{"id":"https://openalex.org/W7225732703","doi":"https://doi.org/10.1001/jamanetworkopen.2026.42232","title":"Inhaled Corticosteroids and Sickle Cell Disease Severity in Adults Without Asthma","display_name":"Inhaled Corticosteroids and Sickle Cell Disease Severity in Adults Without Asthma","publication_year":2026,"publication_date":"2026-11-10","ids":{"openalex":"https://openalex.org/W7225732703","doi":"https://doi.org/10.1001/jamanetworkopen.2026.42232"},"language":"en","primary_location":{"id":"doi:10.1001/jamanetworkopen.2026.42232","doi":"https://doi.org/10.1001/jamanetworkopen.2026.42232","is_oa":true,"landing_page_url":"https://doi.org/10.1001/jamanetworkopen.2026.42232","pdf_url":null,"source":{"id":"https://openalex.org/S4210217848","display_name":"JAMA Network Open","issn_l":"2574-3805","issn":["2574-3805"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAMA Network Open","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1001/jamanetworkopen.2026.42232","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076854740","display_name":"Susanna A. Curtis","orcid":"https://orcid.org/0000-0002-2281-0843","observed_orcids":["https://orcid.org/0000-0002-2281-0843"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susanna A. Curtis","raw_affiliation_strings":["Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080264603","display_name":"Sarah McCuskee","orcid":"https://orcid.org/0000-0002-7489-9894","observed_orcids":["https://orcid.org/0000-0002-7489-9894"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah McCuskee","raw_affiliation_strings":["Department of Emergency Medicine, Icahn School of Medicine at Mount Sinai, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Emergency Medicine, Icahn School of Medicine at Mount Sinai, New York, New York","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068383869","display_name":"Robyn T. Cohen","orcid":"https://orcid.org/0000-0002-6902-3118","observed_orcids":["https://orcid.org/0000-0002-6902-3118"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I1286490081","display_name":"Boston Medical Center","ror":"https://ror.org/010b9wj87","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1286490081"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robyn T. Cohen","raw_affiliation_strings":["Department of Pediatrics, Boston Medical Center, Boston University, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Boston Medical Center, Boston University, Boston, Massachusetts","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I1286490081"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101599751","display_name":"Angela Liu","orcid":"https://orcid.org/0000-0002-6822-1796","observed_orcids":["https://orcid.org/0000-0002-6822-1796"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Angela Liu","raw_affiliation_strings":["Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083518043","display_name":"Marc A. Probst","orcid":"https://orcid.org/0000-0002-1503-7178","observed_orcids":["https://orcid.org/0000-0002-1503-7178"]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marc A. Probst","raw_affiliation_strings":["Department of Emergency Medicine, Columbia University Medical Center, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Emergency Medicine, Columbia University Medical Center, New York, New York","institution_ids":["https://openalex.org/I2799503643"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060524653","display_name":"Tiffany Mitchell","orcid":"https://orcid.org/0000-0002-1498-9054","observed_orcids":["https://orcid.org/0000-0002-1498-9054"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tiffany Mitchell","raw_affiliation_strings":["Department of Emergency Medicine, Icahn School of Medicine at Mount Sinai, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Emergency Medicine, Icahn School of Medicine at Mount Sinai, New York, New York","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109660886","display_name":"Jordan Bellis","orcid":"https://orcid.org/0009-0002-2493-795X","observed_orcids":["https://orcid.org/0009-0002-2493-795X"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jordan Bellis","raw_affiliation_strings":["Department of Emergency Medicine, Icahn School of Medicine at Mount Sinai, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Emergency Medicine, Icahn School of Medicine at Mount Sinai, New York, New York","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161414722","display_name":"Bin Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bin Zhang","raw_affiliation_strings":["Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079389528","display_name":"Xueyan Mei","orcid":"https://orcid.org/0000-0001-7224-7318","observed_orcids":["https://orcid.org/0000-0001-7224-7318"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xueyan Mei","raw_affiliation_strings":["Department of Diagnostic, Molecular, and Interventional Radiology, Icahn School of Medicine at Mount Sinai, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Diagnostic, Molecular, and Interventional Radiology, Icahn School of Medicine at Mount Sinai, New York, New York","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064227028","display_name":"Jeffrey Glassberg","orcid":"https://orcid.org/0000-0002-8188-4412","observed_orcids":["https://orcid.org/0000-0002-8188-4412"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey A. Glassberg","raw_affiliation_strings":["Department of Emergency Medicine, Icahn School of Medicine at Mount Sinai, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Emergency Medicine, Icahn School of Medicine at Mount Sinai, New York, New York","institution_ids":["https://openalex.org/I98704320"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":{"value":3000,"currency":"USD","value_usd":3000},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"9","issue":"11","first_page":"e2642232","last_page":"e2642232"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11330","display_name":"Systemic Sclerosis and Related Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11660","display_name":"Blood groups and transfusion","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C2781348165","wikidata":"https://www.wikidata.org/wiki/Q1044248","display_name":"Mometasone furoate","level":3,"score":0.9355999827384949},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9351000189781189},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.8105000257492065},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.8008999824523926},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5561000108718872},{"id":"https://openalex.org/C2778338976","wikidata":"https://www.wikidata.org/wiki/Q517104","display_name":"Wheeze","level":3,"score":0.4921000003814697},{"id":"https://openalex.org/C2776954882","wikidata":"https://www.wikidata.org/wiki/Q840343","display_name":"Inhalation","level":2,"score":0.45350000262260437},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.3799999952316284},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.37619999051094055},{"id":"https://openalex.org/C207480886","wikidata":"https://www.wikidata.org/wiki/Q42982","display_name":"Allergy","level":2,"score":0.3711000084877014},{"id":"https://openalex.org/C2776804153","wikidata":"https://www.wikidata.org/wiki/Q210420","display_name":"Corticosteroid","level":2,"score":0.3711000084877014},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.3458999991416931},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3424000144004822},{"id":"https://openalex.org/C2776178081","wikidata":"https://www.wikidata.org/wiki/Q3286546","display_name":"Respiratory disease","level":3,"score":0.319599986076355},{"id":"https://openalex.org/C2776768635","wikidata":"https://www.wikidata.org/wiki/Q3427301","display_name":"Volunteer","level":2,"score":0.28380000591278076},{"id":"https://openalex.org/C2991922776","wikidata":"https://www.wikidata.org/wiki/Q210420","display_name":"Inhaled corticosteroids","level":3,"score":0.2833000123500824},{"id":"https://openalex.org/C2777037409","wikidata":"https://www.wikidata.org/wiki/Q107238","display_name":"Eosinophil","level":3,"score":0.2696000039577484}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1001/jamanetworkopen.2026.42232","doi":"https://doi.org/10.1001/jamanetworkopen.2026.42232","is_oa":true,"landing_page_url":"https://doi.org/10.1001/jamanetworkopen.2026.42232","pdf_url":null,"source":{"id":"https://openalex.org/S4210217848","display_name":"JAMA Network Open","issn_l":"2574-3805","issn":["2574-3805"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAMA Network Open","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1001/jamanetworkopen.2026.42232","doi":"https://doi.org/10.1001/jamanetworkopen.2026.42232","is_oa":true,"landing_page_url":"https://doi.org/10.1001/jamanetworkopen.2026.42232","pdf_url":null,"source":{"id":"https://openalex.org/S4210217848","display_name":"JAMA Network Open","issn_l":"2574-3805","issn":["2574-3805"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAMA Network Open","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W1600596293","https://openalex.org/W1735133062","https://openalex.org/W1972709820","https://openalex.org/W1975642553","https://openalex.org/W2002344020","https://openalex.org/W2011159920","https://openalex.org/W2030851049","https://openalex.org/W2038970572","https://openalex.org/W2066694788","https://openalex.org/W2079979502","https://openalex.org/W2080562863","https://openalex.org/W2083067465","https://openalex.org/W2129864843","https://openalex.org/W2143096094","https://openalex.org/W2170133685","https://openalex.org/W2194591602","https://openalex.org/W2334263927","https://openalex.org/W2434240737","https://openalex.org/W2461483782","https://openalex.org/W2518695394","https://openalex.org/W2598384706","https://openalex.org/W2783770047","https://openalex.org/W2915841772","https://openalex.org/W2981067716","https://openalex.org/W4205717973","https://openalex.org/W4224951885","https://openalex.org/W4245666729","https://openalex.org/W4297262534","https://openalex.org/W4321252969","https://openalex.org/W4409417738"],"related_works":[],"abstract_inverted_index":{"Importance":[0],"People":[1],"living":[2],"with":[3,36,91,106,246,293,304,319],"sickle":[4],"cell":[5,61],"disease":[6,69,308],"(SCD)":[7],"who":[8,205],"have":[9,20],"episodic":[10],"cough":[11],"and":[12,26,38,57,79,93,97,135,140,169,196,209,230,286,295,321],"wheeze":[13],"(ECW)":[14],"without":[15,40,88,323],"a":[16,66,163,324],"diagnosis":[17,326],"of":[18,23,45,68,81,151,185,291,299,307,327],"asthma":[19,41,89],"high":[21],"rates":[22],"pain":[24,56],"episodes":[25],"acute":[27],"chest":[28],"syndrome.":[29],"A":[30],"previous":[31],"trial,":[32],"in":[33,71,86,177,212,317],"which":[34],"patients":[35,87,105,204,318],"SCD":[37,92,107,294,320],"ECW":[39,322],"received":[42,148,162,206],"15":[43],"weeks":[44],"inhaled":[46,52,84,121,145,152,219,251,300],"mometasone":[47,53,85,122,146,153,220,252,301,311],"or":[48,123],"placebo,":[49],"showed":[50],"that":[51],"improved":[54],"daily":[55,83],"reduced":[58],"soluble":[59,178,256],"vascular":[60],"adhesion":[62],"molecule":[63],"1":[64],"(VCAM-1),":[65],"marker":[67],"severity":[70],"SCD.":[72],"Objective":[73],"To":[74],"examine":[75],"the":[76,131,202,207,213,247,250,275,279],"biologic":[77],"effects":[78],"safety":[80],"long-term":[82,316],"but":[90],"ECW.":[94],"Design,":[95],"Setting,":[96],"Participants":[98,114],"This":[99],"placebo-controlled":[100],"randomized":[101],"clinical":[102,272],"trial":[103,290],"recruited":[104],"from":[108,181],"December":[109],"2018":[110],"to":[111,118,183,218,234,264],"May":[112],"2022.":[113],"were":[115,136,210,216,232,281,302],"randomly":[116],"assigned":[117,217,233],"receive":[119],"either":[120],"placebo":[124,160,165,235,248,276],"for":[125,271],"48":[126],"weeks.":[127],"Data":[128],"analyses":[129],"followed":[130],"modified":[132],"intention-to-treat":[133],"principle":[134],"performed":[137],"between":[138],"July":[139],"November":[141],"2023.":[142],"Interventions":[143],"The":[144,159,171],"group":[147,161,253],"220":[149],"\u03bcg":[150],"furoate":[154],"dry":[155],"powder":[156],"once":[157],"daily.":[158],"matching":[164],"inhaler.":[166],"Main":[167],"Outcomes":[168],"Measures":[170],"primary":[172],"outcome":[173],"was":[174],"percentage":[175],"change":[176],"VCAM-1":[179,257],"levels":[180,258],"baseline":[182],"end":[184],"study.":[186],"Secondary":[187],"outcomes":[188,273],"included":[189,211],"laboratory":[190],"results,":[191],"functional":[192],"outcomes,":[193,195],"patient-reported":[194],"health":[197],"care":[198],"utilization.":[199],"Results":[200],"Of":[201],"77":[203],"intervention":[208],"analysis,":[214],"40":[215],"(mean":[221,236],"[SD]":[222,237],"age,":[223,238],"36.0":[224],"[11.6]":[225],"years;":[226,241],"26":[227],"females":[228],"[65%])":[229],"37":[231],"31.5":[239],"[8.6]":[240],"19":[242],"males":[243],"[51%]).":[244],"Compared":[245],"group,":[249,277],"increased":[254],"their":[255],"by":[259],"42%":[260],"(95%":[261],"CI,":[262],"\u201311%":[263],"96%;":[265],"P":[266],"=":[267],".02).":[268],"Point":[269],"estimates":[270],"favored":[274],"although":[278],"findings":[280],"not":[282,313],"statistically":[283],"significant.":[284],"Conclusions":[285],"Relevance":[287],"In":[288],"this":[289],"adults":[292],"ECW,":[296],"extended":[297],"courses":[298],"associated":[303],"worsened":[305],"markers":[306],"severity.":[309],"Inhaled":[310],"should":[312],"be":[314],"used":[315],"definitive":[325],"asthma.":[328],"Trial":[329],"Registration":[330],"ClinicalTrials.gov":[331],"Identifier:":[332],"NCT03758950":[333]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-11T00:00:00"}
