{"id":"https://openalex.org/W7225660100","doi":"https://doi.org/10.1002/ps.71470","title":"Synthesis and herbicidal activity of spiro 3\u2010Acyltetramic acid derivatives as endogenous abscisic acid synthesis regulator and HPPD inhibitors","display_name":"Synthesis and herbicidal activity of spiro 3\u2010Acyltetramic acid derivatives as endogenous abscisic acid synthesis regulator and HPPD inhibitors","publication_year":2026,"publication_date":"2026-11-09","ids":{"openalex":"https://openalex.org/W7225660100","doi":"https://doi.org/10.1002/ps.71470","pmid":"https://pubmed.ncbi.nlm.nih.gov/43003691"},"language":"en","primary_location":{"id":"doi:10.1002/ps.71470","doi":"https://doi.org/10.1002/ps.71470","is_oa":true,"landing_page_url":"https://doi.org/10.1002/ps.71470","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ps.71470","source":{"id":"https://openalex.org/S31777576","display_name":"Pest Management Science","issn_l":"1526-498X","issn":["1526-498X","1526-4998"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pest Management Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ps.71470","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061735760","display_name":"Mengjiao Lv","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I140221134","display_name":"Anhui Agricultural University","ror":"https://ror.org/0327f3359","country_code":"CN","type":"education","lineage":["https://openalex.org/I140221134"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mengjiao Lv","raw_affiliation_strings":["Department of Plant and Environmental Health, Anhui Provincial Key Laboratory of Hazardous Factors and Risk Control of Agri\u2010food Quality Safety Anhui Agricultural University  Hefei China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Plant and Environmental Health, Anhui Provincial Key Laboratory of Hazardous Factors and Risk Control of Agri\u2010food Quality Safety Anhui Agricultural University  Hefei China","institution_ids":["https://openalex.org/I140221134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066640095","display_name":"Qikai Zang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I140221134","display_name":"Anhui Agricultural University","ror":"https://ror.org/0327f3359","country_code":"CN","type":"education","lineage":["https://openalex.org/I140221134"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qikai Zang","raw_affiliation_strings":["Department of Plant and Environmental Health, Anhui Provincial Key Laboratory of Hazardous Factors and Risk Control of Agri\u2010food Quality Safety Anhui Agricultural University  Hefei China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Plant and Environmental Health, Anhui Provincial Key Laboratory of Hazardous Factors and Risk Control of Agri\u2010food Quality Safety Anhui Agricultural University  Hefei China","institution_ids":["https://openalex.org/I140221134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161360508","display_name":"Ruixiang Ge","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I140221134","display_name":"Anhui Agricultural University","ror":"https://ror.org/0327f3359","country_code":"CN","type":"education","lineage":["https://openalex.org/I140221134"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ruixiang Ge","raw_affiliation_strings":["Department of Plant and Environmental Health, Anhui Provincial Key Laboratory of Hazardous Factors and Risk Control of Agri\u2010food Quality Safety Anhui Agricultural University  Hefei China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Plant and Environmental Health, Anhui Provincial Key Laboratory of Hazardous Factors and Risk Control of Agri\u2010food Quality Safety Anhui Agricultural University  Hefei China","institution_ids":["https://openalex.org/I140221134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161332273","display_name":"Qing X Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I117965899","display_name":"University of Hawai\u02bbi at M\u0101noa","ror":"https://ror.org/01wspgy28","country_code":"US","type":"education","lineage":["https://openalex.org/I117965899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qing X Li","raw_affiliation_strings":["Department of Molecular Biosciences and Bioengineering University of Hawaii at Manoa  Honolulu USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biosciences and Bioengineering University of Hawaii at Manoa  Honolulu USA","institution_ids":["https://openalex.org/I117965899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021733297","display_name":"Pei Lv","orcid":"https://orcid.org/0000-0002-7519-7640","observed_orcids":["https://orcid.org/0000-0002-7519-7640"]},"institutions":[{"id":"https://openalex.org/I140221134","display_name":"Anhui Agricultural University","ror":"https://ror.org/0327f3359","country_code":"CN","type":"education","lineage":["https://openalex.org/I140221134"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Pei Lv","raw_affiliation_strings":["Department of Plant and Environmental Health, Anhui Provincial Key Laboratory of Hazardous Factors and Risk Control of Agri\u2010food Quality Safety Anhui Agricultural University  Hefei China"],"raw_orcid":"https://orcid.org/0000-0002-7519-7640","affiliations":[{"raw_affiliation_string":"Department of Plant and Environmental Health, Anhui Provincial Key Laboratory of Hazardous Factors and Risk Control of Agri\u2010food Quality Safety Anhui Agricultural University  Hefei China","institution_ids":["https://openalex.org/I140221134"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022826654","display_name":"Rimao Hua","orcid":"https://orcid.org/0000-0002-5601-6568","observed_orcids":["https://orcid.org/0000-0002-5601-6568","https://orcid.org/0000-0002-7894-0102"]},"institutions":[{"id":"https://openalex.org/I140221134","display_name":"Anhui Agricultural University","ror":"https://ror.org/0327f3359","country_code":"CN","type":"education","lineage":["https://openalex.org/I140221134"]},{"id":"https://openalex.org/I4210156464","display_name":"Anhui Xinhua University","ror":"https://ror.org/053d7x641","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210156464"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rimao Hua","raw_affiliation_strings":["Department of Plant and Environmental Health, Anhui Provincial Key Laboratory of Hazardous Factors and Risk Control of Agri\u2010food Quality Safety Anhui Agricultural University  Hefei China","School of Smart\u2010City and Intelligent Manufacturing of Anhui Xinhua University  Hefei China"],"raw_orcid":"https://orcid.org/0000-0002-5601-6568","affiliations":[{"raw_affiliation_string":"Department of Plant and Environmental Health, Anhui Provincial Key Laboratory of Hazardous Factors and Risk Control of Agri\u2010food Quality Safety Anhui Agricultural University  Hefei China","institution_ids":["https://openalex.org/I140221134"]},{"raw_affiliation_string":"School of Smart\u2010City and Intelligent Manufacturing of Anhui Xinhua University  Hefei China","institution_ids":["https://openalex.org/I4210156464"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5021733297"],"corresponding_institution_ids":["https://openalex.org/I140221134"],"apc_list":{"value":5360,"currency":"USD","value_usd":5360},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10774","display_name":"Weed Control and Herbicide Applications","score":0.9643999934196472,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10774","display_name":"Weed Control and Herbicide Applications","score":0.9643999934196472,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12058","display_name":"Allelopathy and phytotoxic interactions","score":0.010900000110268593,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14099","display_name":"Synthesis and Characterization of Heterocyclic Compounds","score":0.0052999998442828655,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/herbicidal-activity","display_name":"herbicidal activity","score":0.8429999947547913},{"id":"https://openalex.org/keywords/hppd-inhibitors","display_name":"HPPD inhibitors","score":0.8500000238418579},{"id":"https://openalex.org/keywords/purslane","display_name":"Portulaca oleracea","score":0.8500000238418579},{"id":"https://openalex.org/keywords/barnyard-grass","display_name":"Echinochloa crus-galli","score":0.9440000057220459},{"id":"https://openalex.org/keywords/chenopodium-album","display_name":"Chenopodium album","score":0.9990000128746033},{"id":"https://openalex.org/keywords/pre-emergence-herbicides","display_name":"pre-emergence herbicides","score":0.859000027179718},{"id":"https://openalex.org/keywords/post-emergence-herbicides","display_name":"post-emergence herbicides","score":0.9869999885559082},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.8539999723434448},{"id":"https://openalex.org/keywords/chlorophyll-and-carotenoid-content","display_name":"chlorophyll and carotenoid content","score":0.8180000185966492},{"id":"https://openalex.org/keywords/mechanism-of-action","display_name":"mechanism of action","score":0.609000027179718}],"concepts":[{"id":"https://openalex.org/C2779591172","wikidata":"https://www.wikidata.org/wiki/Q332211","display_name":"Abscisic acid","level":3,"score":0.9398999810218811},{"id":"https://openalex.org/C16613235","wikidata":"https://www.wikidata.org/wiki/Q285982","display_name":"Endogeny","level":2,"score":0.6287000179290771},{"id":"https://openalex.org/C2779396153","wikidata":"https://www.wikidata.org/wiki/Q901227","display_name":"Natural product","level":2,"score":0.5690000057220459},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.534600019454956},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.49779999256134033},{"id":"https://openalex.org/C2780383148","wikidata":"https://www.wikidata.org/wiki/Q159554","display_name":"Portulaca","level":2,"score":0.484499990940094},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.4749999940395355},{"id":"https://openalex.org/C116073593","wikidata":"https://www.wikidata.org/wiki/Q864491","display_name":"Biological activity","level":3,"score":0.4648999869823456},{"id":"https://openalex.org/C2777752112","wikidata":"https://www.wikidata.org/wiki/Q903238","display_name":"Lead compound","level":3,"score":0.44589999318122864},{"id":"https://openalex.org/C2776593056","wikidata":"https://www.wikidata.org/wiki/Q415945","display_name":"Phytol","level":2,"score":0.3741999864578247},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.3686000108718872},{"id":"https://openalex.org/C2778415121","wikidata":"https://www.wikidata.org/wiki/Q158094","display_name":"Chenopodium","level":3,"score":0.35359999537467957},{"id":"https://openalex.org/C111335760","wikidata":"https://www.wikidata.org/wiki/Q95385166","display_name":"Luciferase","level":4,"score":0.34549999237060547},{"id":"https://openalex.org/C193042331","wikidata":"https://www.wikidata.org/wiki/Q1772003","display_name":"Structure\u2013activity relationship","level":3,"score":0.32170000672340393},{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.3199999928474426},{"id":"https://openalex.org/C28781525","wikidata":"https://www.wikidata.org/wiki/Q191907","display_name":"Carotenoid","level":2,"score":0.31940001249313354},{"id":"https://openalex.org/C113253001","wikidata":"https://www.wikidata.org/wiki/Q864640","display_name":"Bioorganic chemistry","level":3,"score":0.2994000017642975},{"id":"https://openalex.org/C2982966219","wikidata":"https://www.wikidata.org/wiki/Q3045481","display_name":"Plant growth","level":2,"score":0.29409998655319214},{"id":"https://openalex.org/C114373084","wikidata":"https://www.wikidata.org/wiki/Q273499","display_name":"Chemical synthesis","level":3,"score":0.2851000130176544},{"id":"https://openalex.org/C175528265","wikidata":"https://www.wikidata.org/wiki/Q500256","display_name":"Chemical structure","level":2,"score":0.2791999876499176},{"id":"https://openalex.org/C2776373379","wikidata":"https://www.wikidata.org/wiki/Q43177","display_name":"Chlorophyll","level":2,"score":0.2745000123977661},{"id":"https://openalex.org/C2778379183","wikidata":"https://www.wikidata.org/wiki/Q3234924","display_name":"Isoflavonoid","level":4,"score":0.2743000090122223},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2721000015735626},{"id":"https://openalex.org/C41685203","wikidata":"https://www.wikidata.org/wiki/Q1974042","display_name":"Docking (animal)","level":2,"score":0.2662000060081482},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.25290000438690186}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1002/ps.71470","doi":"https://doi.org/10.1002/ps.71470","is_oa":true,"landing_page_url":"https://doi.org/10.1002/ps.71470","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ps.71470","source":{"id":"https://openalex.org/S31777576","display_name":"Pest Management Science","issn_l":"1526-498X","issn":["1526-498X","1526-4998"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pest Management Science","raw_type":"journal-article"},{"id":"pmid:43003691","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/43003691","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pest management science","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1002/ps.71470","doi":"https://doi.org/10.1002/ps.71470","is_oa":true,"landing_page_url":"https://doi.org/10.1002/ps.71470","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ps.71470","source":{"id":"https://openalex.org/S31777576","display_name":"Pest Management Science","issn_l":"1526-498X","issn":["1526-498X","1526-4998"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pest Management Science","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Zero hunger","score":0.5365999937057495,"id":"https://metadata.un.org/sdg/2"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306114","display_name":"U.S. Department of Agriculture","ror":"https://ror.org/01na82s61"},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320334897","display_name":"Natural Science Foundation of Anhui Province","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225660100.pdf","grobid_xml":"https://content.openalex.org/works/W7225660100.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W1964039139","https://openalex.org/W2002062654","https://openalex.org/W2017266319","https://openalex.org/W2037961164","https://openalex.org/W2045515718","https://openalex.org/W2060079863","https://openalex.org/W2065838297","https://openalex.org/W2095719702","https://openalex.org/W2100561975","https://openalex.org/W2103325328","https://openalex.org/W2105103540","https://openalex.org/W2120099260","https://openalex.org/W2121220152","https://openalex.org/W2126090190","https://openalex.org/W2128276019","https://openalex.org/W2134812217","https://openalex.org/W2142175676","https://openalex.org/W2142868265","https://openalex.org/W2147993766","https://openalex.org/W2156312783","https://openalex.org/W2157955045","https://openalex.org/W2183050958","https://openalex.org/W2320589290","https://openalex.org/W2329540625","https://openalex.org/W2580134572","https://openalex.org/W2730538302","https://openalex.org/W2755345273","https://openalex.org/W2949875027","https://openalex.org/W3005781819","https://openalex.org/W3135328326","https://openalex.org/W3161594854","https://openalex.org/W3168436232","https://openalex.org/W3198064876","https://openalex.org/W4306411809","https://openalex.org/W4386911025","https://openalex.org/W4392748114","https://openalex.org/W4407896959","https://openalex.org/W4409802370"],"related_works":["https://openalex.org/W4306411809","https://openalex.org/W2990101312","https://openalex.org/W4402196492","https://openalex.org/W7053079649","https://openalex.org/W4412014781","https://openalex.org/W3133287405","https://openalex.org/W4415251693","https://openalex.org/W3207415891","https://openalex.org/W2054850486","https://openalex.org/W3161594854"],"abstract_inverted_index":{"Abstract":[0],"BACKGROUND":[1],"Potent":[2],"herbicidal":[3,39,94,147],"activity":[4,42,58,95,148],"of":[5,16,22,119,133,160,170],"tetramic":[6,25],"acid":[7,26],"containing":[8],"compounds":[9,46,70],"call":[10],"for":[11,37,157],"studying":[12],"the":[13,65,117,131,134],"structure\u2013activity":[14],"relationship":[15],"its":[17],"derivatives.":[18],"RESULTS":[19],"A":[20],"series":[21],"novel":[23,161],"3\u2010acyl\u20105\u2010spiro":[24],"derivatives":[27],"(":[28],"C1\u2013C12":[29],",":[30,62,99],"L1\u2013L18":[31,69],")":[32],"were":[33],"synthesized":[34],"and":[35,54,88,109,115,125,140,146],"evaluated":[36],"their":[38],"activities.":[40],"Herbicidal":[41],"tests":[43],"showed":[44],"most":[45],"exhibited":[47],">50%":[48],"inhibition":[49],"rate":[50],"against":[51,59,75,96],"Portulaca":[52],"oleracea":[53],"a":[55,153],"certain":[56],"inhibitory":[57],"Echinochloa":[60],"crusgalli":[61],"comparable":[63],"to":[64,104],"commercial":[66],"2,4\u2010D.":[67],"Most":[68],"had":[71],"good":[72],"control":[73,101],"efficiencies":[74],"Chenopodium":[76],"album":[77,98,114],"under":[78],"pre\u2010emergence":[79],"treatment":[80],"at":[81],"500":[82],"g":[83],"ha":[84],"\u22121":[85],";":[86],"L2":[87,106,139,151],"L3":[89],"also":[90],"exerted":[91],"outstanding":[92],"postemergence":[93],"C.":[97,113],"with":[100],"rates":[102],"equivalent":[103],"mesotrione.":[105],"reduced":[107],"chlorophyll":[108],"carotenoid":[110],"contents":[111],"in":[112],"regulated":[116],"synthesis":[118],"endogenous":[120],"abscisic":[121],"acid.":[122],"Molecular":[123],"docking":[124],"molecular":[126],"dynamics":[127],"simulations":[128],"further":[129,158],"verified":[130],"stability":[132],"complex":[135],"formed":[136],"by":[137],"compound":[138,156],"At":[141],"HPPD.":[142],"CONCLUSION":[143],"The":[144],"mode\u2010of\u2010action":[145],"indicate":[149],"that":[150],"is":[152],"potential":[154],"lead":[155],"development":[159],"natural":[162],"product":[163],"derived":[164],"HPPD":[165],"herbicides.":[166],"\u00a9":[167],"2026":[168],"Society":[169],"Chemical":[171],"Industry.":[172]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-10T00:00:00"}