{"id":"https://openalex.org/W7225728627","doi":"https://doi.org/10.5281/zenodo.24108794","title":"Programmable White Blood Cells: A Two-Marker Specificity-Logic Design for Engineered T Cells","display_name":"Programmable White Blood Cells: A Two-Marker Specificity-Logic Design for Engineered T Cells","publication_year":2026,"publication_date":"2026-11-10","ids":{"openalex":"https://openalex.org/W7225728627","doi":"https://doi.org/10.5281/zenodo.24108794"},"language":"en","primary_location":{"id":"doi:10.5281/zenodo.24108794","doi":"https://doi.org/10.5281/zenodo.24108794","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.24108794","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Preprint"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.5281/zenodo.24108794","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5161362375","display_name":"William Alexander Aldred","orcid":"https://orcid.org/0009-0000-1215-577X","observed_orcids":["https://orcid.org/0009-0000-1215-577X"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Aldred, William Alexander","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0000-1215-577X","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5161362375"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.9032999873161316,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.9032999873161316,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.021700000390410423,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10878","display_name":"CRISPR and Genetic Engineering","score":0.010900000110268593,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C81444415","wikidata":"https://www.wikidata.org/wiki/Q7243535","display_name":"Priming (agriculture)","level":3,"score":0.4839000105857849},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.44670000672340393},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.39259999990463257},{"id":"https://openalex.org/C3019111730","wikidata":"https://www.wikidata.org/wiki/Q159236","display_name":"Genetically engineered","level":3,"score":0.3828999996185303},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.34880000352859497},{"id":"https://openalex.org/C45374587","wikidata":"https://www.wikidata.org/wiki/Q12525525","display_name":"Computation","level":2,"score":0.3375999927520752},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3343999981880188},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.290800005197525},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2791000008583069},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2770000100135803},{"id":"https://openalex.org/C19317047","wikidata":"https://www.wikidata.org/wiki/Q412037","display_name":"T-cell receptor","level":4,"score":0.26579999923706055},{"id":"https://openalex.org/C112972136","wikidata":"https://www.wikidata.org/wiki/Q7595718","display_name":"Stability (learning theory)","level":2,"score":0.2563000023365021},{"id":"https://openalex.org/C2994499388","wikidata":"https://www.wikidata.org/wiki/Q656732","display_name":"Gene deletion","level":4,"score":0.25369998812675476},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.2506999969482422}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.5281/zenodo.24108794","doi":"https://doi.org/10.5281/zenodo.24108794","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.24108794","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Preprint"},{"id":"doi:10.5281/zenodo.24108795","doi":"https://doi.org/10.5281/zenodo.24108795","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.24108795","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Preprint"}],"best_oa_location":{"id":"doi:10.5281/zenodo.24108794","doi":"https://doi.org/10.5281/zenodo.24108794","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.24108794","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Preprint"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Design":[0],"paper":[1],"(SIMULATED,":[2],"NOT":[3],"MEASURED)":[4],"specifying":[5],"a":[6,15,23,27,42,50],"two-marker":[7],"AND-gate":[8],"specificity":[9],"logic":[10],"for":[11,18,26,49],"engineered":[12],"T":[13],"cells:":[14],"priming":[16],"receptor":[17,25],"one":[19],"disease":[20],"marker":[21],"induces":[22],"killing":[24],"second,":[28],"so":[29],"firing":[30],"requires":[31],"both":[32],"markers":[33],"on":[34],"the":[35,73],"same":[36],"target":[37],"cell.":[38],"Occupancy":[39],"modelling":[40],"gives":[41],"discrimination":[43],"ratio":[44],"of":[45,72],"25.0":[46],"versus":[47],"2.5":[48],"single-receptor":[51],"design,":[52],"with":[53],"computed":[54],"dose,":[55],"expansion,":[56],"cytokine-risk,":[57],"persistence,":[58],"and":[59,64],"antigen-escape":[60],"budgets,":[61],"failure":[62],"modes,":[63],"quantitative":[65],"stopping":[66],"conditions.":[67],"All":[68],"numbers":[69],"are":[70],"outputs":[71],"accompanying":[74],"computation":[75],"script.":[76],"Nothing":[77],"is":[78],"described":[79],"as":[80],"built":[81],"or":[82],"tested.":[83]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-11T00:00:00"}