{"id":"https://openalex.org/W7225700985","doi":"https://doi.org/10.1021/acsami.6c14503","title":"Porosity Tunable Silk Fibroin Microspheres Enhance Cartilage Repair in Rabbit Model","display_name":"Porosity Tunable Silk Fibroin Microspheres Enhance Cartilage Repair in Rabbit Model","publication_year":2026,"publication_date":"2026-11-10","ids":{"openalex":"https://openalex.org/W7225700985","doi":"https://doi.org/10.1021/acsami.6c14503","pmid":"https://pubmed.ncbi.nlm.nih.gov/43004632"},"language":"en","primary_location":{"id":"doi:10.1021/acsami.6c14503","doi":"https://doi.org/10.1021/acsami.6c14503","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acsami.6c14503","pdf_url":null,"source":{"id":"https://openalex.org/S164001016","display_name":"ACS Applied Materials & Interfaces","issn_l":"1944-8244","issn":["1944-8244","1944-8252"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Applied Materials & Interfaces","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066283438","display_name":"Meenakshi Kamaraj","orcid":"https://orcid.org/0000-0003-2757-2060","observed_orcids":["https://orcid.org/0000-0003-2757-2060"]},"institutions":[{"id":"https://openalex.org/I4210097936","display_name":"Terasaki Foundation","ror":"https://ror.org/012381002","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210097936"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Meenakshi Kamaraj","raw_affiliation_strings":["Terasaki Institute for Biomedical Innovations , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Terasaki Institute for Biomedical Innovations , , ,","institution_ids":["https://openalex.org/I4210097936"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004997318","display_name":"Cheirmadurai Kalirajan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I876193797","display_name":"Vellore Institute of Technology University","ror":"https://ror.org/00qzypv28","country_code":"IN","type":"education","lineage":["https://openalex.org/I876193797"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Cheirmadurai Kalirajan","raw_affiliation_strings":["Vellore Institute of Technology , , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vellore Institute of Technology , , , ,","institution_ids":["https://openalex.org/I876193797"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161369163","display_name":"P.S Unnikrishnan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210097936","display_name":"Terasaki Foundation","ror":"https://ror.org/012381002","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210097936"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P.S Unnikrishnan","raw_affiliation_strings":["Terasaki Institute for Biomedical Innovations , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Terasaki Institute for Biomedical Innovations , , ,","institution_ids":["https://openalex.org/I4210097936"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066810596","display_name":"Rahul Velikkakath Gopi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210097936","display_name":"Terasaki Foundation","ror":"https://ror.org/012381002","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210097936"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rahul V. Gopi","raw_affiliation_strings":["Terasaki Institute for Biomedical Innovations , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Terasaki Institute for Biomedical Innovations , , ,","institution_ids":["https://openalex.org/I4210097936"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030379903","display_name":"Ansheed Raheem","orcid":"https://orcid.org/0000-0002-2607-2630","observed_orcids":["https://orcid.org/0000-0002-2607-2630"]},"institutions":[{"id":"https://openalex.org/I876193797","display_name":"Vellore Institute of Technology University","ror":"https://ror.org/00qzypv28","country_code":"IN","type":"education","lineage":["https://openalex.org/I876193797"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Ansheed Raheem","raw_affiliation_strings":["Vellore Institute of Technology (VIT) , , ,","Vellore Institute of Technology , , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vellore Institute of Technology (VIT) , , ,","institution_ids":["https://openalex.org/I876193797"]},{"raw_affiliation_string":"Vellore Institute of Technology , , , ,","institution_ids":["https://openalex.org/I876193797"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029800626","display_name":"Geetha Manivasagam","orcid":"https://orcid.org/0000-0003-3326-3176","observed_orcids":["https://orcid.org/0000-0003-3326-3176"]},"institutions":[{"id":"https://openalex.org/I876193797","display_name":"Vellore Institute of Technology University","ror":"https://ror.org/00qzypv28","country_code":"IN","type":"education","lineage":["https://openalex.org/I876193797"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Geetha Manivasagam","raw_affiliation_strings":["Vellore Institute of Technology (VIT) , , ,","Vellore Institute of Technology , , , ,"],"raw_orcid":"https://orcid.org/0000-0003-3326-3176","affiliations":[{"raw_affiliation_string":"Vellore Institute of Technology (VIT) , , ,","institution_ids":["https://openalex.org/I876193797"]},{"raw_affiliation_string":"Vellore Institute of Technology , , , ,","institution_ids":["https://openalex.org/I876193797"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157999227","display_name":"Arukshitha Vishnupriya","orcid":"https://orcid.org/0009-0005-2944-6131","observed_orcids":["https://orcid.org/0009-0005-2944-6131"]},"institutions":[{"id":"https://openalex.org/I158688498","display_name":"Yenepoya University","ror":"https://ror.org/029zfa075","country_code":"IN","type":"education","lineage":["https://openalex.org/I158688498"]},{"id":"https://openalex.org/I4405268903","display_name":"Yenepoya Research Centre","ror":"https://ror.org/02ekn8f64","country_code":"IN","type":"facility","lineage":["https://openalex.org/I4405268903"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Arukshitha Vishnupriya","raw_affiliation_strings":["Yenepoya Research Centre, Yenepoya (Deemed to be University) , , University Road, Deralakatte , , ,"],"raw_orcid":"https://orcid.org/0009-0005-2944-6131","affiliations":[{"raw_affiliation_string":"Yenepoya Research Centre, Yenepoya (Deemed to be University) , , University Road, Deralakatte , , ,","institution_ids":["https://openalex.org/I158688498","https://openalex.org/I4405268903"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075499419","display_name":"Saji Uthaman","orcid":"https://orcid.org/0000-0001-6387-7510","observed_orcids":["https://orcid.org/0000-0001-6387-7510"]},"institutions":[{"id":"https://openalex.org/I158688498","display_name":"Yenepoya University","ror":"https://ror.org/029zfa075","country_code":"IN","type":"education","lineage":["https://openalex.org/I158688498"]},{"id":"https://openalex.org/I4405268903","display_name":"Yenepoya Research Centre","ror":"https://ror.org/02ekn8f64","country_code":"IN","type":"facility","lineage":["https://openalex.org/I4405268903"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Saji Uthaman","raw_affiliation_strings":["Yenepoya Research Centre, Yenepoya (Deemed to be University) , , University Road, Deralakatte , , ,"],"raw_orcid":"https://orcid.org/0000-0001-6387-7510","affiliations":[{"raw_affiliation_string":"Yenepoya Research Centre, Yenepoya (Deemed to be University) , , University Road, Deralakatte , , ,","institution_ids":["https://openalex.org/I158688498","https://openalex.org/I4405268903"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074494350","display_name":"Johnson V. John","orcid":"https://orcid.org/0000-0001-8105-0808","observed_orcids":["https://orcid.org/0000-0001-8105-0808"]},"institutions":[{"id":"https://openalex.org/I4210097936","display_name":"Terasaki Foundation","ror":"https://ror.org/012381002","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210097936"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Johnson V. John","raw_affiliation_strings":["Terasaki Institute for Biomedical Innovations , , ,"],"raw_orcid":"https://orcid.org/0000-0001-8105-0808","affiliations":[{"raw_affiliation_string":"Terasaki Institute for Biomedical Innovations , , ,","institution_ids":["https://openalex.org/I4210097936"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5074494350"],"corresponding_institution_ids":["https://openalex.org/I4210097936"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11966","display_name":"Silk-based biomaterials and applications","score":0.9340999722480774,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11966","display_name":"Silk-based biomaterials and applications","score":0.9340999722480774,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.039500001817941666,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.00989999994635582,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/articular-cartilage-repair","display_name":"articular cartilage repair","score":0.8100000023841858},{"id":"https://openalex.org/keywords/porosity-control","display_name":"porosity control","score":0.6389999985694885},{"id":"https://openalex.org/keywords/adipose-derived-stem-cells","display_name":"adipose-derived stem cells","score":0.9639999866485596},{"id":"https://openalex.org/keywords/chondrogenesis","display_name":"chondrogenesis","score":0.8730000257492065},{"id":"https://openalex.org/keywords/cell-adhesion-and-migration","display_name":"cell adhesion and migration","score":0.7020000219345093},{"id":"https://openalex.org/keywords/nutrient-transport","display_name":"nutrient transport","score":0.4560000002384186},{"id":"https://openalex.org/keywords/extracellular-matrix-mimicry","display_name":"extracellular matrix mimicry","score":0.7910000085830688},{"id":"https://openalex.org/keywords/tissue-engineering-scaffolds","display_name":"tissue engineering scaffolds","score":0.6779999732971191}],"concepts":[{"id":"https://openalex.org/C122302759","wikidata":"https://www.wikidata.org/wiki/Q2345087","display_name":"Fibroin","level":3,"score":0.9797000288963318},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.7870000004768372},{"id":"https://openalex.org/C35496256","wikidata":"https://www.wikidata.org/wiki/Q5104524","display_name":"Chondrogenesis","level":3,"score":0.6211000084877014},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.5540000200271606},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.550000011920929},{"id":"https://openalex.org/C49892992","wikidata":"https://www.wikidata.org/wiki/Q1540285","display_name":"Tissue engineering","level":2,"score":0.5196999907493591},{"id":"https://openalex.org/C2780550940","wikidata":"https://www.wikidata.org/wiki/Q502730","display_name":"Cartilage","level":2,"score":0.4921000003814697},{"id":"https://openalex.org/C89429830","wikidata":"https://www.wikidata.org/wiki/Q735710","display_name":"Scaffold","level":2,"score":0.47519999742507935},{"id":"https://openalex.org/C84416704","wikidata":"https://www.wikidata.org/wiki/Q188666","display_name":"Adhesion","level":2,"score":0.4620000123977661},{"id":"https://openalex.org/C2780431358","wikidata":"https://www.wikidata.org/wiki/Q653622","display_name":"SILK","level":2,"score":0.42800000309944153},{"id":"https://openalex.org/C106487976","wikidata":"https://www.wikidata.org/wiki/Q685816","display_name":"Matrix (chemical analysis)","level":2,"score":0.40720000863075256},{"id":"https://openalex.org/C6648577","wikidata":"https://www.wikidata.org/wiki/Q622669","display_name":"Porosity","level":2,"score":0.4050000011920929},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.3873000144958496},{"id":"https://openalex.org/C519885992","wikidata":"https://www.wikidata.org/wiki/Q161","display_name":"Fiber","level":2,"score":0.38530001044273376},{"id":"https://openalex.org/C85789140","wikidata":"https://www.wikidata.org/wiki/Q187640","display_name":"Cell adhesion","level":3,"score":0.38179999589920044},{"id":"https://openalex.org/C2778540859","wikidata":"https://www.wikidata.org/wiki/Q152234","display_name":"Swelling","level":2,"score":0.37209999561309814},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.33480000495910645},{"id":"https://openalex.org/C2778414984","wikidata":"https://www.wikidata.org/wiki/Q865663","display_name":"Biomaterial","level":2,"score":0.33480000495910645},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.33180001378059387},{"id":"https://openalex.org/C2777230088","wikidata":"https://www.wikidata.org/wiki/Q864426","display_name":"Biocompatibility","level":2,"score":0.3231000006198883},{"id":"https://openalex.org/C2777564180","wikidata":"https://www.wikidata.org/wiki/Q3109230","display_name":"Articular cartilage repair","level":5,"score":0.322299987077713},{"id":"https://openalex.org/C105569014","wikidata":"https://www.wikidata.org/wiki/Q3271208","display_name":"Porous medium","level":3,"score":0.3183000087738037},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.3000999987125397},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.2851000130176544},{"id":"https://openalex.org/C189942447","wikidata":"https://www.wikidata.org/wiki/Q61186","display_name":"Microsphere","level":2,"score":0.2840000092983246},{"id":"https://openalex.org/C42360764","wikidata":"https://www.wikidata.org/wiki/Q83588","display_name":"Chemical engineering","level":1,"score":0.2759999930858612}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1021/acsami.6c14503","doi":"https://doi.org/10.1021/acsami.6c14503","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acsami.6c14503","pdf_url":null,"source":{"id":"https://openalex.org/S164001016","display_name":"ACS Applied Materials & Interfaces","issn_l":"1944-8244","issn":["1944-8244","1944-8252"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Applied Materials & Interfaces","raw_type":"journal-article"},{"id":"pmid:43004632","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/43004632","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS applied materials & interfaces","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000916843","display_name":"Engineering the open porous nanofibrous microsphere integrated fibrillar hydrogel for the co-delivery of antibacterial and angiogenic agents aimed at the rapid diabetic wound repair","funder_award_id":"R01DK134903","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":69,"referenced_works":["https://openalex.org/W1968217647","https://openalex.org/W2016519321","https://openalex.org/W2025898370","https://openalex.org/W2026916005","https://openalex.org/W2083359872","https://openalex.org/W2092131394","https://openalex.org/W2134159434","https://openalex.org/W2158587075","https://openalex.org/W2336304896","https://openalex.org/W2509043347","https://openalex.org/W2596246412","https://openalex.org/W2761181567","https://openalex.org/W2762201903","https://openalex.org/W2765355408","https://openalex.org/W2790802034","https://openalex.org/W2791615560","https://openalex.org/W2809255947","https://openalex.org/W2841394286","https://openalex.org/W2921572350","https://openalex.org/W2943865557","https://openalex.org/W2966577644","https://openalex.org/W2971559178","https://openalex.org/W2989720216","https://openalex.org/W3013544570","https://openalex.org/W3026582931","https://openalex.org/W3043491619","https://openalex.org/W3045468740","https://openalex.org/W3083999658","https://openalex.org/W3086490995","https://openalex.org/W3113350633","https://openalex.org/W3137922450","https://openalex.org/W3143873910","https://openalex.org/W3160077162","https://openalex.org/W3185033766","https://openalex.org/W4210748048","https://openalex.org/W4220900412","https://openalex.org/W4221068621","https://openalex.org/W4224233318","https://openalex.org/W4280497372","https://openalex.org/W4292951899","https://openalex.org/W4294864961","https://openalex.org/W4296164586","https://openalex.org/W4309718273","https://openalex.org/W4309875273","https://openalex.org/W4313490979","https://openalex.org/W4315752815","https://openalex.org/W4319989150","https://openalex.org/W4353032072","https://openalex.org/W4377564702","https://openalex.org/W4380087691","https://openalex.org/W4382933529","https://openalex.org/W4387037347","https://openalex.org/W4387037997","https://openalex.org/W4387670529","https://openalex.org/W4390321753","https://openalex.org/W4391483196","https://openalex.org/W4391617780","https://openalex.org/W4391876712","https://openalex.org/W4396495805","https://openalex.org/W4396860202","https://openalex.org/W4403052914","https://openalex.org/W4403395208","https://openalex.org/W4410036398","https://openalex.org/W4412584959","https://openalex.org/W4412625181","https://openalex.org/W4412787427","https://openalex.org/W4416782619","https://openalex.org/W7154842831","https://openalex.org/W7164050147"],"related_works":["https://openalex.org/W2231421908","https://openalex.org/W2419467320","https://openalex.org/W2001260702","https://openalex.org/W2889673843","https://openalex.org/W2023345288","https://openalex.org/W2883768366","https://openalex.org/W4220869232","https://openalex.org/W2085711413","https://openalex.org/W2038987199","https://openalex.org/W4409730925"],"abstract_inverted_index":{"Repairing":[0],"articular":[1],"cartilage":[2,42,185,231],"defects":[3],"is":[4],"particularly":[5],"challenging":[6,40],"due":[7,199],"to":[8,63,81,83,99,124,151,155,200],"the":[9,55,76,85,90,218],"tissue's":[10],"hypovascularity":[11],"and":[12,66,105,128,180,205,225],"limited":[13],"intrinsic":[14],"healing":[15],"capacity,":[16],"which":[17,193],"pose":[18],"significant":[19],"clinical":[20],"challenges.":[21],"Biomaterial-based":[22],"scaffolds":[23],"have":[24],"shown":[25],"promising":[26],"outcomes":[27],"in":[28,41,89,102,110,139,187,192],"terms":[29],"of":[30,92],"repair":[31],"capacity;":[32],"however,":[33],"finding":[34],"a":[35,188],"robust":[36],"scaffold":[37],"system":[38],"remains":[39],"tissue":[43],"engineering.":[44],"In":[45],"this":[46],"study,":[47],"silk":[48,86,213],"fibroin":[49,214],"porous":[50,111,144,194],"microspheres":[51,104,123,133,145,162,195,215],"were":[52,163],"fabricated":[53],"using":[54],"co-axial":[56],"electrospraying":[57],"technique,":[58],"followed":[59],"by":[60],"ethanol":[61,77],"treatment":[62],"induce":[64],"crosslinking":[65],"enhance":[67],"microsphere":[68,87],"stability.":[69],"Interestingly,":[70],"we":[71,114],"observed":[72],"that":[73,212],"while":[74],"changing":[75],"concentration":[78],"from":[79,107],"100%":[80],"75%":[82],"crosslink":[84],"resulted":[88],"formation":[91],"tunable":[93],"micropores,":[94],"with":[95],"pore":[96,158],"sizes":[97],"up":[98],"87":[100],"\u03bcm":[101,109],"nonporous":[103,152,197],"ranging":[106],"80-200":[108],"microspheres.":[112],"Then,":[113],"seeded":[115],"human":[116],"adipose-derived":[117],"mesenchymal":[118],"stem":[119],"cells":[120],"(hAdMSCs)":[121],"onto":[122],"evaluate":[125],"cell":[126,136,148,223],"adhesion":[127,137],"proliferation":[129],"over":[130],"time.":[131],"The":[132],"exhibited":[134],"enhanced":[135,202],"during":[138],"vitro":[140],"cytocompatibility":[141],"assessments.":[142],"Notably,":[143],"displayed":[146],"superior":[147],"migration":[149],"compared":[150],"microspheres,":[153],"attributed":[154],"their":[156,167,201],"interconnected":[157],"architecture.":[159],"Additionally,":[160],"hAdMSCs-laden":[161],"further":[164],"studied":[165],"for":[166,229],"chondrogenic":[168],"potential":[169],"under":[170],"induction":[171],"conditions,":[172],"demonstrating":[173],"cartilage-specific":[174],"marker":[175],"expression.":[176],"Moreover,":[177],"macroscopic":[178],"observations":[179],"histological":[181],"staining":[182],"images":[183],"showed":[184],"regeneration":[186],"rabbit":[189],"cartilage-defect":[190],"model,":[191],"outperformed":[196],"counterparts":[198],"nutrient":[203],"transfer":[204],"host-scaffold":[206],"integration.":[207],"Together,":[208],"these":[209],"results":[210],"suggest":[211],"can":[216],"mimic":[217],"extracellular":[219],"matrix":[220,227],"microenvironment,":[221],"support":[222],"growth,":[224],"promote":[226],"accumulation":[228],"effective":[230],"repair.":[232]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-11-11T00:00:00"}