{"id":"https://openalex.org/W7225732518","doi":"https://doi.org/10.3389/fcell.2026.1989495","title":"Programmed cell death in dementia: advances in pathogenesis and therapeutic strategies","display_name":"Programmed cell death in dementia: advances in pathogenesis and therapeutic strategies","publication_year":2026,"publication_date":"2026-11-10","ids":{"openalex":"https://openalex.org/W7225732518","doi":"https://doi.org/10.3389/fcell.2026.1989495"},"language":"en","primary_location":{"id":"doi:10.3389/fcell.2026.1989495","doi":"https://doi.org/10.3389/fcell.2026.1989495","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcell.2026.1989495","pdf_url":null,"source":{"id":"https://openalex.org/S2596924766","display_name":"Frontiers in Cell and Developmental Biology","issn_l":"2296-634X","issn":["2296-634X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cell and Developmental Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3389/fcell.2026.1989495","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5161406410","display_name":"Sisi Yu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I10899854","display_name":"Jiangxi University of Traditional Chinese Medicine","ror":"https://ror.org/03jy32q83","country_code":"CN","type":"education","lineage":["https://openalex.org/I10899854"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Sisi Yu","raw_affiliation_strings":["Department of Nursing, Jiangxi University of Chinese Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nursing, Jiangxi University of Chinese Medicine","institution_ids":["https://openalex.org/I10899854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023403859","display_name":"Zheng Luo","orcid":"https://orcid.org/0000-0001-9666-8184","observed_orcids":["https://orcid.org/0000-0001-9666-8184"]},"institutions":[{"id":"https://openalex.org/I4210164024","display_name":"First Affiliated Hospital of Nanchang University","ror":"https://ror.org/05gbwr869","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210164024"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zheng Luo","raw_affiliation_strings":["Department of Neurology, The First Affiliated Hospital of Nanchang University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, The First Affiliated Hospital of Nanchang University","institution_ids":["https://openalex.org/I4210164024"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147843121","display_name":"Shuhui Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I10899854","display_name":"Jiangxi University of Traditional Chinese Medicine","ror":"https://ror.org/03jy32q83","country_code":"CN","type":"education","lineage":["https://openalex.org/I10899854"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shuhui Wang","raw_affiliation_strings":["Department of Nursing, Jiangxi University of Chinese Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nursing, Jiangxi University of Chinese Medicine","institution_ids":["https://openalex.org/I10899854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161386166","display_name":"Mu Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I10899854","display_name":"Jiangxi University of Traditional Chinese Medicine","ror":"https://ror.org/03jy32q83","country_code":"CN","type":"education","lineage":["https://openalex.org/I10899854"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mu Li","raw_affiliation_strings":["Department of Nursing, Jiangxi University of Chinese Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nursing, Jiangxi University of Chinese Medicine","institution_ids":["https://openalex.org/I10899854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042183524","display_name":"Cheng Li","orcid":"https://orcid.org/0000-0001-7912-0643","observed_orcids":["https://orcid.org/0000-0001-7912-0643"]},"institutions":[{"id":"https://openalex.org/I10899854","display_name":"Jiangxi University of Traditional Chinese Medicine","ror":"https://ror.org/03jy32q83","country_code":"CN","type":"education","lineage":["https://openalex.org/I10899854"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Cheng Li","raw_affiliation_strings":["Department of Nursing, Jiangxi University of Chinese Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nursing, Jiangxi University of Chinese Medicine","institution_ids":["https://openalex.org/I10899854"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113334453","display_name":"Gui Xiao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I10899854","display_name":"Jiangxi University of Traditional Chinese Medicine","ror":"https://ror.org/03jy32q83","country_code":"CN","type":"education","lineage":["https://openalex.org/I10899854"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Gui Xiao","raw_affiliation_strings":["Department of Nursing, Jiangxi University of Chinese Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nursing, Jiangxi University of Chinese Medicine","institution_ids":["https://openalex.org/I10899854"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5042183524","https://openalex.org/A5113334453"],"corresponding_institution_ids":["https://openalex.org/I10899854"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"14","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9121000170707703,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9121000170707703,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.04580000042915344,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.011599999852478504,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.7336999773979187},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.7271999716758728},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.6801999807357788},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.6266000270843506},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5740000009536743},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.550599992275238},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5351999998092651},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.5004000067710876},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.4925999939441681},{"id":"https://openalex.org/C64903051","wikidata":"https://www.wikidata.org/wiki/Q2198549","display_name":"Drug development","level":3,"score":0.41269999742507935},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.40639999508857727},{"id":"https://openalex.org/C2777952318","wikidata":"https://www.wikidata.org/wiki/Q583908","display_name":"Vascular dementia","level":4,"score":0.36809998750686646},{"id":"https://openalex.org/C2778384578","wikidata":"https://www.wikidata.org/wiki/Q16930687","display_name":"Therapeutic approach","level":3,"score":0.3634999990463257},{"id":"https://openalex.org/C140608501","wikidata":"https://www.wikidata.org/wiki/Q7318358","display_name":"Review article","level":2,"score":0.32739999890327454},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32120001316070557},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.31779998540878296},{"id":"https://openalex.org/C29374701","wikidata":"https://www.wikidata.org/wiki/Q1931388","display_name":"Cause of death","level":3,"score":0.30329999327659607},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.29820001125335693},{"id":"https://openalex.org/C2778548049","wikidata":"https://www.wikidata.org/wiki/Q101245788","display_name":"Dementia with Lewy bodies","level":4,"score":0.28790000081062317},{"id":"https://openalex.org/C2984863031","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Cognitive decline","level":4,"score":0.28439998626708984},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.27379998564720154},{"id":"https://openalex.org/C189014844","wikidata":"https://www.wikidata.org/wiki/Q189118","display_name":"Cell type","level":3,"score":0.2709999978542328},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.2502000033855438}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3389/fcell.2026.1989495","doi":"https://doi.org/10.3389/fcell.2026.1989495","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcell.2026.1989495","pdf_url":null,"source":{"id":"https://openalex.org/S2596924766","display_name":"Frontiers in Cell and Developmental Biology","issn_l":"2296-634X","issn":["2296-634X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cell and Developmental Biology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.3389/fcell.2026.1989495","doi":"https://doi.org/10.3389/fcell.2026.1989495","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcell.2026.1989495","pdf_url":null,"source":{"id":"https://openalex.org/S2596924766","display_name":"Frontiers in Cell and Developmental Biology","issn_l":"2296-634X","issn":["2296-634X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cell and Developmental Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":79,"referenced_works":["https://openalex.org/W1993976394","https://openalex.org/W2015109832","https://openalex.org/W2026544197","https://openalex.org/W2055652883","https://openalex.org/W2068288454","https://openalex.org/W2070325134","https://openalex.org/W2314634699","https://openalex.org/W2472573833","https://openalex.org/W2568579298","https://openalex.org/W2572710398","https://openalex.org/W2701641415","https://openalex.org/W2742515342","https://openalex.org/W2754483429","https://openalex.org/W2754890392","https://openalex.org/W2777928756","https://openalex.org/W2799799804","https://openalex.org/W2964308084","https://openalex.org/W2990312754","https://openalex.org/W2998195866","https://openalex.org/W3000061011","https://openalex.org/W3018835152","https://openalex.org/W3043153371","https://openalex.org/W3092456180","https://openalex.org/W3110053366","https://openalex.org/W3112474963","https://openalex.org/W3119868004","https://openalex.org/W3122324184","https://openalex.org/W3131415498","https://openalex.org/W3137321433","https://openalex.org/W3151821834","https://openalex.org/W3171643940","https://openalex.org/W3173767949","https://openalex.org/W3205755833","https://openalex.org/W3214738104","https://openalex.org/W4206058516","https://openalex.org/W4210278373","https://openalex.org/W4213353020","https://openalex.org/W4376604785","https://openalex.org/W4378515663","https://openalex.org/W4379208937","https://openalex.org/W4380369505","https://openalex.org/W4385498418","https://openalex.org/W4386164136","https://openalex.org/W4386529344","https://openalex.org/W4386629919","https://openalex.org/W4387647310","https://openalex.org/W4390949378","https://openalex.org/W4391428599","https://openalex.org/W4392380527","https://openalex.org/W4394063775","https://openalex.org/W4399471815","https://openalex.org/W4401367185","https://openalex.org/W4401973266","https://openalex.org/W4403855714","https://openalex.org/W4404352299","https://openalex.org/W4407133280","https://openalex.org/W4407209160","https://openalex.org/W4409262177","https://openalex.org/W4409975339","https://openalex.org/W4410849144","https://openalex.org/W4411137438","https://openalex.org/W4411664869","https://openalex.org/W4412590460","https://openalex.org/W4412609508","https://openalex.org/W4412840103","https://openalex.org/W4412925145","https://openalex.org/W4414484724","https://openalex.org/W4416306460","https://openalex.org/W4416758893","https://openalex.org/W7117754729","https://openalex.org/W7118160362","https://openalex.org/W7128905079","https://openalex.org/W7134950468","https://openalex.org/W7138259386","https://openalex.org/W7138945683","https://openalex.org/W7142706768","https://openalex.org/W7155210774","https://openalex.org/W7167806848","https://openalex.org/W7204078668"],"related_works":[],"abstract_inverted_index":{"Dementia":[0],"comprises":[1],"a":[2,43,114,185],"group":[3],"of":[4,21,29,46,55,65,74,146,150,194],"neurodegenerative":[5],"disorders":[6],"characterized":[7],"primarily":[8],"by":[9],"progressive":[10],"cognitive":[11],"decline.":[12],"Its":[13],"central":[14],"pathological":[15,127,144],"feature":[16],"is":[17],"the":[18,26,63,126,140,147,192],"irreversible":[19],"loss":[20,61],"neurons,":[22],"which":[23],"leads":[24],"to":[25,121,183],"continuous":[27],"deterioration":[28],"memory,":[30],"language,":[31],"and":[32,83,97,125,143,154,168,188,198],"executive":[33],"functions.":[34],"In":[35],"recent":[36,175],"years,":[37],"programmed":[38],"cell":[39,48,79],"death":[40],"(PCD),":[41],"as":[42,93],"major":[44,148],"form":[45],"regulated":[47],"death,":[49,80],"has":[50,69],"attracted":[51],"increasing":[52],"attention":[53],"because":[54],"its":[56],"critical":[57],"involvement":[58],"in":[59,88,152,177],"neuronal":[60],"during":[62],"development":[64,193],"dementia.":[66,203],"Accumulating":[67],"evidence":[68],"demonstrated":[70],"that":[71],"multiple":[72],"forms":[73,149],"PCD,":[75],"including":[76,163],"apoptosis,":[77],"autophagic":[78],"necroptosis,":[81],"pyroptosis,":[82],"ferroptosis,":[84],"are":[85,118],"aberrantly":[86],"activated":[87],"common":[89],"dementia":[90,99,131,153],"subtypes":[91,132],"such":[92],"Alzheimer\u2019s":[94],"disease":[95,123],"(AD)":[96],"vascular":[98],"(VaD),":[100],"where":[101],"they":[102],"synergistically":[103],"promote":[104],"neurodegeneration":[105],"through":[106],"distinct":[107],"molecular":[108,141],"mechanisms.":[109],"However,":[110],"therapeutic":[111,158,200],"interventions":[112],"targeting":[113,160],"single":[115],"PCD":[116,151,161],"pathway":[117],"often":[119],"insufficient":[120],"halt":[122],"progression,":[124],"heterogeneity":[128],"among":[129],"different":[130],"further":[133,155],"complicates":[134],"treatment.":[135],"This":[136],"review":[137,181],"systematically":[138],"summarizes":[139],"mechanisms":[142],"contributions":[145],"discusses":[156],"emerging":[157],"strategies":[159,201],"pathways,":[162],"small-molecule":[164],"inhibitors,":[165],"genetic":[166],"modulation,":[167],"nanomedicine-based":[169],"drug":[170],"delivery":[171],"systems.":[172],"By":[173],"integrating":[174],"advances":[176],"this":[178,180],"field,":[179],"aims":[182],"provide":[184],"theoretical":[186],"framework":[187],"translational":[189],"perspectives":[190],"for":[191,202],"early":[195],"diagnostic":[196],"biomarkers":[197],"precision":[199]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-11T00:00:00"}