{"id":"https://openalex.org/W7225659136","doi":"https://doi.org/10.1186/s12957-026-04645-4","title":"Prognostic value of circulating tumor DNA in gastric cancer: a systematic review and meta-analysis with emphasis on postoperative molecular residual disease","display_name":"Prognostic value of circulating tumor DNA in gastric cancer: a systematic review and meta-analysis with emphasis on postoperative molecular residual disease","publication_year":2026,"publication_date":"2026-11-09","ids":{"openalex":"https://openalex.org/W7225659136","doi":"https://doi.org/10.1186/s12957-026-04645-4"},"language":"en","primary_location":{"id":"doi:10.1186/s12957-026-04645-4","doi":"https://doi.org/10.1186/s12957-026-04645-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12957-026-04645-4","pdf_url":null,"source":{"id":"https://openalex.org/S180997207","display_name":"World Journal of Surgical Oncology","issn_l":"1477-7819","issn":["1477-7819"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World Journal of Surgical Oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1186/s12957-026-04645-4","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5144280395","display_name":"Yufang Kong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yufang Kong","raw_affiliation_strings":["Department of Anesthesiology, Changzhou Medical Center, Changzhou Maternal and Child Health Care Hospital, Nanjing Medical University, Changzhou, Jiangsu, 213000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Changzhou Medical Center, Changzhou Maternal and Child Health Care Hospital, Nanjing Medical University, Changzhou, Jiangsu, 213000, China","institution_ids":["https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107937752","display_name":"Ling Yuan","orcid":"https://orcid.org/0009-0002-0916-4696","observed_orcids":["https://orcid.org/0009-0002-0916-4696"]},"institutions":[{"id":"https://openalex.org/I4210152119","display_name":"Jiangsu Province Hospital","ror":"https://ror.org/04py1g812","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210152119"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ling Yuan","raw_affiliation_strings":["Department of Anesthesiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, 210029, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, 210029, China","institution_ids":["https://openalex.org/I4210152119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104264860","display_name":"Rong Kuang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I199305430","display_name":"Nantong University","ror":"https://ror.org/02afcvw97","country_code":"CN","type":"education","lineage":["https://openalex.org/I199305430"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rong Kuang","raw_affiliation_strings":["Department of Anesthesiology, The affiliated Changzhou Children\u2019s Hospital of Nantong University, Changzhou, Jiangsu, 213000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, The affiliated Changzhou Children\u2019s Hospital of Nantong University, Changzhou, Jiangsu, 213000, China","institution_ids":["https://openalex.org/I199305430"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101556476","display_name":"Wen Qian","orcid":"https://orcid.org/0000-0001-6600-8249","observed_orcids":["https://orcid.org/0000-0001-6600-8249"]},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wen Qian","raw_affiliation_strings":["Department of Anesthesiology, Changzhou Medical Center, Changzhou Maternal and Child Health Care Hospital, Nanjing Medical University, Changzhou, Jiangsu, 213000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Changzhou Medical Center, Changzhou Maternal and Child Health Care Hospital, Nanjing Medical University, Changzhou, Jiangsu, 213000, China","institution_ids":["https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161359843","display_name":"Yina Yin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yina Yin","raw_affiliation_strings":["Department of Anesthesiology, Changzhou Medical Center, Changzhou Maternal and Child Health Care Hospital, Nanjing Medical University, Changzhou, Jiangsu, 213000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Changzhou Medical Center, Changzhou Maternal and Child Health Care Hospital, Nanjing Medical University, Changzhou, Jiangsu, 213000, China","institution_ids":["https://openalex.org/I83519826"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111194419","display_name":"Jiali Xiong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jiali Xiong","raw_affiliation_strings":["Department of Obstetrics, Changzhou Maternity and child Health Care Hospital, Changzhou Medical Center, Nanjing Medical University, Changzhou, Jiangsu, 213000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics, Changzhou Maternity and child Health Care Hospital, Changzhou Medical Center, Nanjing Medical University, Changzhou, Jiangsu, 213000, China","institution_ids":["https://openalex.org/I83519826"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5111194419","https://openalex.org/A5161359843"],"corresponding_institution_ids":["https://openalex.org/I83519826"],"apc_list":{"value":2990,"currency":"USD","value_usd":2990},"apc_paid":{"value":2990,"currency":"USD","value_usd":2990},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":0.6211000084877014,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":0.6211000084877014,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.33180001378059387,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11765","display_name":"Circular RNAs in diseases","score":0.003800000064074993,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/circulating-tumor-dna","display_name":"circulating tumor DNA","score":0.949999988079071},{"id":"https://openalex.org/keywords/gastric-cancer","display_name":"gastric cancer","score":0.9879999756813049},{"id":"https://openalex.org/keywords/molecular-residual-disease","display_name":"molecular residual disease","score":0.9760000109672546},{"id":"https://openalex.org/keywords/postoperative-recurrence","display_name":"postoperative recurrence","score":0.7170000076293945},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.9369999766349792},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.7390000224113464},{"id":"https://openalex.org/keywords/disease-free-survival","display_name":"disease-free survival","score":0.8690000176429749},{"id":"https://openalex.org/keywords/cell-free-dna","display_name":"cell-free DNA","score":0.45100000500679016},{"id":"https://openalex.org/keywords/postoperative-risk-stratification","display_name":"postoperative risk stratification","score":0.859000027179718}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9110000133514404},{"id":"https://openalex.org/C2781335228","wikidata":"https://www.wikidata.org/wiki/Q19596321","display_name":"Circulating tumor DNA","level":3,"score":0.7354000210762024},{"id":"https://openalex.org/C2780140570","wikidata":"https://www.wikidata.org/wiki/Q3545481","display_name":"Surgical oncology","level":2,"score":0.7264999747276306},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7179999947547913},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.6628999710083008},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6504999995231628},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.5565000176429749},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.5289000272750854},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.4781000018119812},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.43790000677108765},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.43380001187324524},{"id":"https://openalex.org/C187960798","wikidata":"https://www.wikidata.org/wiki/Q7631152","display_name":"Subgroup analysis","level":3,"score":0.40880000591278076},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3862000107765198},{"id":"https://openalex.org/C10515644","wikidata":"https://www.wikidata.org/wiki/Q543310","display_name":"Survival analysis","level":2,"score":0.337799996137619},{"id":"https://openalex.org/C2779823535","wikidata":"https://www.wikidata.org/wiki/Q6865356","display_name":"Minimal residual disease","level":3,"score":0.3271999955177307},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.32429999113082886},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.32170000672340393},{"id":"https://openalex.org/C520017518","wikidata":"https://www.wikidata.org/wiki/Q178934","display_name":"Occult","level":3,"score":0.32019999623298645},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.31619998812675476},{"id":"https://openalex.org/C3019894029","wikidata":"https://www.wikidata.org/wiki/Q332823","display_name":"Overall survival","level":2,"score":0.28029999136924744},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.2752000093460083},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.2741999924182892},{"id":"https://openalex.org/C2776283816","wikidata":"https://www.wikidata.org/wiki/Q332823","display_name":"Survival rate","level":2,"score":0.27320000529289246},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2694999873638153},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.25220000743865967},{"id":"https://openalex.org/C164465091","wikidata":"https://www.wikidata.org/wiki/Q7248371","display_name":"Prognostic variable","level":3,"score":0.25200000405311584},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2500999867916107}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1186/s12957-026-04645-4","doi":"https://doi.org/10.1186/s12957-026-04645-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12957-026-04645-4","pdf_url":null,"source":{"id":"https://openalex.org/S180997207","display_name":"World Journal of Surgical Oncology","issn_l":"1477-7819","issn":["1477-7819"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World Journal of Surgical Oncology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1186/s12957-026-04645-4","doi":"https://doi.org/10.1186/s12957-026-04645-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12957-026-04645-4","pdf_url":null,"source":{"id":"https://openalex.org/S180997207","display_name":"World Journal of Surgical Oncology","issn_l":"1477-7819","issn":["1477-7819"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World Journal of Surgical Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Systematic Review","id":"https://openalex.org/study-designs/systematic-review"},{"display_name":"Meta-Analysis","id":"https://openalex.org/study-designs/meta-analysis"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7161583668","https://openalex.org/W7163378226","https://openalex.org/W4363646320","https://openalex.org/W4389257699","https://openalex.org/W7225083917","https://openalex.org/W7214087529","https://openalex.org/W4281765677","https://openalex.org/W4406595900","https://openalex.org/W2563979203","https://openalex.org/W4379985036"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Despite":[2],"curative-intent":[3],"surgery,":[4],"recurrence":[5,257],"remains":[6,67],"a":[7,30,41,195,268],"major":[8],"cause":[9],"of":[10,33,58,87,246,297],"mortality":[11],"in":[12,78,111,261,284],"gastric":[13,112,262],"cancer,":[14],"while":[15],"conventional":[16],"clinicopathological":[17],"staging":[18],"provides":[19],"limited":[20],"accuracy":[21],"for":[22,44,91,119,209,270],"postoperative":[23,52,191,276],"risk":[24,277],"stratification.":[25,278],"Circulating":[26],"tumor":[27],"DNA":[28],"(ctDNA),":[29],"promising":[31],"biomarker":[32,269],"molecular":[34,271],"residual":[35,47,272],"disease":[36,48,273],"(MRD),":[37],"has":[38],"emerged":[39],"as":[40,108,267],"potential":[42,266],"tool":[43],"identifying":[45],"occult":[46],"and":[49,64,74,85,98,114,152,178,258,264,275,282,291],"guiding":[50],"personalized":[51],"management.":[53],"However,":[54,279],"the":[55,215,226,244,247],"prognostic":[56,109],"value":[57],"ctDNA":[59,103,163,192,252],"across":[60],"different":[61,219],"clinical":[62],"contexts":[63],"assay":[65,289],"strategies":[66],"incompletely":[68],"defined.":[69],"Methods":[70],"A":[71],"systematic":[72],"review":[73],"meta-analysis":[75],"was":[76,165,236],"conducted":[77],"accordance":[79],"with":[80,126,168,255],"PRISMA":[81],"guidelines.":[82],"PubMed,":[83],"Embase,":[84],"Web":[86],"Science":[88],"were":[89,122,131,144,161],"searched":[90],"eligible":[92],"studies":[93,157],"published":[94],"between":[95],"January":[96],"2019":[97],"May":[99],"2025.":[100],"Studies":[101],"evaluating":[102],"or":[104,135],"broader":[105],"cfDNA-based":[106],"biomarkers":[107],"markers":[110],"cancer":[113,263],"reporting":[115],"hazard":[116],"ratios":[117],"(HRs)":[118],"survival":[120,171,180,220,259],"outcomes":[121,260],"included.":[123,162],"Pooled":[124],"HRs":[125],"95%":[127,175,184],"confidence":[128],"intervals":[129],"(CIs)":[130],"calculated":[132],"using":[133],"fixed-":[134],"random-effects":[136],"models":[137],"according":[138],"to":[139],"heterogeneity.":[140],"Prespecified":[141],"subgroup":[142,189,210],"analyses":[143,242],"performed":[145],"based":[146],"on":[147],"sampling":[148,287],"timing,":[149,288],"detection":[150,239],"strategy,":[151],"geographic":[153],"region.":[154],"Results":[155],"Ten":[156],"involving":[158],"1,487":[159],"patients":[160],"positivity":[164],"significantly":[166],"associated":[167,254],"inferior":[169],"overall":[170],"(HR":[172,181,203],"=":[173,182,204,212],"4.06,":[174],"CI":[176,185],"2.45\u20136.74)":[177],"disease-free/relapse-free":[179],"7.13,":[183],"3.17\u201316.01).":[186],"In":[187],"exploratory":[188],"analysis,":[190],"assessment":[193,202,274],"showed":[194],"larger":[196],"pooled":[197,228,248,298],"effect":[198,229,299],"estimate":[199],"than":[200],"non-postoperative":[201],"7.13":[205],"vs.":[206],"2.73,":[207],"P":[208],"difference":[211,235],"0.03),":[213],"although":[214,231],"two":[216],"subgroups":[217],"represented":[218],"endpoints.":[221],"Tumor-informed":[222],"sequencing":[223],"approaches":[224],"yielded":[225],"largest":[227],"size,":[230],"no":[232],"statistically":[233],"significant":[234],"observed":[237],"among":[238],"methodologies.":[240],"Sensitivity":[241],"confirmed":[243],"robustness":[245],"estimates.":[249,300],"Conclusions":[250],"Postoperative":[251],"is":[253],"adverse":[256],"shows":[265],"substantial":[280],"heterogeneity":[281],"differences":[283],"study":[285],"design,":[286],"methodology,":[290],"endpoint":[292],"composition":[293],"warrant":[294],"cautious":[295],"interpretation":[296]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-10T00:00:00"}
