{"id":"https://openalex.org/W7225711538","doi":"https://doi.org/10.1186/s43066-026-00571-y","title":"Serum platelet-derived growth factor-BB as a noninvasive biomarker of significant liver fibrosis in patients with chronic hepatitis B: a cross-sectional study","display_name":"Serum platelet-derived growth factor-BB as a noninvasive biomarker of significant liver fibrosis in patients with chronic hepatitis B: a cross-sectional study","publication_year":2026,"publication_date":"2026-11-11","ids":{"openalex":"https://openalex.org/W7225711538","doi":"https://doi.org/10.1186/s43066-026-00571-y"},"language":"en","primary_location":{"id":"doi:10.1186/s43066-026-00571-y","doi":"https://doi.org/10.1186/s43066-026-00571-y","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s43066-026-00571-y","pdf_url":null,"source":{"id":"https://openalex.org/S2764852108","display_name":"Egyptian Liver Journal","issn_l":"2090-6218","issn":["2090-6218","2090-6226"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Egyptian Liver Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.1186/s43066-026-00571-y","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5161383070","display_name":"Abdelaty Ibrahim","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Abdelaty Ibrahim","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161406545","display_name":"Hassan Elbatea","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hassan Elbatea","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5150091419","display_name":"hanan soliman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hanan Soliman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072792551","display_name":"Shimaa Mahmoud El Sharawy","orcid":"https://orcid.org/0000-0003-0308-8653","observed_orcids":["https://orcid.org/0000-0003-0308-8653","https://orcid.org/0000-0001-8141-7550"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shimaa El Sharawy","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5161406788","display_name":"Ibrahim Fathi Amer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ibrahim Fathi Amer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":0,"currency":"USD","value_usd":0},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"16","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.9711999893188477,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.9711999893188477,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.010700000450015068,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10337","display_name":"Liver Disease and Transplantation","score":0.004699999932199717,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C2780826214","wikidata":"https://www.wikidata.org/wiki/Q1324974","display_name":"Transient elastography","level":4,"score":0.9254000186920166},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9004999995231628},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.6959999799728394},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6848000288009644},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.6759999990463257},{"id":"https://openalex.org/C3020491458","wikidata":"https://www.wikidata.org/wiki/Q131742","display_name":"Chronic hepatitis","level":3,"score":0.5995000004768372},{"id":"https://openalex.org/C2994217296","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Liver fibrosis","level":3,"score":0.542900025844574},{"id":"https://openalex.org/C2775940106","wikidata":"https://www.wikidata.org/wiki/Q10478733","display_name":"HBeAg","level":5,"score":0.49459999799728394},{"id":"https://openalex.org/C58471807","wikidata":"https://www.wikidata.org/wiki/Q327120","display_name":"Receiver operating characteristic","level":2,"score":0.4848000109195709},{"id":"https://openalex.org/C2777410769","wikidata":"https://www.wikidata.org/wiki/Q2282887","display_name":"HBsAg","level":4,"score":0.4390999972820282},{"id":"https://openalex.org/C41260117","wikidata":"https://www.wikidata.org/wiki/Q668064","display_name":"Hepatology","level":2,"score":0.4163999855518341},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.3978999853134155},{"id":"https://openalex.org/C2777382497","wikidata":"https://www.wikidata.org/wiki/Q6853","display_name":"Hepatitis B","level":2,"score":0.39480000734329224},{"id":"https://openalex.org/C2993667909","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Hepatic fibrosis","level":3,"score":0.3772999942302704},{"id":"https://openalex.org/C2777690781","wikidata":"https://www.wikidata.org/wiki/Q1324974","display_name":"Elastography","level":3,"score":0.36320000886917114},{"id":"https://openalex.org/C2780593183","wikidata":"https://www.wikidata.org/wiki/Q6844","display_name":"Hepatitis B virus","level":3,"score":0.3546999990940094},{"id":"https://openalex.org/C198433322","wikidata":"https://www.wikidata.org/wiki/Q3910099","display_name":"Predictive value of tests","level":2,"score":0.3018999993801117},{"id":"https://openalex.org/C76318530","wikidata":"https://www.wikidata.org/wiki/Q16833590","display_name":"Area under the curve","level":2,"score":0.29660001397132874},{"id":"https://openalex.org/C2777214474","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Cirrhosis","level":2,"score":0.2922999858856201},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.2922999858856201},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2906000018119812},{"id":"https://openalex.org/C2776029263","wikidata":"https://www.wikidata.org/wiki/Q131742","display_name":"Hepatitis","level":2,"score":0.2612999975681305},{"id":"https://openalex.org/C2778217198","wikidata":"https://www.wikidata.org/wiki/Q556977","display_name":"Cutoff","level":2,"score":0.2597000002861023}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1186/s43066-026-00571-y","doi":"https://doi.org/10.1186/s43066-026-00571-y","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s43066-026-00571-y","pdf_url":null,"source":{"id":"https://openalex.org/S2764852108","display_name":"Egyptian Liver Journal","issn_l":"2090-6218","issn":["2090-6218","2090-6226"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Egyptian Liver Journal","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1186/s43066-026-00571-y","doi":"https://doi.org/10.1186/s43066-026-00571-y","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s43066-026-00571-y","pdf_url":null,"source":{"id":"https://openalex.org/S2764852108","display_name":"Egyptian Liver Journal","issn_l":"2090-6218","issn":["2090-6218","2090-6226"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Egyptian Liver Journal","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W166169566","https://openalex.org/W1865056759","https://openalex.org/W1945511967","https://openalex.org/W1997865776","https://openalex.org/W2016293149","https://openalex.org/W2037668591","https://openalex.org/W2045687074","https://openalex.org/W2064387090","https://openalex.org/W2074932800","https://openalex.org/W2088327211","https://openalex.org/W2091595053","https://openalex.org/W2096813909","https://openalex.org/W2099633930","https://openalex.org/W2328176404","https://openalex.org/W2412820859","https://openalex.org/W2605785536","https://openalex.org/W2613759826","https://openalex.org/W2757684426","https://openalex.org/W2760032177","https://openalex.org/W2804763314","https://openalex.org/W2941657849","https://openalex.org/W2982183067","https://openalex.org/W3020992444","https://openalex.org/W3197659780","https://openalex.org/W4280528077","https://openalex.org/W4283017384","https://openalex.org/W4296859879","https://openalex.org/W4311329393","https://openalex.org/W4316036771","https://openalex.org/W4365505095","https://openalex.org/W4389344727","https://openalex.org/W4401116198","https://openalex.org/W4403478817","https://openalex.org/W4404604687","https://openalex.org/W4407121197","https://openalex.org/W4407681822","https://openalex.org/W4408306671","https://openalex.org/W4412468807","https://openalex.org/W4412492985","https://openalex.org/W4414263947","https://openalex.org/W4416759148"],"related_works":[],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Chronic":[2],"hepatitis":[3],"B":[4],"(CHB)":[5],"is":[6,23,65],"a":[7,44,282,351],"major":[8],"cause":[9],"of":[10,38,54,184,234,241,247,250,255,260,266,272,343],"progressive":[11],"liver":[12,68,133],"fibrosis":[13,21,47,60,128,172,227,333],"(LF),":[14],"cirrhosis,":[15],"and":[16,29,96,112,123,148,173,186,269,289,314,361],"hepatocellular":[17],"carcinoma.":[18],"Although":[19],"noninvasive":[20],"assessment":[22],"essential,":[24],"current":[25],"tools":[26],"have":[27],"practical":[28],"diagnostic":[30,83],"limitations.":[31],"Platelet-derived":[32],"growth":[33],"factor-BB":[34],"(PDGF-BB)\u2014a":[35],"profibrogenic":[36],"mediator":[37],"hepatic":[39],"stellate":[40],"cell":[41],"activation\u2014may":[42],"be":[43],"biologically":[45],"relevant":[46],"biomarker.":[48,355],"This":[49,80],"study":[50,85],"examined":[51],"the":[52,149,157,263],"ability":[53],"serum":[55,113,118,196],"PDGF-BB":[56,119,151,197,223,280,326],"to":[57,145],"detect":[58],"significant":[59,127,226,332],"in":[61,182,201,206,334],"CHB":[62,91],"patients":[63,185,202,336],"which":[64],"defined":[66],"as":[67,132,350],"stiffness":[69,134],">":[70,135],"7":[71,136],"kPa":[72],"by":[73,121],"vibration-controlled":[74],"transient":[75],"elastography":[76],"(VCTE;":[77],"FibroScan).":[78],"Methods":[79],"cross-sectional":[81],"exploratory":[82],"accuracy":[84,271],"included":[86],"90":[87,166],"treatment-naive":[88,335],"adults":[89],"with":[90,203,208,238,337],"attending":[92],"Tanta":[93],"University":[94,99],"Hospitals":[95],"Kafr":[97],"El-Sheikh":[98],"Hospitals.":[100],"All":[101],"participants":[102],"underwent":[103],"clinical":[104,366],"evaluation;":[105],"routine":[106],"laboratory":[107],"testing,":[108],"including":[109],"HBsAg,":[110],"HBeAg,":[111],"HBV":[114,188],"DNA;":[115],"abdominal":[116],"ultrasonography;":[117],"measurement":[120],"ELISA;":[122],"FibroScan":[124],"examination.":[125],"VCTE-defined":[126,225,331],"(F2\u2013F4)":[129],"was":[130,143,153,180,190,198],"set":[131],"kPa.":[137],"A":[138],"non-randomized":[139],"convenience":[140],"sampling":[141],"approach":[142],"used":[144],"enroll":[146],"participants,":[147],"optimal":[150],"cutoff":[152,233],"established":[154],"based":[155],"on":[156],"ROC":[158],"curve":[159],"derived":[160,232],"from":[161,311],"this":[162,267],"cohort.":[163],"Results":[164],"Among":[165],"patients,":[167],"69":[168],"(76.7%)":[169],"had":[170,176,281],"F0-F1":[171,209],"21":[174],"(23.3%)":[175],"F2-F4":[177,204],"fibrosis.":[178],"HBeAg":[179],"positive":[181,252],"21.1%":[183],"median":[187],"DNA":[189],"4.47":[191],"(3.68\u20135.31)":[192],"log10":[193],"IU/mL":[194],"Median":[195],"significantly":[199,310],"increased":[200],"than":[205,286],"those":[207],"fibrosis:":[210],"2500.8":[211],"(2028.25-2721.8)":[212],"vs.":[213],"777.13":[214],"(479.21-1743.15)":[215],"pg/mL,":[216,237],"respectively":[217],"(":[218],"p":[219,277],"<":[220,278],"0.001).":[221,279],"Serum":[222,325],"discriminated":[224],"at":[228],"an":[229,239],"exploratory,":[230],"internally":[231],"\u2265":[235],"1885.9":[236],"AUC":[240,285],"0.905":[242],"(95%":[243],"CI":[244],"0.816\u20130.994),":[245],"sensitivity":[246],"85.7%,":[248],"specificity":[249],"84.1%,":[251],"predictive":[253,258,341],"value":[254,259,342],"62.1%,":[256],"negative":[257,340],"95.1%":[261],"(at":[262],"23.3%":[264],"prevalence":[265],"cohort),":[268],"overall":[270],"84.4%":[273],"(Youden":[274],"index":[275],"0.698;":[276],"numerically":[283],"higher":[284],"APRI":[287],"(0.717)":[288],"GPR":[290],"(0.715),":[291],"but":[292],"these":[293,357],"differences":[294],"did":[295,307,315],"not":[296,308,316],"reach":[297],"statistical":[298],"significance":[299],"after":[300],"Bonferroni":[301],"correction":[302],"for":[303,330,370],"multiple":[304],"comparisons.":[305],"It":[306],"differ":[309],"FIB-4":[312],"(0.780)":[313],"outperform":[317],"platelet":[318],"count":[319],"(0.980)":[320],"or":[321,353,368],"INR":[322],"(0.931).":[323],"Conclusions":[324],"demonstrated":[327],"good":[328],"discrimination":[329],"CHB.":[338],"Its":[339],"95%,":[344],"though":[345],"prevalence-dependent,":[346],"suggests":[347],"potential":[348],"utility":[349],"triage":[352],"adjunctive":[354],"However,":[356],"findings":[358],"are":[359],"preliminary":[360],"require":[362],"external":[363],"validation":[364],"before":[365],"implementation":[367],"substitution":[369],"elastography.":[371]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-11T00:00:00"}
