{"id":"https://openalex.org/W7225728843","doi":"https://doi.org/10.3389/fonc.2026.1953732","title":"Therapeutic HPV vaccines for PD-1 blockade\u2013resistant HPV-positive head and neck squamous cell carcinoma: mechanistic rationale, clinical limitations, and biomarker-guided combinations","display_name":"Therapeutic HPV vaccines for PD-1 blockade\u2013resistant HPV-positive head and neck squamous cell carcinoma: mechanistic rationale, clinical limitations, and biomarker-guided combinations","publication_year":2026,"publication_date":"2026-11-10","ids":{"openalex":"https://openalex.org/W7225728843","doi":"https://doi.org/10.3389/fonc.2026.1953732"},"language":"en","primary_location":{"id":"doi:10.3389/fonc.2026.1953732","doi":"https://doi.org/10.3389/fonc.2026.1953732","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fonc.2026.1953732","pdf_url":null,"source":{"id":"https://openalex.org/S2596394214","display_name":"Frontiers in Oncology","issn_l":"2234-943X","issn":["2234-943X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3389/fonc.2026.1953732","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5161364898","display_name":"YanDi Hu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210108565","display_name":"Affiliated Hospital of North Sichuan Medical College","ror":"https://ror.org/01673gn35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210108565"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"YanDi Hu","raw_affiliation_strings":["Otolaryngology Head and Neck Surgery, Affiliated Hospital of North Sichuan Medical College"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Otolaryngology Head and Neck Surgery, Affiliated Hospital of North Sichuan Medical College","institution_ids":["https://openalex.org/I4210108565"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100356661","display_name":"Zhe Li","orcid":"https://orcid.org/0000-0002-6244-9167","observed_orcids":["https://orcid.org/0000-0002-6244-9167","https://orcid.org/0000-0002-6034-4759"]},"institutions":[{"id":"https://openalex.org/I105086349","display_name":"North Sichuan Medical University","ror":"https://ror.org/05k3sdc46","country_code":"CN","type":"education","lineage":["https://openalex.org/I105086349"]},{"id":"https://openalex.org/I4210158828","display_name":"Nanchong Central Hospital","ror":"https://ror.org/05n50qc07","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158828"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhe Li","raw_affiliation_strings":["Department of Ophthalmology, the Second Clinical College of North Sichuan Medical College (NanChong Central Hospital)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, the Second Clinical College of North Sichuan Medical College (NanChong Central Hospital)","institution_ids":["https://openalex.org/I105086349","https://openalex.org/I4210158828"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100772751","display_name":"Hai Liu","orcid":"https://orcid.org/0000-0003-3421-1589","observed_orcids":["https://orcid.org/0000-0003-3421-1589"]},"institutions":[{"id":"https://openalex.org/I4210108565","display_name":"Affiliated Hospital of North Sichuan Medical College","ror":"https://ror.org/01673gn35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210108565"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Hai Liu","raw_affiliation_strings":["Otolaryngology Head and Neck Surgery, Affiliated Hospital of North Sichuan Medical College"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Otolaryngology Head and Neck Surgery, Affiliated Hospital of North Sichuan Medical College","institution_ids":["https://openalex.org/I4210108565"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5161393908","display_name":"Bei Wen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210118397","display_name":"Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital","ror":"https://ror.org/01qh26a66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210118397"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bei Wen","raw_affiliation_strings":["Otolaryngology Head and Neck Surgery, Sichuan Provincial People\u2019s Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Otolaryngology Head and Neck Surgery, Sichuan Provincial People\u2019s Hospital","institution_ids":["https://openalex.org/I4210118397"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5100772751"],"corresponding_institution_ids":["https://openalex.org/I4210108565"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"16","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.8823000192642212,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.8823000192642212,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.07540000230073929,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.03709999844431877,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8147000074386597},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.6243000030517578},{"id":"https://openalex.org/C2776833033","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck squamous-cell carcinoma","level":4,"score":0.6158000230789185},{"id":"https://openalex.org/C2778468042","wikidata":"https://www.wikidata.org/wiki/Q273976","display_name":"Blockade","level":3,"score":0.5587000250816345},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5551999807357788},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.5353000164031982},{"id":"https://openalex.org/C2779399171","wikidata":"https://www.wikidata.org/wiki/Q1483951","display_name":"Malignancy","level":2,"score":0.4837999939918518},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.47940000891685486},{"id":"https://openalex.org/C2780851360","wikidata":"https://www.wikidata.org/wiki/Q21686041","display_name":"Immune checkpoint","level":4,"score":0.46149998903274536},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.44530001282691956},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.4009000062942505},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.3982999920845032},{"id":"https://openalex.org/C2776530083","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck cancer","level":3,"score":0.37059998512268066},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.36340001225471497},{"id":"https://openalex.org/C2778384578","wikidata":"https://www.wikidata.org/wiki/Q16930687","display_name":"Therapeutic approach","level":3,"score":0.35339999198913574},{"id":"https://openalex.org/C3875195","wikidata":"https://www.wikidata.org/wiki/Q5099363","display_name":"Chimeric antigen receptor","level":4,"score":0.31949999928474426},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.31619998812675476},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.31520000100135803},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3093999922275543},{"id":"https://openalex.org/C128544194","wikidata":"https://www.wikidata.org/wiki/Q474859","display_name":"Translational research","level":2,"score":0.30880001187324524},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.29330000281333923},{"id":"https://openalex.org/C3018411727","wikidata":"https://www.wikidata.org/wiki/Q3867488","display_name":"Head and neck","level":2,"score":0.2766999900341034},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2757999897003174},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.2754000127315521},{"id":"https://openalex.org/C148482608","wikidata":"https://www.wikidata.org/wiki/Q17007018","display_name":"Clinical study design","level":3,"score":0.2718000113964081},{"id":"https://openalex.org/C2779998722","wikidata":"https://www.wikidata.org/wiki/Q420296","display_name":"Cetuximab","level":4,"score":0.26930001378059387},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.26840001344680786},{"id":"https://openalex.org/C2994532551","wikidata":"https://www.wikidata.org/wiki/Q184627","display_name":"Human papillomavirus","level":2,"score":0.2680000066757202},{"id":"https://openalex.org/C3019692148","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Therapeutic modalities","level":2,"score":0.2628999948501587},{"id":"https://openalex.org/C2780009117","wikidata":"https://www.wikidata.org/wiki/Q900189","display_name":"HPV vaccines","level":5,"score":0.2574000060558319},{"id":"https://openalex.org/C2781230642","wikidata":"https://www.wikidata.org/wiki/Q492646","display_name":"Targeted therapy","level":3,"score":0.2547999918460846}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3389/fonc.2026.1953732","doi":"https://doi.org/10.3389/fonc.2026.1953732","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fonc.2026.1953732","pdf_url":null,"source":{"id":"https://openalex.org/S2596394214","display_name":"Frontiers in Oncology","issn_l":"2234-943X","issn":["2234-943X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Oncology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.3389/fonc.2026.1953732","doi":"https://doi.org/10.3389/fonc.2026.1953732","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fonc.2026.1953732","pdf_url":null,"source":{"id":"https://openalex.org/S2596394214","display_name":"Frontiers in Oncology","issn_l":"2234-943X","issn":["2234-943X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Oncology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":159,"referenced_works":["https://openalex.org/W1910012553","https://openalex.org/W1918446688","https://openalex.org/W1938515409","https://openalex.org/W1958471581","https://openalex.org/W1983403139","https://openalex.org/W1986847770","https://openalex.org/W2003736549","https://openalex.org/W2005182767","https://openalex.org/W2037837386","https://openalex.org/W2038500217","https://openalex.org/W2040786243","https://openalex.org/W2060786724","https://openalex.org/W2071606440","https://openalex.org/W2076543085","https://openalex.org/W2082303527","https://openalex.org/W2088715566","https://openalex.org/W2096866753","https://openalex.org/W2097555726","https://openalex.org/W2100039832","https://openalex.org/W2103196215","https://openalex.org/W2104822121","https://openalex.org/W2112845420","https://openalex.org/W2118441422","https://openalex.org/W2127225173","https://openalex.org/W2128471759","https://openalex.org/W2129945630","https://openalex.org/W2130301068","https://openalex.org/W2133083268","https://openalex.org/W2138004014","https://openalex.org/W2138779768","https://openalex.org/W2141274038","https://openalex.org/W2143680521","https://openalex.org/W2146906100","https://openalex.org/W2151269016","https://openalex.org/W2155384808","https://openalex.org/W2185075416","https://openalex.org/W2206261849","https://openalex.org/W2262285906","https://openalex.org/W2295202170","https://openalex.org/W2317771600","https://openalex.org/W2329974159","https://openalex.org/W2401455386","https://openalex.org/W2401823071","https://openalex.org/W2461433080","https://openalex.org/W2465860350","https://openalex.org/W2506616866","https://openalex.org/W2514649790","https://openalex.org/W2523194272","https://openalex.org/W2529484692","https://openalex.org/W2537963082","https://openalex.org/W2546524594","https://openalex.org/W2557336488","https://openalex.org/W2558219863","https://openalex.org/W2578528809","https://openalex.org/W2583046667","https://openalex.org/W2589742139","https://openalex.org/W2592666036","https://openalex.org/W2593417837","https://openalex.org/W2602907503","https://openalex.org/W2614824093","https://openalex.org/W2750457495","https://openalex.org/W2750632207","https://openalex.org/W2765314233","https://openalex.org/W2770046733","https://openalex.org/W2785803176","https://openalex.org/W2791483720","https://openalex.org/W2885720383","https://openalex.org/W2886229095","https://openalex.org/W2889646458","https://openalex.org/W2892876553","https://openalex.org/W2900010829","https://openalex.org/W2900578132","https://openalex.org/W2901882961","https://openalex.org/W2903493423","https://openalex.org/W2948246289","https://openalex.org/W2964160738","https://openalex.org/W2973690129","https://openalex.org/W2986633517","https://openalex.org/W2986855084","https://openalex.org/W2989673251","https://openalex.org/W2991171227","https://openalex.org/W2993350522","https://openalex.org/W2998643215","https://openalex.org/W2999410311","https://openalex.org/W3004553637","https://openalex.org/W3007231374","https://openalex.org/W3039675525","https://openalex.org/W3039873193","https://openalex.org/W3080936926","https://openalex.org/W3081408373","https://openalex.org/W3084241168","https://openalex.org/W3091834458","https://openalex.org/W3097515841","https://openalex.org/W3104338697","https://openalex.org/W3107533236","https://openalex.org/W3108792820","https://openalex.org/W3110311626","https://openalex.org/W3120630764","https://openalex.org/W3128646645","https://openalex.org/W3133206205","https://openalex.org/W3154458396","https://openalex.org/W3160367250","https://openalex.org/W3163054185","https://openalex.org/W3176179663","https://openalex.org/W3176460341","https://openalex.org/W3189201491","https://openalex.org/W3192431492","https://openalex.org/W3196420804","https://openalex.org/W3200328701","https://openalex.org/W3207451133","https://openalex.org/W3207811959","https://openalex.org/W4200024804","https://openalex.org/W4210773546","https://openalex.org/W4213312293","https://openalex.org/W4280619006","https://openalex.org/W4281627109","https://openalex.org/W4281633666","https://openalex.org/W4291791341","https://openalex.org/W4295837456","https://openalex.org/W4296681502","https://openalex.org/W4310601716","https://openalex.org/W4311134609","https://openalex.org/W4367610420","https://openalex.org/W4376134919","https://openalex.org/W4383957008","https://openalex.org/W4385751103","https://openalex.org/W4387528422","https://openalex.org/W4387949359","https://openalex.org/W4388409275","https://openalex.org/W4394604207","https://openalex.org/W4394632612","https://openalex.org/W4399395122","https://openalex.org/W4399488354","https://openalex.org/W4399488368","https://openalex.org/W4400604816","https://openalex.org/W4400995418","https://openalex.org/W4401954351","https://openalex.org/W4402560824","https://openalex.org/W4402561285","https://openalex.org/W4403089784","https://openalex.org/W4404465016","https://openalex.org/W4404870559","https://openalex.org/W4406138654","https://openalex.org/W4406865163","https://openalex.org/W4407768113","https://openalex.org/W4409276640","https://openalex.org/W4410039843","https://openalex.org/W4410379880","https://openalex.org/W4410604396","https://openalex.org/W4413113517","https://openalex.org/W4413116040","https://openalex.org/W4413985246","https://openalex.org/W4414055751","https://openalex.org/W4416329637","https://openalex.org/W4417031996","https://openalex.org/W7135206926","https://openalex.org/W7154472526","https://openalex.org/W7156069857","https://openalex.org/W7160504013"],"related_works":[],"abstract_inverted_index":{"Head":[0],"and":[1,50,53,105,123,169,177,182,209],"neck":[2],"squamous":[3,72],"cell":[4,73],"carcinoma":[5,74],"(HNSCC)":[6],"is":[7,197],"a":[8,36,191],"common":[9],"malignancy":[10],"that":[11,194],"continues":[12],"to":[13,100],"present":[14],"substantial":[15],"therapeutic":[16,38,108,137,195],"challenges":[17,183],"despite":[18],"decades":[19],"of":[20,65,212,220],"research.":[21],"Immune":[22],"checkpoint":[23],"blockade":[24,102],"agents":[25],"targeting":[26],"the":[27,62,95,118,132,210,218],"programmed":[28],"death":[29],"receptor-1":[30],"(PD-1)":[31],"axis":[32],"have":[33],"emerged":[34],"as":[35,150],"frontline":[37],"modality":[39],"for":[40,88,135,224],"patients":[41],"with":[42,140],"recurrent/metastatic":[43],"disease.":[44],"However,":[45],"suboptimal":[46],"objective":[47],"response":[48],"rates":[49],"pervasive":[51],"inherent":[52],"acquired":[54],"resistance":[55,99],"mechanisms":[56,97],"significantly":[57],"limit":[58],"clinical":[59,153],"efficacy.":[60],"Notably,":[61],"escalating":[63],"incidence":[64],"human":[66],"papillomavirus":[67],"(HPV)-driven":[68],"HNSCC,":[69],"particularly":[70],"oropharyngeal":[71],"(OPSCC),":[75],"has":[76,155],"necessitated":[77],"novel":[78],"treatment":[79],"paradigms.":[80],"The":[81],"HPV-encoded":[82],"oncoviral":[83],"antigens":[84],"represent":[85],"optimal":[86],"targets":[87],"precision":[89],"immunotherapeutic":[90],"interventions.":[91],"Here,":[92],"we":[93,165,189],"summarize":[94],"multifactorial":[96],"underlying":[98],"PD-1":[101],"in":[103,160,184],"HNSCC":[104],"discuss":[106,178,217],"how":[107],"HPV":[109,138],"vaccines":[110,139],"may":[111],"restore":[112],"antitumor":[113],"immune":[114,120],"responses":[115],"by":[116],"remodeling":[117],"tumor":[119],"microenvironment":[121],"(TIME)":[122],"expanding":[124],"virus-specific":[125],"cytotoxic":[126],"T":[127],"lymphocytes.":[128],"These":[129],"findings":[130],"support":[131],"biological":[133,201],"rationale":[134],"combining":[136],"PD-1/PD-L1":[141],"blockade;":[142],"however,":[143],"this":[144,185,221],"strategy":[145],"should":[146],"still":[147],"be":[148],"regarded":[149],"investigational":[151],"because":[152],"benefit":[154],"not":[156],"been":[157],"consistently":[158],"demonstrated":[159],"randomized":[161],"studies.":[162],"In":[163],"addition,":[164],"review":[166],"recent":[167],"preclinical":[168],"translational":[170],"advances,":[171],"compare":[172],"major":[173],"vaccine":[174],"delivery":[175],"platforms,":[176],"future":[179,225],"research":[180],"directions":[181],"evolving":[186],"field.":[187],"Finally,":[188],"advance":[190],"working":[192],"hypothesis":[193],"efficacy":[196],"contingent":[198],"upon":[199],"three":[200],"prerequisites\u2014intact":[202],"MHC-I":[203],"antigen":[204],"presentation,":[205],"baseline":[206],"PD-L1":[207],"expression,":[208],"absence":[211],"dominant":[213],"non-PD-1":[214],"immunosuppressive":[215],"barriers\u2014and":[216],"implications":[219],"precision-enrichment":[222],"framework":[223],"trial":[226],"design.":[227]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-11T00:00:00"}