States Army Medical Research Institute of Infectious Diseases","ror":"https://ror.org/01pveve47","country_code":"US","type":"facility","lineage":["https://openalex.org/I106965489","https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I2801122164","https://openalex.org/I2802581893"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wendy M. Webster-Zahnow","raw_affiliation_strings":["Bacteriology Division, United States Army Medical Research Institute of Infectious Diseases"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bacteriology Division, United States Army Medical Research Institute of Infectious Diseases","institution_ids":["https://openalex.org/I2801122164"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5143752312","display_name":"Andre Swamotz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801122164","display_name":"United States Army Medical Research Institute of Infectious Diseases","ror":"https://ror.org/01pveve47","country_code":"US","type":"facility","lineage":["https://openalex.org/I106965489","https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I2801122164","https://openalex.org/I2802581893"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andr\u00e9 M. Swamotz","raw_affiliation_strings":["Bacteriology Division, United States Army Medical Research Institute of Infectious Diseases"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bacteriology Division, United States Army Medical Research Institute of Infectious Diseases","institution_ids":["https://openalex.org/I2801122164"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161380984","display_name":"Deven W. Patrick","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801122164","display_name":"United States Army Medical Research Institute of Infectious Diseases","ror":"https://ror.org/01pveve47","country_code":"US","type":"facility","lineage":["https://openalex.org/I106965489","https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I2801122164","https://openalex.org/I2802581893"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Deven W. Patrick","raw_affiliation_strings":["Bacteriology Division, United States Army Medical Research Institute of Infectious Diseases"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bacteriology Division, United States Army Medical Research Institute of Infectious Diseases","institution_ids":["https://openalex.org/I2801122164"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5143800361","display_name":"Tyrique David","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801122164","display_name":"United States Army Medical Research Institute of Infectious Diseases","ror":"https://ror.org/01pveve47","country_code":"US","type":"facility","lineage":["https://openalex.org/I106965489","https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I2801122164","https://openalex.org/I2802581893"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tyrique D. David","raw_affiliation_strings":["Bacteriology Division, United States Army Medical Research Institute of Infectious Diseases"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bacteriology Division, United States Army Medical Research Institute of Infectious Diseases","institution_ids":["https://openalex.org/I2801122164"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5139240748","display_name":"Christopher T. Braun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801122164","display_name":"United States Army Medical Research Institute of Infectious Diseases","ror":"https://ror.org/01pveve47","country_code":"US","type":"facility","lineage":["https://openalex.org/I106965489","https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I2801122164","https://openalex.org/I2802581893"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher T. Braun","raw_affiliation_strings":["Bacteriology Division, United States Army Medical Research Institute of Infectious Diseases"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bacteriology Division, United States Army Medical Research Institute of Infectious Diseases","institution_ids":["https://openalex.org/I2801122164"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5136008238","display_name":"Yunuen Hernandez-Viezcas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801122164","display_name":"United States Army Medical Research Institute of Infectious Diseases","ror":"https://ror.org/01pveve47","country_code":"US","type":"facility","lineage":["https://openalex.org/I106965489","https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I2801122164","https://openalex.org/I2802581893"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yunuen Hernandez-Viezcas","raw_affiliation_strings":["Bacteriology Division, United States Army Medical Research Institute of Infectious Diseases"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bacteriology Division, United States Army Medical Research Institute of Infectious Diseases","institution_ids":["https://openalex.org/I2801122164"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113843600","display_name":"Ju Qiu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801122164","display_name":"United States Army Medical Research Institute of Infectious Diseases","ror":"https://ror.org/01pveve47","country_code":"US","type":"facility","lineage":["https://openalex.org/I106965489","https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I2801122164","https://openalex.org/I2802581893"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ju Qiu","raw_affiliation_strings":["Research Support Branch, United States Army Medical Research Institute of Infectious Diseases"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Support Branch, United States Army Medical Research Institute of Infectious Diseases","institution_ids":["https://openalex.org/I2801122164"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030213061","display_name":"Roberto Maj","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Roberto Maj","raw_affiliation_strings":["Kupando GmbH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kupando GmbH","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065851352","display_name":"Jelmer H. van Puffelen","orcid":"https://orcid.org/0000-0003-3079-027X","observed_orcids":["https://orcid.org/0000-0003-3079-027X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jelmer H. van Puffelen","raw_affiliation_strings":["Kupando GmbH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kupando GmbH","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058606342","display_name":"Johanna Holldack","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Johanna Holldack","raw_affiliation_strings":["Kupando GmbH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kupando GmbH","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066031866","display_name":"Christopher K. Cote","orcid":"https://orcid.org/0009-0005-0997-7584","observed_orcids":["https://orcid.org/0009-0005-0997-7584","https://orcid.org/0000-0002-1615-5432"]},"institutions":[{"id":"https://openalex.org/I2801122164","display_name":"United States Army Medical Research Institute of Infectious Diseases","ror":"https://ror.org/01pveve47","country_code":"US","type":"facility","lineage":["https://openalex.org/I106965489","https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I2801122164","https://openalex.org/I2802581893"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher K. Cote","raw_affiliation_strings":["Bacteriology Division, United States Army Medical Research Institute of Infectious Diseases"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bacteriology Division, United States Army Medical Research Institute of Infectious Diseases","institution_ids":["https://openalex.org/I2801122164"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037231255","display_name":"Sergei S. Biryukov","orcid":"https://orcid.org/0000-0002-1297-2363","observed_orcids":["https://orcid.org/0000-0002-1297-2363"]},"institutions":[{"id":"https://openalex.org/I2801122164","display_name":"United States Army Medical Research Institute of Infectious Diseases","ror":"https://ror.org/01pveve47","country_code":"US","type":"facility","lineage":["https://openalex.org/I106965489","https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I2801122164","https://openalex.org/I2802581893"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Sergei S. Biryukov","raw_affiliation_strings":["Bacteriology Division, United States Army Medical Research Institute of Infectious Diseases"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bacteriology Division, United States Army Medical Research Institute of Infectious Diseases","institution_ids":["https://openalex.org/I2801122164"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5037231255"],"corresponding_institution_ids":["https://openalex.org/I2801122164"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12232","display_name":"Yersinia bacterium, plague, ectoparasites research","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12232","display_name":"Yersinia bacterium, plague, ectoparasites research","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10873","display_name":"Bacterial Infections and Vaccines","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11515","display_name":"Bacillus and Francisella bacterial research","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C2777863537","wikidata":"https://www.wikidata.org/wiki/Q357896","display_name":"Adjuvant","level":2,"score":0.8417999744415283},{"id":"https://openalex.org/C2778222588","wikidata":"https://www.wikidata.org/wiki/Q153875","display_name":"Yersinia pestis","level":4,"score":0.7954999804496765},{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.6851000189781189},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.574999988079071},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5259000062942505},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.49630001187324524},{"id":"https://openalex.org/C2780924562","wikidata":"https://www.wikidata.org/wiki/Q190527","display_name":"Alum","level":2,"score":0.484499990940094},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.46790000796318054},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.4643000066280365},{"id":"https://openalex.org/C189976730","wikidata":"https://www.wikidata.org/wiki/Q3493700","display_name":"Splenocyte","level":3,"score":0.46230000257492065},{"id":"https://openalex.org/C2778059882","wikidata":"https://www.wikidata.org/wiki/Q133780","display_name":"Plague (disease)","level":2,"score":0.4375},{"id":"https://openalex.org/C153726182","wikidata":"https://www.wikidata.org/wiki/Q3720909","display_name":"Intracellular parasite","level":3,"score":0.3763999938964844},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.36070001125335693},{"id":"https://openalex.org/C2776548049","wikidata":"https://www.wikidata.org/wiki/Q1142875","display_name":"Humoral immunity","level":3,"score":0.3479999899864197},{"id":"https://openalex.org/C54602769","wikidata":"https://www.wikidata.org/wiki/Q1810913","display_name":"Attenuated vaccine","level":4,"score":0.3416000008583069},{"id":"https://openalex.org/C2776291583","wikidata":"https://www.wikidata.org/wiki/Q432083","display_name":"Intramuscular injection","level":2,"score":0.33739998936653137},{"id":"https://openalex.org/C3017875465","wikidata":"https://www.wikidata.org/wiki/Q189146","display_name":"Cellular immunity","level":3,"score":0.32600000500679016},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.3215999901294708},{"id":"https://openalex.org/C22801619","wikidata":"https://www.wikidata.org/wiki/Q477471","display_name":"CpG Oligodeoxynucleotide","level":5,"score":0.31769999861717224},{"id":"https://openalex.org/C2779138994","wikidata":"https://www.wikidata.org/wiki/Q15332550","display_name":"TLR9","level":5,"score":0.3075999915599823},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30399999022483826},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.2996000051498413},{"id":"https://openalex.org/C2780801004","wikidata":"https://www.wikidata.org/wiki/Q1415366","display_name":"Immunization","level":3,"score":0.2955000102519989},{"id":"https://openalex.org/C2777760223","wikidata":"https://www.wikidata.org/wiki/Q6889412","display_name":"Modified vaccinia Ankara","level":5,"score":0.2930999994277954},{"id":"https://openalex.org/C2780868878","wikidata":"https://www.wikidata.org/wiki/Q1660197","display_name":"Immunogenicity","level":3,"score":0.266400009393692},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.26429998874664307},{"id":"https://openalex.org/C2777914695","wikidata":"https://www.wikidata.org/wiki/Q12192","display_name":"Pneumonia","level":2,"score":0.2624000012874603},{"id":"https://openalex.org/C2780441014","wikidata":"https://www.wikidata.org/wiki/Q7907952","display_name":"Vaccine efficacy","level":3,"score":0.26010000705718994},{"id":"https://openalex.org/C2779827044","wikidata":"https://www.wikidata.org/wiki/Q948421","display_name":"Poxviridae","level":5,"score":0.2531000077724457}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3389/fmicb.2026.1980811","doi":"https://doi.org/10.3389/fmicb.2026.1980811","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fmicb.2026.1980811","pdf_url":null,"source":{"id":"https://openalex.org/S2484704948","display_name":"Frontiers in Microbiology","issn_l":"1664-302X","issn":["1664-302X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Microbiology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.3389/fmicb.2026.1980811","doi":"https://doi.org/10.3389/fmicb.2026.1980811","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fmicb.2026.1980811","pdf_url":null,"source":{"id":"https://openalex.org/S2484704948","display_name":"Frontiers in Microbiology","issn_l":"1664-302X","issn":["1664-302X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Microbiology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":93,"referenced_works":["https://openalex.org/W1563212223","https://openalex.org/W1571432809","https://openalex.org/W1977171479","https://openalex.org/W1989506775","https://openalex.org/W1997509759","https://openalex.org/W1999182894","https://openalex.org/W1999703538","https://openalex.org/W2008301527","https://openalex.org/W2011338093","https://openalex.org/W2026644566","https://openalex.org/W2026692591","https://openalex.org/W2037968912","https://openalex.org/W2041722442","https://openalex.org/W2045465609","https://openalex.org/W2046941690","https://openalex.org/W2052997401","https://openalex.org/W2055456476","https://openalex.org/W2066751846","https://openalex.org/W2072537229","https://openalex.org/W2087088909","https://openalex.org/W2090713460","https://openalex.org/W2095808278","https://openalex.org/W2096729904","https://openalex.org/W2108829772","https://openalex.org/W2112795010","https://openalex.org/W2116425120","https://openalex.org/W2117684163","https://openalex.org/W2117761826","https://openalex.org/W2127622784","https://openalex.org/W2149120880","https://openalex.org/W2151046254","https://openalex.org/W2168819347","https://openalex.org/W2170264328","https://openalex.org/W2180139059","https://openalex.org/W2299193714","https://openalex.org/W2460436373","https://openalex.org/W2538483139","https://openalex.org/W2555426966","https://openalex.org/W2578412618","https://openalex.org/W2739154332","https://openalex.org/W2782164086","https://openalex.org/W2803421816","https://openalex.org/W2909941656","https://openalex.org/W2917365182","https://openalex.org/W2923355026","https://openalex.org/W2937219765","https://openalex.org/W2952319144","https://openalex.org/W2969191128","https://openalex.org/W2981533670","https://openalex.org/W3013485608","https://openalex.org/W3026795897","https://openalex.org/W3027298380","https://openalex.org/W3041375915","https://openalex.org/W3082127447","https://openalex.org/W3091382149","https://openalex.org/W3108085687","https://openalex.org/W3111746885","https://openalex.org/W3112951694","https://openalex.org/W3130812970","https://openalex.org/W3162991497","https://openalex.org/W3164029425","https://openalex.org/W3164190953","https://openalex.org/W3175903381","https://openalex.org/W3182380278","https://openalex.org/W3188843086","https://openalex.org/W3196990457","https://openalex.org/W3214143101","https://openalex.org/W4213294910","https://openalex.org/W4225726749","https://openalex.org/W4281648823","https://openalex.org/W4285092576","https://openalex.org/W4286560859","https://openalex.org/W4317686413","https://openalex.org/W4323807264","https://openalex.org/W4377242084","https://openalex.org/W4378078065","https://openalex.org/W4386957794","https://openalex.org/W4387013727","https://openalex.org/W4387364457","https://openalex.org/W4389726653","https://openalex.org/W4390176323","https://openalex.org/W4390742923","https://openalex.org/W4396633335","https://openalex.org/W4398175215","https://openalex.org/W4404310551","https://openalex.org/W4408089797","https://openalex.org/W4411651965","https://openalex.org/W4411664565","https://openalex.org/W4414615560","https://openalex.org/W7118546330","https://openalex.org/W7124722275","https://openalex.org/W7135188307","https://openalex.org/W7161540386"],"related_works":[],"abstract_inverted_index":{"Yersinia":[0],"pestis":[1,53,71,152,243],"is":[2,24,60,231],"a":[3,63,82,232,236],"facultative":[4],"intracellular":[5],"bacterium":[6],"that":[7,202,229],"causes":[8],"plague,":[9,29],"which":[10],"manifests":[11],"in":[12,33,72,91,161],"bubonic":[13],"form":[14],"and":[15,20,30,107,111,131,154,170,173,222],"the":[16,34,104,190,215],"more":[17],"severe":[18],"pneumonic":[19],"septicemic":[21],"forms.":[22],"There":[23],"no":[25],"FDA-approved":[26],"vaccine":[27,58,80,124,244],"for":[28,36,147,189,209,240],"those":[31],"used":[32],"past":[35],"human":[37],"prophylaxis":[38],"were":[39,126,136],"suboptimal":[40],"against":[41,51],"aerosol":[42,65,140],"infection":[43],"or":[44,118],"nonencapsulated":[45,69],"strains.":[46],"To":[47],"provide":[48],"broad":[49],"protection":[50,149],"Y.":[52,70,151,242],",":[54],"further":[55],"optimization":[56],"of":[57,93,176,193,217],"formulations":[59],"essential.":[61],"In":[62,98],"lethal":[64],"challenge":[66,153],"model":[67],"using":[68,85,115],"BALB/c":[73],"mice,":[74],"we":[75,100,112,199],"compared":[76,101,113,143],"an":[77],"existing":[78],"benchmark":[79],"to":[81,145,156,196,207,220],"similar":[83,167],"formulation":[84],"novel":[86],"TLR4-TLR7":[87],"dual":[88],"adjuvant":[89,95,234],"KUP101A":[90,116,142,230],"place":[92],"TLR9":[94],"CpG":[96,146],"2006.":[97],"addition,":[99],"vaccination":[102,114,204],"through":[103],"subcutaneous":[105],"(SC)":[106],"intramuscular":[108],"(IM)":[109],"routes,":[110],"with":[117,184,235],"without":[119],"additional":[120],"alum":[121],"adjuvant.":[122],"Two":[123],"doses":[125],"given":[127],"four":[128,132],"weeks":[129,133],"apart,":[130],"later":[134],"mice":[135],"challenged":[137],"via":[138],"whole-body":[139],"exposure.":[141],"favorably":[144],"conferring":[148],"after":[150],"led":[155],"significantly":[157],"lower":[158],"bacterial":[159],"burden":[160],"tissues.":[162],"This":[163,226],"was":[164,182,187,205],"observed":[165],"despite":[166],"humoral":[168],"immunity":[169],"Th1/Th2":[171],"phenotype,":[172],"less":[174],"evidence":[175,201],"splenic":[177],"T":[178],"cell":[179],"memory":[180],"than":[181],"seen":[183],"CpG.":[185,197],"Alum":[186],"necessary":[188],"protective":[191],"effect":[192],"KUP101A,":[194],"similarly":[195],"Finally,":[198],"saw":[200],"IM":[203],"preferable":[206],"SC":[208],"inducing":[210],"Th1":[211],"polarization,":[212],"based":[213],"on":[214],"ratio":[216],"serum":[218],"IgG2a":[219],"IgG1":[221],"splenocyte":[223],"cytokine":[224],"secretion.":[225],"study":[227],"demonstrates":[228],"promising":[233],"favorable":[237],"safety":[238],"profile":[239],"future":[241],"development.":[245]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-11T00:00:00"}
