{"id":"https://openalex.org/W7225720708","doi":"https://doi.org/10.17605/osf.io/xvfre","title":"The Endodontic\u2013Gut\u2013Liver Axis: A Scoping Review of Apical Periodontitis and MASLD-Relevant Changes","display_name":"The Endodontic\u2013Gut\u2013Liver Axis: A Scoping Review of Apical Periodontitis and MASLD-Relevant Changes","publication_year":2026,"publication_date":"2026-09-02","ids":{"openalex":"https://openalex.org/W7225720708","doi":"https://doi.org/10.17605/osf.io/xvfre"},"language":"en","primary_location":{"id":"doi:10.17605/osf.io/xvfre","doi":"https://doi.org/10.17605/osf.io/xvfre","is_oa":true,"landing_page_url":"https://doi.org/10.17605/osf.io/xvfre","pdf_url":null,"source":{"id":"https://openalex.org/S7407050956","display_name":"Open Science Framework","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2799848540","host_organization_name":"Center for Open Science","host_organization_lineage":["https://openalex.org/I2799848540"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"StudyRegistration"},"volume":null,"type":"study-registration","is_traditional":false,"indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.17605/osf.io/xvfre","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109410623","display_name":"Ahmet Kerem Eren","orcid":"https://orcid.org/0009-0009-0806-415X","observed_orcids":["https://orcid.org/0009-0009-0806-415X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ahmet Kerem Eren","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0009-0806-415X","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5116390831","display_name":"Ekin Deniz \u00c7atmabacak","orcid":"https://orcid.org/0009-0007-4471-5760","observed_orcids":["https://orcid.org/0009-0007-4471-5760"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ekin Deniz \u00c7atmabacak","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0007-4471-5760","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.7651000022888184,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.7651000022888184,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10536","display_name":"Endodontics and Root Canal Treatments","score":0.11349999904632568,"subfield":{"id":"https://openalex.org/subfields/3504","display_name":"Oral Surgery"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.0575999990105629,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/apical-periodontitis","display_name":"apical periodontitis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/non-alcoholic-fatty-liver-disease","display_name":"non-alcoholic fatty liver disease","score":0.9309999942779541},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.8679999709129333},{"id":"https://openalex.org/keywords/microbial-metabolites","display_name":"microbial metabolites","score":0.8489999771118164},{"id":"https://openalex.org/keywords/intestinal-barrier-integrity","display_name":"intestinal barrier integrity","score":0.984000027179718},{"id":"https://openalex.org/keywords/liver-inflammation","display_name":"liver inflammation","score":0.902999997138977},{"id":"https://openalex.org/keywords/liver-fibrosis","display_name":"liver fibrosis","score":0.7509999871253967},{"id":"https://openalex.org/keywords/hepatic-steatosis","display_name":"hepatic steatosis","score":0.796999990940094},{"id":"https://openalex.org/keywords/immunometabolism","display_name":"immunometabolism","score":0.8679999709129333}],"concepts":[{"id":"https://openalex.org/C2780385504","wikidata":"https://www.wikidata.org/wiki/Q520127","display_name":"Periodontitis","level":2,"score":0.666700005531311},{"id":"https://openalex.org/C2776175330","wikidata":"https://www.wikidata.org/wiki/Q1365091","display_name":"Steatosis","level":2,"score":0.5968000292778015},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5672000050544739},{"id":"https://openalex.org/C2777165150","wikidata":"https://www.wikidata.org/wiki/Q269334","display_name":"Dysbiosis","level":3,"score":0.46389999985694885},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.35040000081062317},{"id":"https://openalex.org/C539455810","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut flora","level":2,"score":0.33640000224113464},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.3359000086784363},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27869999408721924},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.26930001378059387},{"id":"https://openalex.org/C3018263421","wikidata":"https://www.wikidata.org/wiki/Q80083","display_name":"Human studies","level":2,"score":0.2687999904155731},{"id":"https://openalex.org/C15151743","wikidata":"https://www.wikidata.org/wiki/Q903778","display_name":"Metagenomics","level":3,"score":0.25589999556541443}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.17605/osf.io/xvfre","doi":"https://doi.org/10.17605/osf.io/xvfre","is_oa":true,"landing_page_url":"https://doi.org/10.17605/osf.io/xvfre","pdf_url":null,"source":{"id":"https://openalex.org/S7407050956","display_name":"Open Science Framework","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2799848540","host_organization_name":"Center for Open Science","host_organization_lineage":["https://openalex.org/I2799848540"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"StudyRegistration"}],"best_oa_location":{"id":"doi:10.17605/osf.io/xvfre","doi":"https://doi.org/10.17605/osf.io/xvfre","is_oa":true,"landing_page_url":"https://doi.org/10.17605/osf.io/xvfre","pdf_url":null,"source":{"id":"https://openalex.org/S7407050956","display_name":"Open Science Framework","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2799848540","host_organization_name":"Center for Open Science","host_organization_lineage":["https://openalex.org/I2799848540"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"StudyRegistration"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7129420036","https://openalex.org/W7167668610","https://openalex.org/W4416519239","https://openalex.org/W7140864052","https://openalex.org/W7204077579","https://openalex.org/W7203695985","https://openalex.org/W7139101889","https://openalex.org/W4385621608","https://openalex.org/W7223172887","https://openalex.org/W7204241241"],"abstract_inverted_index":{"This":[0],"scoping":[1,96],"review":[2,23,89],"maps":[3],"and":[4,8,18,39,43,45,58,74,98],"conceptually":[5],"synthesises":[6],"human":[7],"experimental":[9],"evidence":[10,25,53],"linking":[11],"apical":[12],"periodontitis":[13],"(AP)":[14],"with":[15],"intestinal":[16,34],"perturbations":[17],"MASLD-relevant":[19],"hepatic":[20,37,72],"alterations.":[21],"The":[22,88],"examines":[24],"for":[26,95],"changes":[27],"in":[28],"gut":[29],"microbial":[30,32],"ecology,":[31],"metabolites,":[33],"barrier":[35],"integrity,":[36],"inflammatory":[38],"molecular":[40],"responses,":[41],"steatosis":[42],"fibrogenesis,":[44],"evaluates":[46],"the":[47,51,66,78],"extent":[48],"to":[49,65,75,102],"which":[50],"available":[52],"supports":[54],"gut-independent,":[55],"putative":[56],"gut-mediated":[57],"immunometabolic":[59],"pathways.":[60],"Particular":[61],"attention":[62],"is":[63,99],"given":[64],"influence":[67],"of":[68,77],"pre-existing":[69],"metabolic":[70],"or":[71,85],"susceptibility":[73],"components":[76],"proposed":[79],"endodontic\u2013gut\u2013liver":[80],"axis":[81],"that":[82],"remain":[83],"unsupported":[84],"experimentally":[86],"untested.":[87],"follows":[90],"Joanna":[91],"Briggs":[92],"Institute":[93],"guidance":[94],"reviews":[97],"reported":[100],"according":[101],"PRISMA-ScR.":[103]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-11-11T00:00:00"}