{"id":"https://openalex.org/W7225704208","doi":"https://doi.org/10.1007/s00277-026-07349-7","title":"Identification of high-frequency genes in non-severe aplastic anemia and their impact on therapeutic response","display_name":"Identification of high-frequency genes in non-severe aplastic anemia and their impact on therapeutic response","publication_year":2026,"publication_date":"2026-11-11","ids":{"openalex":"https://openalex.org/W7225704208","doi":"https://doi.org/10.1007/s00277-026-07349-7"},"language":"en","primary_location":{"id":"doi:10.1007/s00277-026-07349-7","doi":"https://doi.org/10.1007/s00277-026-07349-7","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00277-026-07349-7","pdf_url":null,"source":{"id":"https://openalex.org/S163204731","display_name":"Annals of Hematology","issn_l":"0939-5555","issn":["0939-5555","1432-0584"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Hematology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1007/s00277-026-07349-7","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091331506","display_name":"Nanxi Dong","orcid":"https://orcid.org/0000-0003-2663-4848","observed_orcids":["https://orcid.org/0000-0003-2663-4848"]},"institutions":[{"id":"https://openalex.org/I114539943","display_name":"Zhejiang Chinese Medical University","ror":"https://ror.org/04epb4p87","country_code":"CN","type":"education","lineage":["https://openalex.org/I114539943"]},{"id":"https://openalex.org/I4210095527","display_name":"Zhejiang Provincial Hospital of TCM","ror":"https://ror.org/00mzdyq43","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210095527"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Nanxi Dong","raw_affiliation_strings":["Department of Hematology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, Zhejiang, China","Laboratory of Integrated Traditional Chinese and Western Medicine for Hematology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, Zhejiang, China","The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, Zhejiang, China","institution_ids":["https://openalex.org/I114539943","https://openalex.org/I4210095527"]},{"raw_affiliation_string":"Laboratory of Integrated Traditional Chinese and Western Medicine for Hematology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, Zhejiang, China","institution_ids":["https://openalex.org/I114539943","https://openalex.org/I4210095527"]},{"raw_affiliation_string":"The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China","institution_ids":["https://openalex.org/I114539943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161408532","display_name":"Jingjing Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114539943","display_name":"Zhejiang Chinese Medical University","ror":"https://ror.org/04epb4p87","country_code":"CN","type":"education","lineage":["https://openalex.org/I114539943"]},{"id":"https://openalex.org/I4210095527","display_name":"Zhejiang Provincial Hospital of TCM","ror":"https://ror.org/00mzdyq43","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210095527"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jingjing Liu","raw_affiliation_strings":["Department of Hematology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, Zhejiang, China","Laboratory of Integrated Traditional Chinese and Western Medicine for Hematology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, Zhejiang, China","The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, Zhejiang, China","institution_ids":["https://openalex.org/I114539943","https://openalex.org/I4210095527"]},{"raw_affiliation_string":"Laboratory of Integrated Traditional Chinese and Western Medicine for Hematology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, Zhejiang, China","institution_ids":["https://openalex.org/I114539943","https://openalex.org/I4210095527"]},{"raw_affiliation_string":"The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China","institution_ids":["https://openalex.org/I114539943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114191764","display_name":"Yingying Shen","orcid":"https://orcid.org/0009-0007-3581-7175","observed_orcids":["https://orcid.org/0009-0007-3581-7175"]},"institutions":[{"id":"https://openalex.org/I114539943","display_name":"Zhejiang Chinese Medical University","ror":"https://ror.org/04epb4p87","country_code":"CN","type":"education","lineage":["https://openalex.org/I114539943"]},{"id":"https://openalex.org/I4210095527","display_name":"Zhejiang Provincial Hospital of TCM","ror":"https://ror.org/00mzdyq43","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210095527"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yingying Shen","raw_affiliation_strings":["Department of Hematology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, Zhejiang, China","Laboratory of Integrated Traditional Chinese and Western Medicine for Hematology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, Zhejiang, China","The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, Zhejiang, China","institution_ids":["https://openalex.org/I114539943","https://openalex.org/I4210095527"]},{"raw_affiliation_string":"Laboratory of Integrated Traditional Chinese and Western Medicine for Hematology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, Zhejiang, China","institution_ids":["https://openalex.org/I114539943","https://openalex.org/I4210095527"]},{"raw_affiliation_string":"The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China","institution_ids":["https://openalex.org/I114539943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027225185","display_name":"Xinru Jia","orcid":"https://orcid.org/0000-0003-1352-712X","observed_orcids":["https://orcid.org/0000-0003-1352-712X","https://orcid.org/0000-0002-0174-1543"]},"institutions":[{"id":"https://openalex.org/I114539943","display_name":"Zhejiang Chinese Medical University","ror":"https://ror.org/04epb4p87","country_code":"CN","type":"education","lineage":["https://openalex.org/I114539943"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinru Jia","raw_affiliation_strings":["The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China","The First School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China","institution_ids":["https://openalex.org/I114539943"]},{"raw_affiliation_string":"The First School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China","institution_ids":["https://openalex.org/I114539943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5122911822","display_name":"Rudan Zheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114539943","display_name":"Zhejiang Chinese Medical University","ror":"https://ror.org/04epb4p87","country_code":"CN","type":"education","lineage":["https://openalex.org/I114539943"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rudan Zheng","raw_affiliation_strings":["The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China","The First School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China","institution_ids":["https://openalex.org/I114539943"]},{"raw_affiliation_string":"The First School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China","institution_ids":["https://openalex.org/I114539943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112857185","display_name":"Peicheng Wang","orcid":"https://orcid.org/0009-0002-6649-1474","observed_orcids":["https://orcid.org/0009-0002-6649-1474"]},"institutions":[{"id":"https://openalex.org/I114539943","display_name":"Zhejiang Chinese Medical University","ror":"https://ror.org/04epb4p87","country_code":"CN","type":"education","lineage":["https://openalex.org/I114539943"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Peicheng Wang","raw_affiliation_strings":["The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China","The First School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China","institution_ids":["https://openalex.org/I114539943"]},{"raw_affiliation_string":"The First School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China","institution_ids":["https://openalex.org/I114539943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159113565","display_name":"Qiuqin Cheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114539943","display_name":"Zhejiang Chinese Medical University","ror":"https://ror.org/04epb4p87","country_code":"CN","type":"education","lineage":["https://openalex.org/I114539943"]},{"id":"https://openalex.org/I4210095527","display_name":"Zhejiang Provincial Hospital of TCM","ror":"https://ror.org/00mzdyq43","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210095527"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qiuqin Cheng","raw_affiliation_strings":["Department of Hematology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, Zhejiang, China","Laboratory of Integrated Traditional Chinese and Western Medicine for Hematology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, Zhejiang, China","The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, Zhejiang, China","institution_ids":["https://openalex.org/I114539943","https://openalex.org/I4210095527"]},{"raw_affiliation_string":"Laboratory of Integrated Traditional Chinese and Western Medicine for Hematology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, Zhejiang, China","institution_ids":["https://openalex.org/I114539943","https://openalex.org/I4210095527"]},{"raw_affiliation_string":"The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China","institution_ids":["https://openalex.org/I114539943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161373911","display_name":"Yu Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114539943","display_name":"Zhejiang Chinese Medical University","ror":"https://ror.org/04epb4p87","country_code":"CN","type":"education","lineage":["https://openalex.org/I114539943"]},{"id":"https://openalex.org/I4210095527","display_name":"Zhejiang Provincial Hospital of TCM","ror":"https://ror.org/00mzdyq43","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210095527"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yu Zhang","raw_affiliation_strings":["Department of Hematology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, Zhejiang, China","Laboratory of Integrated Traditional Chinese and Western Medicine for Hematology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, Zhejiang, China","The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, Zhejiang, China","institution_ids":["https://openalex.org/I114539943","https://openalex.org/I4210095527"]},{"raw_affiliation_string":"Laboratory of Integrated Traditional Chinese and Western Medicine for Hematology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, Zhejiang, China","institution_ids":["https://openalex.org/I114539943","https://openalex.org/I4210095527"]},{"raw_affiliation_string":"The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China","institution_ids":["https://openalex.org/I114539943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092401837","display_name":"Bo Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114539943","display_name":"Zhejiang Chinese Medical University","ror":"https://ror.org/04epb4p87","country_code":"CN","type":"education","lineage":["https://openalex.org/I114539943"]},{"id":"https://openalex.org/I4210095527","display_name":"Zhejiang Provincial Hospital of TCM","ror":"https://ror.org/00mzdyq43","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210095527"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bo Wang","raw_affiliation_strings":["Department of Hematology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, Zhejiang, China","Laboratory of Integrated Traditional Chinese and Western Medicine for Hematology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, Zhejiang, China","The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, Zhejiang, China","institution_ids":["https://openalex.org/I114539943","https://openalex.org/I4210095527"]},{"raw_affiliation_string":"Laboratory of Integrated Traditional Chinese and Western Medicine for Hematology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, Zhejiang, China","institution_ids":["https://openalex.org/I114539943","https://openalex.org/I4210095527"]},{"raw_affiliation_string":"The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China","institution_ids":["https://openalex.org/I114539943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5121142134","display_name":"Ningning Zhu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114539943","display_name":"Zhejiang Chinese Medical University","ror":"https://ror.org/04epb4p87","country_code":"CN","type":"education","lineage":["https://openalex.org/I114539943"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ningning Zhu","raw_affiliation_strings":["The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China","The First School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China","institution_ids":["https://openalex.org/I114539943"]},{"raw_affiliation_string":"The First School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China","institution_ids":["https://openalex.org/I114539943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161378703","display_name":"Zhengwei Tan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114539943","display_name":"Zhejiang Chinese Medical University","ror":"https://ror.org/04epb4p87","country_code":"CN","type":"education","lineage":["https://openalex.org/I114539943"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhengwei Tan","raw_affiliation_strings":["The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China","The First School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China","institution_ids":["https://openalex.org/I114539943"]},{"raw_affiliation_string":"The First School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China","institution_ids":["https://openalex.org/I114539943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081012936","display_name":"Hangchao Li","orcid":"https://orcid.org/0000-0002-7097-8667","observed_orcids":["https://orcid.org/0000-0002-7097-8667"]},"institutions":[{"id":"https://openalex.org/I114539943","display_name":"Zhejiang Chinese Medical University","ror":"https://ror.org/04epb4p87","country_code":"CN","type":"education","lineage":["https://openalex.org/I114539943"]},{"id":"https://openalex.org/I4210095527","display_name":"Zhejiang Provincial Hospital of TCM","ror":"https://ror.org/00mzdyq43","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210095527"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hangchao Li","raw_affiliation_strings":["Department of Hematology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, Zhejiang, China","Laboratory of Integrated Traditional Chinese and Western Medicine for Hematology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, Zhejiang, China","The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, Zhejiang, China","institution_ids":["https://openalex.org/I114539943","https://openalex.org/I4210095527"]},{"raw_affiliation_string":"Laboratory of Integrated Traditional Chinese and Western Medicine for Hematology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, Zhejiang, China","institution_ids":["https://openalex.org/I114539943","https://openalex.org/I4210095527"]},{"raw_affiliation_string":"The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China","institution_ids":["https://openalex.org/I114539943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063456456","display_name":"\u5434\u8fea\u70af","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114539943","display_name":"Zhejiang Chinese Medical University","ror":"https://ror.org/04epb4p87","country_code":"CN","type":"education","lineage":["https://openalex.org/I114539943"]},{"id":"https://openalex.org/I4210095527","display_name":"Zhejiang Provincial Hospital of TCM","ror":"https://ror.org/00mzdyq43","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210095527"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Dijiong Wu","raw_affiliation_strings":["Department of Hematology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, Zhejiang, China","Laboratory of Integrated Traditional Chinese and Western Medicine for Hematology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, Zhejiang, China","The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, Zhejiang, China","institution_ids":["https://openalex.org/I114539943","https://openalex.org/I4210095527"]},{"raw_affiliation_string":"Laboratory of Integrated Traditional Chinese and Western Medicine for Hematology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, Zhejiang, China","institution_ids":["https://openalex.org/I114539943","https://openalex.org/I4210095527"]},{"raw_affiliation_string":"The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China","institution_ids":["https://openalex.org/I114539943"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023501428","display_name":"Baodong Ye","orcid":"https://orcid.org/0000-0001-5912-2633","observed_orcids":["https://orcid.org/0000-0001-5912-2633"]},"institutions":[{"id":"https://openalex.org/I114539943","display_name":"Zhejiang Chinese Medical University","ror":"https://ror.org/04epb4p87","country_code":"CN","type":"education","lineage":["https://openalex.org/I114539943"]},{"id":"https://openalex.org/I4210095527","display_name":"Zhejiang Provincial Hospital of TCM","ror":"https://ror.org/00mzdyq43","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210095527"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Baodong Ye","raw_affiliation_strings":["Department of Hematology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, Zhejiang, China","Laboratory of Integrated Traditional Chinese and Western Medicine for Hematology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, Zhejiang, China","The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, Zhejiang, China","institution_ids":["https://openalex.org/I114539943","https://openalex.org/I4210095527"]},{"raw_affiliation_string":"Laboratory of Integrated Traditional Chinese and Western Medicine for Hematology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, Zhejiang, China","institution_ids":["https://openalex.org/I114539943","https://openalex.org/I4210095527"]},{"raw_affiliation_string":"The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China","institution_ids":["https://openalex.org/I114539943"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5023501428","https://openalex.org/A5063456456"],"corresponding_institution_ids":["https://openalex.org/I114539943","https://openalex.org/I4210095527"],"apc_list":{"value":4590,"currency":"USD","value_usd":4590},"apc_paid":{"value":4590,"currency":"USD","value_usd":4590},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12919","display_name":"Blood disorders and treatments","score":0.763700008392334,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12919","display_name":"Blood disorders and treatments","score":0.763700008392334,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.1881999969482422,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.013799999840557575,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aplastic-anemia","display_name":"aplastic anemia","score":0.9610000252723694},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.699999988079071},{"id":"https://openalex.org/keywords/treatment-response","display_name":"treatment response","score":0.902999997138977},{"id":"https://openalex.org/keywords/non-severe-aplastic-anemia","display_name":"non-severe aplastic anemia","score":0.8209999799728394}],"concepts":[{"id":"https://openalex.org/C194409129","wikidata":"https://www.wikidata.org/wiki/Q103824","display_name":"Hematology","level":2,"score":0.7477999925613403},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.704800009727478},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.6825000047683716},{"id":"https://openalex.org/C2781440808","wikidata":"https://www.wikidata.org/wiki/Q846316","display_name":"Aplastic anemia","level":3,"score":0.626800000667572},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5673999786376953},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5260999798774719},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.38580000400543213},{"id":"https://openalex.org/C3019096185","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Complete response","level":3,"score":0.3580000102519989},{"id":"https://openalex.org/C2778248108","wikidata":"https://www.wikidata.org/wiki/Q5445","display_name":"Anemia","level":2,"score":0.3125},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3098999857902527},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.29510000348091125},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.27790001034736633}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/s00277-026-07349-7","doi":"https://doi.org/10.1007/s00277-026-07349-7","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00277-026-07349-7","pdf_url":null,"source":{"id":"https://openalex.org/S163204731","display_name":"Annals of Hematology","issn_l":"0939-5555","issn":["0939-5555","1432-0584"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Hematology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1007/s00277-026-07349-7","doi":"https://doi.org/10.1007/s00277-026-07349-7","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00277-026-07349-7","pdf_url":null,"source":{"id":"https://openalex.org/S163204731","display_name":"Annals of Hematology","issn_l":"0939-5555","issn":["0939-5555","1432-0584"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Hematology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2252450000","https://openalex.org/W4307336085","https://openalex.org/W4367396205","https://openalex.org/W2092675371","https://openalex.org/W2072897505","https://openalex.org/W2982284553","https://openalex.org/W2567501969","https://openalex.org/W2360957990","https://openalex.org/W2971192868","https://openalex.org/W4388902570"],"abstract_inverted_index":{"Non-severe":[0],"aplastic":[1],"anemia":[2],"(NSAA)":[3],"is":[4],"a":[5,141,153],"hematopoietic":[6,17],"disorder":[7],"characterized":[8],"by":[9,21],"variable":[10],"treatment":[11,26,105,202],"responses.":[12],"However,":[13],"the":[14,41,80,88],"relationship":[15],"between":[16,186],"clonal":[18],"mutations":[19,51,69,101,111,120,156,165],"harbored":[20],"NSAA":[22],"patients":[23,46,84,158,204],"and":[24,28,59,63,94,189],"their":[25],"outcomes":[27],"prognosis":[29,143],"remains":[30],"unclear.":[31],"In":[32],"this":[33,193],"study,":[34],"whole-exome":[35],"sequencing":[36],"was":[37],"performed":[38],"to":[39,91,123,126,173],"analyze":[40],"genetic":[42],"landscape":[43],"of":[44,79],"87":[45],"with":[47,99,109,132,168,206],"NSAA,":[48],"identifying":[49],"high-frequency":[50],"in":[52,73,82,87,144,157],"CSMD1":[53],",":[54,56,58],"PIGA":[55,100],"FAT1":[57,110,174],"BCOR/L1":[60,134,145,155],"(":[61],"BCOR":[62],"its":[64],"homolog":[65],"BCORL1":[66],").":[67],"Missense":[68],"were":[70,121,166],"predominant,":[71],"particularly":[72,129],"transfusion-dependent":[74],"NSAA.":[75,207],"Gene":[76],"ontology":[77],"analysis":[78,151],"genes":[81],"nonresponding":[83],"revealed":[85,152],"enrichment":[86],"pathways":[89],"related":[90],"protein,":[92],"ATP,":[93],"metal":[95],"ion":[96],"binding.":[97],"Patients":[98],"showed":[102],"significantly":[103],"better":[104],"responses,":[106],"whereas":[107],"those":[108,130],"exhibited":[112],"poorer":[113],"outcomes.":[114],"Notably,":[115],"bone":[116,161],"marrow":[117,162],"failure-related":[118,163],"germline":[119,164,187],"linked":[122],"reduced":[124],"responses":[125],"immunosuppressive":[127],"therapy,":[128],"coexisting":[131,160],"somatic":[133,190],"mutations.":[135,175],"Although":[136],"previous":[137],"studies":[138],"have":[139],"suggested":[140],"favorable":[142],"-mutated":[146],"AA":[147],"patients,":[148],"our":[149],"survival":[150],"paradox:":[154],"harboring":[159],"associated":[167],"inferior":[169],"event-free":[170],"survival,":[171],"similar":[172],"This":[176],"discrepancy":[177],"may":[178,198],"reflect":[179],"distinct":[180],"mutation":[181],"subtypes":[182],"or":[183],"epistatic":[184],"interactions":[185],"predisposition":[188],"lesions.":[191],"Overall,":[192],"study":[194],"provides":[195],"insights":[196],"that":[197],"help":[199],"optimize":[200],"personalized":[201],"for":[203],"strategies":[205]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-11-11T00:00:00"}