{"id":"https://openalex.org/W7225737046","doi":"https://doi.org/10.1007/s00018-026-06510-9","title":"Salicin alleviates osteoporosis by reducing oxidative stress and promoting MSC osteogenesis through AMPK-ULK1 signaling","display_name":"Salicin alleviates osteoporosis by reducing oxidative stress and promoting MSC osteogenesis through AMPK-ULK1 signaling","publication_year":2026,"publication_date":"2026-11-11","ids":{"openalex":"https://openalex.org/W7225737046","doi":"https://doi.org/10.1007/s00018-026-06510-9"},"language":"en","primary_location":{"id":"doi:10.1007/s00018-026-06510-9","doi":"https://doi.org/10.1007/s00018-026-06510-9","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00018-026-06510-9","pdf_url":null,"source":{"id":"https://openalex.org/S60362788","display_name":"Cellular and Molecular Life Sciences","issn_l":"1420-682X","issn":["1420-682X","1420-9071"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular and Molecular Life Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1007/s00018-026-06510-9","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5158653592","display_name":"Menglong Hu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4210095659","display_name":"Peking University School and Hospital of Stomatology","ror":"https://ror.org/00s2xkh70","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210095659"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Menglong Hu","raw_affiliation_strings":["Department of Prosthodontics, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & Beijing Key Laboratory of Digital Stomatology & NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory for Dental Materials, No.22, Zhongguancun South Avenue, Haidian District, Beijing, 100081, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Prosthodontics, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & Beijing Key Laboratory of Digital Stomatology & NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory for Dental Materials, No.22, Zhongguancun South Avenue, Haidian District, Beijing, 100081, PR China","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4210095659"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030215558","display_name":"Jia Qing","orcid":"https://orcid.org/0000-0002-2851-6848","observed_orcids":["https://orcid.org/0000-0002-2851-6848"]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4210095659","display_name":"Peking University School and Hospital of Stomatology","ror":"https://ror.org/00s2xkh70","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210095659"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jia Qing","raw_affiliation_strings":["Department of Prosthodontics, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & Beijing Key Laboratory of Digital Stomatology & NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory for Dental Materials, No.22, Zhongguancun South Avenue, Haidian District, Beijing, 100081, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Prosthodontics, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & Beijing Key Laboratory of Digital Stomatology & NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory for Dental Materials, No.22, Zhongguancun South Avenue, Haidian District, Beijing, 100081, PR China","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4210095659"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5125742912","display_name":"Erfan Wei","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4210095659","display_name":"Peking University School and Hospital of Stomatology","ror":"https://ror.org/00s2xkh70","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210095659"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Erfan Wei","raw_affiliation_strings":["Department of Prosthodontics, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & Beijing Key Laboratory of Digital Stomatology & NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory for Dental Materials, No.22, Zhongguancun South Avenue, Haidian District, Beijing, 100081, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Prosthodontics, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & Beijing Key Laboratory of Digital Stomatology & NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory for Dental Materials, No.22, Zhongguancun South Avenue, Haidian District, Beijing, 100081, PR China","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4210095659"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113236183","display_name":"Qiyue Zhu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4210095659","display_name":"Peking University School and Hospital of Stomatology","ror":"https://ror.org/00s2xkh70","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210095659"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qiyue Zhu","raw_affiliation_strings":["Department of Prosthodontics, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & Beijing Key Laboratory of Digital Stomatology & NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory for Dental Materials, No.22, Zhongguancun South Avenue, Haidian District, Beijing, 100081, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Prosthodontics, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & Beijing Key Laboratory of Digital Stomatology & NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory for Dental Materials, No.22, Zhongguancun South Avenue, Haidian District, Beijing, 100081, PR China","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4210095659"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5125693982","display_name":"Likun Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4210095659","display_name":"Peking University School and Hospital of Stomatology","ror":"https://ror.org/00s2xkh70","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210095659"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Likun Wu","raw_affiliation_strings":["Department of Prosthodontics, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & Beijing Key Laboratory of Digital Stomatology & NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory for Dental Materials, No.22, Zhongguancun South Avenue, Haidian District, Beijing, 100081, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Prosthodontics, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & Beijing Key Laboratory of Digital Stomatology & NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory for Dental Materials, No.22, Zhongguancun South Avenue, Haidian District, Beijing, 100081, PR China","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4210095659"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108938318","display_name":"Xingtong Pan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4210095659","display_name":"Peking University School and Hospital of Stomatology","ror":"https://ror.org/00s2xkh70","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210095659"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xingtong Pan","raw_affiliation_strings":["Department of Prosthodontics, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & Beijing Key Laboratory of Digital Stomatology & NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory for Dental Materials, No.22, Zhongguancun South Avenue, Haidian District, Beijing, 100081, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Prosthodontics, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & Beijing Key Laboratory of Digital Stomatology & NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory for Dental Materials, No.22, Zhongguancun South Avenue, Haidian District, Beijing, 100081, PR China","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4210095659"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161392443","display_name":"Xiuyun Xv","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4210095659","display_name":"Peking University School and Hospital of Stomatology","ror":"https://ror.org/00s2xkh70","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210095659"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiuyun Xv","raw_affiliation_strings":["Department of Prosthodontics, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & Beijing Key Laboratory of Digital Stomatology & NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory for Dental Materials, No.22, Zhongguancun South Avenue, Haidian District, Beijing, 100081, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Prosthodontics, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & Beijing Key Laboratory of Digital Stomatology & NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory for Dental Materials, No.22, Zhongguancun South Avenue, Haidian District, Beijing, 100081, PR China","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4210095659"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012295945","display_name":"Xinyi Dong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210095659","display_name":"Peking University School and Hospital of Stomatology","ror":"https://ror.org/00s2xkh70","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210095659"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinyi Dong","raw_affiliation_strings":["Central Laboratory, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & Beijing Key Laboratory of Digital Stomatology & NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory for Dental Materials, No.22, Zhongguancun South Avenue, Haidian District, Beijing, 100081, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central Laboratory, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & Beijing Key Laboratory of Digital Stomatology & NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory for Dental Materials, No.22, Zhongguancun South Avenue, Haidian District, Beijing, 100081, PR China","institution_ids":["https://openalex.org/I4210095659"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161383366","display_name":"Hao Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210095659","display_name":"Peking University School and Hospital of Stomatology","ror":"https://ror.org/00s2xkh70","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210095659"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Hao Liu","raw_affiliation_strings":["Central Laboratory, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & Beijing Key Laboratory of Digital Stomatology & NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory for Dental Materials, No.22, Zhongguancun South Avenue, Haidian District, Beijing, 100081, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central Laboratory, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & Beijing Key Laboratory of Digital Stomatology & NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory for Dental Materials, No.22, Zhongguancun South Avenue, Haidian District, Beijing, 100081, PR China","institution_ids":["https://openalex.org/I4210095659"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161388160","display_name":"Yongsheng Zhou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4210095659","display_name":"Peking University School and Hospital of Stomatology","ror":"https://ror.org/00s2xkh70","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210095659"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yongsheng Zhou","raw_affiliation_strings":["Department of Prosthodontics, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & Beijing Key Laboratory of Digital Stomatology & NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory for Dental Materials, No.22, Zhongguancun South Avenue, Haidian District, Beijing, 100081, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Prosthodontics, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & Beijing Key Laboratory of Digital Stomatology & NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory for Dental Materials, No.22, Zhongguancun South Avenue, Haidian District, Beijing, 100081, PR China","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4210095659"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045899101","display_name":"Yunsong Liu","orcid":"https://orcid.org/0000-0001-8364-1898","observed_orcids":["https://orcid.org/0000-0001-8364-1898"]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4210095659","display_name":"Peking University School and Hospital of Stomatology","ror":"https://ror.org/00s2xkh70","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210095659"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yunsong Liu","raw_affiliation_strings":["Department of Prosthodontics, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & Beijing Key Laboratory of Digital Stomatology & NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory for Dental Materials, No.22, Zhongguancun South Avenue, Haidian District, Beijing, 100081, PR China"],"raw_orcid":"https://orcid.org/0000-0001-8364-1898","affiliations":[{"raw_affiliation_string":"Department of Prosthodontics, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & Beijing Key Laboratory of Digital Stomatology & NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory for Dental Materials, No.22, Zhongguancun South Avenue, Haidian District, Beijing, 100081, PR China","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4210095659"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5045899101","https://openalex.org/A5161383366","https://openalex.org/A5161388160"],"corresponding_institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4210095659"],"apc_list":{"value":4290,"currency":"USD","value_usd":4290},"apc_paid":{"value":4290,"currency":"USD","value_usd":4290},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.9599999785423279,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.9599999785423279,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.024000000208616257,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14331","display_name":"Medicinal Plant Pharmacodynamics Research","score":0.012000000104308128,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/salicin","display_name":"salicin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/osteoporosis","display_name":"osteoporosis","score":1.0},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9309999942779541},{"id":"https://openalex.org/keywords/mesenchymal-stem-cells","display_name":"mesenchymal stem cells","score":0.9670000076293945},{"id":"https://openalex.org/keywords/bone-formation","display_name":"bone formation","score":0.9290000200271606},{"id":"https://openalex.org/keywords/ampk","display_name":"AMPK","score":0.8510000109672546},{"id":"https://openalex.org/keywords/ulk1","display_name":"ULK1","score":0.9950000047683716},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.859000027179718}],"concepts":[{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.8094000220298767},{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.6672000288963318},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5827999711036682},{"id":"https://openalex.org/C2780220376","wikidata":"https://www.wikidata.org/wiki/Q419173","display_name":"Salicin","level":2,"score":0.5504000186920166},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.48649999499320984},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.45190000534057617},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4507000148296356},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3573000133037567},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.35420000553131104},{"id":"https://openalex.org/C57600042","wikidata":"https://www.wikidata.org/wiki/Q227564","display_name":"Oxidative phosphorylation","level":2,"score":0.3188999891281128},{"id":"https://openalex.org/C2986274086","wikidata":"https://www.wikidata.org/wiki/Q199678","display_name":"Ascorbic acid","level":2,"score":0.3095000088214874},{"id":"https://openalex.org/C2776033226","wikidata":"https://www.wikidata.org/wiki/Q828410","display_name":"Osteoclast","level":3,"score":0.30090001225471497},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.28780001401901245},{"id":"https://openalex.org/C2778401633","wikidata":"https://www.wikidata.org/wiki/Q418661","display_name":"Malondialdehyde","level":3,"score":0.2849999964237213},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.2827000021934509},{"id":"https://openalex.org/C2775838275","wikidata":"https://www.wikidata.org/wiki/Q410776","display_name":"Superoxide dismutase","level":3,"score":0.2678000032901764}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/s00018-026-06510-9","doi":"https://doi.org/10.1007/s00018-026-06510-9","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00018-026-06510-9","pdf_url":null,"source":{"id":"https://openalex.org/S60362788","display_name":"Cellular and Molecular Life Sciences","issn_l":"1420-682X","issn":["1420-682X","1420-9071"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular and Molecular Life Sciences","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1007/s00018-026-06510-9","doi":"https://doi.org/10.1007/s00018-026-06510-9","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00018-026-06510-9","pdf_url":null,"source":{"id":"https://openalex.org/S60362788","display_name":"Cellular and Molecular Life Sciences","issn_l":"1420-682X","issn":["1420-682X","1420-9071"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular and Molecular Life Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4380730907","https://openalex.org/W4410525944","https://openalex.org/W1989264965","https://openalex.org/W3173787708","https://openalex.org/W2305116952","https://openalex.org/W3114290663","https://openalex.org/W4391269219","https://openalex.org/W2366298441","https://openalex.org/W2028075618","https://openalex.org/W2243698640"],"abstract_inverted_index":{"Osteoporosis":[0,57],"is":[1,47],"a":[2,48],"common":[3],"metabolic":[4],"bone":[5,10,15,19,24,114,193],"disorder":[6],"in":[7,17,83,116,195],"which":[8,18,214],"progressive":[9],"loss":[11,194],"results":[12],"from":[13],"dysregulated":[14],"remodeling,":[16],"resorption":[20],"by":[21,26],"osteoclasts":[22],"surpasses":[23],"formation":[25],"osteoblasts.":[27],"Current":[28],"pharmacological":[29],"treatments":[30],"for":[31,42,165],"osteoporosis":[32,202],"are":[33],"associated":[34],"with":[35,51],"various":[36],"adverse":[37],"effects,":[38],"highlighting":[39],"the":[40,75,125,141,154,171,210,217],"need":[41],"safer":[43],"therapeutic":[44,76,163],"strategies.":[45],"Salicin":[46,103,169],"small-molecule":[49],"drug":[50],"anti-inflammatory,":[52],"antioxidant,":[53],"and":[54,65,78,95,112,119,143,159,179,198],"other":[55],"properties.":[56],"usually":[58],"manifests":[59],"as":[60],"an":[61],"increased":[62],"inflammatory":[63],"microenvironment":[64],"elevated":[66],"levels":[67],"of":[68,81,110,124,146,157,173,188,219],"cellular":[69],"oxidative":[70,101,182],"stress.":[71,102],"Here,":[72],"we":[73],"investigated":[74],"potential":[77,162],"underlying":[79],"mechanisms":[80],"salicin":[82,89,191],"osteoporosis.":[84,166],"In":[85],"vitro,":[86],"10":[87,105],"mg/L":[88,106],"optimally":[90],"enhanced":[91],"hMSC":[92],"proliferation,":[93],"migration,":[94],"osteogenic":[96,186,222],"differentiation":[97,187],"while":[98],"attenuating":[99],"intracellular":[100,181],"at":[104],"promoted":[107,170],"heterotopic":[108],"osteogenesis":[109],"hBMSCs":[111],"preserved":[113],"mass":[115],"both":[117],"OVX":[118],"TS":[120],"models.":[121,203],"Mechanistically,":[122],"activation":[123],"adenosine":[126],"5\u2032-monophosphate-activated":[127],"protein":[128],"kinase":[129,134],"(AMPK)-unc-51":[130],"like":[131],"autophagy":[132],"activating":[133],"1":[135],"(ULK1)":[136],"signaling":[137,212],"axis":[138],"contributed":[139],"to":[140,221],"antioxidant":[142],"pro-osteogenic":[144],"effects":[145,156,205],"salicin.":[147],"These":[148,204],"findings":[149],"provide":[150],"novel":[151],"perspectives":[152],"into":[153],"physiological":[155],"salicin,":[158],"expand":[160],"its":[161],"uses":[164],"Scheme":[167],"1.":[168],"proliferation":[172],"human":[174],"mesenchymal":[175],"stem":[176],"cells":[177],"(hMSCs)":[178],"reduces":[180],"stress,":[183],"thereby":[184],"enhancing":[185],"hMSCs.":[189],"Additionally,":[190],"alleviates":[192],"ovariectomy":[196],"(OVX)":[197],"tail":[199],"suspension":[200],"(TS)":[201],"may":[206],"be":[207],"mediated":[208],"through":[209],"AMPK":[211],"pathway,":[213],"potentially":[215],"facilitates":[216],"commitment":[218],"hMSCs":[220],"lineages":[223]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-11-11T00:00:00"}