{"id":"https://openalex.org/W7225736465","doi":"https://doi.org/10.1111/bjh.70944","title":"Orelabrutinib plus R\u2010 CHOP in patients with newly diagnosed non\u2010 GCB double\u2010expressor DLBCL : A single\u2010arm, phase II study","display_name":"Orelabrutinib plus R\u2010 CHOP in patients with newly diagnosed non\u2010 GCB double\u2010expressor DLBCL : A single\u2010arm, phase II study","publication_year":2026,"publication_date":"2026-11-10","ids":{"openalex":"https://openalex.org/W7225736465","doi":"https://doi.org/10.1111/bjh.70944"},"language":"en","primary_location":{"id":"doi:10.1111/bjh.70944","doi":"https://doi.org/10.1111/bjh.70944","is_oa":false,"landing_page_url":"https://doi.org/10.1111/bjh.70944","pdf_url":null,"source":{"id":"https://openalex.org/S153015021","display_name":"British Journal of Haematology","issn_l":"0007-1048","issn":["0007-1048","1365-2141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Haematology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100397369","display_name":"Yang Yang","orcid":"https://orcid.org/0000-0001-5171-6226","observed_orcids":["https://orcid.org/0000-0001-5171-6226"]},"institutions":[{"id":"https://openalex.org/I4210166576","display_name":"First Affiliated Hospital Zhejiang University","ror":"https://ror.org/05m1p5x56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166576"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yang Yang","raw_affiliation_strings":["Bone Marrow Transplantation Center, Department of Hematology, The First Affiliated Hospital, School of Medicine Zhejiang University  Hangzhou Zhejiang China"],"raw_orcid":"https://orcid.org/0000-0001-5171-6226","affiliations":[{"raw_affiliation_string":"Bone Marrow Transplantation Center, Department of Hematology, The First Affiliated Hospital, School of Medicine Zhejiang University  Hangzhou Zhejiang China","institution_ids":["https://openalex.org/I4210166576","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102015133","display_name":"Yi Zhao","orcid":"https://orcid.org/0000-0002-3506-9468","observed_orcids":["https://orcid.org/0000-0002-3506-9468","https://orcid.org/0000-0003-4593-8353"]},"institutions":[{"id":"https://openalex.org/I4210166576","display_name":"First Affiliated Hospital Zhejiang University","ror":"https://ror.org/05m1p5x56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166576"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yi Zhao","raw_affiliation_strings":["Bone Marrow Transplantation Center, Department of Hematology, The First Affiliated Hospital, School of Medicine Zhejiang University  Hangzhou Zhejiang China"],"raw_orcid":"https://orcid.org/0000-0003-4593-8353","affiliations":[{"raw_affiliation_string":"Bone Marrow Transplantation Center, Department of Hematology, The First Affiliated Hospital, School of Medicine Zhejiang University  Hangzhou Zhejiang China","institution_ids":["https://openalex.org/I4210166576","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023197528","display_name":"Chenxin Shang","orcid":"https://orcid.org/0000-0001-9669-7970","observed_orcids":["https://orcid.org/0000-0001-9669-7970"]},"institutions":[{"id":"https://openalex.org/I4210166576","display_name":"First Affiliated Hospital Zhejiang University","ror":"https://ror.org/05m1p5x56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166576"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenjun Wu","raw_affiliation_strings":["Bone Marrow Transplantation Center, Department of Hematology, The First Affiliated Hospital, School of Medicine Zhejiang University  Hangzhou Zhejiang China"],"raw_orcid":"https://orcid.org/0000-0001-9669-7970","affiliations":[{"raw_affiliation_string":"Bone Marrow Transplantation Center, Department of Hematology, The First Affiliated Hospital, School of Medicine Zhejiang University  Hangzhou Zhejiang China","institution_ids":["https://openalex.org/I4210166576","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102340426","display_name":"Gaofeng Zheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210166576","display_name":"First Affiliated Hospital Zhejiang University","ror":"https://ror.org/05m1p5x56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166576"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Gaofeng Zheng","raw_affiliation_strings":["Bone Marrow Transplantation Center, Department of Hematology, The First Affiliated Hospital, School of Medicine Zhejiang University  Hangzhou Zhejiang China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bone Marrow Transplantation Center, Department of Hematology, The First Affiliated Hospital, School of Medicine Zhejiang University  Hangzhou Zhejiang China","institution_ids":["https://openalex.org/I4210166576","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103188284","display_name":"Donghua He","orcid":"https://orcid.org/0000-0002-9268-8732","observed_orcids":["https://orcid.org/0000-0002-9268-8732"]},"institutions":[{"id":"https://openalex.org/I4210166576","display_name":"First Affiliated Hospital Zhejiang University","ror":"https://ror.org/05m1p5x56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166576"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Donghua He","raw_affiliation_strings":["Bone Marrow Transplantation Center, Department of Hematology, The First Affiliated Hospital, School of Medicine Zhejiang University  Hangzhou Zhejiang China"],"raw_orcid":"https://orcid.org/0000-0002-5089-7579","affiliations":[{"raw_affiliation_string":"Bone Marrow Transplantation Center, Department of Hematology, The First Affiliated Hospital, School of Medicine Zhejiang University  Hangzhou Zhejiang China","institution_ids":["https://openalex.org/I4210166576","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101801614","display_name":"Yang Li","orcid":"https://orcid.org/0000-0002-8805-4980","observed_orcids":["https://orcid.org/0000-0002-8805-4980"]},"institutions":[{"id":"https://openalex.org/I4210166576","display_name":"First Affiliated Hospital Zhejiang University","ror":"https://ror.org/05m1p5x56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166576"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li Yang","raw_affiliation_strings":["Bone Marrow Transplantation Center, Department of Hematology, The First Affiliated Hospital, School of Medicine Zhejiang University  Hangzhou Zhejiang China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bone Marrow Transplantation Center, Department of Hematology, The First Affiliated Hospital, School of Medicine Zhejiang University  Hangzhou Zhejiang China","institution_ids":["https://openalex.org/I4210166576","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100421653","display_name":"Yi Li","orcid":"https://orcid.org/0000-0002-8876-0041","observed_orcids":["https://orcid.org/0000-0002-8876-0041","https://orcid.org/0009-0000-9256-2876"]},"institutions":[{"id":"https://openalex.org/I4210166576","display_name":"First Affiliated Hospital Zhejiang University","ror":"https://ror.org/05m1p5x56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166576"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yi Li","raw_affiliation_strings":["Bone Marrow Transplantation Center, Department of Hematology, The First Affiliated Hospital, School of Medicine Zhejiang University  Hangzhou Zhejiang China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bone Marrow Transplantation Center, Department of Hematology, The First Affiliated Hospital, School of Medicine Zhejiang University  Hangzhou Zhejiang China","institution_ids":["https://openalex.org/I4210166576","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019681762","display_name":"Fuming Zi","orcid":"https://orcid.org/0000-0002-9952-8993","observed_orcids":["https://orcid.org/0000-0002-9952-8993"]},"institutions":[{"id":"https://openalex.org/I4210108480","display_name":"Second Affiliated Hospital of Nanchang University","ror":"https://ror.org/01nxv5c88","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210108480"]},{"id":"https://openalex.org/I4210121544","display_name":"Second Hospital of Nanchang","ror":"https://ror.org/0261d1g37","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121544"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fuming Zi","raw_affiliation_strings":["Department of Hematology The Second Affiliated Hospital of Nanchang University  Nanchang Jiangxi China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology The Second Affiliated Hospital of Nanchang University  Nanchang Jiangxi China","institution_ids":["https://openalex.org/I4210108480","https://openalex.org/I4210121544"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101350301","display_name":"Fengping Zhou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802390878","display_name":"Sir Run Run Shaw Hospital","ror":"https://ror.org/00ka6rp58","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802390878"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fengping Zhou","raw_affiliation_strings":["Department of Hematology, Sir Run Run Shaw Hospital Zhejiang University  Hangzhou Zhejiang China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Sir Run Run Shaw Hospital Zhejiang University  Hangzhou Zhejiang China","institution_ids":["https://openalex.org/I2802390878","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043485157","display_name":"Cai Wu","orcid":"https://orcid.org/0000-0001-5629-7163","observed_orcids":["https://orcid.org/0000-0001-5629-7163"]},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Cai Wu","raw_affiliation_strings":["Department of Hematology, The Fourth Affiliated Hospital, School of Medicine Zhejiang University  Yiwu Zhejiang China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, The Fourth Affiliated Hospital, School of Medicine Zhejiang University  Yiwu Zhejiang China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036246435","display_name":"Jingsong He","orcid":"https://orcid.org/0000-0002-1190-1037","observed_orcids":["https://orcid.org/0000-0002-1190-1037","https://orcid.org/0000-0003-1138-089X"]},"institutions":[{"id":"https://openalex.org/I4210166576","display_name":"First Affiliated Hospital Zhejiang University","ror":"https://ror.org/05m1p5x56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166576"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jingsong He","raw_affiliation_strings":["Bone Marrow Transplantation Center, Department of Hematology, The First Affiliated Hospital, School of Medicine Zhejiang University  Hangzhou Zhejiang China"],"raw_orcid":"https://orcid.org/0000-0002-1190-1037","affiliations":[{"raw_affiliation_string":"Bone Marrow Transplantation Center, Department of Hematology, The First Affiliated Hospital, School of Medicine Zhejiang University  Hangzhou Zhejiang China","institution_ids":["https://openalex.org/I4210166576","https://openalex.org/I76130692"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100459777","display_name":"Zhen Cai","orcid":"https://orcid.org/0000-0001-6026-3804","observed_orcids":["https://orcid.org/0000-0001-6026-3804"]},"institutions":[{"id":"https://openalex.org/I4210166576","display_name":"First Affiliated Hospital Zhejiang University","ror":"https://ror.org/05m1p5x56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166576"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhen Cai","raw_affiliation_strings":["Bone Marrow Transplantation Center, Department of Hematology, The First Affiliated Hospital, School of Medicine Zhejiang University  Hangzhou Zhejiang China"],"raw_orcid":"https://orcid.org/0000-0001-6026-3804","affiliations":[{"raw_affiliation_string":"Bone Marrow Transplantation Center, Department of Hematology, The First Affiliated Hospital, School of Medicine Zhejiang University  Hangzhou Zhejiang China","institution_ids":["https://openalex.org/I4210166576","https://openalex.org/I76130692"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5190,"currency":"USD","value_usd":5190},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12212","display_name":"CNS Lymphoma Diagnosis and Treatment","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8223999738693237},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6151999831199646},{"id":"https://openalex.org/C2777063308","wikidata":"https://www.wikidata.org/wiki/Q1435822","display_name":"Neutropenia","level":3,"score":0.5565999746322632},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.5440999865531921},{"id":"https://openalex.org/C2779725641","wikidata":"https://www.wikidata.org/wiki/Q1076228","display_name":"CHOP","level":3,"score":0.5268999934196472},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5181000232696533},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.5027999877929688},{"id":"https://openalex.org/C31760486","wikidata":"https://www.wikidata.org/wiki/Q7180990","display_name":"Phases of clinical research","level":3,"score":0.4659000039100647},{"id":"https://openalex.org/C2776283816","wikidata":"https://www.wikidata.org/wiki/Q332823","display_name":"Survival rate","level":2,"score":0.36149999499320984},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.3531999886035919},{"id":"https://openalex.org/C2780653079","wikidata":"https://www.wikidata.org/wiki/Q412323","display_name":"Rituximab","level":3,"score":0.3465999960899353},{"id":"https://openalex.org/C2778559949","wikidata":"https://www.wikidata.org/wiki/Q2626074","display_name":"Diffuse large B-cell lymphoma","level":3,"score":0.3215999901294708},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.30880001187324524},{"id":"https://openalex.org/C3019894029","wikidata":"https://www.wikidata.org/wiki/Q332823","display_name":"Overall survival","level":2,"score":0.3070000112056732},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.30250000953674316},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3012999892234802},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.2935999929904938},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.27459999918937683},{"id":"https://openalex.org/C183786373","wikidata":"https://www.wikidata.org/wiki/Q5964993","display_name":"Signal transducing adaptor protein","level":3,"score":0.2703999876976013},{"id":"https://openalex.org/C2778850193","wikidata":"https://www.wikidata.org/wiki/Q3775974","display_name":"Febrile neutropenia","level":4,"score":0.26489999890327454},{"id":"https://openalex.org/C2781230642","wikidata":"https://www.wikidata.org/wiki/Q492646","display_name":"Targeted therapy","level":3,"score":0.2612000107765198},{"id":"https://openalex.org/C2780739268","wikidata":"https://www.wikidata.org/wiki/Q2112244","display_name":"Progression-free survival","level":3,"score":0.25619998574256897}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1111/bjh.70944","doi":"https://doi.org/10.1111/bjh.70944","is_oa":false,"landing_page_url":"https://doi.org/10.1111/bjh.70944","pdf_url":null,"source":{"id":"https://openalex.org/S153015021","display_name":"British Journal of Haematology","issn_l":"0007-1048","issn":["0007-1048","1365-2141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Haematology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W1979816280","https://openalex.org/W2016079550","https://openalex.org/W2056641238","https://openalex.org/W2096596684","https://openalex.org/W2156802525","https://openalex.org/W2159862107","https://openalex.org/W2166337170","https://openalex.org/W2280269954","https://openalex.org/W2310716991","https://openalex.org/W2341926683","https://openalex.org/W2525478941","https://openalex.org/W2588717998","https://openalex.org/W2765685049","https://openalex.org/W2797584152","https://openalex.org/W2894196895","https://openalex.org/W2909854490","https://openalex.org/W2923453543","https://openalex.org/W3025752489","https://openalex.org/W3083372956","https://openalex.org/W3092613904","https://openalex.org/W3134746818","https://openalex.org/W3182360203","https://openalex.org/W3187620104","https://openalex.org/W3190394261","https://openalex.org/W4200083379","https://openalex.org/W4200197309","https://openalex.org/W4206837782","https://openalex.org/W4210708921","https://openalex.org/W4283756450","https://openalex.org/W4301396684","https://openalex.org/W4317780658","https://openalex.org/W4317989607","https://openalex.org/W4366462743","https://openalex.org/W4386271684","https://openalex.org/W4387131821","https://openalex.org/W4388017804","https://openalex.org/W4401056416","https://openalex.org/W4401500934","https://openalex.org/W4404200876","https://openalex.org/W4406049179","https://openalex.org/W4407944724","https://openalex.org/W4408379233","https://openalex.org/W4411436591","https://openalex.org/W4413050309","https://openalex.org/W4415780956","https://openalex.org/W4417001704","https://openalex.org/W7155207907"],"related_works":[],"abstract_inverted_index":{"Summary":[0],"Double\u2010expressor":[1],"diffuse":[2],"large":[3],"B\u2010cell":[4,17],"lymphoma":[5,18],"(DE\u2010DLBCL)":[6],"patients,":[7,161],"defined":[8],"by":[9],"co\u2010expression":[10],"of":[11,46,83,129,160,173],"MYC":[12],"proto\u2010oncogene":[13],"protein":[14,20],"(\u226540%)":[15],"and":[16,44,55,93,100,106,120,141,203],"2":[19],"(\u226550%),":[21],"typically":[22],"have":[23],"poor":[24],"outcomes":[25],"with":[26,61,162,214],"the":[27,42,101,127,131,142,166,180],"traditional":[28],"first\u2010line":[29,47,228],"R\u2010CHOP":[30,50],"regimen.":[31,229],"We":[32],"conducted":[33],"a":[34,80,215,227],"multicentre,":[35],"single\u2010arm,":[36],"phase":[37],"II":[38],"study":[39],"to":[40,71],"evaluate":[41],"efficacy":[43,213],"safety":[45,217],"orelabrutinib":[48],"plus":[49],"(rituximab,":[51],"cyclophosphamide,":[52],"doxorubicin,":[53],"vincristine,":[54],"prednisone),":[56],"designated":[57],"O\u2010RCHOP,":[58],"in":[59,158,219],"patients":[60,76,170],"non\u2010germinal":[62],"centre":[63],"B\u2010cell\u2010like":[64],"(non\u2010GCB)":[65],"DE\u2010DLBCL.":[66],"From":[67],"19":[68],"November":[69],"2021":[70],"6":[72],"February":[73],"2025,":[74],"49":[75],"were":[77,97,109,184],"enrolled.":[78],"With":[79],"median":[81,86],"follow\u2010up":[82],"26.6":[84],"months,":[85],"event\u2010free":[87],"survival":[88,91,95],"(EFS),":[89],"progression\u2010free":[90],"(PFS)":[92],"overall":[94],"(OS)":[96],"not":[98],"reached,":[99],"estimated":[102],"2\u2010year":[103],"EFS,":[104],"PFS":[105],"OS":[107],"rates":[108],"82.0%":[110,116],"(95%":[111,117,122],"confidence":[112],"intervals":[113],"[CIs]:":[114],"71.2%\u201394.3%),":[115],"CI:":[118,123,139,150],"71.2%\u201394.3%)":[119],"97.9%":[121],"94.0%\u2013100.0%)":[124],"respectively.":[125],"At":[126],"end":[128],"treatment,":[130],"complete":[132],"response":[133,144],"rate":[134,145],"was":[135,146],"89.8%":[136],"(44/49;":[137],"95%":[138,149],"77.8%\u201396.6%),":[140],"objective":[143],"95.9%":[147],"(47/49;":[148],"86.0%\u201399.5%).":[151],"Grade":[152],"\u22653":[153],"adverse":[154],"events":[155],"(AEs)":[156],"occurred":[157],"51.0%":[159],"neutropenia":[163],"(38.8%)":[164],"being":[165],"most":[167],"common.":[168],"No":[169],"died":[171],"because":[172],"AEs.":[174],"Genetic":[175],"alteration":[176],"profiling":[177],"revealed":[178],"that":[179],"frequently":[181],"mutated":[182],"genes":[183],"Pim\u20101":[185],"proto\u2010oncogene,":[186],"serine/threonine":[187],"kinase":[188],"(":[189,199,206],"PIM1":[190],";":[191,201,208],"63.6%),":[192],"MYD88":[193,200],"innate":[194],"immune":[195],"signal":[196],"transduction":[197],"adaptor":[198],"(51.5%)":[202],"CD79b":[204],"molecule":[205],"CD79B":[207],"48.5%).":[209],"O\u2010RCHOP":[210],"achieved":[211],"encouraging":[212],"manageable":[216],"profile":[218],"newly":[220],"diagnosed":[221],"DE\u2010DLBCL,":[222],"supporting":[223],"its":[224],"feasibility":[225],"as":[226]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-11T00:00:00"}
