{"id":"https://openalex.org/W7225664415","doi":"https://doi.org/10.1016/j.biopha.2026.120028","title":"Formononetin disrupts MRSA biofilm via potential SarA-associated regulatory modulation","display_name":"Formononetin disrupts MRSA biofilm via potential SarA-associated regulatory modulation","publication_year":2026,"publication_date":"2026-11-09","ids":{"openalex":"https://openalex.org/W7225664415","doi":"https://doi.org/10.1016/j.biopha.2026.120028","pmid":"https://pubmed.ncbi.nlm.nih.gov/43002829"},"language":"en","primary_location":{"id":"doi:10.1016/j.biopha.2026.120028","doi":"https://doi.org/10.1016/j.biopha.2026.120028","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.biopha.2026.120028","pdf_url":null,"source":{"id":"https://openalex.org/S15111687","display_name":"Biomedicine & Pharmacotherapy","issn_l":"0753-3322","issn":["0753-3322","1950-6007"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-2","ki-jl-1","medline","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicine & Pharmacotherapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.biopha.2026.120028","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027732012","display_name":"Atlanta Borah","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210092980","display_name":"National Institute of Animal Biotechnology","ror":"https://ror.org/00f6a9h42","country_code":"IN","type":"facility","lineage":["https://openalex.org/I4210092980"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Atlanta Borah","raw_affiliation_strings":["Biotechnology Research Innovation Council - National Institute of Animal Biotechnology (BRIC-NIAB), Gachibowli, Hyderabad, Telangana 500032, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biotechnology Research Innovation Council - National Institute of Animal Biotechnology (BRIC-NIAB), Gachibowli, Hyderabad, Telangana 500032, India","institution_ids":["https://openalex.org/I4210092980"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161352820","display_name":"Jashaswi Priyadarshini Jena","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210092980","display_name":"National Institute of Animal Biotechnology","ror":"https://ror.org/00f6a9h42","country_code":"IN","type":"facility","lineage":["https://openalex.org/I4210092980"]},{"id":"https://openalex.org/I4210094671","display_name":"Regional Centre for Biotechnology","ror":"https://ror.org/00nc5f834","country_code":"IN","type":"government","lineage":["https://openalex.org/I4210094671"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Jashaswi Priyadarshini Jena","raw_affiliation_strings":["Biotechnology Research Innovation Council - National Institute of Animal Biotechnology (BRIC-NIAB), Gachibowli, Hyderabad, Telangana 500032, India; Regional Centre for Biotechnology (RCB), Faridabad, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biotechnology Research Innovation Council - National Institute of Animal Biotechnology (BRIC-NIAB), Gachibowli, Hyderabad, Telangana 500032, India; Regional Centre for Biotechnology (RCB), Faridabad, India","institution_ids":["https://openalex.org/I4210092980","https://openalex.org/I4210094671"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080156300","display_name":"Macha Vijay","orcid":"https://orcid.org/0000-0002-8884-3429","observed_orcids":["https://orcid.org/0000-0002-8884-3429"]},"institutions":[{"id":"https://openalex.org/I4210092980","display_name":"National Institute of Animal Biotechnology","ror":"https://ror.org/00f6a9h42","country_code":"IN","type":"facility","lineage":["https://openalex.org/I4210092980"]},{"id":"https://openalex.org/I4210094671","display_name":"Regional Centre for Biotechnology","ror":"https://ror.org/00nc5f834","country_code":"IN","type":"government","lineage":["https://openalex.org/I4210094671"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Macha Vijay","raw_affiliation_strings":["Biotechnology Research Innovation Council - National Institute of Animal Biotechnology (BRIC-NIAB), Gachibowli, Hyderabad, Telangana 500032, India; Regional Centre for Biotechnology (RCB), Faridabad, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biotechnology Research Innovation Council - National Institute of Animal Biotechnology (BRIC-NIAB), Gachibowli, Hyderabad, Telangana 500032, India; Regional Centre for Biotechnology (RCB), Faridabad, India","institution_ids":["https://openalex.org/I4210092980","https://openalex.org/I4210094671"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068369998","display_name":"Annie Okram","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210092980","display_name":"National Institute of Animal Biotechnology","ror":"https://ror.org/00f6a9h42","country_code":"IN","type":"facility","lineage":["https://openalex.org/I4210092980"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Annie Okram","raw_affiliation_strings":["Biotechnology Research Innovation Council - National Institute of Animal Biotechnology (BRIC-NIAB), Gachibowli, Hyderabad, Telangana 500032, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biotechnology Research Innovation Council - National Institute of Animal Biotechnology (BRIC-NIAB), Gachibowli, Hyderabad, Telangana 500032, India","institution_ids":["https://openalex.org/I4210092980"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161315073","display_name":"Gowtham M","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I179420787","display_name":"Indian Council of Agricultural Research","ror":"https://ror.org/04fw54a43","country_code":"IN","type":"government","lineage":["https://openalex.org/I179420787"]},{"id":"https://openalex.org/I4210131297","display_name":"ICAR - National Meat Research Institute","ror":"https://ror.org/03bjcbf76","country_code":"IN","type":"facility","lineage":["https://openalex.org/I179420787","https://openalex.org/I4210131297"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Gowtham M","raw_affiliation_strings":["Indian Council of Agricultural Research - National Meat Research Institute (NMRI), Hyderabad, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indian Council of Agricultural Research - National Meat Research Institute (NMRI), Hyderabad, India","institution_ids":["https://openalex.org/I179420787","https://openalex.org/I4210131297"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161311660","display_name":"Niveditha P","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I179420787","display_name":"Indian Council of Agricultural Research","ror":"https://ror.org/04fw54a43","country_code":"IN","type":"government","lineage":["https://openalex.org/I179420787"]},{"id":"https://openalex.org/I4210131297","display_name":"ICAR - National Meat Research Institute","ror":"https://ror.org/03bjcbf76","country_code":"IN","type":"facility","lineage":["https://openalex.org/I179420787","https://openalex.org/I4210131297"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Niveditha P","raw_affiliation_strings":["Indian Council of Agricultural Research - National Meat Research Institute (NMRI), Hyderabad, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indian Council of Agricultural Research - National Meat Research Institute (NMRI), Hyderabad, India","institution_ids":["https://openalex.org/I179420787","https://openalex.org/I4210131297"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050574611","display_name":"Sukhadeo Baliram Barbuddhe","orcid":"https://orcid.org/0000-0002-6543-9757","observed_orcids":["https://orcid.org/0000-0002-6543-9757"]},"institutions":[{"id":"https://openalex.org/I179420787","display_name":"Indian Council of Agricultural Research","ror":"https://ror.org/04fw54a43","country_code":"IN","type":"government","lineage":["https://openalex.org/I179420787"]},{"id":"https://openalex.org/I4210131297","display_name":"ICAR - National Meat Research Institute","ror":"https://ror.org/03bjcbf76","country_code":"IN","type":"facility","lineage":["https://openalex.org/I179420787","https://openalex.org/I4210131297"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sukhadeo B. Barbuddhe","raw_affiliation_strings":["Indian Council of Agricultural Research - National Meat Research Institute (NMRI), Hyderabad, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indian Council of Agricultural Research - National Meat Research Institute (NMRI), Hyderabad, India","institution_ids":["https://openalex.org/I179420787","https://openalex.org/I4210131297"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053470353","display_name":"Nagendra R. Hegde","orcid":"https://orcid.org/0000-0001-5260-2159","observed_orcids":["https://orcid.org/0000-0001-5260-2159"]},"institutions":[{"id":"https://openalex.org/I4210092980","display_name":"National Institute of Animal Biotechnology","ror":"https://ror.org/00f6a9h42","country_code":"IN","type":"facility","lineage":["https://openalex.org/I4210092980"]},{"id":"https://openalex.org/I4210094671","display_name":"Regional Centre for Biotechnology","ror":"https://ror.org/00nc5f834","country_code":"IN","type":"government","lineage":["https://openalex.org/I4210094671"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Nagendra R. Hegde","raw_affiliation_strings":["Biotechnology Research Innovation Council - National Institute of Animal Biotechnology (BRIC-NIAB), Gachibowli, Hyderabad, Telangana 500032, India; Regional Centre for Biotechnology (RCB), Faridabad, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biotechnology Research Innovation Council - National Institute of Animal Biotechnology (BRIC-NIAB), Gachibowli, Hyderabad, Telangana 500032, India; Regional Centre for Biotechnology (RCB), Faridabad, India","institution_ids":["https://openalex.org/I4210092980","https://openalex.org/I4210094671"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035706545","display_name":"Deepak Bhiva Rawool","orcid":"https://orcid.org/0000-0002-6173-4708","observed_orcids":["https://orcid.org/0000-0002-6173-4708"]},"institutions":[{"id":"https://openalex.org/I179420787","display_name":"Indian Council of Agricultural Research","ror":"https://ror.org/04fw54a43","country_code":"IN","type":"government","lineage":["https://openalex.org/I179420787"]},{"id":"https://openalex.org/I4210131297","display_name":"ICAR - National Meat Research Institute","ror":"https://ror.org/03bjcbf76","country_code":"IN","type":"facility","lineage":["https://openalex.org/I179420787","https://openalex.org/I4210131297"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Deepak B. Rawool","raw_affiliation_strings":["Indian Council of Agricultural Research - National Meat Research Institute (NMRI), Hyderabad, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indian Council of Agricultural Research - National Meat Research Institute (NMRI), Hyderabad, India","institution_ids":["https://openalex.org/I179420787","https://openalex.org/I4210131297"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060982236","display_name":"Anand Srivastava","orcid":"https://orcid.org/0000-0002-2031-4643","observed_orcids":["https://orcid.org/0000-0002-2031-4643"]},"institutions":[{"id":"https://openalex.org/I4210092980","display_name":"National Institute of Animal Biotechnology","ror":"https://ror.org/00f6a9h42","country_code":"IN","type":"facility","lineage":["https://openalex.org/I4210092980"]},{"id":"https://openalex.org/I4210094671","display_name":"Regional Centre for Biotechnology","ror":"https://ror.org/00nc5f834","country_code":"IN","type":"government","lineage":["https://openalex.org/I4210094671"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Anand Srivastava","raw_affiliation_strings":["Biotechnology Research Innovation Council - National Institute of Animal Biotechnology (BRIC-NIAB), Gachibowli, Hyderabad, Telangana 500032, India; Regional Centre for Biotechnology (RCB), Faridabad, India. Electronic address: anand@niab.org.in"],"raw_orcid":"https://orcid.org/0000-0002-2031-4643","affiliations":[{"raw_affiliation_string":"Biotechnology Research Innovation Council - National Institute of Animal Biotechnology (BRIC-NIAB), Gachibowli, Hyderabad, Telangana 500032, India; Regional Centre for Biotechnology (RCB), Faridabad, India. Electronic address: anand@niab.org.in","institution_ids":["https://openalex.org/I4210092980","https://openalex.org/I4210094671"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5060982236"],"corresponding_institution_ids":["https://openalex.org/I4210092980","https://openalex.org/I4210094671"],"apc_list":{"value":3610,"currency":"USD","value_usd":3610},"apc_paid":{"value":3610,"currency":"USD","value_usd":3610},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"205","issue":null,"first_page":"120028","last_page":"120028"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10593","display_name":"Bacterial biofilms and quorum sensing","score":0.7056000232696533,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10593","display_name":"Bacterial biofilms and quorum sensing","score":0.7056000232696533,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10195","display_name":"Antimicrobial Resistance in Staphylococcus","score":0.2797999978065491,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10225","display_name":"Essential Oils and Antimicrobial Activity","score":0.006599999964237213,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/formononetin","display_name":"formononetin","score":1.0},{"id":"https://openalex.org/keywords/methicillin-resistant-staphylococcus-aureus","display_name":"methicillin-resistant Staphylococcus aureus","score":0.9599999785423279},{"id":"https://openalex.org/keywords/biofilm-eradication","display_name":"biofilm eradication","score":0.7590000033378601},{"id":"https://openalex.org/keywords/licorice","display_name":"licorice","score":0.9810000061988831},{"id":"https://openalex.org/keywords/natural-antibacterial-agents","display_name":"natural antibacterial agents","score":0.5870000123977661},{"id":"https://openalex.org/keywords/antibiotic-synergy","display_name":"antibiotic synergy","score":0.6600000262260437},{"id":"https://openalex.org/keywords/galleria-mellonella-infection-model","display_name":"Galleria mellonella infection model","score":0.7590000033378601},{"id":"https://openalex.org/keywords/hemolytic-activity","display_name":"hemolytic activity","score":0.8740000128746033},{"id":"https://openalex.org/keywords/agrc","display_name":"AgrC","score":0.9739999771118164},{"id":"https://openalex.org/keywords/dna-binding-sites","display_name":"DNA binding sites","score":0.40700000524520874},{"id":"https://openalex.org/keywords/binding-affinity","display_name":"binding affinity","score":0.3490000069141388}],"concepts":[{"id":"https://openalex.org/C2776578907","wikidata":"https://www.wikidata.org/wiki/Q408859","display_name":"Formononetin","level":4,"score":0.9502999782562256},{"id":"https://openalex.org/C58123911","wikidata":"https://www.wikidata.org/wiki/Q467410","display_name":"Biofilm","level":3,"score":0.8051000237464905},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7199000120162964},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.49050000309944153},{"id":"https://openalex.org/C25824698","wikidata":"https://www.wikidata.org/wiki/Q6840012","display_name":"Microscale thermophoresis","level":2,"score":0.45320001244544983},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.43320000171661377},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.39969998598098755},{"id":"https://openalex.org/C2779489039","wikidata":"https://www.wikidata.org/wiki/Q188121","display_name":"Staphylococcus aureus","level":3,"score":0.3950999975204468},{"id":"https://openalex.org/C183978625","wikidata":"https://www.wikidata.org/wiki/Q903596","display_name":"Electrophoretic mobility shift assay","level":4,"score":0.39419999718666077},{"id":"https://openalex.org/C2776460866","wikidata":"https://www.wikidata.org/wiki/Q170065","display_name":"Pathogen","level":2,"score":0.299699991941452},{"id":"https://openalex.org/C201663137","wikidata":"https://www.wikidata.org/wiki/Q21198990","display_name":"Periplasmic space","level":4,"score":0.28929999470710754},{"id":"https://openalex.org/C176947019","wikidata":"https://www.wikidata.org/wiki/Q597889","display_name":"Minimum inhibitory concentration","level":3,"score":0.28790000081062317},{"id":"https://openalex.org/C2780133158","wikidata":"https://www.wikidata.org/wiki/Q414501","display_name":"Piperine","level":2,"score":0.26510000228881836},{"id":"https://openalex.org/C41685203","wikidata":"https://www.wikidata.org/wiki/Q1974042","display_name":"Docking (animal)","level":2,"score":0.2639999985694885},{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.26350000500679016},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.2524000108242035}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1016/j.biopha.2026.120028","doi":"https://doi.org/10.1016/j.biopha.2026.120028","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.biopha.2026.120028","pdf_url":null,"source":{"id":"https://openalex.org/S15111687","display_name":"Biomedicine & Pharmacotherapy","issn_l":"0753-3322","issn":["0753-3322","1950-6007"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-2","ki-jl-1","medline","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicine & Pharmacotherapy","raw_type":"journal-article"},{"id":"pmid:43002829","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/43002829","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.biopha.2026.120028","doi":"https://doi.org/10.1016/j.biopha.2026.120028","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.biopha.2026.120028","pdf_url":null,"source":{"id":"https://openalex.org/S15111687","display_name":"Biomedicine & Pharmacotherapy","issn_l":"0753-3322","issn":["0753-3322","1950-6007"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-2","ki-jl-1","medline","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicine & Pharmacotherapy","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8999999761581421,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320717","display_name":"Department of Biotechnology, Ministry of Science and Technology, India","ror":"https://ror.org/03tjsyq23"},{"id":"https://openalex.org/F4320320720","display_name":"Indian Council of Medical Research","ror":"https://ror.org/0492wrx28"},{"id":"https://openalex.org/F4320334771","display_name":"Science and Engineering Research Board","ror":"https://ror.org/03ffdsr55"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":58,"referenced_works":["https://openalex.org/W118828521","https://openalex.org/W1513764702","https://openalex.org/W1538375169","https://openalex.org/W1752957988","https://openalex.org/W1970783326","https://openalex.org/W1976771829","https://openalex.org/W1989118643","https://openalex.org/W1989224306","https://openalex.org/W1997820125","https://openalex.org/W2003486401","https://openalex.org/W2077993131","https://openalex.org/W2080752012","https://openalex.org/W2086503399","https://openalex.org/W2096801003","https://openalex.org/W2099540110","https://openalex.org/W2107277218","https://openalex.org/W2119727748","https://openalex.org/W2121897239","https://openalex.org/W2127221429","https://openalex.org/W2158217645","https://openalex.org/W2165161053","https://openalex.org/W2278515847","https://openalex.org/W2288375302","https://openalex.org/W2463195069","https://openalex.org/W2468138006","https://openalex.org/W2474255949","https://openalex.org/W2604994651","https://openalex.org/W2735275709","https://openalex.org/W2774721119","https://openalex.org/W2775396984","https://openalex.org/W2797582253","https://openalex.org/W2797883126","https://openalex.org/W2886070608","https://openalex.org/W2912673401","https://openalex.org/W2923656972","https://openalex.org/W2926414609","https://openalex.org/W2934994345","https://openalex.org/W2964456700","https://openalex.org/W2997022986","https://openalex.org/W3018446827","https://openalex.org/W3082880901","https://openalex.org/W3083440017","https://openalex.org/W3119686502","https://openalex.org/W3119952098","https://openalex.org/W3163306930","https://openalex.org/W3207844981","https://openalex.org/W4220831425","https://openalex.org/W4283079091","https://openalex.org/W4288080891","https://openalex.org/W4308687857","https://openalex.org/W4311572736","https://openalex.org/W4313546100","https://openalex.org/W4318262992","https://openalex.org/W4324304732","https://openalex.org/W4390483054","https://openalex.org/W4390663502","https://openalex.org/W4396519787","https://openalex.org/W4405561049"],"related_works":["https://openalex.org/W4389136695","https://openalex.org/W6977060153","https://openalex.org/W2969434391","https://openalex.org/W3200077388","https://openalex.org/W7212358804","https://openalex.org/W3026982736","https://openalex.org/W4401259053","https://openalex.org/W4405981793","https://openalex.org/W4223537922","https://openalex.org/W3046804192"],"abstract_inverted_index":{"Biofilm":[0],"formation":[1],"is":[2,35],"a":[3,26,55,89,99,132,193],"crucial":[4],"aspect":[5],"of":[6,25,52,64,79,119,144,166,175],"Methicillin-resistant":[7],"Staphylococcus":[8],"aureus":[9],"(MRSA)":[10],"pathogenesis":[11],"and":[12,47,74,86,139,177,183],"contributes":[13],"to":[14,109,159],"its":[15,155,160],"resistance":[16],"against":[17,37],"conventional":[18],"antibiotics.":[19],"This":[20],"study":[21],"reports":[22],"the":[23,49,61,71,110,123,145],"identification":[24],"bioactive":[27],"molecule,":[28],"formononetin,":[29],"from":[30],"Glycyrrhiza":[31],"glabra":[32],"L.,":[33],"that":[34,188],"effective":[36],"MRSA.":[38],"Formononetin":[39,58],"significantly":[40],"inhibited":[41],"biofilm":[42],"formation,":[43],"disrupted":[44],"sessile":[45],"biofilm,":[46],"reduced":[48,149],"hemolytic":[50],"activity":[51,157],"MRSA":[53,167,198],"in":[54,127],"dose-dependent":[56],"manner.":[57],"also":[59],"increased":[60],"survival":[62],"rate":[63],"MRSA-infected":[65],"G.":[66],"mellonella":[67],"larvae":[68],"by":[69],"decreasing":[70],"bacterial":[72],"load":[73],"increasing":[75],"melanization.":[76],"The":[77],"combination":[78],"formononetin":[80,106,152,171,189],"with":[81,114,170],"antibiotics,":[82],"like":[83],"oxacillin,":[84],"ampicillin,":[85],"streptomycin,":[87],"showed":[88,105,148,172],"fractional":[90],"inhibitory":[91],"concentration":[92],"index":[93],"(FICI)":[94],"\u2264":[95],"0.5,":[96],"which":[97],"indicates":[98],"synergistic":[100],"effect.":[101],"Molecular":[102],"docking":[103],"studies":[104],"can":[107],"bind":[108],"global":[111],"regulator,":[112],"SarA,":[113],"an":[115],"estimated":[116],"binding":[117,133],"score":[118],"-6.176":[120],"kcal/mol.":[121],"Further,":[122,163],"aspartate":[124],"residue":[125],"(D20)":[126],"SarA":[128,176],"was":[129],"identified":[130],"as":[131,181,192],"site":[134],"for":[135,196],"formononetin.":[136],"Microscale":[137],"thermophoresis":[138],"electrophoretic":[140],"mobility":[141],"shift":[142],"assay":[143],"SarAD20A":[146],"mutant":[147],"affinity":[150],"towards":[151],"without":[153],"affecting":[154],"DNA-binding":[156],"compared":[158],"wild-type":[161],"counterpart.":[162],"proteomic":[164],"profiling":[165],"upon":[168],"treatment":[169],"significant":[173],"modulation":[174],"SarA-related":[178],"pathways,":[179],"such":[180],"scdA":[182],"agrC.":[184],"Our":[185],"findings":[186],"suggest":[187],"holds":[190],"promise":[191],"natural":[194],"agent":[195],"combating":[197],"biofilm.":[199]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-10T00:00:00"}