{"id":"https://openalex.org/W7225733137","doi":"https://doi.org/10.1177/13860291261502270","title":"Blood cell aggregation as a hemorheological marker of long-term clinical outcome after percutaneous coronary intervention in patients with coronary artery disease","display_name":"Blood cell aggregation as a hemorheological marker of long-term clinical outcome after percutaneous coronary intervention in patients with coronary artery disease","publication_year":2026,"publication_date":"2026-11-10","ids":{"openalex":"https://openalex.org/W7225733137","doi":"https://doi.org/10.1177/13860291261502270","pmid":"https://pubmed.ncbi.nlm.nih.gov/43006715"},"language":"en","primary_location":{"id":"doi:10.1177/13860291261502270","doi":"https://doi.org/10.1177/13860291261502270","is_oa":false,"landing_page_url":"https://doi.org/10.1177/13860291261502270","pdf_url":null,"source":{"id":"https://openalex.org/S74293116","display_name":"Clinical Hemorheology and Microcirculation","issn_l":"1386-0291","issn":["1386-0291","1875-8622"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Hemorheology and Microcirculation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5161385198","display_name":"Spartak Lekveishvili","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I7848551","display_name":"Tbilisi State Medical University","ror":"https://ror.org/020jbrt22","country_code":"GE","type":"education","lineage":["https://openalex.org/I7848551"]}],"countries":["GE"],"is_corresponding":false,"raw_author_name":"Spartak Lekveishvili","raw_affiliation_strings":["Tbilisi State Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tbilisi State Medical University","institution_ids":["https://openalex.org/I7848551"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062086384","display_name":"V. Kapetivadze","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I7848551","display_name":"Tbilisi State Medical University","ror":"https://ror.org/020jbrt22","country_code":"GE","type":"education","lineage":["https://openalex.org/I7848551"]}],"countries":["GE"],"is_corresponding":false,"raw_author_name":"Vera Kapetivadze","raw_affiliation_strings":["Tbilisi State Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tbilisi State Medical University","institution_ids":["https://openalex.org/I7848551"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091861216","display_name":"\u041d\u0430\u043d\u0430 \u041c\u043e\u043c\u0446\u0435\u043b\u0438\u0434\u0437\u0435","orcid":"https://orcid.org/0000-0003-3065-1405","observed_orcids":["https://orcid.org/0000-0003-3065-1405","https://orcid.org/0000-0001-6907-2000"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nana Momtselidze","raw_affiliation_strings":["Ivane Beritashvili Center of Experimental Biomedicine"],"raw_orcid":"https://orcid.org/0000-0003-3065-1405","affiliations":[{"raw_affiliation_string":"Ivane Beritashvili Center of Experimental Biomedicine","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056815341","display_name":"G. Kuchava","orcid":"https://orcid.org/0000-0001-6907-2000","observed_orcids":["https://orcid.org/0000-0001-6907-2000","https://orcid.org/0000-0001-7860-0872"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Giorgi Kuchava","raw_affiliation_strings":["Ivane Beritashvili Center of Experimental Biomedicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ivane Beritashvili Center of Experimental Biomedicine","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036673750","display_name":"\u041c\u0430\u0439\u0430 \u041c\u0430\u043d\u0446\u043a\u0430\u0432\u0430","orcid":"https://orcid.org/0000-0002-4632-3097","observed_orcids":["https://orcid.org/0000-0002-4632-3097"]},"institutions":[{"id":"https://openalex.org/I7848551","display_name":"Tbilisi State Medical University","ror":"https://ror.org/020jbrt22","country_code":"GE","type":"education","lineage":["https://openalex.org/I7848551"]}],"countries":["GE"],"is_corresponding":true,"raw_author_name":"Maka (Maia) Mantskava","raw_affiliation_strings":["Ivane Beritashvili Center of Experimental Biomedicine","Tbilisi State Medical University"],"raw_orcid":"https://orcid.org/0000-0002-4632-3097","affiliations":[{"raw_affiliation_string":"Ivane Beritashvili Center of Experimental Biomedicine","institution_ids":[]},{"raw_affiliation_string":"Tbilisi State Medical University","institution_ids":["https://openalex.org/I7848551"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5036673750"],"corresponding_institution_ids":["https://openalex.org/I7848551"],"apc_list":{"value":4150,"currency":"USD","value_usd":4150},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"13860291261502270","last_page":"13860291261502270"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11721","display_name":"Blood properties and coagulation","score":0.9193999767303467,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11721","display_name":"Blood properties and coagulation","score":0.9193999767303467,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10193","display_name":"Coronary Interventions and Diagnostics","score":0.03060000017285347,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11355","display_name":"Inflammatory Biomarkers in Disease Prognosis","score":0.023000000044703484,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8535000085830688},{"id":"https://openalex.org/C45393284","wikidata":"https://www.wikidata.org/wiki/Q191012","display_name":"Conventional PCI","level":3,"score":0.7731999754905701},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7085999846458435},{"id":"https://openalex.org/C2778213512","wikidata":"https://www.wikidata.org/wiki/Q844935","display_name":"Coronary artery disease","level":2,"score":0.6791999936103821},{"id":"https://openalex.org/C2779036427","wikidata":"https://www.wikidata.org/wiki/Q381899","display_name":"Fibrinogen","level":2,"score":0.616100013256073},{"id":"https://openalex.org/C2780400711","wikidata":"https://www.wikidata.org/wiki/Q2008344","display_name":"Percutaneous coronary intervention","level":3,"score":0.5842000246047974},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.567300021648407},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.5231999754905701},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.5231000185012817},{"id":"https://openalex.org/C2779464278","wikidata":"https://www.wikidata.org/wiki/Q7317735","display_name":"Revascularization","level":3,"score":0.42289999127388},{"id":"https://openalex.org/C2776557347","wikidata":"https://www.wikidata.org/wiki/Q37187","display_name":"Red blood cell","level":2,"score":0.3885999917984009},{"id":"https://openalex.org/C2777426075","wikidata":"https://www.wikidata.org/wiki/Q17119113","display_name":"Erythrocyte aggregation","level":3,"score":0.385699987411499},{"id":"https://openalex.org/C2779979121","wikidata":"https://www.wikidata.org/wiki/Q211709","display_name":"Blood cell","level":2,"score":0.3646000027656555},{"id":"https://openalex.org/C2993802102","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet aggregation","level":3,"score":0.361299991607666},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.3547999858856201},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3418000042438507},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.32899999618530273},{"id":"https://openalex.org/C2777466421","wikidata":"https://www.wikidata.org/wiki/Q1266890","display_name":"Vascular disease","level":2,"score":0.30970001220703125},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.3073999881744385},{"id":"https://openalex.org/C2778488018","wikidata":"https://www.wikidata.org/wiki/Q42395","display_name":"White blood cell","level":2,"score":0.3043999969959259},{"id":"https://openalex.org/C2776820930","wikidata":"https://www.wikidata.org/wiki/Q9655","display_name":"Artery","level":2,"score":0.272599995136261},{"id":"https://openalex.org/C30036603","wikidata":"https://www.wikidata.org/wiki/Q17125150","display_name":"Severity of illness","level":2,"score":0.26489999890327454}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1177/13860291261502270","doi":"https://doi.org/10.1177/13860291261502270","is_oa":false,"landing_page_url":"https://doi.org/10.1177/13860291261502270","pdf_url":null,"source":{"id":"https://openalex.org/S74293116","display_name":"Clinical Hemorheology and Microcirculation","issn_l":"1386-0291","issn":["1386-0291","1875-8622"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Hemorheology and Microcirculation","raw_type":"journal-article"},{"id":"pmid:43006715","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/43006715","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical hemorheology and microcirculation","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W1640107375","https://openalex.org/W2007341569","https://openalex.org/W2022348895","https://openalex.org/W2121221073","https://openalex.org/W2150460525","https://openalex.org/W2152495860","https://openalex.org/W2566133168","https://openalex.org/W2884875795","https://openalex.org/W3011549096","https://openalex.org/W3037801707","https://openalex.org/W4283455601","https://openalex.org/W4361213297","https://openalex.org/W4410862708","https://openalex.org/W4412070386","https://openalex.org/W4415144285"],"related_works":[],"abstract_inverted_index":{"Background":[0],"We":[1,18],"evaluated":[2],"serial":[3],"blood":[4],"cell":[5],"aggregation":[6,42,95,159,201],"changes":[7],"after":[8],"PCI":[9,23],"in":[10,165,196,245],"CAD":[11,24,69,167],"patients":[12,25,70],"and":[13,26,38,60,93,174,230,233],"their":[14],"12-month":[15],"outcomes.":[16],"Methods":[17],"prospectively":[19],"enrolled":[20],"120":[21],"elective":[22],"50":[27],"frequency-matched":[28],"controls.":[29,105],"Blood":[30],"was":[31,45,202],"collected":[32],"pre-PCI,":[33],"on":[34],"Days":[35],"3,":[36],"8,":[37],"Month":[39,179],"3.":[40],"Erythrocyte":[41],"index":[43],"(EAI)":[44],"assessed":[46],"by":[47,178],"TAS-plus":[48],"aggregometry.":[49],"Patients":[50],"were":[51],"grouped":[52],"into":[53],"Group":[54,61,126,143],"I":[55,127],"(favorable,":[56],"n":[57,65],"=":[58,66,118,121,156,189],"106)":[59],"II":[62,144],"(repeat":[63],"PCI,":[64],"14).":[67],"Results":[68],"showed":[71,128],"higher":[72],"baseline":[73,177],"EAI":[74,115,130,147],"(0.43":[75],"\u00b1":[76,78,85,87,97,99,133,137,149,153,170,172,182,186,210,212],"0.06vs.0.29":[77],"0.04,":[79],"p":[80,90,101,120,139,155,188,214],"<":[81,91,102,140,215],"0.001),":[82,92,141],"fibrinogen":[83],"(4.1":[84],"0.6vs.2.9":[86],"0.4":[88],"g/L,":[89],"leukocyte":[94],"(32.4":[96],"5.8%vs.21.4":[98],"4.2%,":[100],"0.001)":[103,216],"than":[104],"Linear":[106],"mixed-effects":[107],"modeling":[108],"revealed":[109],"a":[110,236],"significant":[111],"group-by-time":[112],"interaction":[113],"for":[114,239],"(F(3,":[116],"354)":[117],"5.12,":[119],"0.002).":[122],"Over":[123],"3":[124,164,180,208],"months,":[125],"progressive":[129],"normalization":[131],"(0.42":[132],"0.05":[134],"to":[135,151,176],"0.31":[136],"0.03,":[138],"whereas":[142],"maintained":[145],"elevated":[146],"(0.46":[148],"0.07":[150],"0.44":[152],"0.06,":[154],"0.245).":[157],"Leukocyte":[158],"increased":[160],"transiently":[161],"at":[162,206],"Day":[163,207],"both":[166],"groups":[168],"(39.8":[169],"6.7%vs.40.1":[171],"6.5%)":[173],"returned":[175],"(31.8":[181],"5.4%":[183],"vs.":[184],"32.1":[185],"5.5%,":[187],"0.842),":[190],"showing":[191],"no":[192],"persistent":[193],"between-group":[194,218],"differences":[195],"this":[197],"cohort.":[198],"ADP-induced":[199],"platelet":[200],"significantly":[203],"suppressed":[204],"post-PCI":[205,224],"(50.2":[209],"7.6%vs.50.7":[211],"7.4%,":[213],"without":[217],"differences.":[219],"Conclusions":[220],"Persistent":[221],"erythrocyte":[222],"hyperaggregation":[223],"is":[225],"associated":[226],"with":[227],"recurrent":[228],"ischemia":[229],"repeat":[231],"revascularization":[232],"may":[234],"represent":[235],"potential":[237],"biomarker":[238],"clinical":[240],"risk":[241],"stratification,":[242],"pending":[243],"validation":[244],"larger,":[246],"multicenter":[247],"prospective":[248],"studies.":[249]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-11T00:00:00"}