{"id":"https://openalex.org/W7225664249","doi":"https://doi.org/10.1161/circulationaha.126.083732","title":"Myocardial Responses to Eplontersen in Transthyretin Amyloid Cardiomyopathy: The CARDIO-TTRansform CMR study","display_name":"Myocardial Responses to Eplontersen in Transthyretin Amyloid Cardiomyopathy: The CARDIO-TTRansform CMR study","publication_year":2026,"publication_date":"2026-11-09","ids":{"openalex":"https://openalex.org/W7225664249","doi":"https://doi.org/10.1161/circulationaha.126.083732","pmid":"https://pubmed.ncbi.nlm.nih.gov/43002382"},"language":"en","primary_location":{"id":"doi:10.1161/circulationaha.126.083732","doi":"https://doi.org/10.1161/circulationaha.126.083732","is_oa":false,"landing_page_url":"https://doi.org/10.1161/circulationaha.126.083732","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072399610","display_name":"Yousuf Razvi","orcid":"https://orcid.org/0000-0003-4766-3293","observed_orcids":["https://orcid.org/0000-0003-4766-3293"]},"institutions":[{"id":"https://openalex.org/I2801138448","display_name":"The Royal Free Hospital","ror":"https://ror.org/01ge67z96","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I169248724","https://openalex.org/I2801138448"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Yousuf Razvi","raw_affiliation_strings":["National Amyloidosis Centre, Division of Medicine, University College London, Royal Free Hospital, London, UK"],"raw_orcid":"https://orcid.org/0000-0003-4766-3293","affiliations":[{"raw_affiliation_string":"National Amyloidosis Centre, Division of Medicine, University College London, Royal Free Hospital, London, UK","institution_ids":["https://openalex.org/I2801138448","https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054830306","display_name":"Scott David Solomon","orcid":"https://orcid.org/0000-0003-3698-9597","observed_orcids":["https://orcid.org/0000-0003-3698-9597"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott D. Solomon","raw_affiliation_strings":["Cardiovascular Division, Brigham and Women's Hospital, Boston, MA"],"raw_orcid":"https://orcid.org/0000-0003-3698-9597","affiliations":[{"raw_affiliation_string":"Cardiovascular Division, Brigham and Women's Hospital, Boston, MA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045641510","display_name":"Sarah A. M. Cuddy","orcid":"https://orcid.org/0000-0002-2124-2151","observed_orcids":["https://orcid.org/0000-0002-2124-2151"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah A.M. Cuddy","raw_affiliation_strings":["Cardiovascular Division, Brigham and Women's Hospital, Boston, MA"],"raw_orcid":"https://orcid.org/0000-0002-2124-2151","affiliations":[{"raw_affiliation_string":"Cardiovascular Division, Brigham and Women's Hospital, Boston, MA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026698883","display_name":"Lucia Venneri","orcid":"https://orcid.org/0009-0006-2551-7403","observed_orcids":["https://orcid.org/0009-0006-2551-7403"]},"institutions":[{"id":"https://openalex.org/I2801138448","display_name":"The Royal Free Hospital","ror":"https://ror.org/01ge67z96","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I169248724","https://openalex.org/I2801138448"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Lucia Venneri","raw_affiliation_strings":["National Amyloidosis Centre, Division of Medicine, University College London, Royal Free Hospital, London, UK"],"raw_orcid":"https://orcid.org/0009-0006-2551-7403","affiliations":[{"raw_affiliation_string":"National Amyloidosis Centre, Division of Medicine, University College London, Royal Free Hospital, London, UK","institution_ids":["https://openalex.org/I2801138448","https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090961709","display_name":"Ana Martinez\u2013Naharro","orcid":"https://orcid.org/0000-0003-3595-6988","observed_orcids":["https://orcid.org/0000-0003-3595-6988"]},"institutions":[{"id":"https://openalex.org/I2801138448","display_name":"The Royal Free Hospital","ror":"https://ror.org/01ge67z96","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I169248724","https://openalex.org/I2801138448"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ana Martinez-Naharro","raw_affiliation_strings":["National Amyloidosis Centre, Division of Medicine, University College London, Royal Free Hospital, London, UK"],"raw_orcid":"https://orcid.org/0000-0003-3595-6988","affiliations":[{"raw_affiliation_string":"National Amyloidosis Centre, Division of Medicine, University College London, Royal Free Hospital, London, UK","institution_ids":["https://openalex.org/I2801138448","https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079197025","display_name":"Francesco Cappelli","orcid":"https://orcid.org/0000-0002-1622-0732","observed_orcids":["https://orcid.org/0000-0002-1622-0732"]},"institutions":[{"id":"https://openalex.org/I4210115393","display_name":"Azienda Ospedaliero-Universitaria Careggi","ror":"https://ror.org/02crev113","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210115393"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesco Cappelli","raw_affiliation_strings":["Tuscan Regional Amyloidosis Center, Department of Clinical and Experimental Medicine, University Hospital Careggi, Florence, Italy"],"raw_orcid":"https://orcid.org/0000-0002-1622-0732","affiliations":[{"raw_affiliation_string":"Tuscan Regional Amyloidosis Center, Department of Clinical and Experimental Medicine, University Hospital Careggi, Florence, Italy","institution_ids":["https://openalex.org/I4210115393"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010078370","display_name":"Alberto Cipriani","orcid":"https://orcid.org/0000-0001-7842-6202","observed_orcids":["https://orcid.org/0000-0001-7842-6202"]},"institutions":[{"id":"https://openalex.org/I138689650","display_name":"University of Padua","ror":"https://ror.org/00240q980","country_code":"IT","type":"education","lineage":["https://openalex.org/I138689650"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alberto Cipriani","raw_affiliation_strings":["Department of Cardio-Thoraco-Vascular Sciences and Public Health, University of Padua, Padua, Italy"],"raw_orcid":"https://orcid.org/0000-0001-7842-6202","affiliations":[{"raw_affiliation_string":"Department of Cardio-Thoraco-Vascular Sciences and Public Health, University of Padua, Padua, Italy","institution_ids":["https://openalex.org/I138689650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062816598","display_name":"Pablo Garc\u00eda\u2010Pav\u00eda","orcid":"https://orcid.org/0000-0002-5470-2257","observed_orcids":["https://orcid.org/0000-0002-5470-2257"]},"institutions":[{"id":"https://openalex.org/I2809107791","display_name":"Spanish National Centre for Cardiovascular Research","ror":"https://ror.org/02qs1a797","country_code":"ES","type":"facility","lineage":["https://openalex.org/I2801357902","https://openalex.org/I2809107791","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I4210095014","display_name":"Centro de Investigaci\u00f3n en Red en Enfermedades Cardiovasculares","ror":"https://ror.org/00s29fn93","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210095014"]},{"id":"https://openalex.org/I4210105637","display_name":"Hospital Universitario Puerta de Hierro Majadahonda","ror":"https://ror.org/01e57nb43","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210105637","https://openalex.org/I4210139293"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Pablo Garcia-Pavia","raw_affiliation_strings":["Department of Cardiology, Hospital Universitario Puerta de Hierro Majadahonda, IDIPHISA, CIBERCV and Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain"],"raw_orcid":"https://orcid.org/0000-0002-5470-2257","affiliations":[{"raw_affiliation_string":"Department of Cardiology, Hospital Universitario Puerta de Hierro Majadahonda, IDIPHISA, CIBERCV and Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain","institution_ids":["https://openalex.org/I2809107791","https://openalex.org/I4210095014","https://openalex.org/I4210105637"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065594480","display_name":"Ahmad Masri","orcid":"https://orcid.org/0000-0002-6390-6526","observed_orcids":["https://orcid.org/0000-0002-6390-6526"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ahmad Masri","raw_affiliation_strings":["Division of Cardiovascular Medicine, Oregon Health and Science University, Portland, OR"],"raw_orcid":"https://orcid.org/0000-0002-6390-6526","affiliations":[{"raw_affiliation_string":"Division of Cardiovascular Medicine, Oregon Health and Science University, Portland, OR","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031016722","display_name":"Awais Sheikh","orcid":"https://orcid.org/0000-0002-7707-226X","observed_orcids":["https://orcid.org/0000-0002-7707-226X"]},"institutions":[{"id":"https://openalex.org/I2801138448","display_name":"The Royal Free Hospital","ror":"https://ror.org/01ge67z96","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I169248724","https://openalex.org/I2801138448"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Awais Sheikh","raw_affiliation_strings":["National Amyloidosis Centre, Division of Medicine, University College London, Royal Free Hospital, London, UK"],"raw_orcid":"https://orcid.org/0000-0002-7707-226X","affiliations":[{"raw_affiliation_string":"National Amyloidosis Centre, Division of Medicine, University College London, Royal Free Hospital, London, UK","institution_ids":["https://openalex.org/I2801138448","https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068751608","display_name":"Noem\u00ed Ramos","orcid":"https://orcid.org/0000-0002-0868-1707","observed_orcids":["https://orcid.org/0000-0002-0868-1707"]},"institutions":[{"id":"https://openalex.org/I2809107791","display_name":"Spanish National Centre for Cardiovascular Research","ror":"https://ror.org/02qs1a797","country_code":"ES","type":"facility","lineage":["https://openalex.org/I2801357902","https://openalex.org/I2809107791","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I4210095014","display_name":"Centro de Investigaci\u00f3n en Red en Enfermedades Cardiovasculares","ror":"https://ror.org/00s29fn93","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210095014"]},{"id":"https://openalex.org/I4210105637","display_name":"Hospital Universitario Puerta de Hierro Majadahonda","ror":"https://ror.org/01e57nb43","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210105637","https://openalex.org/I4210139293"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Noemi Ramos-Lopez","raw_affiliation_strings":["Department of Cardiology, Hospital Universitario Puerta de Hierro Majadahonda, IDIPHISA, CIBERCV and Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain"],"raw_orcid":"https://orcid.org/0000-0002-0868-1707","affiliations":[{"raw_affiliation_string":"Department of Cardiology, Hospital Universitario Puerta de Hierro Majadahonda, IDIPHISA, CIBERCV and Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain","institution_ids":["https://openalex.org/I2809107791","https://openalex.org/I4210095014","https://openalex.org/I4210105637"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073466645","display_name":"Priya Sekar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Priya Sekar","raw_affiliation_strings":["Late-Stage Development, Cardiovascular, Renal, and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Rockville, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Late-Stage Development, Cardiovascular, Renal, and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Rockville, MD","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5137411729","display_name":"Tom Conrad","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tom Conrad","raw_affiliation_strings":["Statistics, Cardiovascular, Renal, and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Rockville, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Statistics, Cardiovascular, Renal, and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Rockville, MD","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010456790","display_name":"Brian Lee Claggett","orcid":"https://orcid.org/0000-0002-4215-9218","observed_orcids":["https://orcid.org/0000-0002-4215-9218","https://orcid.org/0009-0009-1748-4340"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian Claggett","raw_affiliation_strings":["Cardiovascular Division, Brigham and Women's Hospital, Boston, MA"],"raw_orcid":"https://orcid.org/0009-0009-1748-4340","affiliations":[{"raw_affiliation_string":"Cardiovascular Division, Brigham and Women's Hospital, Boston, MA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019338538","display_name":"Peter Kellman","orcid":"https://orcid.org/0000-0002-9875-6070","observed_orcids":["https://orcid.org/0000-0002-9875-6070"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter Kellman","raw_affiliation_strings":["National Heart, Lung, and Blood Institute, National Institutes of Health, DHHS, Bethesda, MD"],"raw_orcid":"https://orcid.org/0000-0002-9875-6070","affiliations":[{"raw_affiliation_string":"National Heart, Lung, and Blood Institute, National Institutes of Health, DHHS, Bethesda, MD","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053175918","display_name":"Farooq H. Sheikh","orcid":"https://orcid.org/0000-0001-9687-9475","observed_orcids":["https://orcid.org/0000-0001-9687-9475"]},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I4210154815","display_name":"MedStar Heart & Vascular Institute","ror":"https://ror.org/0405m4551","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210154815","https://openalex.org/I86755215"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Farooq H. Sheikh","raw_affiliation_strings":["Georgetown University School of Medicine, Washington, DC; Advanced Heart Failure Program, MedStar Heart & Vascular Institute, Washington DC"],"raw_orcid":"https://orcid.org/0000-0001-9687-9475","affiliations":[{"raw_affiliation_string":"Georgetown University School of Medicine, Washington, DC; Advanced Heart Failure Program, MedStar Heart & Vascular Institute, Washington DC","institution_ids":["https://openalex.org/I184565670","https://openalex.org/I4210154815"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037939005","display_name":"Justin Lee Grodin","orcid":"https://orcid.org/0000-0003-2400-3196","observed_orcids":["https://orcid.org/0000-0003-2400-3196","https://orcid.org/0000-0002-6264-777X"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Justin L. Grodin","raw_affiliation_strings":["Division of Cardiology, UT Southwestern Medical Center, Dallas, TX"],"raw_orcid":"https://orcid.org/0000-0003-2400-3196","affiliations":[{"raw_affiliation_string":"Division of Cardiology, UT Southwestern Medical Center, Dallas, TX","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046915918","display_name":"Charlotte Manisty","orcid":"https://orcid.org/0000-0003-0245-7090","observed_orcids":["https://orcid.org/0000-0003-0245-7090"]},"institutions":[{"id":"https://openalex.org/I1307195382","display_name":"St Bartholomew's Hospital","ror":"https://ror.org/00nh9x179","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1307195382","https://openalex.org/I225661044"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Charlotte Manisty","raw_affiliation_strings":["MyCardium AI Imaging Core Lab, Institute of Cardiovascular Science, University College London and Barts Heart Centre, St Bartholomew's Hospital, London, UK"],"raw_orcid":"https://orcid.org/0000-0003-0245-7090","affiliations":[{"raw_affiliation_string":"MyCardium AI Imaging Core Lab, Institute of Cardiovascular Science, University College London and Barts Heart Centre, St Bartholomew's Hospital, London, UK","institution_ids":["https://openalex.org/I1307195382","https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061883337","display_name":"George D. Thornton","orcid":"https://orcid.org/0000-0003-3289-2413","observed_orcids":["https://orcid.org/0000-0003-3289-2413"]},"institutions":[{"id":"https://openalex.org/I1307195382","display_name":"St Bartholomew's Hospital","ror":"https://ror.org/00nh9x179","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1307195382","https://openalex.org/I225661044"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"George D. Thornton","raw_affiliation_strings":["MyCardium AI Imaging Core Lab, Institute of Cardiovascular Science, University College London and Barts Heart Centre, St Bartholomew's Hospital, London, UK"],"raw_orcid":"https://orcid.org/0000-0003-3289-2413","affiliations":[{"raw_affiliation_string":"MyCardium AI Imaging Core Lab, Institute of Cardiovascular Science, University College London and Barts Heart Centre, St Bartholomew's Hospital, London, UK","institution_ids":["https://openalex.org/I1307195382","https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003474421","display_name":"James Moon","orcid":"https://orcid.org/0000-0001-8071-1491","observed_orcids":["https://orcid.org/0000-0001-8071-1491","https://orcid.org/0000-0002-9763-1436"]},"institutions":[{"id":"https://openalex.org/I1307195382","display_name":"St Bartholomew's Hospital","ror":"https://ror.org/00nh9x179","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1307195382","https://openalex.org/I225661044"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"James C. Moon","raw_affiliation_strings":["MyCardium AI Imaging Core Lab, Institute of Cardiovascular Science, University College London and Barts Heart Centre, St Bartholomew's Hospital, London, UK"],"raw_orcid":"https://orcid.org/0000-0001-8071-1491","affiliations":[{"raw_affiliation_string":"MyCardium AI Imaging Core Lab, Institute of Cardiovascular Science, University College London and Barts Heart Centre, St Bartholomew's Hospital, London, UK","institution_ids":["https://openalex.org/I1307195382","https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056298622","display_name":"Mathew S. Maurer","orcid":"https://orcid.org/0000-0001-5400-5008","observed_orcids":["https://orcid.org/0000-0001-5400-5008","https://orcid.org/0000-0002-1867-0526"]},"institutions":[{"id":"https://openalex.org/I1340179700","display_name":"NewYork\u2013Presbyterian Hospital","ror":"https://ror.org/03gzbrs57","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1340179700"]},{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mathew S. Maurer","raw_affiliation_strings":["Cardiac Amyloidosis Program, Paul Seymour and Gloria Milstein Division of Cardiology, Department of Medicine, Columbia University Irving Medical Centre and New York-Presbyterian Hospital, NY"],"raw_orcid":"https://orcid.org/0000-0001-5400-5008","affiliations":[{"raw_affiliation_string":"Cardiac Amyloidosis Program, Paul Seymour and Gloria Milstein Division of Cardiology, Department of Medicine, Columbia University Irving Medical Centre and New York-Presbyterian Hospital, NY","institution_ids":["https://openalex.org/I1340179700","https://openalex.org/I2799503643","https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103518828","display_name":"Franca S. Angeli","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Franca S. Angeli","raw_affiliation_strings":["AstraZeneca, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AstraZeneca, Boston, MA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108101737","display_name":"Jersey Chen","orcid":"https://orcid.org/0009-0004-7834-3596","observed_orcids":["https://orcid.org/0009-0004-7834-3596","https://orcid.org/0009-0002-0583-9107"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jersey Chen","raw_affiliation_strings":["Late-Stage Development, Cardiovascular, Renal, and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD"],"raw_orcid":"https://orcid.org/0009-0004-7834-3596","affiliations":[{"raw_affiliation_string":"Late-Stage Development, Cardiovascular, Renal, and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091030211","display_name":"Sotirios Tsimikas","orcid":"https://orcid.org/0000-0001-9834-9494","observed_orcids":["https://orcid.org/0000-0001-9834-9494"]},"institutions":[{"id":"https://openalex.org/I2800035258","display_name":"Ionis Pharmaceuticals (United States)","ror":"https://ror.org/00t8bew53","country_code":"US","type":"company","lineage":["https://openalex.org/I2800035258"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sotirios Tsimikas","raw_affiliation_strings":["Ionis Pharmaceuticals, Carlsbad, CA"],"raw_orcid":"https://orcid.org/0000-0001-9834-9494","affiliations":[{"raw_affiliation_string":"Ionis Pharmaceuticals, Carlsbad, CA","institution_ids":["https://openalex.org/I2800035258"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057365396","display_name":"Julian David Gillmore","orcid":"https://orcid.org/0000-0001-6174-9232","observed_orcids":["https://orcid.org/0000-0001-6174-9232"]},"institutions":[{"id":"https://openalex.org/I2801138448","display_name":"The Royal Free Hospital","ror":"https://ror.org/01ge67z96","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I169248724","https://openalex.org/I2801138448"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Julian D. Gillmore","raw_affiliation_strings":["National Amyloidosis Centre, Division of Medicine, University College London, Royal Free Hospital, London, UK"],"raw_orcid":"https://orcid.org/0000-0001-6174-9232","affiliations":[{"raw_affiliation_string":"National Amyloidosis Centre, Division of Medicine, University College London, Royal Free Hospital, London, UK","institution_ids":["https://openalex.org/I2801138448","https://openalex.org/I45129253"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050125018","display_name":"Marianna Fontana","orcid":"https://orcid.org/0000-0002-9233-9831","observed_orcids":["https://orcid.org/0000-0002-9233-9831"]},"institutions":[{"id":"https://openalex.org/I2801138448","display_name":"The Royal Free Hospital","ror":"https://ror.org/01ge67z96","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I169248724","https://openalex.org/I2801138448"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Marianna Fontana","raw_affiliation_strings":["National Amyloidosis Centre, Division of Medicine, University College London, Royal Free Hospital, London, UK"],"raw_orcid":"https://orcid.org/0000-0002-9233-9831","affiliations":[{"raw_affiliation_string":"National Amyloidosis Centre, Division of Medicine, University College London, Royal Free Hospital, London, UK","institution_ids":["https://openalex.org/I2801138448","https://openalex.org/I45129253"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":19,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11305","display_name":"Amyloidosis: Diagnosis, Treatment, Outcomes","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2724","display_name":"Internal Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11305","display_name":"Amyloidosis: Diagnosis, Treatment, Outcomes","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2724","display_name":"Internal Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/transthyretin-amyloid-cardiomyopathy","display_name":"transthyretin amyloid cardiomyopathy","score":0.9520000219345093},{"id":"https://openalex.org/keywords/extracellular-volume","display_name":"extracellular volume","score":0.9629999995231628},{"id":"https://openalex.org/keywords/native-t1-mapping","display_name":"native T1 mapping","score":0.7360000014305115},{"id":"https://openalex.org/keywords/cardiac-remodeling","display_name":"cardiac remodeling","score":0.8180000185966492},{"id":"https://openalex.org/keywords/left-ventricular-mass","display_name":"left ventricular mass","score":0.7990000247955322},{"id":"https://openalex.org/keywords/myocardial-strain","display_name":"myocardial strain","score":0.8450000286102295},{"id":"https://openalex.org/keywords/ejection-fraction","display_name":"ejection fraction","score":0.7710000276565552},{"id":"https://openalex.org/keywords/cardiac-magnetic-resonance","display_name":"cardiac magnetic resonance","score":0.4429999887943268}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9272000193595886},{"id":"https://openalex.org/C121157162","wikidata":"https://www.wikidata.org/wiki/Q419999","display_name":"Transthyretin","level":2,"score":0.8916000127792358},{"id":"https://openalex.org/C78085059","wikidata":"https://www.wikidata.org/wiki/Q641303","display_name":"Ejection fraction","level":3,"score":0.743399977684021},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.7337999939918518},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.705299973487854},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.5310999751091003},{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.5047000050544739},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.44110000133514404},{"id":"https://openalex.org/C2778797674","wikidata":"https://www.wikidata.org/wiki/Q847583","display_name":"Cardiomyopathy","level":3,"score":0.43959999084472656},{"id":"https://openalex.org/C2776008845","wikidata":"https://www.wikidata.org/wiki/Q5038325","display_name":"Cardiac magnetic resonance imaging","level":3,"score":0.435699999332428},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.4097999930381775},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.376800000667572},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.3630000054836273},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.3488999903202057},{"id":"https://openalex.org/C2987145844","wikidata":"https://www.wikidata.org/wiki/Q5038325","display_name":"Cardiac magnetic resonance","level":3,"score":0.29989999532699585},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.29809999465942383},{"id":"https://openalex.org/C2779951007","wikidata":"https://www.wikidata.org/wiki/Q816798","display_name":"Amyloidosis","level":2,"score":0.295199990272522},{"id":"https://openalex.org/C80461066","wikidata":"https://www.wikidata.org/wiki/Q1698533","display_name":"Stroke volume","level":4,"score":0.2896000146865845},{"id":"https://openalex.org/C21143770","wikidata":"https://www.wikidata.org/wiki/Q3366819","display_name":"End-diastolic volume","level":5,"score":0.28139999508857727},{"id":"https://openalex.org/C2777607188","wikidata":"https://www.wikidata.org/wiki/Q5038315","display_name":"Cardiac amyloidosis","level":3,"score":0.2524000108242035}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1161/circulationaha.126.083732","doi":"https://doi.org/10.1161/circulationaha.126.083732","is_oa":false,"landing_page_url":"https://doi.org/10.1161/circulationaha.126.083732","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},{"id":"pmid:43002382","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/43002382","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320314430","display_name":"Ionis Pharmaceuticals","ror":"https://ror.org/00t8bew53"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4403819273","https://openalex.org/W7204590761","https://openalex.org/W4389409349","https://openalex.org/W7160711145","https://openalex.org/W7162891178","https://openalex.org/W7204718146","https://openalex.org/W4390791953","https://openalex.org/W7223558398","https://openalex.org/W4392660466","https://openalex.org/W4388594556"],"abstract_inverted_index":{"BACKGROUND:":[0],"Transthyretin-lowering":[1],"therapies":[2],"target":[3],"the":[4,27,55],"underlying":[5],"cause":[6],"of":[7,30,274],"transthyretin":[8,32,246,291],"amyloid":[9,17,94,225],"cardiomyopathy":[10],"(ATTR-CM),":[11],"but":[12],"their":[13],"effects":[14,29],"on":[15,278],"myocardial":[16,28,224,254,266,293,305],"burden":[18],"and":[19,67,75,96,104,124,166,177,203,209,212,256,265,298],"cardiac":[20,260],"remodelling":[21],"remain":[22],"incompletely":[23],"characterized.":[24],"We":[25,118],"evaluated":[26,81],"sustained":[31],"suppression":[33,247],"with":[34,122,151,248,269],"eplontersen":[35,145,231,249],"using":[36,87],"serial":[37,300],"multiparametric":[38,301],"cardiovascular":[39],"magnetic":[40],"resonance":[41],"(CMR).":[42],"METHODS:":[43],"This":[44],"CMR":[45,64,85,127,302],"study":[46,52],"was":[47],"a":[48,272],"pre-specified,":[49],"international,":[50],"prospective":[51],"embedded":[53],"within":[54],"randomized,":[56],"placebo-controlled":[57],"phase":[58],"3":[59],"CARDIO-TTRansform":[60],"trial.":[61],"Participants":[62],"underwent":[63],"at":[65,70,281],"baseline":[66,123,139],"planned":[68],"assessments":[69],"weeks":[71],"25,":[72],"49,":[73],"97,":[74],"140.":[76],"The":[77],"primary":[78],"imaging":[79],"analysis":[80],"longitudinal":[82,215],"changes":[83,258],"in":[84,106,147,228,239,251,259,271,296],"parameters":[86],"mixed":[88],"models":[89],"for":[90,303],"repeated":[91],"measures.":[92],"Myocardial":[93],"regression":[95,226],"progression":[97,237,295],"were":[98,114],"defined":[99],"as":[100],"\u22655":[101],"percentage-point":[102],"decreases":[103],"increases":[105],"extracellular":[107],"volume":[108],"(ECV),":[109],"respectively.":[110,243],"All":[111],"other":[112],"patients":[113,275],"considered":[115],"stable.":[116],"RESULTS:":[117],"enrolled":[119],"120":[120],"participants":[121],"\u22651":[125],"follow-up":[126],"assessment":[128],"(eplontersen,":[129],"n=58;":[130],"placebo,":[131,235],"n=62;":[132],"mean":[133,154],"age,":[134],"76.7\u00b16.5":[135],"years;":[136],"95%":[137],"male;":[138],"stabilizer,":[140],"12.5%).":[141],"At":[142,222],"week":[143],"140":[144],"resulted":[146,250],"lower":[148,167,253],"ECV,":[149],"compared":[150,219,268],"placebo":[152,270],"(least-squares":[153],"difference":[155],"[95%":[156],"CI],":[157],"-6.7":[158],"percentage":[159],"points":[160],"[":[161],"-8.7":[162],"to":[163,173,183,220],"-4.7];":[164],"P<0.001)":[165],"native":[168],"T1":[169],"(":[170],"-25.9ms":[171],"[-41.7":[172],"-10.2":[174],"];":[175],"P=0.002)":[176],"left":[178,189,204],"ventricular":[179,190,197,205,214],"mass":[180],"(-19.1g":[181],"[-28.0":[182],"-10.2];":[184],"P<0.001).":[185],"Eplontersen":[186],"also":[187],"increased":[188],"ejection":[191,198],"fraction":[192,199],"(+5.1%":[193],"[1.8-8.3];":[194],"P=0.002),":[195],"right":[196,213],"(+4.6%":[200],"[0.6-8.7];":[201],"P=0.03),":[202],"global":[206],"longitudinal,":[207],"circumferential,":[208],"radial":[210],"strain":[211,216],"(all":[217],"P<0.05),":[218],"placebo.":[221],"week-140,":[223],"occurred":[227,238],"12.5%":[229,240],"receiving":[230,234],"versus":[232,241],"0%":[233],"whereas":[236],"76%,":[242],"CONCLUSIONS:":[244],"Sustained":[245],"substantially":[252],"ECV":[255],"favorable":[257],"structure,":[261],"biventricular":[262],"systolic":[263],"function,":[264],"deformation":[267],"cohort":[273],"mostly":[276],"not":[277],"background":[279],"stabilizer":[280],"baseline.":[282],"These":[283],"findings":[284],"provide":[285],"randomized":[286],"evidence":[287],"that":[288],"lowering":[289],"circulating":[290],"modifies":[292],"disease":[294],"ATTR-CM":[297],"support":[299],"characterizing":[304],"treatment":[306],"response.":[307]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-10T00:00:00"}
