{"id":"https://openalex.org/W7225731650","doi":"https://doi.org/10.1016/j.jrras.2026.102801","title":"Exosomal PD-L1 from ovarian carcinoma promotes CD8+ T cell dysfunction via PI3K/AKT/mTOR inhibition and facilitates cisplatin resistance","display_name":"Exosomal PD-L1 from ovarian carcinoma promotes CD8+ T cell dysfunction via PI3K/AKT/mTOR inhibition and facilitates cisplatin resistance","publication_year":2026,"publication_date":"2026-11-10","ids":{"openalex":"https://openalex.org/W7225731650","doi":"https://doi.org/10.1016/j.jrras.2026.102801"},"language":"en","primary_location":{"id":"doi:10.1016/j.jrras.2026.102801","doi":"https://doi.org/10.1016/j.jrras.2026.102801","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jrras.2026.102801","pdf_url":null,"source":{"id":"https://openalex.org/S2764632503","display_name":"Journal of Radiation Research and Applied Sciences","issn_l":"1687-8507","issn":["1687-8507","2314-7164"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Radiation Research and Applied Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.jrras.2026.102801","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5161362470","display_name":"Yongxing Yuan","orcid":"https://orcid.org/0009-0000-4944-5420","observed_orcids":["https://orcid.org/0009-0000-4944-5420"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Yongxing Yuan","raw_affiliation_strings":["Department of Gynecology, Xi'an International Medical Center Hospital, Xi'an, 710000, Shaanxi, China"],"raw_orcid":"https://orcid.org/0009-0000-4944-5420","affiliations":[{"raw_affiliation_string":"Department of Gynecology, Xi'an International Medical Center Hospital, Xi'an, 710000, Shaanxi, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5121466661","display_name":"Hailin Wang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hailin Wang","raw_affiliation_strings":["Department of Gynecology, Xi'an International Medical Center Hospital, Xi'an, 710000, Shaanxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynecology, Xi'an International Medical Center Hospital, Xi'an, 710000, Shaanxi, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161386552","display_name":"Meirong Lu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Meirong Lu","raw_affiliation_strings":["Department of Gynecology, Xi'an International Medical Center Hospital, Xi'an, 710000, Shaanxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynecology, Xi'an International Medical Center Hospital, Xi'an, 710000, Shaanxi, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161376792","display_name":"Jianjian Gao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jianjian Gao","raw_affiliation_strings":["Department of Gynecology, Xi'an International Medical Center Hospital, Xi'an, 710000, Shaanxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynecology, Xi'an International Medical Center Hospital, Xi'an, 710000, Shaanxi, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161414310","display_name":"Suyun Han","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Suyun Han","raw_affiliation_strings":["Department of Gynecology, Xi'an International Medical Center Hospital, Xi'an, 710000, Shaanxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynecology, Xi'an International Medical Center Hospital, Xi'an, 710000, Shaanxi, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161398728","display_name":"Lisha Xiao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lisha Xiao","raw_affiliation_strings":["Department of Gynecology, Xi'an International Medical Center Hospital, Xi'an, 710000, Shaanxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynecology, Xi'an International Medical Center Hospital, Xi'an, 710000, Shaanxi, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161417840","display_name":"Liangliang Sun","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Liangliang Sun","raw_affiliation_strings":["Department of Gynecology, Xi'an International Medical Center Hospital, Xi'an, 710000, Shaanxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynecology, Xi'an International Medical Center Hospital, Xi'an, 710000, Shaanxi, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161371628","display_name":"Cong Li","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cong Li","raw_affiliation_strings":["Department of Gynecology, Xi'an International Medical Center Hospital, Xi'an, 710000, Shaanxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynecology, Xi'an International Medical Center Hospital, Xi'an, 710000, Shaanxi, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161363522","display_name":"Yu Yan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yu Yan","raw_affiliation_strings":["Department of Gynecology, Xi'an International Medical Center Hospital, Xi'an, 710000, Shaanxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynecology, Xi'an International Medical Center Hospital, Xi'an, 710000, Shaanxi, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161396914","display_name":"Qingqing Yao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Qingqing Yao","raw_affiliation_strings":["Department of Gynecology, Xi'an International Medical Center Hospital, Xi'an, 710000, Shaanxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynecology, Xi'an International Medical Center Hospital, Xi'an, 710000, Shaanxi, China","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5161370293","display_name":"Wenqian Liang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wenqian Liang","raw_affiliation_strings":["Department of Gynecology, Xi'an International Medical Center Hospital, Xi'an, 710000, Shaanxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynecology, Xi'an International Medical Center Hospital, Xi'an, 710000, Shaanxi, China","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5161362470"],"corresponding_institution_ids":[],"apc_list":{"value":1400,"currency":"USD","value_usd":1400},"apc_paid":{"value":1400,"currency":"USD","value_usd":1400},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"19","issue":"4","first_page":"102801","last_page":"102801"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.9487000107765198,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.9487000107765198,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.04780000075697899,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.8429999947547913},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.718500018119812},{"id":"https://openalex.org/C20518536","wikidata":"https://www.wikidata.org/wiki/Q6840469","display_name":"Microvesicles","level":4,"score":0.7071999907493591},{"id":"https://openalex.org/C2781261824","wikidata":"https://www.wikidata.org/wiki/Q903634","display_name":"Exosome","level":5,"score":0.683899998664856},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6798999905586243},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.5486999750137329},{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.5486000180244446},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5307999849319458},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.4828000068664551},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.48089998960494995},{"id":"https://openalex.org/C3019054536","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian carcinoma","level":4,"score":0.46639999747276306},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.3801000118255615},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.34929999709129333},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34529998898506165},{"id":"https://openalex.org/C114684123","wikidata":"https://www.wikidata.org/wiki/Q419458","display_name":"CD3","level":4,"score":0.3361999988555908},{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.3343000113964081},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.30880001187324524},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.30480000376701355},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30090001225471497},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.2976999878883362},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.2818000018596649},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.27390000224113464},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.2734000086784363},{"id":"https://openalex.org/C2777609662","wikidata":"https://www.wikidata.org/wiki/Q416356","display_name":"PTEN","level":4,"score":0.26829999685287476},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.2606000006198883}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.jrras.2026.102801","doi":"https://doi.org/10.1016/j.jrras.2026.102801","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jrras.2026.102801","pdf_url":null,"source":{"id":"https://openalex.org/S2764632503","display_name":"Journal of Radiation Research and Applied Sciences","issn_l":"1687-8507","issn":["1687-8507","2314-7164"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Radiation Research and Applied Sciences","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.jrras.2026.102801","doi":"https://doi.org/10.1016/j.jrras.2026.102801","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jrras.2026.102801","pdf_url":null,"source":{"id":"https://openalex.org/S2764632503","display_name":"Journal of Radiation Research and Applied Sciences","issn_l":"1687-8507","issn":["1687-8507","2314-7164"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Radiation Research and Applied Sciences","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W2953502892","https://openalex.org/W2995671942","https://openalex.org/W3181245501","https://openalex.org/W3196550489","https://openalex.org/W3201325011","https://openalex.org/W4210274138","https://openalex.org/W4210407765","https://openalex.org/W4213352574","https://openalex.org/W4309246226","https://openalex.org/W4327811717","https://openalex.org/W4380149145","https://openalex.org/W4385442340","https://openalex.org/W4387232117","https://openalex.org/W4391173411","https://openalex.org/W4391322579","https://openalex.org/W4402125753","https://openalex.org/W4408089146","https://openalex.org/W4410300554","https://openalex.org/W4410369059","https://openalex.org/W4414422813","https://openalex.org/W4415106466","https://openalex.org/W4416137504","https://openalex.org/W4416729322","https://openalex.org/W7118087916","https://openalex.org/W7128496997"],"related_works":[],"abstract_inverted_index":{"Background":[0],"Cisplatin":[1],"resistance":[2,236],"is":[3,28],"a":[4,277],"problem":[5],"for":[6],"the":[7,22,79,164,230,234,253],"clinical":[8],"treatment":[9],"of":[10,70,83,213],"ovarian":[11,35,241],"cancer.":[12],"The":[13,186,208],"basic":[14],"path":[15],"by":[16,56,136],"which":[17],"cancer-secreted":[18],"exosomal":[19,37,84,274],"PD-L1":[20,38,85,132,245,275],"modifies":[21],"immune":[23,231],"environment":[24],"to":[25,53,246,256,280],"promote":[26],"chemoresistance":[27],"not":[29,227],"known.":[30],"This":[31],"study":[32,54,209],"investigated":[33],"how":[34],"carcinoma":[36],"promotes":[39],"CD8":[40,57,121,137,196,217,248,281],"+":[41,58,122,138,197,218,249,282],"T":[42,59,112,123,139,192,198,250,258],"cell":[43,113,259],"dysfunction":[44,75,220,284],"and":[45,74,81,105,115,141,148,194,221,285,296],"cisplatin":[46,96,109,157,172,223,268,287],"resistance.":[47,269],"Methods":[48],"SKOV3-originating":[49],"exosomes":[50,243],"were":[51,90,125,133,142,168,177,181],"used":[52],"uptake":[55],"cells,":[60,161,193,251],"PD-1":[61,146],"expression,":[62],"phosphoinositide":[63],"3-kinase":[64],"(PI3K)/protein":[65],"kinase":[66],"B":[67],"(AKT)/mechanistic":[68],"target":[69],"rapamycin":[71],"(mTOR)":[72],"pathway,":[73],"markers,":[76],"both":[77,175],"in":[78,92,99,118,159,163,238,291],"presence":[80],"absence":[82],"silencing.":[86],"Mice":[87],"bearing":[88],"tumours":[89],"treated":[91],"vivo":[93],"with":[94,101,144,170,216],"either":[95],"alone":[97],"or":[98,293],"combination":[100],"SKOV3":[102,160],"exosomes/shPD-L1":[103],"exosomes,":[104],"then":[106],"tumour":[107,120],"expansion,":[108],"efficacy,":[110],"exhausted":[111,191],"ratios":[114],"PI3K/AKT/mTOR":[116,202,254],"activation":[117],"isolated":[119],"cells":[124,140,199],"assessed.":[126],"Results":[127],"Ovarian":[128],"cancer-derived":[129],"vesicles":[130,155,180,215],"carrying":[131],"taken":[134],"up":[135],"associated":[143,169],"increased":[145,156],"expression":[147],"impaired":[149],"effector":[150],"function.":[151],"In":[152],"vitro,":[153],"SKOV3-derived":[154,214],"tolerance":[158],"whereas":[162],"xenograft":[165],"experiment":[166],"they":[167],"reduced":[171,201,286],"tumor-growth":[173],"inhibition;":[174],"effects":[176],"attenuated":[178],"when":[179],"derived":[182],"from":[183],"PD-L1-silenced":[184],"cells.":[185],"exosome":[187],"group":[188],"had":[189],"more":[190],"tumor-derived":[195],"showed":[200],"signalling;":[203],"shPD-L1":[204],"restored":[205],"this":[206],"signalisation.":[207],"demonstrates":[210],"parallel":[211],"associations":[212],"T-cell":[219,283],"tumor-cell":[222],"tolerance;":[224],"it":[225],"does":[226],"establish":[228],"that":[229,266],"phenotype":[232],"causes":[233],"tumor-cell-autonomous":[235],"observed":[237],"vitro.":[239],"Conclusion":[240],"cancer":[242],"deliver":[244],"tumour-resident":[247],"inhibit":[252],"pathway":[255],"induce":[257],"dysfunction,":[260],"thereby":[261],"fostering":[262],"an":[263],"immunosuppressive":[264],"microenvironment":[265],"supports":[267],"These":[270],"preclinical":[271],"findings":[272],"identify":[273],"as":[276],"candidate":[278],"contributor":[279],"sensitivity,":[288],"warranting":[289],"validation":[290],"immunocompetent":[292],"humanized":[294],"models":[295],"patient-derived":[297],"samples.":[298]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-11T00:00:00"}
