{"id":"https://openalex.org/W7225728452","doi":"https://doi.org/10.1186/s44477-026-00059-4","title":"Chimeric models of neurodegenerative diseases: from disease mechanisms to regenerative therapies","display_name":"Chimeric models of neurodegenerative diseases: from disease mechanisms to regenerative therapies","publication_year":2026,"publication_date":"2026-11-10","ids":{"openalex":"https://openalex.org/W7225728452","doi":"https://doi.org/10.1186/s44477-026-00059-4"},"language":"en","primary_location":{"id":"doi:10.1186/s44477-026-00059-4","doi":"https://doi.org/10.1186/s44477-026-00059-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s44477-026-00059-4","pdf_url":null,"source":{"id":"https://openalex.org/S5407047695","display_name":"Molecular Neurodegeneration Advances","issn_l":"3059-4944","issn":["3059-4944"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["ki-jl-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Neurodegeneration Advances","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1186/s44477-026-00059-4","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5161399730","display_name":"Laura C\u00e1ceres-Palomo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Laura C\u00e1ceres-Palomo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004704628","display_name":"Mar\u00eda Alfonso-Triguero","orcid":"https://orcid.org/0000-0002-5213-0259","observed_orcids":["https://orcid.org/0000-0002-5213-0259"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mar\u00eda Alfonso-Triguero","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010054822","display_name":"Arantzazu Belloso-Iguerategui","orcid":"https://orcid.org/0000-0002-6327-6392","observed_orcids":["https://orcid.org/0000-0002-6327-6392"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Arantzazu Belloso-Iguerategui","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006298918","display_name":"Estibaliz Santiago-Mujika","orcid":"https://orcid.org/0000-0002-5809-5300","observed_orcids":["https://orcid.org/0000-0002-5809-5300"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Estibaliz Santiago-Mujika","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5116089444","display_name":"Marta Miron-Alcala","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marta Mir\u00f3n-Alcal\u00e1","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5088411067","display_name":"Amaia M. Arranz","orcid":"https://orcid.org/0000-0002-8314-7870","observed_orcids":["https://orcid.org/0000-0002-8314-7870"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Amaia M. Arranz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"2","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.7455999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.7455999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.09179999679327011,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.04560000076889992,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C2777619251","wikidata":"https://www.wikidata.org/wiki/Q7312279","display_name":"Remyelination","level":4,"score":0.7401999831199646},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6948000192642212},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.654699981212616},{"id":"https://openalex.org/C107459253","wikidata":"https://www.wikidata.org/wiki/Q674925","display_name":"Induced pluripotent stem cell","level":4,"score":0.6402000188827515},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5084999799728394},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4496999979019165},{"id":"https://openalex.org/C136834591","wikidata":"https://www.wikidata.org/wiki/Q2944097","display_name":"Neural stem cell","level":3,"score":0.4090999960899353},{"id":"https://openalex.org/C2780596555","wikidata":"https://www.wikidata.org/wiki/Q206901","display_name":"Amyotrophic lateral sclerosis","level":3,"score":0.3953999876976013},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.34450000524520874},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.32839998602867126},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3133000135421753},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.30550000071525574},{"id":"https://openalex.org/C19843653","wikidata":"https://www.wikidata.org/wiki/Q213907","display_name":"Model organism","level":3,"score":0.30379998683929443},{"id":"https://openalex.org/C10882517","wikidata":"https://www.wikidata.org/wiki/Q15268054","display_name":"Cell therapy","level":3,"score":0.28679999709129333},{"id":"https://openalex.org/C2988867146","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Human disease","level":3,"score":0.2766000032424927},{"id":"https://openalex.org/C144501496","wikidata":"https://www.wikidata.org/wiki/Q5533489","display_name":"Genome editing","level":4,"score":0.26759999990463257},{"id":"https://openalex.org/C98108389","wikidata":"https://www.wikidata.org/wiki/Q412563","display_name":"CRISPR","level":3,"score":0.26440000534057617},{"id":"https://openalex.org/C15729860","wikidata":"https://www.wikidata.org/wiki/Q2329919","display_name":"Progenitor","level":4,"score":0.2624000012874603},{"id":"https://openalex.org/C189014844","wikidata":"https://www.wikidata.org/wiki/Q189118","display_name":"Cell type","level":3,"score":0.25870001316070557},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.25589999556541443}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1186/s44477-026-00059-4","doi":"https://doi.org/10.1186/s44477-026-00059-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s44477-026-00059-4","pdf_url":null,"source":{"id":"https://openalex.org/S5407047695","display_name":"Molecular Neurodegeneration Advances","issn_l":"3059-4944","issn":["3059-4944"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["ki-jl-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Neurodegeneration Advances","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1186/s44477-026-00059-4","doi":"https://doi.org/10.1186/s44477-026-00059-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s44477-026-00059-4","pdf_url":null,"source":{"id":"https://openalex.org/S5407047695","display_name":"Molecular Neurodegeneration Advances","issn_l":"3059-4944","issn":["3059-4944"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["ki-jl-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Neurodegeneration Advances","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":193,"referenced_works":["https://openalex.org/W1502634090","https://openalex.org/W1535621098","https://openalex.org/W1607206274","https://openalex.org/W1967750892","https://openalex.org/W1971125401","https://openalex.org/W1977543000","https://openalex.org/W1980505651","https://openalex.org/W1980775054","https://openalex.org/W1984767115","https://openalex.org/W1991480442","https://openalex.org/W2012663773","https://openalex.org/W2013212946","https://openalex.org/W2016453349","https://openalex.org/W2023769419","https://openalex.org/W2027835288","https://openalex.org/W2028244731","https://openalex.org/W2041482977","https://openalex.org/W2043726739","https://openalex.org/W2044928246","https://openalex.org/W2048323087","https://openalex.org/W2049230645","https://openalex.org/W2051129517","https://openalex.org/W2057284222","https://openalex.org/W2057335179","https://openalex.org/W2062521126","https://openalex.org/W2073162672","https://openalex.org/W2074948481","https://openalex.org/W2081440662","https://openalex.org/W2082314612","https://openalex.org/W2085420949","https://openalex.org/W2089683266","https://openalex.org/W2090620788","https://openalex.org/W2094539666","https://openalex.org/W2099548919","https://openalex.org/W2103824500","https://openalex.org/W2111199774","https://openalex.org/W2117987556","https://openalex.org/W2118619368","https://openalex.org/W2121396070","https://openalex.org/W2126464081","https://openalex.org/W2130419298","https://openalex.org/W2132551489","https://openalex.org/W2134964344","https://openalex.org/W2146830478","https://openalex.org/W2147554232","https://openalex.org/W2154945114","https://openalex.org/W2157440761","https://openalex.org/W2158174988","https://openalex.org/W2160249662","https://openalex.org/W2170256902","https://openalex.org/W2186898572","https://openalex.org/W2191292005","https://openalex.org/W2257936017","https://openalex.org/W2265799967","https://openalex.org/W2302166322","https://openalex.org/W2411185224","https://openalex.org/W2412924086","https://openalex.org/W2441138583","https://openalex.org/W2462775742","https://openalex.org/W2467511189","https://openalex.org/W2525538087","https://openalex.org/W2530855489","https://openalex.org/W2577340531","https://openalex.org/W2583345010","https://openalex.org/W2590949976","https://openalex.org/W2605401453","https://openalex.org/W2611225933","https://openalex.org/W2620989164","https://openalex.org/W2621213207","https://openalex.org/W2751466955","https://openalex.org/W2754967293","https://openalex.org/W2771032903","https://openalex.org/W2771530468","https://openalex.org/W2782565650","https://openalex.org/W2784363986","https://openalex.org/W2795647315","https://openalex.org/W2802796971","https://openalex.org/W2802819025","https://openalex.org/W2805999712","https://openalex.org/W2807380934","https://openalex.org/W2891042228","https://openalex.org/W2896561023","https://openalex.org/W2904655759","https://openalex.org/W2917194175","https://openalex.org/W2920359971","https://openalex.org/W2939007813","https://openalex.org/W2944786249","https://openalex.org/W2945776234","https://openalex.org/W2945804912","https://openalex.org/W2947276475","https://openalex.org/W2950277645","https://openalex.org/W2964143382","https://openalex.org/W2964755252","https://openalex.org/W2969956278","https://openalex.org/W2972368830","https://openalex.org/W2974868767","https://openalex.org/W2974933008","https://openalex.org/W2979935062","https://openalex.org/W2981248429","https://openalex.org/W2982115290","https://openalex.org/W2982463677","https://openalex.org/W2988909735","https://openalex.org/W3006081887","https://openalex.org/W3012646333","https://openalex.org/W3015931662","https://openalex.org/W3016614566","https://openalex.org/W3026471331","https://openalex.org/W3030610227","https://openalex.org/W3034958546","https://openalex.org/W3037983184","https://openalex.org/W3039614810","https://openalex.org/W3045806571","https://openalex.org/W3049633837","https://openalex.org/W3087966723","https://openalex.org/W3091445440","https://openalex.org/W3093649979","https://openalex.org/W3095299648","https://openalex.org/W3107069844","https://openalex.org/W3114016256","https://openalex.org/W3151909457","https://openalex.org/W3202968500","https://openalex.org/W4200065894","https://openalex.org/W4205555379","https://openalex.org/W4206448713","https://openalex.org/W4211044101","https://openalex.org/W4280535518","https://openalex.org/W4281620037","https://openalex.org/W4282918296","https://openalex.org/W4282922342","https://openalex.org/W4294543123","https://openalex.org/W4294636879","https://openalex.org/W4295269662","https://openalex.org/W4312174343","https://openalex.org/W4313340421","https://openalex.org/W4320725280","https://openalex.org/W4372046968","https://openalex.org/W4376133370","https://openalex.org/W4379376094","https://openalex.org/W4384008545","https://openalex.org/W4384207726","https://openalex.org/W4384522233","https://openalex.org/W4386736890","https://openalex.org/W4387077509","https://openalex.org/W4387424166","https://openalex.org/W4387451853","https://openalex.org/W4388448512","https://openalex.org/W4388625926","https://openalex.org/W4388909452","https://openalex.org/W4389893606","https://openalex.org/W4392086699","https://openalex.org/W4392656549","https://openalex.org/W4393205148","https://openalex.org/W4393225316","https://openalex.org/W4399734981","https://openalex.org/W4399775612","https://openalex.org/W4399997148","https://openalex.org/W4400362370","https://openalex.org/W4400722728","https://openalex.org/W4400869311","https://openalex.org/W4401438547","https://openalex.org/W4403253596","https://openalex.org/W4403581238","https://openalex.org/W4404023645","https://openalex.org/W4405035908","https://openalex.org/W4406730722","https://openalex.org/W4406973442","https://openalex.org/W4407481743","https://openalex.org/W4407731828","https://openalex.org/W4408876365","https://openalex.org/W4409343065","https://openalex.org/W4409412562","https://openalex.org/W4409501791","https://openalex.org/W4409887740","https://openalex.org/W4410232696","https://openalex.org/W4410735111","https://openalex.org/W4411174506","https://openalex.org/W4413111737","https://openalex.org/W4413324190","https://openalex.org/W4413846150","https://openalex.org/W4414001878","https://openalex.org/W4414700101","https://openalex.org/W4415143417","https://openalex.org/W4415243947","https://openalex.org/W4416182391","https://openalex.org/W4416599633","https://openalex.org/W4416624751","https://openalex.org/W4416869603","https://openalex.org/W4417521773","https://openalex.org/W7117990652","https://openalex.org/W7119075333","https://openalex.org/W7125385252","https://openalex.org/W7131839906","https://openalex.org/W7201949844"],"related_works":[],"abstract_inverted_index":{"Abstract":[0],"Human-rodent":[1],"chimeric":[2,77],"CNS":[3,45],"models":[4,24,78,102,158],"provide":[5],"a":[6],"unique":[7,99],"platform":[8],"for":[9,153],"investigating":[10],"human-specific":[11,106],"aspects":[12],"of":[13,19,46,76,137],"neurodegeneration":[14],"within":[15,57],"the":[16,20,44,74,98,147],"physiological":[17],"environment":[18],"living":[21],"CNS.":[22],"These":[23],"are":[25],"generated":[26],"by":[27],"transplanting":[28],"human":[29,52],"pluripotent":[30],"stem":[31],"cell-derived":[32],"neurons,":[33],"astrocytes,":[34],"microglia,":[35],"oligodendrocytes,":[36],"or":[37,39],"neural":[38],"glial":[40,111,130],"progenitor":[41],"cells":[42,53],"into":[43,105],"permissive":[47],"host":[48,58],"animals.":[49],"Following":[50],"transplantation,":[51],"mature,":[54],"functionally":[55],"integrate":[56],"tissue,":[59],"and":[60,65,93,113,133,150,163],"retain":[61],"key":[62],"species-specific":[63],"molecular":[64],"cellular":[66,107],"features.":[67],"Here,":[68],"we":[69,145],"review":[70],"recent":[71],"advances":[72],"in":[73,83,116],"use":[75],"to":[79],"investigate":[80],"disease":[81,161],"mechanisms":[82],"Alzheimer's":[84],"disease,":[85,87,89],"Parkinson's":[86],"Huntington's":[88],"Amyotrophic":[90],"Lateral":[91],"Sclerosis,":[92],"demyelinating":[94],"disorders.":[95],"We":[96,119],"highlight":[97],"insights":[100],"these":[101],"have":[103,139],"provided":[104],"vulnerabilities,":[108],"genotype-dependent":[109],"phenotypes,":[110],"responses,":[112],"neuroimmune":[114],"interactions":[115],"vivo":[117],".":[118],"also":[120],"discuss":[121],"emerging":[122],"translational":[123,164],"applications,":[124],"including":[125],"cell":[126],"replacement":[127],"therapies,":[128],"engineered":[129],"delivery":[131],"platforms,":[132],"remyelination":[134],"strategies,":[135],"some":[136],"which":[138],"progressed":[140],"toward":[141],"clinical":[142],"translation.":[143],"Finally,":[144],"outline":[146],"current":[148],"limitations":[149],"future":[151],"directions":[152],"developing":[154],"next-generation":[155],"multi-lineage":[156],"humanized":[157],"with":[159],"enhanced":[160],"fidelity":[162],"potential.":[165]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-11T00:00:00"}