{"id":"https://openalex.org/W7225731056","doi":"https://doi.org/10.1186/s12985-026-03355-3","title":"Immunoinformatics-based design of a multi-epitope vaccine candidate targeting VP5 and VP7 of colorado tick fever virus","display_name":"Immunoinformatics-based design of a multi-epitope vaccine candidate targeting VP5 and VP7 of colorado tick fever virus","publication_year":2026,"publication_date":"2026-11-10","ids":{"openalex":"https://openalex.org/W7225731056","doi":"https://doi.org/10.1186/s12985-026-03355-3"},"language":"en","primary_location":{"id":"doi:10.1186/s12985-026-03355-3","doi":"https://doi.org/10.1186/s12985-026-03355-3","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12985-026-03355-3","pdf_url":null,"source":{"id":"https://openalex.org/S115714813","display_name":"Virology Journal","issn_l":"1743-422X","issn":["1743-422X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Virology Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1186/s12985-026-03355-3","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041864130","display_name":"Fawzyah Obeedallah Albaldi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Fawzyah Obeedallah Albaldi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5041864130"],"corresponding_institution_ids":[],"apc_list":{"value":3290,"currency":"USD","value_usd":3290},"apc_paid":{"value":3290,"currency":"USD","value_usd":3290},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8172000050544739},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.720300018787384},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.684499979019165},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.5807999968528748},{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.548799991607666},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5349000096321106},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.43779999017715454},{"id":"https://openalex.org/C2779620486","wikidata":"https://www.wikidata.org/wiki/Q10304508","display_name":"Tick","level":2,"score":0.4156999886035919},{"id":"https://openalex.org/C41685203","wikidata":"https://www.wikidata.org/wiki/Q1974042","display_name":"Docking (animal)","level":2,"score":0.36970001459121704},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3528999984264374},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.34869998693466187},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.29499998688697815},{"id":"https://openalex.org/C2781031778","wikidata":"https://www.wikidata.org/wiki/Q16000255","display_name":"Novel virus","level":4,"score":0.2921999990940094},{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.25589999556541443}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1186/s12985-026-03355-3","doi":"https://doi.org/10.1186/s12985-026-03355-3","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12985-026-03355-3","pdf_url":null,"source":{"id":"https://openalex.org/S115714813","display_name":"Virology Journal","issn_l":"1743-422X","issn":["1743-422X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Virology Journal","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1186/s12985-026-03355-3","doi":"https://doi.org/10.1186/s12985-026-03355-3","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12985-026-03355-3","pdf_url":null,"source":{"id":"https://openalex.org/S115714813","display_name":"Virology Journal","issn_l":"1743-422X","issn":["1743-422X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Virology Journal","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Colorado":[2,228],"tick":[3,229],"fever":[4,230],"virus":[5,24,53,231],"is":[6,16,20,34],"an":[7,55,128],"understudied":[8],"tick-borne":[9],"pathogen":[10],"for":[11,89,145,149,166,169,181],"which":[12],"no":[13,119],"preventive":[14],"vaccine":[15,49,225],"currently":[17],"available.":[18],"It":[19],"a":[21,47,76,174,223],"double-stranded":[22],"RNA":[23],"of":[25,133,143,158,206,222],"the":[26,30,52,155,203,207,211,220],"genus":[27],"Coltivirus":[28],"within":[29],"family":[31],"Spinareoviridae":[32],"and":[33,63,71,73,81,109,127,147,187,198],"primarily":[35],"transmitted":[36],"by":[37],"infected":[38],"Dermacentor":[39],"andersoni":[40],"ticks.":[41],"This":[42],"study":[43],"aimed":[44],"to":[45],"design":[46,221],"multi-epitope":[48,224],"candidate":[50,226],"against":[51,227],"through":[54],"immunoinformatics-based":[56],"strategy.":[57],"Methods":[58],"Conserved":[59],"B-cell,":[60],"helper":[61],"T-cell,":[62],"cytotoxic":[64],"T-cell":[65],"epitopes":[66],"were":[67],"selected":[68],"from":[69],"VP5":[70],"VP7":[72],"integrated":[74],"into":[75],"228-amino-acid":[77],"construct":[78,86,115],"containing":[79],"\u03b2-defensin-3":[80],"appropriate":[82],"linker":[83],"sequences.":[84],"The":[85,114],"was":[87],"evaluated":[88],"antigenicity,":[90,118],"allergenicity,":[91,121],"solubility,":[92,123],"structural":[93,125,163],"characteristics,":[94,126],"population":[95,131],"coverage,":[96],"receptor":[97],"docking,":[98],"molecular":[99],"dynamics":[100,152],"behavior,":[101],"binding-energy":[102],"estimates,":[103],"simulated":[104],"immune":[105],"responses,":[106],"codon":[107],"optimization,":[108],"bacterial":[110],"cloning":[111,201],"compatibility.":[112],"Results":[113],"showed":[116],"predicted":[117,120,185],"favorable":[122,177],"satisfactory":[124],"estimated":[129],"worldwide":[130],"coverage":[132],"approximately":[134],"95%.":[135],"Protein\u2013protein":[136],"docking":[137,141],"produced":[138],"ClusPro":[139],"weighted":[140],"scores":[142],"\u2212\u200b1684.5":[144],"vaccine\u2013TLR2":[146,167],"\u2212\u200b1235.0":[148],"vaccine\u2013TLR3.":[150,170],"Molecular":[151],"simulations":[153],"characterized":[154],"conformational":[156],"behavior":[157],"both":[159],"complexes,":[160],"with":[161,210],"lower":[162],"deviations":[164],"observed":[165],"than":[168],"MM-GBSA":[171],"calculations":[172],"provided":[173],"comparatively":[175],"more":[176],"relative":[178],"energetic":[179],"estimate":[180],"vaccine\u2013TLR2.":[182],"Immune":[183],"simulation":[184],"humoral":[186],"cellular":[188],"immune-response":[189],"patterns":[190],"following":[191],"repeated":[192],"in":[193,199],"silico":[194,200],"administration.":[195],"Codon":[196],"optimization":[197],"supported":[202],"potential":[204],"compatibility":[205],"optimized":[208],"sequence":[209],"pET-28a(+)":[212],"expression":[213],"system.":[214],"Conclusions":[215],"These":[216],"computational":[217],"findings":[218],"present":[219],"that":[232],"requires":[233],"further":[234],"experimental":[235],"validation.":[236]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-11T00:00:00"}