{"id":"https://openalex.org/W7225735693","doi":"https://doi.org/10.1245/s10434-026-20869-w","title":"Perioperative Circulating Tumor DNA Dynamics in Patients Undergoing Cytoreductive Surgery for Colorectal Peritoneal Metastases","display_name":"Perioperative Circulating Tumor DNA Dynamics in Patients Undergoing Cytoreductive Surgery for Colorectal Peritoneal Metastases","publication_year":2026,"publication_date":"2026-11-10","ids":{"openalex":"https://openalex.org/W7225735693","doi":"https://doi.org/10.1245/s10434-026-20869-w"},"language":"en","primary_location":{"id":"doi:10.1245/s10434-026-20869-w","doi":"https://doi.org/10.1245/s10434-026-20869-w","is_oa":true,"landing_page_url":"https://doi.org/10.1245/s10434-026-20869-w","pdf_url":null,"source":{"id":"https://openalex.org/S177486402","display_name":"Annals of Surgical Oncology","issn_l":"1068-9265","issn":["1068-9265","1534-4681"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Surgical Oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1245/s10434-026-20869-w","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5123314805","display_name":"Kilian G M Brown","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kilian G. M. Brown","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078042635","display_name":"Taylor Neilson","orcid":"https://orcid.org/0009-0003-5304-2239","observed_orcids":["https://orcid.org/0009-0003-5304-2239"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Taylor Neilson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063634715","display_name":"Megan E. Delisle","orcid":"https://orcid.org/0000-0001-5890-0456","observed_orcids":["https://orcid.org/0000-0001-5890-0456"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Megan Delisle","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014062586","display_name":"Ryan B. Morgan","orcid":"https://orcid.org/0000-0002-4201-166X","observed_orcids":["https://orcid.org/0000-0002-4201-166X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ryan B. Morgan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039151918","display_name":"Yossi Maman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yossi Maman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161393382","display_name":"Tim DiPeri","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tim DiPeri","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029218766","display_name":"LaDonna E. Kearse","orcid":"https://orcid.org/0000-0002-3076-8374","observed_orcids":["https://orcid.org/0000-0002-3076-8374"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"LaDonna Kearse","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103060821","display_name":"Y. Nancy You","orcid":"https://orcid.org/0000-0002-5294-288X","observed_orcids":["https://orcid.org/0000-0002-5294-288X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y. Nancy You","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065553888","display_name":"Brian K. Bednarski","orcid":"https://orcid.org/0000-0002-8022-2476","observed_orcids":["https://orcid.org/0000-0002-8022-2476"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Brian Bednarski","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079609151","display_name":"Tsuyoshi Konishi","orcid":"https://orcid.org/0000-0002-5336-0785","observed_orcids":["https://orcid.org/0000-0002-5336-0785"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tsuyoshi Konishi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085190234","display_name":"Ramy S. Behman","orcid":"https://orcid.org/0000-0003-2283-974X","observed_orcids":["https://orcid.org/0000-0003-2283-974X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ramy Behman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043993476","display_name":"Jeongyoon Moon","orcid":"https://orcid.org/0000-0001-8722-9892","observed_orcids":["https://orcid.org/0000-0001-8722-9892"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jeongyoon Moon","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089703059","display_name":"Craig A. Messick","orcid":"https://orcid.org/0000-0003-0714-5037","observed_orcids":["https://orcid.org/0000-0003-0714-5037"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Craig Messick","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065156415","display_name":"Montserrat Guraieb-Trueba","orcid":"https://orcid.org/0000-0002-3189-1059","observed_orcids":["https://orcid.org/0000-0002-3189-1059"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Montserrat Guraieb-Trueba","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080692116","display_name":"Miguel A. Rodr\u00edguez-Bigas","orcid":"https://orcid.org/0000-0002-3235-2102","observed_orcids":["https://orcid.org/0000-0002-3235-2102"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Miguel Rodriguez-Bigas","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050429899","display_name":"George J. Chang","orcid":"https://orcid.org/0000-0002-9758-5361","observed_orcids":["https://orcid.org/0000-0002-9758-5361"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"George J. Chang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161411677","display_name":"J. Joshua Smith","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. Joshua Smith","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5122759435","display_name":"Yun Song","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yun Song","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078220680","display_name":"Beth Ann Helmink","orcid":"https://orcid.org/0000-0002-8206-0351","observed_orcids":["https://orcid.org/0000-0002-8206-0351"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Beth Helmink","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110841177","display_name":"Paul Mansfield","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paul Mansfield","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023336828","display_name":"Keith F. Fournier","orcid":"https://orcid.org/0000-0002-7882-9826","observed_orcids":["https://orcid.org/0000-0002-7882-9826"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Keith Fournier","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5158541662","display_name":"Jason Willis","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jason Willis","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067047453","display_name":"Ian Hu","orcid":"https://orcid.org/0009-0009-8605-0036","observed_orcids":["https://orcid.org/0009-0009-8605-0036"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ian Hu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161393953","display_name":"Arvind N. Dasari","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Arvind N. Dasari","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055653978","display_name":"Paula Marincola Smith","orcid":"https://orcid.org/0000-0001-9550-6626","observed_orcids":["https://orcid.org/0000-0001-9550-6626"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paula Marincola Smith","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5027704030","display_name":"Michael Geoffrey White","orcid":"https://orcid.org/0000-0001-5022-5505","observed_orcids":["https://orcid.org/0000-0001-5022-5505"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael G. White","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4590,"currency":"USD","value_usd":4590},"apc_paid":{"value":4590,"currency":"USD","value_usd":4590},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12064","display_name":"Intraperitoneal and Appendiceal Malignancies","score":0.82669997215271,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12064","display_name":"Intraperitoneal and Appendiceal Malignancies","score":0.82669997215271,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.055799998342990875,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.04560000076889992,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9386000037193298},{"id":"https://openalex.org/C31174226","wikidata":"https://www.wikidata.org/wiki/Q64855140","display_name":"Perioperative","level":2,"score":0.8388000130653381},{"id":"https://openalex.org/C2780140570","wikidata":"https://www.wikidata.org/wiki/Q3545481","display_name":"Surgical oncology","level":2,"score":0.7523000240325928},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.6710000038146973},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6182000041007996},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.5940999984741211},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.5774999856948853},{"id":"https://openalex.org/C2781335228","wikidata":"https://www.wikidata.org/wiki/Q19596321","display_name":"Circulating tumor DNA","level":3,"score":0.5742999911308289},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5605999827384949},{"id":"https://openalex.org/C2994223192","wikidata":"https://www.wikidata.org/wiki/Q96375802","display_name":"Cytoreductive surgery","level":4,"score":0.5105999708175659},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.4372999966144562},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3743000030517578},{"id":"https://openalex.org/C3019894029","wikidata":"https://www.wikidata.org/wiki/Q332823","display_name":"Overall survival","level":2,"score":0.35100001096725464},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.3449000120162964},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.3431999981403351},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.32749998569488525},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.32120001316070557},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.30799999833106995},{"id":"https://openalex.org/C10515644","wikidata":"https://www.wikidata.org/wiki/Q543310","display_name":"Survival analysis","level":2,"score":0.2842999994754791},{"id":"https://openalex.org/C2778292576","wikidata":"https://www.wikidata.org/wiki/Q6991934","display_name":"Neoadjuvant therapy","level":4,"score":0.2759999930858612},{"id":"https://openalex.org/C61238886","wikidata":"https://www.wikidata.org/wiki/Q5121689","display_name":"Circulating tumor cell","level":4,"score":0.2574000060558319},{"id":"https://openalex.org/C2776283816","wikidata":"https://www.wikidata.org/wiki/Q332823","display_name":"Survival rate","level":2,"score":0.25220000743865967}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1245/s10434-026-20869-w","doi":"https://doi.org/10.1245/s10434-026-20869-w","is_oa":true,"landing_page_url":"https://doi.org/10.1245/s10434-026-20869-w","pdf_url":null,"source":{"id":"https://openalex.org/S177486402","display_name":"Annals of Surgical Oncology","issn_l":"1068-9265","issn":["1068-9265","1534-4681"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Surgical Oncology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1245/s10434-026-20869-w","doi":"https://doi.org/10.1245/s10434-026-20869-w","is_oa":true,"landing_page_url":"https://doi.org/10.1245/s10434-026-20869-w","pdf_url":null,"source":{"id":"https://openalex.org/S177486402","display_name":"Annals of Surgical Oncology","issn_l":"1068-9265","issn":["1068-9265","1534-4681"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Surgical Oncology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W17791541","https://openalex.org/W2531203326","https://openalex.org/W2808317411","https://openalex.org/W3033507389","https://openalex.org/W3047401551","https://openalex.org/W3116440272","https://openalex.org/W3126104714","https://openalex.org/W4206091813","https://openalex.org/W4280584035","https://openalex.org/W4361273497","https://openalex.org/W4383999288","https://openalex.org/W4388849802","https://openalex.org/W4391091075","https://openalex.org/W4391435914","https://openalex.org/W4402582106","https://openalex.org/W4407428366","https://openalex.org/W4408234715","https://openalex.org/W4409895728","https://openalex.org/W4410805202","https://openalex.org/W4411183557","https://openalex.org/W4414542925","https://openalex.org/W4414566488"],"related_works":[],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Circulating":[2],"tumor":[3,255],"DNA":[4],"(ctDNA)":[5],"is":[6,230],"a":[7,64,99,112],"strong":[8],"prognostic":[9],"biomarker":[10],"in":[11,19,34,126],"resectable":[12],"colorectal":[13,22],"cancer":[14],"but":[15],"remains":[16],"poorly":[17],"studied":[18],"patients":[20,35,108,213],"with":[21,52,111,148,179,214,222,233],"peritoneal":[23,189],"metastases":[24],"(CRPM).":[25],"This":[26],"study":[27],"aims":[28],"to":[29,249,259],"report":[30],"perioperative":[31,76,240],"ctDNA":[32,48,77,94,123,144,175,218,228,241,247],"dynamics":[33],"undergoing":[36],"cytoreductive":[37],"surgery":[38],"(CRS)":[39],"for":[40,61],"CRPM":[41,62,215],"and":[42,46,54,69,71,84,121,135,164,198,235,238,257],"evaluate":[43],"whether":[44],"pre-":[45],"postoperative":[47],"detection":[49],"was":[50,124,146,177],"associated":[51,147,178,232],"recurrence":[53,234],"survival.":[55],"Methods":[56],"Patients":[57],"who":[58],"underwent":[59],"CRS":[60],"at":[63,219],"single":[65],"center":[66],"between":[67],"2021":[68],"2025":[70],"had":[72],"one":[73],"or":[74],"more":[75],"result":[78],"available":[79],"were":[80,87,96,109],"included.":[81],"Clinicopathological,":[82],"recurrence,":[83],"survival":[85,151,166,200],"data":[86],"retrospectively":[88],"collected":[89],"from":[90,98],"electronic":[91],"medical":[92],"records.":[93],"results":[95],"extracted":[97],"prospectively":[100],"maintained":[101],"institutional":[102],"database.":[103],"Results":[104],"In":[105],"total,":[106],"87":[107],"included,":[110],"median":[113],"follow-up":[114],"of":[115,129,133,138,140,212],"26.2":[116],"months.":[117],"Pre-neoadjuvant":[118],"therapy,":[119],"post-neoadjuvant/pre-CRS,":[120],"post-CRS":[122,227],"detectable":[125,217],"65%":[127],"(22":[128],"34),":[130],"27%":[131],"(10":[132],"37),":[134],"36%":[136],"(30":[137],"83)":[139],"patients,":[141],"respectively.":[142],"Post-neoadjuvant/pre-CRS":[143],"positivity":[145,176,229],"shorter":[149,180],"recurrence-free":[150],"(RFS;":[152],"hazard":[153],"ratio":[154],"[HR]":[155],"2.59;":[156],"95%":[157,169,184,193,203],"confidence":[158],"interval":[159],"[CI]":[160],"1.06\u20136.34,":[161],"p":[162,172,187,196,206],"=0.037)":[163],"overall":[165,199],"(HR":[167,182,191,201],"5.73;":[168],"CI":[170,185,194,204],"0.92\u201335.5,":[171],"=0.061).":[173],"Post-CRS":[174],"RFS":[181,190],"3.5;":[183],"2.1\u20135.9,":[186],"<0.001),":[188,197],"3.1;":[192],"1.7\u20135.5,":[195],"6.7;":[202],"2.3\u201319.7,":[205],"=0.001).":[207],"Conclusions":[208],"A":[209],"smaller":[210],"proportion":[211],"have":[216],"presentation":[220],"compared":[221],"other":[223],"anatomic":[224],"sites.":[225],"However,":[226],"strongly":[231],"poorer":[236],"survival,":[237],"dynamic":[239],"changes":[242],"may":[243,252],"be":[244],"prognostically":[245],"informative.":[246],"response":[248,258],"neoadjuvant":[250],"treatment":[251],"demonstrate":[253],"favorable":[254],"biology":[256],"treatment.":[260]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-11T00:00:00"}