{"id":"https://openalex.org/W7225734237","doi":"https://doi.org/10.64898/2026.11.07.765104","title":"Telotrons: spliceosomal introns composed of telomeric repeats","display_name":"Telotrons: spliceosomal introns composed of telomeric repeats","publication_year":2026,"publication_date":"2026-11-10","ids":{"openalex":"https://openalex.org/W7225734237","doi":"https://doi.org/10.64898/2026.11.07.765104"},"language":"en","primary_location":{"id":"doi:10.64898/2026.11.07.765104","doi":"https://doi.org/10.64898/2026.11.07.765104","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.11.07.765104","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.64898/2026.11.07.765104","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070626366","display_name":"Alexander Kr\u00e4mer","orcid":"https://orcid.org/0000-0003-3630-3209","observed_orcids":["https://orcid.org/0000-0003-3630-3209"]},"institutions":[{"id":"https://openalex.org/I185103710","display_name":"University of California, Santa Cruz","ror":"https://ror.org/03s65by71","country_code":"US","type":"education","lineage":["https://openalex.org/I185103710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexander M Kramer","raw_affiliation_strings":["University of California, Santa Cruz"],"raw_orcid":"https://orcid.org/0000-0003-3630-3209","affiliations":[{"raw_affiliation_string":"University of California, Santa Cruz","institution_ids":["https://openalex.org/I185103710"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076593250","display_name":"Russell B Corbett-Detig","orcid":"https://orcid.org/0000-0001-6535-2478","observed_orcids":["https://orcid.org/0000-0001-6535-2478"]},"institutions":[{"id":"https://openalex.org/I185103710","display_name":"University of California, Santa Cruz","ror":"https://ror.org/03s65by71","country_code":"US","type":"education","lineage":["https://openalex.org/I185103710"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Russ Corbett-Detig","raw_affiliation_strings":["University of California, Santa Cruz"],"raw_orcid":"https://orcid.org/0000-0001-6535-2478","affiliations":[{"raw_affiliation_string":"University of California, Santa Cruz","institution_ids":["https://openalex.org/I185103710"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5076593250"],"corresponding_institution_ids":["https://openalex.org/I185103710"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10434","display_name":"Chromosomal and Genetic Variations","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10434","display_name":"Chromosomal and Genetic Variations","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.005900000222027302,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C94671646","wikidata":"https://www.wikidata.org/wiki/Q207551","display_name":"Intron","level":3,"score":0.7773000001907349},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.718500018119812},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.6699000000953674},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5964999794960022},{"id":"https://openalex.org/C64962909","wikidata":"https://www.wikidata.org/wiki/Q5611160","display_name":"Group II intron","level":5,"score":0.5770000219345093},{"id":"https://openalex.org/C177336024","wikidata":"https://www.wikidata.org/wiki/Q14872779","display_name":"Telomere","level":3,"score":0.5659000277519226},{"id":"https://openalex.org/C60542250","wikidata":"https://www.wikidata.org/wiki/Q21105762","display_name":"Minor spliceosome","level":5,"score":0.4986000061035156},{"id":"https://openalex.org/C54458228","wikidata":"https://www.wikidata.org/wiki/Q237218","display_name":"RNA splicing","level":4,"score":0.49639999866485596},{"id":"https://openalex.org/C4918238","wikidata":"https://www.wikidata.org/wiki/Q121438","display_name":"Transposable element","level":4,"score":0.4832000136375427},{"id":"https://openalex.org/C94581717","wikidata":"https://www.wikidata.org/wiki/Q331839","display_name":"Telomerase","level":3,"score":0.4523000121116638},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.40849998593330383},{"id":"https://openalex.org/C118346598","wikidata":"https://www.wikidata.org/wiki/Q5611164","display_name":"Group I catalytic intron","level":5,"score":0.3725999891757965},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.35190001130104065},{"id":"https://openalex.org/C2780989783","wikidata":"https://www.wikidata.org/wiki/Q7578557","display_name":"splice","level":3,"score":0.32440000772476196},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.3206000030040741},{"id":"https://openalex.org/C174600577","wikidata":"https://www.wikidata.org/wiki/Q5533491","display_name":"Genome evolution","level":4,"score":0.29739999771118164},{"id":"https://openalex.org/C169802333","wikidata":"https://www.wikidata.org/wiki/Q424473","display_name":"Repeated sequence","level":4,"score":0.2973000109195709},{"id":"https://openalex.org/C80116771","wikidata":"https://www.wikidata.org/wiki/Q5408688","display_name":"Eukaryotic chromosome fine structure","level":4,"score":0.2912999987602234},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.28380000591278076},{"id":"https://openalex.org/C121346293","wikidata":"https://www.wikidata.org/wiki/Q1340715","display_name":"Endogenous retrovirus","level":4,"score":0.27059999108314514},{"id":"https://openalex.org/C75934600","wikidata":"https://www.wikidata.org/wiki/Q419245","display_name":"Ribonucleoprotein","level":4,"score":0.2685000002384186},{"id":"https://openalex.org/C194232998","wikidata":"https://www.wikidata.org/wiki/Q1606712","display_name":"Transition (genetics)","level":3,"score":0.2551000118255615}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.11.07.765104","doi":"https://doi.org/10.64898/2026.11.07.765104","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.11.07.765104","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.11.07.765104","doi":"https://doi.org/10.64898/2026.11.07.765104","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.11.07.765104","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Spliceosomal":[0],"intron":[1,16,105,149],"numbers":[2],"vary":[3],"widely":[4],"across":[5],"eukaryotes,":[6],"but":[7],"the":[8,19,70,75],"only":[9],"established":[10],"mechanism":[11],"for":[12],"large":[13],"bursts":[14],"of":[15,21,32,38,100,133,145],"gain":[17],"is":[18],"spread":[20],"transposable":[22],"introner":[23],"elements.":[24],"We":[25],"describe":[26],"telotrons,":[27],"spliceosomal":[28],"introns":[29,46],"composed":[30],"predominantly":[31],"telomeric":[33,49],"repeats.":[34],"In":[35,117],"a":[36,67],"survey":[37],"10,310":[39],"eukaryotic":[40],"genome":[41],"assemblies,":[42],"we":[43],"identified":[44],"7,008":[45],"with":[47,56,97],">85%":[48],"repeat":[50,93],"coverage":[51],"and":[52,74,87,104,119,151],"an":[53,142],"additional":[54],"44,423":[55],">50%":[57],"to":[58,139],"\u226485%":[59],"coverage,":[60],"in":[61,110],"25":[62],"genomes":[63],"spanning":[64],"haptophytes,":[65],"dinoflagellates,":[66],"cryptophyte,":[68],"stramenopiles,":[69],"apicomplexan":[71],"Eimeria":[72,118],",":[73,121],"nematode":[76],"Mesorhabditis":[77,120],".":[78],"Most":[79],"telotrons":[80,122],"carry":[81,128],"GT\u2013AG":[82],"or":[83],"GC\u2013AG":[84],"splice":[85],"boundaries,":[86],"RNA-seq":[88],"supports":[89,112],"their":[90],"splicing.":[91],"Their":[92],"orientations":[94],"are":[95],"consistent":[96],"telomerase":[98,140],"extension":[99],"broken":[101],"DNA":[102],"ends,":[103],"absence":[106],"at":[107],"corresponding":[108],"positions":[109,125],"orthologs":[111,127],"widespread":[113],"de":[114],"novo":[115],"gain.":[116],"instead":[123],"occupy":[124],"where":[126],"ordinary":[129],"introns,":[130],"suggesting":[131],"modification":[132],"existing":[134],"introns.":[135],"Telotrons":[136],"thus":[137],"point":[138],"as":[141],"endogenous":[143],"driver":[144],"structural":[146],"innovation":[147],"through":[148],"creation":[150],"remodeling.":[152]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-11T00:00:00"}
