{"id":"https://openalex.org/W7225659756","doi":"https://doi.org/10.1038/s41598-026-79314-3","title":"Pre-conceptional microbiome alterations in women with recurrent spontaneous abortion: a pilot study","display_name":"Pre-conceptional microbiome alterations in women with recurrent spontaneous abortion: a pilot study","publication_year":2026,"publication_date":"2026-11-10","ids":{"openalex":"https://openalex.org/W7225659756","doi":"https://doi.org/10.1038/s41598-026-79314-3"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-026-79314-3","doi":"https://doi.org/10.1038/s41598-026-79314-3","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-026-79314-3","pdf_url":"https://www.nature.com/articles/s41598-026-79314-3.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-026-79314-3.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5117594854","display_name":"Stefanie Dietz\u2010Ziegler","orcid":"https://orcid.org/0009-0005-6326-6281","observed_orcids":["https://orcid.org/0009-0005-6326-6281"]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]},{"id":"https://openalex.org/I4210125796","display_name":"University Children's Hospital T\u00fcbingen","ror":"https://ror.org/03esvmb28","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210094118","https://openalex.org/I4210125796"]},{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Stefanie Dietz-Ziegler","raw_affiliation_strings":["Department of Neonatology, University Children\u2019s Hospital, Im Neuenheimer Feld 430, 69120, Heidelberg, Germany","Department of Neonatology, University Children\u2019s Hospital, Tuebingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neonatology, University Children\u2019s Hospital, Im Neuenheimer Feld 430, 69120, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909","https://openalex.org/I2802164966"]},{"raw_affiliation_string":"Department of Neonatology, University Children\u2019s Hospital, Tuebingen, Germany","institution_ids":["https://openalex.org/I4210125796","https://openalex.org/I8087733"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161309546","display_name":"Anna Herbst","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210125796","display_name":"University Children's Hospital T\u00fcbingen","ror":"https://ror.org/03esvmb28","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210094118","https://openalex.org/I4210125796"]},{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Anna Herbst","raw_affiliation_strings":["Department of Neonatology, University Children\u2019s Hospital, Tuebingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neonatology, University Children\u2019s Hospital, Tuebingen, Germany","institution_ids":["https://openalex.org/I4210125796","https://openalex.org/I8087733"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161314976","display_name":"Jessica Ruehle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jessica Ruehle","raw_affiliation_strings":["Department of Neonatology, University Children\u2019s Hospital, Im Neuenheimer Feld 430, 69120, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neonatology, University Children\u2019s Hospital, Im Neuenheimer Feld 430, 69120, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909","https://openalex.org/I2802164966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083818743","display_name":"Jennifer M\u00fcller","orcid":"https://orcid.org/0000-0002-7907-2669","observed_orcids":["https://orcid.org/0000-0002-7907-2669","https://orcid.org/0009-0000-8909-2287"]},"institutions":[{"id":"https://openalex.org/I4210094118","display_name":"Universit\u00e4tsklinikum T\u00fcbingen","ror":"https://ror.org/00pjgxh97","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210094118"]},{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jennifer M\u00fcller","raw_affiliation_strings":["Institute for Medical Microbiology and Hygiene, University Hospital Tuebingen, Tuebingen, Germany","NGS-Competence Center, Institute for Medical Microbiology and Hygiene, University Hospital, Tuebingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Medical Microbiology and Hygiene, University Hospital Tuebingen, Tuebingen, Germany","institution_ids":["https://openalex.org/I4210094118"]},{"raw_affiliation_string":"NGS-Competence Center, Institute for Medical Microbiology and Hygiene, University Hospital, Tuebingen, Germany","institution_ids":["https://openalex.org/I4210094118","https://openalex.org/I8087733"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020909799","display_name":"Ulrich Schoppmeier","orcid":"https://orcid.org/0009-0004-0769-6845","observed_orcids":["https://orcid.org/0009-0004-0769-6845"]},"institutions":[{"id":"https://openalex.org/I4210094118","display_name":"Universit\u00e4tsklinikum T\u00fcbingen","ror":"https://ror.org/00pjgxh97","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210094118"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ulrich Schoppmeier","raw_affiliation_strings":["Institute for Medical Microbiology and Hygiene, University Hospital Tuebingen, Tuebingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Medical Microbiology and Hygiene, University Hospital Tuebingen, Tuebingen, Germany","institution_ids":["https://openalex.org/I4210094118"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071039809","display_name":"Dominik Wolff","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]},{"id":"https://openalex.org/I94509681","display_name":"Technische Universit\u00e4t Braunschweig","ror":"https://ror.org/010nsgg66","country_code":"DE","type":"education","lineage":["https://openalex.org/I94509681"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Dominik Wolff","raw_affiliation_strings":["Peter L. Reichertz Institute for Medical Informatics of TU Braunschweig, Hannover Medical School, Hannover, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Peter L. Reichertz Institute for Medical Informatics of TU Braunschweig, Hannover Medical School, Hannover, Germany","institution_ids":["https://openalex.org/I34809795","https://openalex.org/I94509681"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078716321","display_name":"Christian Friedrich Poets","orcid":"https://orcid.org/0000-0002-1072-0066","observed_orcids":["https://orcid.org/0000-0002-1072-0066"]},"institutions":[{"id":"https://openalex.org/I4210125796","display_name":"University Children's Hospital T\u00fcbingen","ror":"https://ror.org/03esvmb28","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210094118","https://openalex.org/I4210125796"]},{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christian F. Poets","raw_affiliation_strings":["Department of Neonatology, University Children\u2019s Hospital, Tuebingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neonatology, University Children\u2019s Hospital, Tuebingen, Germany","institution_ids":["https://openalex.org/I4210125796","https://openalex.org/I8087733"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108740174","display_name":"Jana Hauke","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jana Hauke","raw_affiliation_strings":["Medical Faculty Heidelberg, Department of Pediatrics I, Center for Pediatric and Adolescent Medicine, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Faculty Heidelberg, Department of Pediatrics I, Center for Pediatric and Adolescent Medicine, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110880219","display_name":"J\u00fcrgen G. Okun","orcid":"https://orcid.org/0000-0003-2975-1054","observed_orcids":["https://orcid.org/0000-0003-2975-1054"]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"J\u00fcrgen G. Okun","raw_affiliation_strings":["Medical Faculty Heidelberg, Department of Pediatrics I, Center for Pediatric and Adolescent Medicine, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Faculty Heidelberg, Department of Pediatrics I, Center for Pediatric and Adolescent Medicine, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045369940","display_name":"Melanie Henes","orcid":"https://orcid.org/0000-0002-8844-5922","observed_orcids":["https://orcid.org/0000-0002-8844-5922"]},"institutions":[{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Melanie Henes","raw_affiliation_strings":["Department of Women\u2019s Health, University of Tuebingen, Tuebingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Women\u2019s Health, University of Tuebingen, Tuebingen, Germany","institution_ids":["https://openalex.org/I8087733"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082248999","display_name":"Christian Gille","orcid":"https://orcid.org/0000-0002-1215-6235","observed_orcids":["https://orcid.org/0000-0002-1215-6235"]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christian Gille","raw_affiliation_strings":["Department of Neonatology, University Children\u2019s Hospital, Im Neuenheimer Feld 430, 69120, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neonatology, University Children\u2019s Hospital, Im Neuenheimer Feld 430, 69120, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909","https://openalex.org/I2802164966"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037894211","display_name":"Natascha K\u00f6stlin\u2010Gille","orcid":"https://orcid.org/0000-0003-3718-5507","observed_orcids":["https://orcid.org/0000-0003-3718-5507"]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]},{"id":"https://openalex.org/I4210125796","display_name":"University Children's Hospital T\u00fcbingen","ror":"https://ror.org/03esvmb28","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210094118","https://openalex.org/I4210125796"]},{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Natascha K\u00f6stlin-Gille","raw_affiliation_strings":["Department of Neonatology, University Children\u2019s Hospital, Im Neuenheimer Feld 430, 69120, Heidelberg, Germany","Department of Neonatology, University Children\u2019s Hospital, Tuebingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neonatology, University Children\u2019s Hospital, Im Neuenheimer Feld 430, 69120, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909","https://openalex.org/I2802164966"]},{"raw_affiliation_string":"Department of Neonatology, University Children\u2019s Hospital, Tuebingen, Germany","institution_ids":["https://openalex.org/I4210125796","https://openalex.org/I8087733"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5037894211"],"corresponding_institution_ids":["https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I4210125796","https://openalex.org/I8087733"],"apc_list":{"value":2690,"currency":"USD","value_usd":2690},"apc_paid":{"value":2690,"currency":"USD","value_usd":2690},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"16","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11510","display_name":"Reproductive System and Pregnancy","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10428","display_name":"Reproductive tract infections research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/recurrent-pregnancy-loss","display_name":"recurrent pregnancy loss","score":1.0},{"id":"https://openalex.org/keywords/miscarriage","display_name":"miscarriage","score":0.8059999942779541},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.9940000176429749},{"id":"https://openalex.org/keywords/microbial-diversity","display_name":"microbial diversity","score":0.800000011920929},{"id":"https://openalex.org/keywords/firmicutes-bacteroidetes-ratio","display_name":"Firmicutes/Bacteroidetes ratio","score":0.9850000143051147},{"id":"https://openalex.org/keywords/lipopolysaccharide-biosynthesis","display_name":"lipopolysaccharide biosynthesis","score":0.9580000042915344},{"id":"https://openalex.org/keywords/amino-acid-catabolism","display_name":"amino acid catabolism","score":0.9079999923706055},{"id":"https://openalex.org/keywords/serum-metabolomics","display_name":"serum metabolomics","score":0.7900000214576721},{"id":"https://openalex.org/keywords/tryptophan","display_name":"tryptophan","score":0.9539999961853027},{"id":"https://openalex.org/keywords/acylcarnitines","display_name":"acylcarnitines","score":0.921999990940094},{"id":"https://openalex.org/keywords/women-s-health","display_name":"women's health","score":0.5270000100135803}],"concepts":[{"id":"https://openalex.org/C143121216","wikidata":"https://www.wikidata.org/wiki/Q1330402","display_name":"Microbiome","level":2,"score":0.817799985408783},{"id":"https://openalex.org/C2777695942","wikidata":"https://www.wikidata.org/wiki/Q149075","display_name":"Firmicutes","level":4,"score":0.7035999894142151},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.621399998664856},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.5038999915122986},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.4715000092983246},{"id":"https://openalex.org/C122325731","wikidata":"https://www.wikidata.org/wiki/Q3738459","display_name":"Relative species abundance","level":3,"score":0.4629000127315521},{"id":"https://openalex.org/C23913935","wikidata":"https://www.wikidata.org/wiki/Q2650881","display_name":"Alpha diversity","level":3,"score":0.41940000653266907},{"id":"https://openalex.org/C2910160754","wikidata":"https://www.wikidata.org/wiki/Q1500347","display_name":"Oral Microbiome","level":3,"score":0.41510000824928284},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.39410001039505005},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.37880000472068787},{"id":"https://openalex.org/C2777385719","wikidata":"https://www.wikidata.org/wiki/Q1061265","display_name":"Bacteroidetes","level":4,"score":0.3776000142097473},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.35989999771118164},{"id":"https://openalex.org/C25147867","wikidata":"https://www.wikidata.org/wiki/Q36039","display_name":"Beta diversity","level":3,"score":0.3513999879360199},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3433000147342682},{"id":"https://openalex.org/C539455810","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut flora","level":2,"score":0.3418999910354614},{"id":"https://openalex.org/C2777165150","wikidata":"https://www.wikidata.org/wiki/Q269334","display_name":"Dysbiosis","level":3,"score":0.3384999930858612},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.33410000801086426},{"id":"https://openalex.org/C15151743","wikidata":"https://www.wikidata.org/wiki/Q903778","display_name":"Metagenomics","level":3,"score":0.3303000032901764},{"id":"https://openalex.org/C77077793","wikidata":"https://www.wikidata.org/wiki/Q336019","display_name":"Abundance (ecology)","level":2,"score":0.32510000467300415},{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.31869998574256897},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.30149999260902405},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.289900004863739},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.28630000352859497},{"id":"https://openalex.org/C91066513","wikidata":"https://www.wikidata.org/wiki/Q38348","display_name":"Phylum","level":3,"score":0.28040000796318054},{"id":"https://openalex.org/C2780221984","wikidata":"https://www.wikidata.org/wiki/Q131191","display_name":"Body mass index","level":2,"score":0.28040000796318054},{"id":"https://openalex.org/C91478284","wikidata":"https://www.wikidata.org/wiki/Q6623796","display_name":"Human microbiome","level":3,"score":0.2791999876499176},{"id":"https://openalex.org/C71640776","wikidata":"https://www.wikidata.org/wiki/Q16521","display_name":"Taxon","level":2,"score":0.26330000162124634},{"id":"https://openalex.org/C3019978661","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut microbiome","level":3,"score":0.25870001316070557},{"id":"https://openalex.org/C63363279","wikidata":"https://www.wikidata.org/wiki/Q5133848","display_name":"Clinical significance","level":2,"score":0.2572000026702881}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1038/s41598-026-79314-3","doi":"https://doi.org/10.1038/s41598-026-79314-3","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-026-79314-3","pdf_url":"https://www.nature.com/articles/s41598-026-79314-3.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1038/s41598-026-79314-3","doi":"https://doi.org/10.1038/s41598-026-79314-3","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-026-79314-3","pdf_url":"https://www.nature.com/articles/s41598-026-79314-3.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320311808","display_name":"J\u00fcrgen Manchot Stiftung","ror":"https://ror.org/026zsn751"},{"id":"https://openalex.org/F4320321989","display_name":"Reinhold Beitlich Stiftung","ror":"https://ror.org/023kcy720"},{"id":"https://openalex.org/F4320330130","display_name":"Universit\u00e4tsklinikum Heidelberg","ror":"https://ror.org/013czdx64"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225659756.pdf","grobid_xml":"https://content.openalex.org/works/W7225659756.grobid-xml"},"referenced_works_count":54,"referenced_works":["https://openalex.org/W1969882260","https://openalex.org/W1983363718","https://openalex.org/W1997113758","https://openalex.org/W2004549986","https://openalex.org/W2006082797","https://openalex.org/W2007378076","https://openalex.org/W2015260577","https://openalex.org/W2034285706","https://openalex.org/W2047798386","https://openalex.org/W2073332363","https://openalex.org/W2080283023","https://openalex.org/W2093500216","https://openalex.org/W2096346081","https://openalex.org/W2101238009","https://openalex.org/W2103761010","https://openalex.org/W2113882071","https://openalex.org/W2117468070","https://openalex.org/W2129937015","https://openalex.org/W2167062509","https://openalex.org/W2343597029","https://openalex.org/W2401404581","https://openalex.org/W2432815617","https://openalex.org/W2501157782","https://openalex.org/W2563720483","https://openalex.org/W2604622795","https://openalex.org/W2605897695","https://openalex.org/W2765745983","https://openalex.org/W2806532887","https://openalex.org/W2951912016","https://openalex.org/W2963276645","https://openalex.org/W2966112307","https://openalex.org/W2969718750","https://openalex.org/W2987962964","https://openalex.org/W2995308649","https://openalex.org/W2997780966","https://openalex.org/W3006653136","https://openalex.org/W3031621681","https://openalex.org/W3091976808","https://openalex.org/W3094521503","https://openalex.org/W3138039660","https://openalex.org/W3159330305","https://openalex.org/W3177829248","https://openalex.org/W4253046392","https://openalex.org/W4254687493","https://openalex.org/W4295750166","https://openalex.org/W4381158089","https://openalex.org/W4388284381","https://openalex.org/W4391529550","https://openalex.org/W4400014436","https://openalex.org/W4400197162","https://openalex.org/W4400738798","https://openalex.org/W4403479110","https://openalex.org/W4409353289","https://openalex.org/W4417435158"],"related_works":["https://openalex.org/W3208413011","https://openalex.org/W4283753247","https://openalex.org/W7162008367","https://openalex.org/W4281295937","https://openalex.org/W7225648231","https://openalex.org/W4390950164","https://openalex.org/W4416287103","https://openalex.org/W7163071585","https://openalex.org/W3195756134","https://openalex.org/W7202123508"],"abstract_inverted_index":{"Abstract":[0],"Recurrent":[1],"spontaneous":[2],"abortion":[3],"(RSA)":[4],"remains":[5],"one":[6,90],"of":[7,57,64,77,97,121,132,191,197,283,293],"the":[8,17,55,58,62,73,156,175,180,273,290],"greatest":[9],"challenges":[10],"in":[11,30,40,61,72,102,201,211,234,244,253],"reproductive":[12],"medicine.":[13],"In":[14,66],"many":[15],"cases,":[16],"underlying":[18],"cause":[19],"cannot":[20],"be":[21,270],"identified.":[22],"The":[23],"gut":[24,59,263],"microbiome":[25,60,75,264],"plays":[26],"a":[27,168,187,202],"crucial":[28],"role":[29,56],"maintaining":[31],"health":[32],"and":[33,38,83,94,107,113,135,158,193,217,240,265,280],"contributing":[34],"to":[35,46,162,237,272,288],"disease":[36],"development,":[37],"alterations":[39,233,268],"its":[41],"composition":[42,76],"have":[43],"been":[44],"linked":[45,271],"numerous":[47],"chronic":[48],"diseases.":[49],"However,":[50],"little":[51],"is":[52],"known":[53],"about":[54],"pathogenesis":[63],"miscarriage.":[65,98],"this":[67],"study,":[68],"we":[69],"analyzed":[70],"differences":[71,210],"pre-conceptional":[74,261],"fifteen":[78],"women":[79],"with":[80,87,145,186],"unexplained":[81],"RSA":[82,146,183,215,254],"twenty-two":[84],"healthy":[85],"controls":[86],"at":[88],"least":[89],"prior":[91],"successful":[92],"pregnancy":[93],"no":[95],"history":[96],"Samples":[99],"were":[100,123],"collected\u200b":[101],"Germany":[103],"between":[104,172,214],"February":[105],"2021":[106],"May":[108],"2023.":[109],"Microbial":[110],"taxonomic":[111],"alpha":[112,151],"beta":[114],"diversity":[115,165],"as":[116,118,153],"well":[117],"differential":[119],"abundance":[120,190,196],"taxa":[122],"assessed":[124,139,154],"by":[125,140,155],"16":[126],"s":[127],"rRNA":[128],"sequencing.":[129],"Differential":[130],"expression":[131],"serum":[133,266],"acyl-carnitines":[134],"amino":[136,241],"acids":[137],"was":[138,184],"tandem":[141],"mass":[142],"spectrometry.":[143],"Women":[144],"exhibited":[147],"significantly":[148,203],"reduced":[149,188,250],"microbial":[150],"diversity,":[152],"Shannon":[157],"Simpson":[159],"indices,":[160],"compared":[161],"controls.":[163],"Beta":[164],"analysis":[166,208],"revealed":[167,249],"continuous":[169],"compositional":[170],"shift":[171],"groups":[173],"along":[174],"primary":[176],"principal":[177],"coordinate.":[178],"At":[179],"phylum":[181],"level,":[182],"associated":[185],"relative":[189,212],"Firmicutes":[192],"an":[194],"increased":[195],"Bacteroidota":[198],",":[199],"resulting":[200],"lower":[204],"Firmicutes/Bacteroidota":[205],"ratio.":[206],"Genus-level":[207],"suggested":[209,231],"abundances":[213],"patients":[216],"controls,":[218],"but":[219],"none":[220],"remained":[221],"statistically":[222],"significant":[223],"after":[224],"correction":[225],"for":[226,275],"multiple":[227],"testing.":[228],"Functional":[229],"prediction":[230],"potential":[232,292],"pathways":[235],"related":[236],"lipopolysaccharide":[238],"biosynthesis":[239],"acid":[242],"degradation":[243],"RSA-associated":[245],"microbiomes.":[246],"Serum":[247],"metabolomics":[248],"tryptophan":[251],"levels":[252],"patients.":[255],"Our":[256],"findings":[257],"suggest":[258],"that":[259],"specific":[260],"existing":[262],"metabolic":[267],"may":[269],"risk":[274],"RSA.":[276],"Larger":[277],"cohort":[278],"studies":[279],"functional":[281],"characterization":[282],"these":[284],"changes":[285],"are":[286],"warranted":[287],"validate":[289],"translational":[291],"our":[294],"results.":[295]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-10T00:00:00"}
