{"id":"https://openalex.org/W7225664506","doi":"https://doi.org/10.3389/fimmu.2026.1969319","title":"Gut microbiome dysbiosis as a convergent contributor of neurodegenerative disease: unifying mechanistic pathways and emerging precision microbiome-directed therapies","display_name":"Gut microbiome dysbiosis as a convergent contributor of neurodegenerative disease: unifying mechanistic pathways and emerging precision microbiome-directed therapies","publication_year":2026,"publication_date":"2026-11-09","ids":{"openalex":"https://openalex.org/W7225664506","doi":"https://doi.org/10.3389/fimmu.2026.1969319"},"language":"en","primary_location":{"id":"doi:10.3389/fimmu.2026.1969319","doi":"https://doi.org/10.3389/fimmu.2026.1969319","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2026.1969319","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1969319/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1969319/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002765725","display_name":"Yangtian Chen","orcid":"https://orcid.org/0000-0001-5674-6774","observed_orcids":["https://orcid.org/0000-0001-5674-6774"]},"institutions":[{"id":"https://openalex.org/I199305430","display_name":"Nantong University","ror":"https://ror.org/02afcvw97","country_code":"CN","type":"education","lineage":["https://openalex.org/I199305430"]},{"id":"https://openalex.org/I4210086801","display_name":"Affiliated Hospital of Nantong University","ror":"https://ror.org/001rahr89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210086801"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yangtian Chen","raw_affiliation_strings":["Department of Anesthesiology, Affiliated Hospital of Nantong University, Medical School of Nantong University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Affiliated Hospital of Nantong University, Medical School of Nantong University","institution_ids":["https://openalex.org/I199305430","https://openalex.org/I4210086801"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161333677","display_name":"Yiwen Cheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210166576","display_name":"First Affiliated Hospital Zhejiang University","ror":"https://ror.org/05m1p5x56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166576"]},{"id":"https://openalex.org/I4391768041","display_name":"State Key Laboratory of Diagnosis and Treatment of Infectious Diseases","ror":"https://ror.org/00325dg83","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4391768041","https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yiwen Cheng","raw_affiliation_strings":["State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, National Medical Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, National Medical Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine","institution_ids":["https://openalex.org/I4210166576","https://openalex.org/I4391768041"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161324114","display_name":"Shengyu Huang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210166576","display_name":"First Affiliated Hospital Zhejiang University","ror":"https://ror.org/05m1p5x56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166576"]},{"id":"https://openalex.org/I4391768041","display_name":"State Key Laboratory of Diagnosis and Treatment of Infectious Diseases","ror":"https://ror.org/00325dg83","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4391768041","https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shengyu Huang","raw_affiliation_strings":["State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, National Medical Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, National Medical Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine","institution_ids":["https://openalex.org/I4210166576","https://openalex.org/I4391768041"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161337555","display_name":"Xia Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210166576","display_name":"First Affiliated Hospital Zhejiang University","ror":"https://ror.org/05m1p5x56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166576"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xia Liu","raw_affiliation_strings":["Department of Intensive Care Unit, The First Affiliated Hospital, Zhejiang University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Intensive Care Unit, The First Affiliated Hospital, Zhejiang University School of Medicine","institution_ids":["https://openalex.org/I4210166576","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074899069","display_name":"Xiaocui Xu","orcid":"https://orcid.org/0000-0003-2488-3664","observed_orcids":["https://orcid.org/0000-0003-2488-3664"]},"institutions":[{"id":"https://openalex.org/I199305430","display_name":"Nantong University","ror":"https://ror.org/02afcvw97","country_code":"CN","type":"education","lineage":["https://openalex.org/I199305430"]},{"id":"https://openalex.org/I4210086801","display_name":"Affiliated Hospital of Nantong University","ror":"https://ror.org/001rahr89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210086801"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaocui Xu","raw_affiliation_strings":["Department of Anesthesiology, Affiliated Hospital of Nantong University, Medical School of Nantong University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Affiliated Hospital of Nantong University, Medical School of Nantong University","institution_ids":["https://openalex.org/I199305430","https://openalex.org/I4210086801"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5123981781","display_name":"Pingping Hu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I199305430","display_name":"Nantong University","ror":"https://ror.org/02afcvw97","country_code":"CN","type":"education","lineage":["https://openalex.org/I199305430"]},{"id":"https://openalex.org/I4210086801","display_name":"Affiliated Hospital of Nantong University","ror":"https://ror.org/001rahr89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210086801"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Pingping Hu","raw_affiliation_strings":["Department of Anesthesiology, Affiliated Hospital of Nantong University, Medical School of Nantong University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Affiliated Hospital of Nantong University, Medical School of Nantong University","institution_ids":["https://openalex.org/I199305430","https://openalex.org/I4210086801"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101277380","display_name":"Lingbin Wu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lingbin Wu","raw_affiliation_strings":["Department of Laboratory Medicine, Lishui Second People\u2019s Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, Lishui Second People\u2019s Hospital","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003094236","display_name":"Zongxin Ling","orcid":"https://orcid.org/0000-0001-9662-099X","observed_orcids":["https://orcid.org/0000-0001-9662-099X"]},"institutions":[{"id":"https://openalex.org/I4210166576","display_name":"First Affiliated Hospital Zhejiang University","ror":"https://ror.org/05m1p5x56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166576"]},{"id":"https://openalex.org/I4391768041","display_name":"State Key Laboratory of Diagnosis and Treatment of Infectious Diseases","ror":"https://ror.org/00325dg83","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4391768041","https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zongxin Ling","raw_affiliation_strings":["State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, National Medical Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, National Medical Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine","institution_ids":["https://openalex.org/I4210166576","https://openalex.org/I4391768041"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5126608910","display_name":"Yongtao Gao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I199305430","display_name":"Nantong University","ror":"https://ror.org/02afcvw97","country_code":"CN","type":"education","lineage":["https://openalex.org/I199305430"]},{"id":"https://openalex.org/I4210086801","display_name":"Affiliated Hospital of Nantong University","ror":"https://ror.org/001rahr89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210086801"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yongtao Gao","raw_affiliation_strings":["Department of Anesthesiology, Affiliated Hospital of Nantong University, Medical School of Nantong University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Affiliated Hospital of Nantong University, Medical School of Nantong University","institution_ids":["https://openalex.org/I199305430","https://openalex.org/I4210086801"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070595242","display_name":"Guangyong Cai","orcid":"https://orcid.org/0009-0005-0628-140X","observed_orcids":["https://orcid.org/0009-0005-0628-140X"]},"institutions":[{"id":"https://openalex.org/I4210125219","display_name":"Lishui City People's Hospital","ror":"https://ror.org/028yz2737","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210125219"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Guangyong Cai","raw_affiliation_strings":["Lishui Key Laboratory of Brain Health and Severe Brain Disorders, Department of Rehabilitation, Lishui Second People\u2019s Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lishui Key Laboratory of Brain Health and Severe Brain Disorders, Department of Rehabilitation, Lishui Second People\u2019s Hospital","institution_ids":["https://openalex.org/I4210125219"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5003094236","https://openalex.org/A5070595242","https://openalex.org/A5126608910"],"corresponding_institution_ids":["https://openalex.org/I199305430","https://openalex.org/I4210086801","https://openalex.org/I4210125219","https://openalex.org/I4210166576","https://openalex.org/I4391768041"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gut-dysbiosis","display_name":"gut dysbiosis","score":0.9350000023841858},{"id":"https://openalex.org/keywords/neurodegenerative-diseases","display_name":"neurodegenerative diseases","score":0.9869999885559082},{"id":"https://openalex.org/keywords/microbiota-gut-brain-axis","display_name":"microbiota-gut-brain axis","score":0.9950000047683716},{"id":"https://openalex.org/keywords/host-microbiome-interactions","display_name":"host-microbiome interactions","score":0.902999997138977},{"id":"https://openalex.org/keywords/metabolic-reprogramming","display_name":"metabolic reprogramming","score":0.9869999885559082},{"id":"https://openalex.org/keywords/mitochondrial-dysfunction","display_name":"mitochondrial dysfunction","score":0.9570000171661377},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":1.0},{"id":"https://openalex.org/keywords/protein-aggregation","display_name":"protein aggregation","score":0.8190000057220459},{"id":"https://openalex.org/keywords/probiotics","display_name":"probiotics","score":0.7749999761581421},{"id":"https://openalex.org/keywords/fecal-microbiota-transplantation","display_name":"fecal microbiota transplantation","score":0.9279999732971191},{"id":"https://openalex.org/keywords/dietary-modulation","display_name":"dietary modulation","score":0.9089999794960022},{"id":"https://openalex.org/keywords/patient-stratification","display_name":"patient stratification","score":0.9620000123977661}],"concepts":[{"id":"https://openalex.org/C2777165150","wikidata":"https://www.wikidata.org/wiki/Q269334","display_name":"Dysbiosis","level":3,"score":0.76419997215271},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.691100001335144},{"id":"https://openalex.org/C143121216","wikidata":"https://www.wikidata.org/wiki/Q1330402","display_name":"Microbiome","level":2,"score":0.65420001745224},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6136000156402588},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6122999787330627},{"id":"https://openalex.org/C539455810","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut flora","level":2,"score":0.5849000215530396},{"id":"https://openalex.org/C177857423","wikidata":"https://www.wikidata.org/wiki/Q17077315","display_name":"Gut\u2013brain axis","level":3,"score":0.5717999935150146},{"id":"https://openalex.org/C3019978661","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut microbiome","level":3,"score":0.5060999989509583},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4903999865055084},{"id":"https://openalex.org/C2777439022","wikidata":"https://www.wikidata.org/wiki/Q586582","display_name":"Enteric nervous system","level":2,"score":0.41850000619888306},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.4081999957561493},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.40720000863075256},{"id":"https://openalex.org/C15151743","wikidata":"https://www.wikidata.org/wiki/Q903778","display_name":"Metagenomics","level":3,"score":0.4025999903678894},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.38609999418258667},{"id":"https://openalex.org/C2781071285","wikidata":"https://www.wikidata.org/wiki/Q17141320","display_name":"Intestinal permeability","level":2,"score":0.3752000033855438},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.37209999561309814},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3628999888896942},{"id":"https://openalex.org/C137923570","wikidata":"https://www.wikidata.org/wiki/Q2121103","display_name":"Fecal bacteriotherapy","level":4,"score":0.35429999232292175},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.3052999973297119},{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.3034999966621399},{"id":"https://openalex.org/C2778271842","wikidata":"https://www.wikidata.org/wiki/Q838966","display_name":"Irritable bowel syndrome","level":2,"score":0.29440000653266907},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2791999876499176},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.27790001034736633},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.27790001034736633},{"id":"https://openalex.org/C3018449070","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signalling pathways","level":3,"score":0.2759000062942505},{"id":"https://openalex.org/C2908713948","wikidata":"https://www.wikidata.org/wiki/Q104117645","display_name":"Intestinal Microbiome","level":3,"score":0.26600000262260437},{"id":"https://openalex.org/C3017616150","wikidata":"https://www.wikidata.org/wiki/Q1069330","display_name":"Diagnostic biomarker","level":3,"score":0.26440000534057617},{"id":"https://openalex.org/C545706735","wikidata":"https://www.wikidata.org/wiki/Q9404","display_name":"Nervous system","level":2,"score":0.258899986743927},{"id":"https://openalex.org/C19843653","wikidata":"https://www.wikidata.org/wiki/Q213907","display_name":"Model organism","level":3,"score":0.25130000710487366}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3389/fimmu.2026.1969319","doi":"https://doi.org/10.3389/fimmu.2026.1969319","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2026.1969319","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1969319/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.3389/fimmu.2026.1969319","doi":"https://doi.org/10.3389/fimmu.2026.1969319","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2026.1969319","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1969319/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320327046","display_name":"State Key Laboratory for Diagnosis and Treatment of Infectious Diseases","ror":"https://ror.org/00325dg83"},{"id":"https://openalex.org/F4320335787","display_name":"Fundamental Research Funds for the Central Universities","ror":null},{"id":"https://openalex.org/F4320338464","display_name":"Natural Science Foundation of Zhejiang Province","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225664506.pdf","grobid_xml":"https://content.openalex.org/works/W7225664506.grobid-xml"},"referenced_works_count":218,"referenced_works":["https://openalex.org/W1903888485","https://openalex.org/W1934236512","https://openalex.org/W2011348831","https://openalex.org/W2050286820","https://openalex.org/W2084357246","https://openalex.org/W2149074973","https://openalex.org/W2288501492","https://openalex.org/W2426632426","https://openalex.org/W2508213551","https://openalex.org/W2558041282","https://openalex.org/W2587959748","https://openalex.org/W2596435933","https://openalex.org/W2608965099","https://openalex.org/W2612729422","https://openalex.org/W2751157908","https://openalex.org/W2761210275","https://openalex.org/W2793397992","https://openalex.org/W2799884346","https://openalex.org/W2890247534","https://openalex.org/W2944552216","https://openalex.org/W2951517287","https://openalex.org/W2977367243","https://openalex.org/W2997490540","https://openalex.org/W3000157665","https://openalex.org/W3006768295","https://openalex.org/W3012484557","https://openalex.org/W3025223791","https://openalex.org/W3027118763","https://openalex.org/W3037122402","https://openalex.org/W3045452138","https://openalex.org/W3082564026","https://openalex.org/W3089396603","https://openalex.org/W3097064104","https://openalex.org/W3118415136","https://openalex.org/W3120841302","https://openalex.org/W3127379712","https://openalex.org/W3132116259","https://openalex.org/W3146836254","https://openalex.org/W3175256745","https://openalex.org/W3195808516","https://openalex.org/W3203109723","https://openalex.org/W3209951581","https://openalex.org/W3211533091","https://openalex.org/W3214125514","https://openalex.org/W3214589207","https://openalex.org/W3215471611","https://openalex.org/W3215904323","https://openalex.org/W4205338927","https://openalex.org/W4205343758","https://openalex.org/W4221131751","https://openalex.org/W4224256339","https://openalex.org/W4283465314","https://openalex.org/W4284664007","https://openalex.org/W4285727748","https://openalex.org/W4285740412","https://openalex.org/W4285744853","https://openalex.org/W4293288643","https://openalex.org/W4294090794","https://openalex.org/W4295977667","https://openalex.org/W4308542736","https://openalex.org/W4309109636","https://openalex.org/W4310356800","https://openalex.org/W4313414699","https://openalex.org/W4313442714","https://openalex.org/W4318680477","https://openalex.org/W4320919870","https://openalex.org/W4362671036","https://openalex.org/W4366090812","https://openalex.org/W4367835000","https://openalex.org/W4372332826","https://openalex.org/W4379094985","https://openalex.org/W4379795387","https://openalex.org/W4380363720","https://openalex.org/W4380551368","https://openalex.org/W4384558382","https://openalex.org/W4384665281","https://openalex.org/W4385336362","https://openalex.org/W4385393692","https://openalex.org/W4385828734","https://openalex.org/W4386049932","https://openalex.org/W4386530908","https://openalex.org/W4387339892","https://openalex.org/W4388785129","https://openalex.org/W4388871750","https://openalex.org/W4389740423","https://openalex.org/W4389752501","https://openalex.org/W4390053591","https://openalex.org/W4390456305","https://openalex.org/W4390696068","https://openalex.org/W4391533329","https://openalex.org/W4391541669","https://openalex.org/W4391992243","https://openalex.org/W4392195768","https://openalex.org/W4392783067","https://openalex.org/W4393224953","https://openalex.org/W4393392928","https://openalex.org/W4394702428","https://openalex.org/W4396242074","https://openalex.org/W4396611146","https://openalex.org/W4396615455","https://openalex.org/W4396814673","https://openalex.org/W4398160665","https://openalex.org/W4399861320","https://openalex.org/W4399916283","https://openalex.org/W4400102126","https://openalex.org/W4400309919","https://openalex.org/W4401338644","https://openalex.org/W4401433678","https://openalex.org/W4401662525","https://openalex.org/W4401846764","https://openalex.org/W4401858405","https://openalex.org/W4401909814","https://openalex.org/W4402168452","https://openalex.org/W4402348774","https://openalex.org/W4402405870","https://openalex.org/W4402713418","https://openalex.org/W4402781784","https://openalex.org/W4403044398","https://openalex.org/W4403687184","https://openalex.org/W4403785417","https://openalex.org/W4403790644","https://openalex.org/W4403888562","https://openalex.org/W4404091177","https://openalex.org/W4404092745","https://openalex.org/W4404277710","https://openalex.org/W4404295857","https://openalex.org/W4405484004","https://openalex.org/W4405577416","https://openalex.org/W4406200860","https://openalex.org/W4406597262","https://openalex.org/W4407040316","https://openalex.org/W4407399904","https://openalex.org/W4407592267","https://openalex.org/W4407595040","https://openalex.org/W4407665388","https://openalex.org/W4407756881","https://openalex.org/W4407792011","https://openalex.org/W4407942411","https://openalex.org/W4408072034","https://openalex.org/W4408072726","https://openalex.org/W4408162031","https://openalex.org/W4409013794","https://openalex.org/W4409194855","https://openalex.org/W4409379390","https://openalex.org/W4409380011","https://openalex.org/W4409434073","https://openalex.org/W4409525758","https://openalex.org/W4409739257","https://openalex.org/W4409835317","https://openalex.org/W4409872336","https://openalex.org/W4409962634","https://openalex.org/W4410005726","https://openalex.org/W4410041831","https://openalex.org/W4410106680","https://openalex.org/W4410166485","https://openalex.org/W4410302178","https://openalex.org/W4410556362","https://openalex.org/W4410810945","https://openalex.org/W4410816243","https://openalex.org/W4410910218","https://openalex.org/W4410983686","https://openalex.org/W4411371560","https://openalex.org/W4411423642","https://openalex.org/W4411705110","https://openalex.org/W4412158343","https://openalex.org/W4412175910","https://openalex.org/W4412177470","https://openalex.org/W4412521029","https://openalex.org/W4412711610","https://openalex.org/W4412734819","https://openalex.org/W4412833275","https://openalex.org/W4412998209","https://openalex.org/W4413094752","https://openalex.org/W4413106888","https://openalex.org/W4413111678","https://openalex.org/W4413115178","https://openalex.org/W4413178434","https://openalex.org/W4413274991","https://openalex.org/W4413426387","https://openalex.org/W4413601453","https://openalex.org/W4413910463","https://openalex.org/W4414168707","https://openalex.org/W4414292105","https://openalex.org/W4414701880","https://openalex.org/W4415054501","https://openalex.org/W4415147134","https://openalex.org/W4415205332","https://openalex.org/W4415362006","https://openalex.org/W4415407174","https://openalex.org/W4415461903","https://openalex.org/W4415560195","https://openalex.org/W4415671602","https://openalex.org/W4416003472","https://openalex.org/W4416145061","https://openalex.org/W4416180316","https://openalex.org/W4416291839","https://openalex.org/W4416377658","https://openalex.org/W4416721874","https://openalex.org/W4416851806","https://openalex.org/W4416988162","https://openalex.org/W4417241826","https://openalex.org/W7117482957","https://openalex.org/W7117586183","https://openalex.org/W7117739308","https://openalex.org/W7127562126","https://openalex.org/W7128614759","https://openalex.org/W7130502496","https://openalex.org/W7133303255","https://openalex.org/W7140059822","https://openalex.org/W7154481540","https://openalex.org/W7155648564","https://openalex.org/W7158905090","https://openalex.org/W7160504269","https://openalex.org/W7161858611","https://openalex.org/W7163925783","https://openalex.org/W7164888415","https://openalex.org/W7165148984","https://openalex.org/W7196961168"],"related_works":["https://openalex.org/W4405137363","https://openalex.org/W7221806429","https://openalex.org/W7160847255","https://openalex.org/W7203458605","https://openalex.org/W3211236278","https://openalex.org/W4412702381","https://openalex.org/W4414168707","https://openalex.org/W7219267708","https://openalex.org/W4386568406","https://openalex.org/W4401930970"],"abstract_inverted_index":{"Neurodegenerative":[0],"diseases":[1],"(NDDs)":[2],"are":[3],"increasingly":[4],"recognized":[5],"as":[6],"systemic":[7],"disorders":[8],"shaped":[9],"by":[10,23,30],"the":[11,42,71],"microbiota-gut-brain":[12],"axis.":[13],"Within":[14],"this":[15],"framework,":[16],"gut":[17],"microbiome":[18],"dysbiosis":[19],"is":[20],"better":[21],"defined":[22],"reproducible":[24],"modules":[25],"of":[26],"functional":[27],"imbalance":[28],"than":[29],"isolated":[31],"taxonomic":[32],"shifts.":[33],"These":[34],"aberrant":[35,55],"microbial":[36],"networks":[37],"transmit":[38],"peripheral":[39,62],"signals":[40],"to":[41,99],"central":[43],"nervous":[44],"system":[45],"through":[46],"three":[47],"interconnected":[48],"routes:":[49],"immune-inflammatory":[50],"activation,":[51],"metabolic":[52],"reprogramming,":[53],"and":[54,57,80,101,112,130],"vagal":[56],"humoral":[58],"neural":[59],"transmission.":[60],"Because":[61],"inputs":[63],"may":[64,97],"converge":[65],"on":[66],"shared":[67],"downstream":[68],"pathways":[69],"within":[70],"brain,":[72],"they":[73],"can":[74],"drive":[75],"mitochondrial":[76],"decompensation,":[77],"oxidative":[78],"stress,":[79],"pathological":[81],"protein":[82],"aggregation.":[83],"This":[84],"review":[85],"integrates":[86],"current":[87],"evidence":[88],"into":[89],"a":[90,121,132],"conceptual":[91],"framework":[92],"describing":[93],"how":[94],"host-microbiome":[95],"interactions":[96],"contribute":[98],"neurodegeneration":[100],"then":[102],"critically":[103],"appraises":[104],"microbiome-targeted":[105],"interventions,":[106],"including":[107],"dietary":[108],"modulation,":[109],"next-generation":[110],"probiotics,":[111],"fecal":[113],"microbiota":[114],"transplantation.":[115],"Moving":[116],"from":[117],"correlation-based":[118],"reasoning":[119],"toward":[120,134],"causal,":[122],"mechanism-driven":[123],"account,":[124],"we":[125],"argue":[126],"for":[127],"patient":[128],"stratification":[129],"outline":[131],"path":[133],"precision":[135],"microecological":[136],"therapies":[137],"against":[138],"NDDs.":[139]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-10T00:00:00"}
