{"id":"https://openalex.org/W7225734575","doi":"https://doi.org/10.1002/ccd.70956","title":"Impact of Opioid Exposure on the Coronary Microvasculature in ANOCA: A Coronary Microvascular Disease Registry Analysis","display_name":"Impact of Opioid Exposure on the Coronary Microvasculature in ANOCA: A Coronary Microvascular Disease Registry Analysis","publication_year":2026,"publication_date":"2026-11-10","ids":{"openalex":"https://openalex.org/W7225734575","doi":"https://doi.org/10.1002/ccd.70956","pmid":"https://pubmed.ncbi.nlm.nih.gov/43006347"},"language":"en","primary_location":{"id":"doi:10.1002/ccd.70956","doi":"https://doi.org/10.1002/ccd.70956","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ccd.70956","pdf_url":null,"source":{"id":"https://openalex.org/S41314575","display_name":"Catheterization and Cardiovascular Interventions","issn_l":"1522-1946","issn":["1522-1946","1522-726X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Catheterization and Cardiovascular Interventions","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044579633","display_name":"Jason Galo","orcid":"https://orcid.org/0000-0001-9036-7049","observed_orcids":["https://orcid.org/0000-0001-9036-7049"]},"institutions":[{"id":"https://openalex.org/I1285739803","display_name":"MedStar Washington Hospital Center","ror":"https://ror.org/05ry42w04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285739803","https://openalex.org/I86755215"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jason Galo","raw_affiliation_strings":["Section of Interventional Cardiology MedStar Washington Hospital Center Washington DC USA"],"raw_orcid":"https://orcid.org/0000-0001-9036-7049","affiliations":[{"raw_affiliation_string":"Section of Interventional Cardiology MedStar Washington Hospital Center Washington DC USA","institution_ids":["https://openalex.org/I1285739803"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5116406840","display_name":"Abdullah Al Qaraghuli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285739803","display_name":"MedStar Washington Hospital Center","ror":"https://ror.org/05ry42w04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285739803","https://openalex.org/I86755215"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Abdullah Al Qaraghuli","raw_affiliation_strings":["Department of Internal Medicine MedStar Washington Hospital Center Washington DC USA"],"raw_orcid":"https://orcid.org/0009-0003-1429-8557","affiliations":[{"raw_affiliation_string":"Department of Internal Medicine MedStar Washington Hospital Center Washington DC USA","institution_ids":["https://openalex.org/I1285739803"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050170381","display_name":"Kalyan R. Chitturi","orcid":"https://orcid.org/0000-0003-0602-2684","observed_orcids":["https://orcid.org/0000-0003-0602-2684"]},"institutions":[{"id":"https://openalex.org/I1285739803","display_name":"MedStar Washington Hospital Center","ror":"https://ror.org/05ry42w04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285739803","https://openalex.org/I86755215"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kalyan R. Chitturi","raw_affiliation_strings":["Section of Interventional Cardiology MedStar Washington Hospital Center Washington DC USA"],"raw_orcid":"https://orcid.org/0000-0003-0602-2684","affiliations":[{"raw_affiliation_string":"Section of Interventional Cardiology MedStar Washington Hospital Center Washington DC USA","institution_ids":["https://openalex.org/I1285739803"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111172716","display_name":"Sevket Tolga Ozturk","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sevket Ozturk","raw_affiliation_strings":["MedStar Cardiovascular Research Network Washington DC USA"],"raw_orcid":"https://orcid.org/0009-0003-0172-4342","affiliations":[{"raw_affiliation_string":"MedStar Cardiovascular Research Network Washington DC USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065261146","display_name":"Vaishnavi Sawant","orcid":"https://orcid.org/0009-0007-4623-600X","observed_orcids":["https://orcid.org/0009-0007-4623-600X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vaishnavi Sawant","raw_affiliation_strings":["MedStar Cardiovascular Research Network Washington DC USA"],"raw_orcid":"https://orcid.org/0009-0007-4623-600X","affiliations":[{"raw_affiliation_string":"MedStar Cardiovascular Research Network Washington DC USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5130776505","display_name":"Ronald Cadillo Hernandez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285739803","display_name":"MedStar Washington Hospital Center","ror":"https://ror.org/05ry42w04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285739803","https://openalex.org/I86755215"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ronald Cadillo Hernandez","raw_affiliation_strings":["Department of Internal Medicine MedStar Washington Hospital Center Washington DC USA"],"raw_orcid":"https://orcid.org/0009-0008-5215-8084","affiliations":[{"raw_affiliation_string":"Department of Internal Medicine MedStar Washington Hospital Center Washington DC USA","institution_ids":["https://openalex.org/I1285739803"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053462438","display_name":"Shuchi Abhishek","orcid":"https://orcid.org/0000-0001-9348-9869","observed_orcids":["https://orcid.org/0000-0001-9348-9869"]},"institutions":[{"id":"https://openalex.org/I1285739803","display_name":"MedStar Washington Hospital Center","ror":"https://ror.org/05ry42w04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285739803","https://openalex.org/I86755215"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shuchi Abhishek","raw_affiliation_strings":["Department of Internal Medicine MedStar Washington Hospital Center Washington DC USA"],"raw_orcid":"https://orcid.org/0000-0001-9348-9869","affiliations":[{"raw_affiliation_string":"Department of Internal Medicine MedStar Washington Hospital Center Washington DC USA","institution_ids":["https://openalex.org/I1285739803"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020345821","display_name":"Nicolas Cimino","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nicolas Cimino","raw_affiliation_strings":["MedStar Cardiovascular Research Network Washington DC USA"],"raw_orcid":"https://orcid.org/0000-0002-1200-2236","affiliations":[{"raw_affiliation_string":"MedStar Cardiovascular Research Network Washington DC USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159254493","display_name":"Matteo Cellamare","orcid":"https://orcid.org/0000-0001-7185-9136","observed_orcids":["https://orcid.org/0000-0001-7185-9136"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Matteo Cellamare","raw_affiliation_strings":["MedStar Cardiovascular Research Network Washington DC USA"],"raw_orcid":"https://orcid.org/0000-0001-7185-9136","affiliations":[{"raw_affiliation_string":"MedStar Cardiovascular Research Network Washington DC USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161363842","display_name":"Cheng Zhang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cheng Zhang","raw_affiliation_strings":["MedStar Cardiovascular Research Network Washington DC USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MedStar Cardiovascular Research Network Washington DC USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021693095","display_name":"Beni Rai Verma","orcid":"https://orcid.org/0000-0003-0970-2028","observed_orcids":["https://orcid.org/0000-0003-0970-2028"]},"institutions":[{"id":"https://openalex.org/I1285739803","display_name":"MedStar Washington Hospital Center","ror":"https://ror.org/05ry42w04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285739803","https://openalex.org/I86755215"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Beni R. Verma","raw_affiliation_strings":["Section of Interventional Cardiology MedStar Washington Hospital Center Washington DC USA"],"raw_orcid":"https://orcid.org/0000-0003-0970-2028","affiliations":[{"raw_affiliation_string":"Section of Interventional Cardiology MedStar Washington Hospital Center Washington DC USA","institution_ids":["https://openalex.org/I1285739803"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101657281","display_name":"Anirudh Rao","orcid":"https://orcid.org/0000-0003-2548-0082","observed_orcids":["https://orcid.org/0000-0003-2548-0082"]},"institutions":[{"id":"https://openalex.org/I1285739803","display_name":"MedStar Washington Hospital Center","ror":"https://ror.org/05ry42w04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285739803","https://openalex.org/I86755215"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anirudh Rao","raw_affiliation_strings":["Department of Palliative Care MedStar Washington Hospital Center Washington DC USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Palliative Care MedStar Washington Hospital Center Washington DC USA","institution_ids":["https://openalex.org/I1285739803"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081547954","display_name":"H\u00e9ctor M. Garc\u00eda\u2010Garc\u00eda","orcid":"https://orcid.org/0000-0001-5100-0471","observed_orcids":["https://orcid.org/0000-0001-5100-0471"]},"institutions":[{"id":"https://openalex.org/I1285739803","display_name":"MedStar Washington Hospital Center","ror":"https://ror.org/05ry42w04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285739803","https://openalex.org/I86755215"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hector M. Garcia\u2010Garcia","raw_affiliation_strings":["Section of Interventional Cardiology MedStar Washington Hospital Center Washington DC USA"],"raw_orcid":"https://orcid.org/0000-0001-5100-0471","affiliations":[{"raw_affiliation_string":"Section of Interventional Cardiology MedStar Washington Hospital Center Washington DC USA","institution_ids":["https://openalex.org/I1285739803"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002279235","display_name":"Ron Waksman","orcid":"https://orcid.org/0000-0002-4063-9226","observed_orcids":["https://orcid.org/0000-0002-4063-9226","https://orcid.org/0000-0002-9514-3367"]},"institutions":[{"id":"https://openalex.org/I1285739803","display_name":"MedStar Washington Hospital Center","ror":"https://ror.org/05ry42w04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285739803","https://openalex.org/I86755215"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ron Waksman","raw_affiliation_strings":["Section of Interventional Cardiology MedStar Washington Hospital Center Washington DC USA"],"raw_orcid":"https://orcid.org/0000-0002-4063-9226","affiliations":[{"raw_affiliation_string":"Section of Interventional Cardiology MedStar Washington Hospital Center Washington DC USA","institution_ids":["https://openalex.org/I1285739803"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072737422","display_name":"Hayder Dhafir Hashim","orcid":"https://orcid.org/0000-0003-2194-5428","observed_orcids":["https://orcid.org/0000-0003-2194-5428"]},"institutions":[{"id":"https://openalex.org/I1285739803","display_name":"MedStar Washington Hospital Center","ror":"https://ror.org/05ry42w04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285739803","https://openalex.org/I86755215"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hayder Hashim","raw_affiliation_strings":["Section of Interventional Cardiology MedStar Washington Hospital Center Washington DC USA"],"raw_orcid":"https://orcid.org/0000-0003-2194-5428","affiliations":[{"raw_affiliation_string":"Section of Interventional Cardiology MedStar Washington Hospital Center Washington DC USA","institution_ids":["https://openalex.org/I1285739803"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078150348","display_name":"Brian C. Case","orcid":"https://orcid.org/0000-0001-5355-9594","observed_orcids":["https://orcid.org/0000-0001-5355-9594"]},"institutions":[{"id":"https://openalex.org/I1285739803","display_name":"MedStar Washington Hospital Center","ror":"https://ror.org/05ry42w04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285739803","https://openalex.org/I86755215"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian C. Case","raw_affiliation_strings":["Section of Interventional Cardiology MedStar Washington Hospital Center Washington DC USA"],"raw_orcid":"https://orcid.org/0000-0001-5355-9594","affiliations":[{"raw_affiliation_string":"Section of Interventional Cardiology MedStar Washington Hospital Center Washington DC USA","institution_ids":["https://openalex.org/I1285739803"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4490,"currency":"USD","value_usd":4490},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10372","display_name":"Cardiac Imaging and Diagnostics","score":0.6977999806404114,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10372","display_name":"Cardiac Imaging and Diagnostics","score":0.6977999806404114,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10193","display_name":"Coronary Interventions and Diagnostics","score":0.1973000019788742,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10576","display_name":"Opioid Use Disorder Treatment","score":0.03139999881386757,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9805999994277954},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.723800003528595},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6758999824523926},{"id":"https://openalex.org/C2778707443","wikidata":"https://www.wikidata.org/wiki/Q3936479","display_name":"Coronary flow reserve","level":3,"score":0.6442000269889832},{"id":"https://openalex.org/C2778653478","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Kidney disease","level":2,"score":0.5112000107765198},{"id":"https://openalex.org/C2781063702","wikidata":"https://www.wikidata.org/wiki/Q427523","display_name":"Opioid","level":3,"score":0.5026000142097473},{"id":"https://openalex.org/C2777987666","wikidata":"https://www.wikidata.org/wiki/Q1440572","display_name":"Fractional flow reserve","level":4,"score":0.41659998893737793},{"id":"https://openalex.org/C12722491","wikidata":"https://www.wikidata.org/wiki/Q1632335","display_name":"Microcirculation","level":2,"score":0.38339999318122864},{"id":"https://openalex.org/C2778213512","wikidata":"https://www.wikidata.org/wiki/Q844935","display_name":"Coronary artery disease","level":2,"score":0.3781000077724457},{"id":"https://openalex.org/C2778425758","wikidata":"https://www.wikidata.org/wiki/Q180762","display_name":"Angina","level":3,"score":0.36820000410079956},{"id":"https://openalex.org/C2778704086","wikidata":"https://www.wikidata.org/wiki/Q693058","display_name":"Chest pain","level":2,"score":0.34360000491142273},{"id":"https://openalex.org/C58245268","wikidata":"https://www.wikidata.org/wiki/Q456026","display_name":"Vascular resistance","level":3,"score":0.34150001406669617},{"id":"https://openalex.org/C2991716557","wikidata":"https://www.wikidata.org/wiki/Q12252367","display_name":"Coronary atherosclerosis","level":3,"score":0.33469998836517334},{"id":"https://openalex.org/C2779159551","wikidata":"https://www.wikidata.org/wiki/Q1414874","display_name":"Comorbidity","level":2,"score":0.32710000872612},{"id":"https://openalex.org/C2776157398","wikidata":"https://www.wikidata.org/wiki/Q497232","display_name":"Coronary circulation","level":3,"score":0.3246999979019165},{"id":"https://openalex.org/C120770815","wikidata":"https://www.wikidata.org/wiki/Q14859627","display_name":"Vasodilation","level":2,"score":0.3109000027179718},{"id":"https://openalex.org/C43376680","wikidata":"https://www.wikidata.org/wiki/Q6580786","display_name":"Bolus (digestion)","level":2,"score":0.3077999949455261},{"id":"https://openalex.org/C2909076160","wikidata":"https://www.wikidata.org/wiki/Q14859627","display_name":"Coronary vasodilator","level":3,"score":0.2978000044822693},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.2883000075817108},{"id":"https://openalex.org/C3019128504","wikidata":"https://www.wikidata.org/wiki/Q948806","display_name":"Reactive hyperemia","level":3,"score":0.28189998865127563},{"id":"https://openalex.org/C2777466421","wikidata":"https://www.wikidata.org/wiki/Q1266890","display_name":"Vascular disease","level":2,"score":0.27489998936653137},{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.272599995136261},{"id":"https://openalex.org/C2778742706","wikidata":"https://www.wikidata.org/wiki/Q18361829","display_name":"Coronary arteries","level":3,"score":0.26460000872612},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.2500999867916107}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1002/ccd.70956","doi":"https://doi.org/10.1002/ccd.70956","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ccd.70956","pdf_url":null,"source":{"id":"https://openalex.org/S41314575","display_name":"Catheterization and Cardiovascular Interventions","issn_l":"1522-1946","issn":["1522-1946","1522-726X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Catheterization and Cardiovascular Interventions","raw_type":"journal-article"},{"id":"pmid:43006347","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/43006347","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W1990355279","https://openalex.org/W2005662282","https://openalex.org/W2079243472","https://openalex.org/W2129120003","https://openalex.org/W2172419556","https://openalex.org/W2293548706","https://openalex.org/W2426677536","https://openalex.org/W2901491112","https://openalex.org/W2999420193","https://openalex.org/W3008159865","https://openalex.org/W3039015991","https://openalex.org/W3120286722","https://openalex.org/W3201739740","https://openalex.org/W4200205471","https://openalex.org/W4200256560","https://openalex.org/W4206269588","https://openalex.org/W4220873995","https://openalex.org/W4285037103","https://openalex.org/W4291003818","https://openalex.org/W4308369850","https://openalex.org/W4319072934","https://openalex.org/W4321371739","https://openalex.org/W4381716577","https://openalex.org/W4386694469","https://openalex.org/W4389042691","https://openalex.org/W4391935364","https://openalex.org/W4393167370","https://openalex.org/W4393227359","https://openalex.org/W4401188890","https://openalex.org/W4402709521","https://openalex.org/W4405349362","https://openalex.org/W4406874679","https://openalex.org/W4409033194","https://openalex.org/W4411153750","https://openalex.org/W4411401928","https://openalex.org/W4413110197","https://openalex.org/W4413916615","https://openalex.org/W7116889658","https://openalex.org/W7140073656"],"related_works":[],"abstract_inverted_index":{"BACKGROUND:":[0],"Angina":[1],"with":[2,19,59,395],"non-obstructive":[3],"coronary":[4,24,41,54,103,117,308],"arteries":[5],"(ANOCA)":[6],"accounts":[7],"for":[8,16,34,230],"up":[9],"to":[10,23,32,108,371],"50%":[11],"of":[12,89,125,198,226,331],"patients":[13,33,58,92],"undergoing":[14],"angiography":[15],"chest":[17],"pain,":[18],"many":[20],"cases":[21],"due":[22],"microvascular":[25,55,83,131,437],"dysfunction":[26,56],"(CMD).":[27],"Opioids":[28],"are":[29,43],"often":[30],"prescribed":[31],"multiple":[35],"indications,":[36],"and":[37,53,69,74,76,123,163,180,201,233,246,251,400,413,417,445],"their":[38],"effects":[39],"on":[40,62,359],"microcirculation":[42],"unclear.":[44],"AIMS:":[45],"To":[46],"investigate":[47],"the":[48,94,151,159,196,219,349,360,378],"association":[49],"between":[50,71,207,335,421],"opioid":[51,72,78,170,272,291,318,388,425],"exposure":[52,79,149,208,426],"in":[57,64,290,317,451],"ANOCA,":[60,387],"focusing":[61],"differences":[63],"CMD":[65,113,199,266,414],"prevalence,":[66,415],"CFR,":[67,416],"IMR,":[68,205],"MRR":[70,228,314,350,407],"users":[73,171,239,273,292,319,389],"non-users,":[75,179],"whether":[77],"independently":[80,435],"predicts":[81],"impaired":[82,138,307],"vasodilatory":[84,139,438],"function.":[85,439],"METHODS:":[86],"A":[87],"total":[88],"367":[90],"ANOCA":[91],"from":[93,158],"Coronary":[95,456],"Microvascular":[96,457],"Disease":[97,458],"Registry":[98],"(NCT05960474)":[99],"who":[100],"underwent":[101],"invasive":[102],"function":[104],"testing":[105,155],"(August":[106],"2021":[107],"March":[109],"2025)":[110],"were":[111,143,167,217,419],"analyzed.":[112],"was":[114,156,195,268,288,315,333,352,377],"defined":[115],"by":[116,145],"flow":[118],"reserve":[119,133],"(CFR)":[120],"<":[121,135,264],"2.5":[122],"index":[124],"microcirculatory":[126],"resistance":[127,132],"(IMR)":[128],"\u2265":[129],"25;":[130],"(MRR)":[134],"3.0":[136],"indicated":[137],"capacity.":[140],"All":[141],"indices":[142],"measured":[144],"bolus":[146],"thermodilution.":[147],"Opioid":[148,238],"during":[150],"12":[152],"months":[153],"preceding":[154],"obtained":[157],"electronic":[160],"health":[161],"record":[162],"Surescripts":[164],"database.":[165],"Patients":[166],"categorized":[168],"as":[169,182],"(\u2265":[172,189],"1":[173],"prescription":[174],">":[175],"3":[176],"days)":[177,186],"or":[178,187],"stratified":[181],"short-term":[183],"(<":[184],"90":[185,190],"long-term":[188],"days).":[191],"The":[192],"primary":[193,220],"outcome":[194],"comparison":[197],"prevalence":[200,267],"physiologic":[202],"parameters":[203],"(CFR,":[204],"MRR)":[206],"groups.":[209],"Because":[210],"groups":[211,336],"differed":[212],"at":[213],"baseline,":[214],"unadjusted":[215,311,406],"comparisons":[216],"descriptive;":[218],"interpretation":[221],"used":[222],"a":[223,304,391,428],"multivariable":[224],"model":[225],"log-transformed":[227],"adjusted":[229],"hypertension,":[231,242],"hemoglobin,":[232,399],"chronic":[234,243],"kidney":[235,244],"disease.":[236],"RESULTS:":[237],"had":[240],"more":[241,401,429],"disease,":[245],"CCS":[247],"class":[248],"IV":[249],"angina,":[250],"lower":[252,289,316,366,398,405],"hemoglobin":[253,376],"(12.38":[254],"\u00b1":[255,259,294,298,321,325,338,342],"1.60":[256],"vs.":[257,296,323,340],"13.32":[258],"1.58":[260],"g/dL;":[261],"all":[262],"p":[263,300,327,344,373],"0.05).":[265],"numerically":[269],"higher":[270],"among":[271],"(19/55;":[274],"34.5%)":[275],"versus":[276],"non-users":[277],"(85/312;":[278],"27.2%),":[279],"but":[280],"not":[281,409],"significantly":[282],"(p":[283,382],"=":[284,301,328,345,357,374,383],"0.27).":[285],"Mean":[286,330],"CFR":[287],"(2.84":[293],"1.65":[295],"3.32":[297],"1.80;":[299],"0.06),":[302],"suggesting":[303,423],"trend":[305],"toward":[306],"flow.":[309],"In":[310,386],"analysis,":[312],"mean":[313],"(3.27":[320],"1.78":[322],"4.02":[324],"2.32;":[326],"0.01).":[329],"IMR":[332,418],"similar":[334,420],"(18.51":[337],"10.58":[339],"18.60":[341],"12.24;":[343],"0.96).":[346],"After":[347],"adjustment,":[348,412],"difference":[351],"no":[353],"longer":[354],"significant":[355],"(\u03b2":[356],"-0.11":[358],"log":[361],"scale,":[362],"an":[363],"estimated":[364],"10.5%":[365],"MRR;":[367],"95%":[368],"CI":[369],"-0.30":[370],"0.08;":[372],"0.25);":[375],"only":[379],"independent":[380],"correlate":[381],"0.011).":[384],"CONCLUSIONS:":[385],"represented":[390],"distinct":[392],"clinical":[393,431],"phenotype":[394],"greater":[396],"comorbidity,":[397],"severe":[402],"angina.":[403],"Their":[404],"did":[408],"persist":[410],"after":[411],"groups,":[422],"that":[424],"marks":[427],"complex":[430],"state":[432],"rather":[433],"than":[434],"impairing":[436],"Residual":[440],"confounding":[441],"cannot":[442],"be":[443],"excluded,":[444],"these":[446],"exploratory":[447],"findings":[448],"require":[449],"confirmation":[450],"larger":[452],"studies.":[453],"TRIAL":[454],"REGISTRATION:":[455],"Registry,":[459],"clinicaltrials.gov,":[460],"NCT05960474.":[461]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-11T00:00:00"}