{"id":"https://openalex.org/W7225736828","doi":"https://doi.org/10.1001/jamanetworkopen.2026.42745","title":"Ibuprofen Use and Acute Kidney Injury Among Adults Admitted to the Hospital","display_name":"Ibuprofen Use and Acute Kidney Injury Among Adults Admitted to the Hospital","publication_year":2026,"publication_date":"2026-11-10","ids":{"openalex":"https://openalex.org/W7225736828","doi":"https://doi.org/10.1001/jamanetworkopen.2026.42745"},"language":"en","primary_location":{"id":"doi:10.1001/jamanetworkopen.2026.42745","doi":"https://doi.org/10.1001/jamanetworkopen.2026.42745","is_oa":true,"landing_page_url":"https://doi.org/10.1001/jamanetworkopen.2026.42745","pdf_url":null,"source":{"id":"https://openalex.org/S4210217848","display_name":"JAMA Network Open","issn_l":"2574-3805","issn":["2574-3805"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAMA Network Open","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1001/jamanetworkopen.2026.42745","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087952855","display_name":"Haedi E Thelen","orcid":"https://orcid.org/0000-0001-8357-2255","observed_orcids":["https://orcid.org/0000-0001-8357-2255"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Haedi E. Thelen","raw_affiliation_strings":["Department of Biostatistics, Epidemiology and Statistics, University of Pennsylvania, Philadelphia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, Epidemiology and Statistics, University of Pennsylvania, Philadelphia","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161415105","display_name":"Luke J. Keele","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Luke J. Keele","raw_affiliation_strings":["Center for Surgery and Health Economics, Perelman School of Medicine, University of Pennsylvania, Philadelphia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Surgery and Health Economics, Perelman School of Medicine, University of Pennsylvania, Philadelphia","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114432732","display_name":"Christina HW Brotman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christina Brotman","raw_affiliation_strings":["Department of Biostatistics, Epidemiology and Statistics, University of Pennsylvania, Philadelphia","Renal, Electrolyte, and Hypertension Division, Perelman School of Medicine, University of Pennsylvania, Philadelphia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, Epidemiology and Statistics, University of Pennsylvania, Philadelphia","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Renal, Electrolyte, and Hypertension Division, Perelman School of Medicine, University of Pennsylvania, Philadelphia","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007375842","display_name":"Michael G. S. Shashaty","orcid":"https://orcid.org/0000-0002-8766-3418","observed_orcids":["https://orcid.org/0000-0002-8766-3418"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael G.S. Shashaty","raw_affiliation_strings":["Pulmonary, Allergy, and Critical Care Division, Department of Medicine, University of Pennsylvania, Philadelphia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pulmonary, Allergy, and Critical Care Division, Department of Medicine, University of Pennsylvania, Philadelphia","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037598335","display_name":"Todd A. Miano","orcid":"https://orcid.org/0000-0002-3832-6212","observed_orcids":["https://orcid.org/0000-0002-3832-6212"]},"institutions":[{"id":"https://openalex.org/I2799810409","display_name":"Hospital of the University of Pennsylvania","ror":"https://ror.org/02917wp91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799810409","https://openalex.org/I4210143392"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Todd A. Miano","raw_affiliation_strings":["Department of Biostatistics, Epidemiology and Statistics, University of Pennsylvania, Philadelphia","Department of Pharmacy, Hospital of the University of Pennsylvania, Philadelphia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, Epidemiology and Statistics, University of Pennsylvania, Philadelphia","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Pharmacy, Hospital of the University of Pennsylvania, Philadelphia","institution_ids":["https://openalex.org/I2799810409"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":{"value":3000,"currency":"USD","value_usd":3000},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"9","issue":"11","first_page":"e2642745","last_page":"e2642745"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12962","display_name":"Nephrotoxicity and Medicinal Plants","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9588000178337097},{"id":"https://openalex.org/C2780472472","wikidata":"https://www.wikidata.org/wiki/Q424337","display_name":"Acute kidney injury","level":2,"score":0.7936000227928162},{"id":"https://openalex.org/C2779944601","wikidata":"https://www.wikidata.org/wiki/Q186969","display_name":"Ibuprofen","level":2,"score":0.6335999965667725},{"id":"https://openalex.org/C2778653478","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Kidney disease","level":2,"score":0.5540000200271606},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.5145999789237976},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.4700999855995178},{"id":"https://openalex.org/C73269764","wikidata":"https://www.wikidata.org/wiki/Q954529","display_name":"Poisson regression","level":3,"score":0.46549999713897705},{"id":"https://openalex.org/C2776029756","wikidata":"https://www.wikidata.org/wiki/Q407535","display_name":"Oxycodone","level":4,"score":0.4571000039577484},{"id":"https://openalex.org/C2780306776","wikidata":"https://www.wikidata.org/wiki/Q426660","display_name":"Creatinine","level":2,"score":0.4359000027179718},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.423799991607666},{"id":"https://openalex.org/C194828623","wikidata":"https://www.wikidata.org/wiki/Q2861470","display_name":"Emergency medicine","level":1,"score":0.42100000381469727},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.37279999256134033},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.35920000076293945},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.35580000281333923},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.34950000047683716},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.3449999988079071},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.33570000529289246},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.32690000534057617},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.31060001254081726},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.29409998655319214},{"id":"https://openalex.org/C2779541074","wikidata":"https://www.wikidata.org/wiki/Q185643","display_name":"Renal replacement therapy","level":2,"score":0.2874999940395355},{"id":"https://openalex.org/C82789193","wikidata":"https://www.wikidata.org/wiki/Q2142611","display_name":"Relative risk","level":3,"score":0.28299999237060547},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.27559998631477356},{"id":"https://openalex.org/C12174686","wikidata":"https://www.wikidata.org/wiki/Q1058438","display_name":"Risk assessment","level":2,"score":0.2734000086784363},{"id":"https://openalex.org/C2778722691","wikidata":"https://www.wikidata.org/wiki/Q57055","display_name":"Acetaminophen","level":2,"score":0.2711000144481659},{"id":"https://openalex.org/C30036603","wikidata":"https://www.wikidata.org/wiki/Q17125150","display_name":"Severity of illness","level":2,"score":0.25529998540878296}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1001/jamanetworkopen.2026.42745","doi":"https://doi.org/10.1001/jamanetworkopen.2026.42745","is_oa":true,"landing_page_url":"https://doi.org/10.1001/jamanetworkopen.2026.42745","pdf_url":null,"source":{"id":"https://openalex.org/S4210217848","display_name":"JAMA Network Open","issn_l":"2574-3805","issn":["2574-3805"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAMA Network Open","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1001/jamanetworkopen.2026.42745","doi":"https://doi.org/10.1001/jamanetworkopen.2026.42745","is_oa":true,"landing_page_url":"https://doi.org/10.1001/jamanetworkopen.2026.42745","pdf_url":null,"source":{"id":"https://openalex.org/S4210217848","display_name":"JAMA Network Open","issn_l":"2574-3805","issn":["2574-3805"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAMA Network Open","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W1592228396","https://openalex.org/W1849521086","https://openalex.org/W1940757296","https://openalex.org/W1971918017","https://openalex.org/W2023243818","https://openalex.org/W2026274122","https://openalex.org/W2049491523","https://openalex.org/W2128615039","https://openalex.org/W2132318897","https://openalex.org/W2141701308","https://openalex.org/W2155965977","https://openalex.org/W2156074554","https://openalex.org/W2167501720","https://openalex.org/W2582613914","https://openalex.org/W2793811202","https://openalex.org/W2929633637","https://openalex.org/W2949231968","https://openalex.org/W2984947744","https://openalex.org/W3007817819","https://openalex.org/W3019453600","https://openalex.org/W3041814657","https://openalex.org/W3048953016","https://openalex.org/W3050896041","https://openalex.org/W3083648019","https://openalex.org/W3092729598","https://openalex.org/W3111626731","https://openalex.org/W3114351496","https://openalex.org/W3148390503","https://openalex.org/W3212384997","https://openalex.org/W4220970233","https://openalex.org/W4246756145","https://openalex.org/W4368359338","https://openalex.org/W4382203196","https://openalex.org/W4382584158","https://openalex.org/W4388567232","https://openalex.org/W4393156535","https://openalex.org/W4406746791","https://openalex.org/W4408246296","https://openalex.org/W4409212852","https://openalex.org/W4411175847","https://openalex.org/W4414127328","https://openalex.org/W4414567987","https://openalex.org/W7124463107"],"related_works":[],"abstract_inverted_index":{"Importance":[0],"Although":[1],"nonsteroidal":[2],"anti-inflammatory":[3],"drugs":[4],"(NSAIDs)":[5],"are":[6],"the":[7,20,27,71],"most":[8],"effective":[9],"nonopioid":[10],"analgesics":[11],"for":[12,161,191,258],"acute":[13,30,162],"pain,":[14],"they":[15],"may":[16,393],"be":[17,394],"underused":[18],"in":[19,66,112,121,176,294,362,384],"inpatient":[21,35,364],"setting":[22],"due":[23],"to":[24,37,100,108,189,199,396],"uncertainty":[25],"regarding":[26],"risk":[28,45,76,324,351,381,392],"of":[29,88,155,249,269,374],"kidney":[31,96,181,333],"injury":[32],"(AKI).":[33],"Whether":[34],"exposure":[36],"NSAIDs,":[38],"such":[39],"as":[40],"ibuprofen,":[41,335],"substantially":[42],"increases":[43],"AKI":[44,49,65,75,240,271,278,350,375],"and":[46,69,81,166,179,194,205,284,306,358,376],"how":[47],"ibuprofen-associated":[48],"varies":[50,73],"across":[51,74],"patient":[52],"subgroups":[53],"remain":[54],"unknown.":[55],"Objective":[56],"To":[57],"determine":[58],"whether":[59,70],"ibuprofen":[60,158,227,264,344,368,398],"use":[61],"is":[62],"associated":[63,347,370],"with":[64,124,157,226,263,348,371],"hospitalized":[67,89],"patients":[68,90,214,261,321,385],"finding":[72],"factor":[77],"subgroups.":[78],"Design,":[79],"Setting,":[80],"Participants":[82],"A":[83],"retrospective":[84],"active-comparator":[85],"cohort":[86,365],"study":[87,210,361],"(aged":[91],"\u226518":[92],"years)":[93],"without":[94,332],"end-stage":[95],"disease":[97],"or":[98,134,159,231],"contraindications":[99],"NSAID":[101],"treatment":[102,130,156],"admitted":[103],"from":[104,144],"January":[105],"1,":[106],"2004,":[107],"June":[109],"30,":[110],"2017,":[111],"a":[113,266],"large":[114],"academic":[115],"health":[116],"system":[117],"including":[118],"3":[119],"hospitals":[120],"Philadelphia,":[122],"Pennsylvania,":[123],"follow-up":[125,250],"until":[126],"48":[127],"hours":[128,154],"after":[129],"end,":[131],"hospital":[132],"discharge,":[133],"14":[135],"days":[136,248],"elapsed,":[137],"whichever":[138],"occurred":[139],"first.":[140],"Analyses":[141],"were":[142,187,238,292,401],"conducted":[143],"March":[145],"2023":[146],"through":[147],"August":[148],"2026.":[149],"Exposures":[150],"At":[151],"least":[152],"24":[153],"oxycodone":[160,232],"pain.":[163],"Main":[164],"Outcomes":[165],"Measures":[167],"The":[168],"primary":[169],"outcome":[170],"was":[171,345,369,382],"AKI,":[172],"defined":[173],"by":[174],"changes":[175],"serum":[177],"creatinine":[178],"incident":[180],"replacement":[182],"therapy":[183],"(KRT).":[184],"Balancing":[185],"weights":[186],"used":[188,198],"adjust":[190],"baseline":[192,259],"covariates":[193],"weighted":[195],"Poisson":[196],"regression":[197],"estimate":[200],"incidence":[201],"rate":[202,268],"ratios":[203],"(IRRs)":[204],"95%":[206,274,281,288,354],"CIs.":[207],"Results":[208],"This":[209,360],"included":[211],"78":[212],"656":[213],"(median":[215],"age,":[216],"59":[217],"[IQR,":[218],"47-69]":[219],"years;":[220],"38":[221],"092":[222],"females":[223],"[48%])":[224],"treated":[225,262],"(n":[228,233],"=":[229,234,337,341],"6313)":[230],"72":[235],"343).":[236],"There":[237],"4799":[239],"events":[241,252],"(79%":[242],"stage":[243],"1)":[244],"during":[245],"270":[246],"472":[247],"(17.7":[251],"per":[253],"1000":[254],"days).":[255],"After":[256],"adjustment":[257],"differences,":[260],"had":[265],"higher":[267,349,372],"any":[270],"(IRR,":[272,279,286,296,309,352],"1.22;":[273],"CI,":[275,282,289,299,304,312,317,355],"1.09-1.38),":[276],"severe":[277],"1.36;":[280],"1.08-1.72),":[283],"KRT":[285],"3.29;":[287],"1.35-8.03).":[290],"IRRs":[291],"greater":[293],"postoperative":[295],"1.70":[297],"[95%":[298,303,311,316],"1.28-2.27]":[300],"vs":[301,314],"1.12":[302],"0.98-1.28])":[305],"critically":[307],"ill":[308],"1.65":[310],"1.29-2.11]":[313],"1.16":[315],"1.02-1.33])":[318],"patients.":[319],"In":[320],"at":[322,386,390],"low":[323,391],"(those":[325],"non\u2013critically":[326],"ill,":[327],"nonpostoperative,":[328],"aged":[329],"<60":[330],"years":[331],"dysfunction;":[334],"n":[336,340],"2966;":[338],"oxycodone,":[339],"20":[342],"440),":[343],"not":[346],"0.94;":[353],"0.75-1.18).":[356],"Conclusions":[357],"Relevance":[359],"an":[363],"found":[366],"that":[367],"rates":[373],"KRT,":[377],"but":[378],"this":[379],"excess":[380],"concentrated":[383],"high":[387],"risk.":[388],"Patients":[389],"able":[395],"receive":[397],"safely":[399],"yet":[400],"often":[402],"prescribed":[403],"oxycodone.":[404]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-11T00:00:00"}