{"id":"https://openalex.org/W7225737526","doi":"https://doi.org/10.20944/preprints202611.0958.v1","title":"Diffuse Large B-Cell Lymphoma in Young and Older Patients: Treatment Patterns and Outcomes Based on Data from the Moscow Cancer Registry","display_name":"Diffuse Large B-Cell Lymphoma in Young and Older Patients: Treatment Patterns and Outcomes Based on Data from the Moscow Cancer Registry","publication_year":2026,"publication_date":"2026-11-10","ids":{"openalex":"https://openalex.org/W7225737526","doi":"https://doi.org/10.20944/preprints202611.0958.v1"},"language":"en","primary_location":{"id":"doi:10.20944/preprints202611.0958.v1","doi":"https://doi.org/10.20944/preprints202611.0958.v1","is_oa":true,"landing_page_url":"https://doi.org/10.20944/preprints202611.0958.v1","pdf_url":null,"source":{"id":"https://openalex.org/S6309402219","display_name":"Preprints.org","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.20944/preprints202611.0958.v1","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016640781","display_name":"Marat Albertovich Mingalimov","orcid":"https://orcid.org/0000-0002-8491-2140","observed_orcids":["https://orcid.org/0000-0002-8491-2140"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Marat Mingalimov","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025177149","display_name":"Elena Alexandrovna Baryakh","orcid":"https://orcid.org/0000-0001-6880-9269","observed_orcids":["https://orcid.org/0000-0001-6880-9269"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elena Baryakh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5117368222","display_name":"Polina Chernova","orcid":"https://orcid.org/0009-0000-3468-9115","observed_orcids":["https://orcid.org/0009-0000-3468-9115"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Polina Chernova","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103088847","display_name":"Andrey Vitalievich Misyurin","orcid":"https://orcid.org/0000-0003-0558-8969","observed_orcids":["https://orcid.org/0000-0003-0558-8969"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrey Misyurin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020721974","display_name":"Elena N Misyurina","orcid":"https://orcid.org/0000-0003-2419-4850","observed_orcids":["https://orcid.org/0000-0003-2419-4850"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elena Misyurina","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5126926024","display_name":"Mariia Orlova","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mariia Orlova","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109088072","display_name":"Tatiana Tolstykh","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tatiana Tolstykh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5133608482","display_name":"Ekaterina Zotina","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ekaterina Zotina","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161385412","display_name":"Liliia Shimanovskaia","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Liliia Shimanovskaia","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007222665","display_name":"\u0422. \u0421. \u0427\u0443\u0434\u043d\u043e\u0432\u0430","orcid":"https://orcid.org/0000-0002-8012-1640","observed_orcids":["https://orcid.org/0000-0002-8012-1640"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tatiana Chudnova","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072718836","display_name":"\u041e. \u041b. \u041a\u043e\u0447\u043d\u0435\u0432\u0430","orcid":"https://orcid.org/0000-0003-1338-8203","observed_orcids":["https://orcid.org/0000-0003-1338-8203"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Olga Kochneva","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161407220","display_name":"Daria Steposhina","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daria Steposhina","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161416874","display_name":"Ksenia Tsurkina","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ksenia Tsurkina","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5126916236","display_name":"Dmitry Lebedev","orcid":"https://orcid.org/0009-0001-8480-5505","observed_orcids":["https://orcid.org/0009-0001-8480-5505"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dmitry Lebedev","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5126894010","display_name":"Georgii Tyshkevich","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Georgii Tyshkevich","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5126919950","display_name":"Viktoriia Basova","orcid":"https://orcid.org/0009-0001-1653-8388","observed_orcids":["https://orcid.org/0009-0001-1653-8388"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Viktoriia Basova","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5139675842","display_name":"Mira Suvorina","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mira Suvorina","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161394234","display_name":"\u041cikhail Donskoy","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u041cikhail Donskoy","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031363990","display_name":"Ivan S. Abramov","orcid":"https://orcid.org/0000-0002-6954-1564","observed_orcids":["https://orcid.org/0000-0002-6954-1564"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ivan Abramov","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016925642","display_name":"\u041d. \u0410. \u0411\u043e\u0434\u0443\u043d\u043e\u0432\u0430","orcid":"https://orcid.org/0000-0002-3119-7673","observed_orcids":["https://orcid.org/0000-0002-3119-7673","https://orcid.org/0009-0008-5135-4841","https://orcid.org/0000-0001-6045-7334"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Natalia Bodunova","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076947661","display_name":"\u0413\u0430\u0434\u0436\u0438\u0435\u0432\u0430 \u0421\u0430\u0438\u0434\u0430 \u041c\u0435\u0440\u0434\u0430\u043d\u043e\u0432\u043d\u0430","orcid":"https://orcid.org/0009-0008-3455-493X","observed_orcids":["https://orcid.org/0009-0008-3455-493X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Saida Gadzhieva","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064479434","display_name":"Tatiana Semina","orcid":"https://orcid.org/0000-0002-5873-8919","observed_orcids":["https://orcid.org/0000-0002-5873-8919"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tatiana Semina","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5122830984","display_name":"Sergey Andreev","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sergey Andreev","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5104083554","display_name":"Mariana A. Lysenko","orcid":"https://orcid.org/0000-0001-6010-7975","observed_orcids":["https://orcid.org/0000-0001-6010-7975"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mariana Lysenko","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5016640781"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12212","display_name":"CNS Lymphoma Diagnosis and Treatment","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9259999990463257},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6179999709129333},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.567300021648407},{"id":"https://openalex.org/C2778527826","wikidata":"https://www.wikidata.org/wiki/Q1787017","display_name":"Cancer registry","level":3,"score":0.5609999895095825},{"id":"https://openalex.org/C23131810","wikidata":"https://www.wikidata.org/wiki/Q818574","display_name":"Observational study","level":2,"score":0.5397999882698059},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.453000009059906},{"id":"https://openalex.org/C2777319248","wikidata":"https://www.wikidata.org/wiki/Q5550843","display_name":"Geriatric oncology","level":3,"score":0.43459999561309814},{"id":"https://openalex.org/C2776907518","wikidata":"https://www.wikidata.org/wiki/Q1734165","display_name":"Performance status","level":3,"score":0.4336000084877014},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4101000130176544},{"id":"https://openalex.org/C2778476033","wikidata":"https://www.wikidata.org/wiki/Q1667625","display_name":"International Prognostic Index","level":4,"score":0.37369999289512634},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.3723999857902527},{"id":"https://openalex.org/C3019894029","wikidata":"https://www.wikidata.org/wiki/Q332823","display_name":"Overall survival","level":2,"score":0.3702000081539154},{"id":"https://openalex.org/C205545832","wikidata":"https://www.wikidata.org/wiki/Q17156455","display_name":"Young adult","level":2,"score":0.36899998784065247},{"id":"https://openalex.org/C10515644","wikidata":"https://www.wikidata.org/wiki/Q543310","display_name":"Survival analysis","level":2,"score":0.3555999994277954},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.3237999975681305},{"id":"https://openalex.org/C107130276","wikidata":"https://www.wikidata.org/wiki/Q133805","display_name":"Epidemiology","level":2,"score":0.3093999922275543},{"id":"https://openalex.org/C2778959093","wikidata":"https://www.wikidata.org/wiki/Q5282128","display_name":"Disease registry","level":3,"score":0.29739999771118164},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.29510000348091125},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.2858999967575073},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.27720001339912415},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.27489998936653137},{"id":"https://openalex.org/C2780558122","wikidata":"https://www.wikidata.org/wiki/Q7310803","display_name":"Relative survival","level":4,"score":0.2709999978542328},{"id":"https://openalex.org/C2779159551","wikidata":"https://www.wikidata.org/wiki/Q1414874","display_name":"Comorbidity","level":2,"score":0.26170000433921814},{"id":"https://openalex.org/C2776283816","wikidata":"https://www.wikidata.org/wiki/Q332823","display_name":"Survival rate","level":2,"score":0.26159998774528503},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.26080000400543213},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.26010000705718994},{"id":"https://openalex.org/C2778559949","wikidata":"https://www.wikidata.org/wiki/Q2626074","display_name":"Diffuse large B-cell lymphoma","level":3,"score":0.25929999351501465},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.25600001215934753}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.20944/preprints202611.0958.v1","doi":"https://doi.org/10.20944/preprints202611.0958.v1","is_oa":true,"landing_page_url":"https://doi.org/10.20944/preprints202611.0958.v1","pdf_url":null,"source":{"id":"https://openalex.org/S6309402219","display_name":"Preprints.org","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.20944/preprints202611.0958.v1","doi":"https://doi.org/10.20944/preprints202611.0958.v1","is_oa":true,"landing_page_url":"https://doi.org/10.20944/preprints202611.0958.v1","pdf_url":null,"source":{"id":"https://openalex.org/S6309402219","display_name":"Preprints.org","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Background:":[0],"Diffuse":[1],"large":[2],"B-cell":[3],"lymphoma":[4],"(DLBCL)":[5],"predominantly":[6],"affects":[7],"older":[8,41,74,162,248],"adults,":[9],"who":[10],"often":[11,140],"have":[12],"poorer":[13],"outcomes":[14,37],"compared":[15,32],"to":[16,106],"younger":[17,157],"patients.":[18],"Real-world":[19],"data":[20],"on":[21],"treatment":[22,33,84,143],"patterns":[23,34],"and":[24,35,40,73,86,99,128,159,172,197,209,241],"age-related":[25],"prognostic":[26,109,189],"factors":[27,196],"remain":[28],"limited.":[29],"This":[30,53],"study":[31,57],"survival":[36,87,91,94],"in":[38,156,161],"young":[39,67],"patients":[42,60,113,138,158,163,249],"with":[43,61,204,224,250],"newly":[44,62],"diagnosed":[45,63],"DLBCL":[46],"using":[47],"the":[48,234],"Moscow":[49],"Cancer":[50],"Registry.":[51],"Methods:":[52],"retrospective,":[54],"multicenter":[55],"observational":[56],"included":[58],"1,060":[59],"DLBCL,":[64],"stratified":[65],"into":[66,244],"(\u226465":[68],"years;":[69,76],"n":[70,77],"=":[71,78,165],"419)":[72],"(>65":[75],"641)":[79],"groups.":[80],"Clinicodemographic":[81],"characteristics,":[82],"first-line":[83],"regimens,":[85],"outcomes,":[88,226],"including":[89],"progression-free":[90],"(PFS),":[92],"overall":[93],"(OS),":[95],"were":[96,104,202],"analyzed.":[97],"Univariable":[98],"multivariable":[100,179],"Cox":[101],"regression":[102],"analyses":[103],"used":[105],"identify":[107],"independent":[108,187],"factors.":[110],"Results:":[111],"Older":[112],"more":[114,139],"frequently":[115],"had":[116],"poor":[117],"performance":[118,205],"status":[119],"(ECOG":[120],"\u22652),":[121],"high":[122],"International":[123],"Prognostic":[124],"Index":[125],"(IPI)":[126],"risk,":[127,208],"received":[129,141],"reduced-intensity":[130],"(R-miniCHOP)":[131],"or":[132],"anthracycline-free":[133,220],"(BR,":[134],"R-CVP)":[135],"regimens.":[136],"Younger":[137],"intensive":[142],"protocols.":[144],"At":[145],"a":[146],"median":[147],"follow-up":[148],"of":[149,219,236],"24":[150],"months,":[151],"2-year":[152,168],"PFS":[153],"was":[154,170,184,222],"51%":[155],"40%":[160],"(p":[164,175],"0.047),":[166],"while":[167],"OS":[169],"77%":[171],"66%,":[173],"respectively":[174],"<":[176],"0.0001).":[177],"In":[178],"analyses,":[180],"age":[181,215],">65":[182],"years":[183],"not":[185],"an":[186],"adverse":[188],"factor":[190],"after":[191],"accounting":[192],"for":[193,247],"clinical":[194],"risk":[195],"tumor":[198,210],"immunophenotype.":[199],"Conclusions:":[200],"Outcomes":[201],"associated":[203,223],"status,":[206],"IPI":[207],"immunophenotype,":[211],"rather":[212],"than":[213],"chronological":[214],"alone.":[216],"The":[217],"use":[218],"regimens":[221],"inferior":[225],"likely":[227],"reflecting":[228],"baseline":[229],"comorbidities.":[230],"These":[231],"findings":[232],"underscore":[233],"necessity":[235],"integrating":[237],"comprehensive":[238],"geriatric":[239],"assessment":[240],"molecular":[242],"profiling":[243],"management":[245],"algorithms":[246],"DLBCL.":[251]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-11T00:00:00"}