{"id":"https://openalex.org/W7225734840","doi":"https://doi.org/10.1080/08998280.2026.2757493","title":"Local complications of peripheral intravenous vasopressor use with phentolamine as an antidote: a retrospective review","display_name":"Local complications of peripheral intravenous vasopressor use with phentolamine as an antidote: a retrospective review","publication_year":2026,"publication_date":"2026-11-10","ids":{"openalex":"https://openalex.org/W7225734840","doi":"https://doi.org/10.1080/08998280.2026.2757493","pmid":"https://pubmed.ncbi.nlm.nih.gov/43006831"},"language":"en","primary_location":{"id":"doi:10.1080/08998280.2026.2757493","doi":"https://doi.org/10.1080/08998280.2026.2757493","is_oa":false,"landing_page_url":"https://doi.org/10.1080/08998280.2026.2757493","pdf_url":null,"source":{"id":"https://openalex.org/S4210173034","display_name":"Baylor University Medical Center Proceedings","issn_l":"0899-8280","issn":["0899-8280","1525-3252"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","medline","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Baylor University Medical Center Proceedings","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5161362457","display_name":"David Crossland","orcid":"https://orcid.org/0009-0008-8670-3626","observed_orcids":["https://orcid.org/0009-0008-8670-3626"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]},{"id":"https://openalex.org/I4210160418","display_name":"Baylor Scott & White Health","ror":"https://ror.org/05wevan27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210160418"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Crossland","raw_affiliation_strings":["Department of Medicine, Baylor Scott and White Health/Baylor College of Medicine"],"raw_orcid":"https://orcid.org/0009-0008-8670-3626","affiliations":[{"raw_affiliation_string":"Department of Medicine, Baylor Scott and White Health/Baylor College of Medicine","institution_ids":["https://openalex.org/I181547552","https://openalex.org/I4210160418"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065710922","display_name":"Nithin Kesireddy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]},{"id":"https://openalex.org/I4210160418","display_name":"Baylor Scott & White Health","ror":"https://ror.org/05wevan27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210160418"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nithin Kesireddy","raw_affiliation_strings":["Department of Medicine, Baylor Scott and White Health/Baylor College of Medicine","Division of Pulmonary and Critical Care, Baylor Scott and White Health/Baylor College of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Baylor Scott and White Health/Baylor College of Medicine","institution_ids":["https://openalex.org/I181547552","https://openalex.org/I4210160418"]},{"raw_affiliation_string":"Division of Pulmonary and Critical Care, Baylor Scott and White Health/Baylor College of Medicine","institution_ids":["https://openalex.org/I181547552","https://openalex.org/I4210160418"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057077651","display_name":"TAYLER ACTON","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]},{"id":"https://openalex.org/I4210160418","display_name":"Baylor Scott & White Health","ror":"https://ror.org/05wevan27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210160418"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tayler Acton","raw_affiliation_strings":["Department of Medicine, Baylor Scott and White Health/Baylor College of Medicine","Division of Pulmonary and Critical Care, Baylor Scott and White Health/Baylor College of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Baylor Scott and White Health/Baylor College of Medicine","institution_ids":["https://openalex.org/I181547552","https://openalex.org/I4210160418"]},{"raw_affiliation_string":"Division of Pulmonary and Critical Care, Baylor Scott and White Health/Baylor College of Medicine","institution_ids":["https://openalex.org/I181547552","https://openalex.org/I4210160418"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5117508724","display_name":"I. Fillerup","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]},{"id":"https://openalex.org/I4210160418","display_name":"Baylor Scott & White Health","ror":"https://ror.org/05wevan27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210160418"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ian Fillerup","raw_affiliation_strings":["Department of Medicine, Baylor Scott and White Health/Baylor College of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Baylor Scott and White Health/Baylor College of Medicine","institution_ids":["https://openalex.org/I181547552","https://openalex.org/I4210160418"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161380249","display_name":"Kasey Halila-Dalirifar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]},{"id":"https://openalex.org/I4210160418","display_name":"Baylor Scott & White Health","ror":"https://ror.org/05wevan27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210160418"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kasey Halila-Dalirifar","raw_affiliation_strings":["Department of Medicine, Baylor Scott and White Health/Baylor College of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Baylor Scott and White Health/Baylor College of Medicine","institution_ids":["https://openalex.org/I181547552","https://openalex.org/I4210160418"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031681079","display_name":"Carl D. Boethel","orcid":"https://orcid.org/0000-0002-2854-4195","observed_orcids":["https://orcid.org/0000-0002-2854-4195"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]},{"id":"https://openalex.org/I4210160418","display_name":"Baylor Scott & White Health","ror":"https://ror.org/05wevan27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210160418"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carl Boethel","raw_affiliation_strings":["Department of Medicine, Baylor Scott and White Health/Baylor College of Medicine","Division of Pulmonary and Critical Care, Baylor Scott and White Health/Baylor College of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Baylor Scott and White Health/Baylor College of Medicine","institution_ids":["https://openalex.org/I181547552","https://openalex.org/I4210160418"]},{"raw_affiliation_string":"Division of Pulmonary and Critical Care, Baylor Scott and White Health/Baylor College of Medicine","institution_ids":["https://openalex.org/I181547552","https://openalex.org/I4210160418"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103100476","display_name":"Alfredo Vazquez-Sandoval","orcid":"https://orcid.org/0000-0002-0979-7808","observed_orcids":["https://orcid.org/0000-0002-0979-7808"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]},{"id":"https://openalex.org/I4210160418","display_name":"Baylor Scott & White Health","ror":"https://ror.org/05wevan27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210160418"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alfredo Vazquez Sandoval","raw_affiliation_strings":["Department of Medicine, Baylor Scott and White Health/Baylor College of Medicine","Division of Pulmonary and Critical Care, Baylor Scott and White Health/Baylor College of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Baylor Scott and White Health/Baylor College of Medicine","institution_ids":["https://openalex.org/I181547552","https://openalex.org/I4210160418"]},{"raw_affiliation_string":"Division of Pulmonary and Critical Care, Baylor Scott and White Health/Baylor College of Medicine","institution_ids":["https://openalex.org/I181547552","https://openalex.org/I4210160418"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050921588","display_name":"Max Holder","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802366037","display_name":"Baylor University Medical Center","ror":"https://ror.org/03nxfhe13","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802366037","https://openalex.org/I4210160418"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Max Holder","raw_affiliation_strings":["Baylor University Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Baylor University Medical Center","institution_ids":["https://openalex.org/I2802366037"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062950237","display_name":"Shekhar A Ghamande","orcid":"https://orcid.org/0000-0001-6924-9494","observed_orcids":["https://orcid.org/0000-0001-6924-9494"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]},{"id":"https://openalex.org/I4210160418","display_name":"Baylor Scott & White Health","ror":"https://ror.org/05wevan27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210160418"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Shekhar Ghamande","raw_affiliation_strings":["Department of Medicine, Baylor Scott and White Health/Baylor College of Medicine","Division of Pulmonary and Critical Care, Baylor Scott and White Health/Baylor College of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Baylor Scott and White Health/Baylor College of Medicine","institution_ids":["https://openalex.org/I181547552","https://openalex.org/I4210160418"]},{"raw_affiliation_string":"Division of Pulmonary and Critical Care, Baylor Scott and White Health/Baylor College of Medicine","institution_ids":["https://openalex.org/I181547552","https://openalex.org/I4210160418"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5062950237"],"corresponding_institution_ids":["https://openalex.org/I181547552","https://openalex.org/I4210160418"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10641","display_name":"Central Venous Catheters and Hemodialysis","score":0.649399995803833,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10641","display_name":"Central Venous Catheters and Hemodialysis","score":0.649399995803833,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11700","display_name":"Hemodynamic Monitoring and Therapy","score":0.09769999980926514,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14189","display_name":"Intravenous Infusion Technology and Safety","score":0.07699999958276749,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C2780253649","wikidata":"https://www.wikidata.org/wiki/Q420360","display_name":"Phentolamine","level":3,"score":0.9667999744415283},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9470999836921692},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.6330000162124634},{"id":"https://openalex.org/C46762472","wikidata":"https://www.wikidata.org/wiki/Q178648","display_name":"Peripheral","level":2,"score":0.5479999780654907},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.5478000044822693},{"id":"https://openalex.org/C2779540182","wikidata":"https://www.wikidata.org/wiki/Q1076345","display_name":"Extravasation","level":2,"score":0.5325000286102295},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.4805000126361847},{"id":"https://openalex.org/C2780214079","wikidata":"https://www.wikidata.org/wiki/Q228537","display_name":"Forearm","level":2,"score":0.39309999346733093},{"id":"https://openalex.org/C2780868729","wikidata":"https://www.wikidata.org/wiki/Q261327","display_name":"Thrombosis","level":2,"score":0.36970001459121704},{"id":"https://openalex.org/C2777202286","wikidata":"https://www.wikidata.org/wiki/Q9609","display_name":"Vein","level":2,"score":0.3508000075817108},{"id":"https://openalex.org/C2780011451","wikidata":"https://www.wikidata.org/wiki/Q2751330","display_name":"Venous thrombosis","level":3,"score":0.328900009393692},{"id":"https://openalex.org/C2777466421","wikidata":"https://www.wikidata.org/wiki/Q1266890","display_name":"Vascular disease","level":2,"score":0.3208000063896179},{"id":"https://openalex.org/C2776651062","wikidata":"https://www.wikidata.org/wiki/Q2143681","display_name":"Seldinger technique","level":3,"score":0.29750001430511475},{"id":"https://openalex.org/C2781267111","wikidata":"https://www.wikidata.org/wiki/Q652297","display_name":"Catheter","level":2,"score":0.2840999960899353},{"id":"https://openalex.org/C2778994108","wikidata":"https://www.wikidata.org/wiki/Q1868462","display_name":"Local anesthetic","level":2,"score":0.2800000011920929},{"id":"https://openalex.org/C2776376669","wikidata":"https://www.wikidata.org/wiki/Q5094647","display_name":"Intensive care unit","level":2,"score":0.26570001244544983},{"id":"https://openalex.org/C2778959117","wikidata":"https://www.wikidata.org/wiki/Q430892","display_name":"Deep vein","level":3,"score":0.2549000084400177}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1080/08998280.2026.2757493","doi":"https://doi.org/10.1080/08998280.2026.2757493","is_oa":false,"landing_page_url":"https://doi.org/10.1080/08998280.2026.2757493","pdf_url":null,"source":{"id":"https://openalex.org/S4210173034","display_name":"Baylor University Medical Center Proceedings","issn_l":"0899-8280","issn":["0899-8280","1525-3252"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","medline","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Baylor University Medical Center Proceedings","raw_type":"journal-article"},{"id":"pmid:43006831","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/43006831","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings (Baylor University. Medical Center)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W1962642315","https://openalex.org/W2047102248","https://openalex.org/W2074225649","https://openalex.org/W2096998881","https://openalex.org/W2574261120","https://openalex.org/W2979921637","https://openalex.org/W3202647386","https://openalex.org/W4230882235","https://openalex.org/W4327894170","https://openalex.org/W4386033978","https://openalex.org/W4390619421","https://openalex.org/W7140083370"],"related_works":[],"abstract_inverted_index":{"BACKGROUND:":[0],"Prior":[1],"studies":[2],"have":[3,168],"indicated":[4],"that":[5],"peripheral":[6,35,85,140,242],"administration":[7,37,144,155],"of":[8,24,61,64,75,95,121,134,139,150,163,177,199,211,237],"vasopressors,":[9],"particularly":[10],"norepinephrine,":[11],"can":[12],"be":[13],"considered":[14],"safe,":[15],"with":[16,39,173,239,245],"local":[17,31,62,194,246],"complications":[18,33],"occurring":[19],"in":[20,41,216,224],"0%":[21],"to":[22,137,153],"1.8%":[23],"patients.":[25],"Our":[26],"study":[27],"further":[28],"explored":[29],"the":[30,125,217,225],"skin":[32,195,251],"from":[34,241],"vasopressor":[36,71],"treated":[38],"phentolamine":[40,58,77,143,154,247],"a":[42,202],"large":[43,235],"health":[44],"care":[45,219],"system.":[46],"METHODS:":[47],"A":[48],"retrospective":[49],"chart":[50],"review":[51],"was":[52,145,158,213,230,256],"performed":[53],"on":[54,100],"patients":[55,101,164,178,200,238],"who":[56,102],"received":[57],"for":[59,69],"effects":[60],"infiltration":[63],"pressors.":[65],"Data":[66,99],"were":[67,113,124],"collected":[68],"demographics,":[70],"dose":[72,78],"and":[73,79,97,104,129,175,183,193,221,227],"duration":[74],"use,":[76],"time":[80],"after":[81,156],"extravasation":[82,138,157,240],"until":[83],"administration,":[84,248],"intravenous":[86,122],"characteristics,":[87],"as":[88,90,93],"well":[89],"outcomes":[91],"such":[92],"length":[94,210],"stay":[96,212],"mortality.":[98],"did":[103,105,165],"not":[106,166],"require":[107],"central":[108,204],"venous":[109,205],"catheter":[110],"placement":[111],"postextravasation":[112],"compared.":[114],"RESULTS:":[115],".":[116],"The":[117,208],"most":[118],"common":[119],"sites":[120],"access":[123],"antecubital":[126],"fossa":[127],"(33%)":[128],"forearm":[130],"(27%).":[131],"Mean":[132,148],"number":[133,149],"hours":[135],"prior":[136,152],"vasopressors":[141,243],"requiring":[142],"21":[146],"hours.":[147],"minutes":[151],"131":[159],"minutes.":[160],"Seventy-six":[161],"percent":[162,198],"any":[167],"significant":[169,186],"ischemic":[170],"tissue":[171,250,254],"injury":[172,255],"extravasation,":[174],"24%":[176],"had":[179],"only":[180],"minor":[181],"bruising":[182],"erythema.":[184],"Two":[185],"reactions":[187],"occurred,":[188],"including":[189],"deep":[190],"vein":[191],"thrombosis":[192],"necrosis.":[196],"Fifty-two":[197],"required":[201],"subsequent":[203],"line":[206],"placement.":[207],"mean":[209],"5.4":[214],"days":[215,223],"intensive":[218],"unit":[220],"11.8":[222],"hospital,":[226],"in-patient":[228],"mortality":[229],"17%.":[231],"CONCLUSION:":[232],"In":[233],"our":[234],"cohort":[236],"managed":[244],"severe":[249],"or":[252],"soft":[253],"rare.":[257]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-11T00:00:00"}
