{"id":"https://openalex.org/W7225658745","doi":"https://doi.org/10.3389/fcell.2026.1996111","title":"Oxeiptosis-related transcriptional heterogeneity in lung adenocarcinoma: prognostic modeling and functional prioritization of PSMD2","display_name":"Oxeiptosis-related transcriptional heterogeneity in lung adenocarcinoma: prognostic modeling and functional prioritization of PSMD2","publication_year":2026,"publication_date":"2026-11-09","ids":{"openalex":"https://openalex.org/W7225658745","doi":"https://doi.org/10.3389/fcell.2026.1996111"},"language":"en","primary_location":{"id":"doi:10.3389/fcell.2026.1996111","doi":"https://doi.org/10.3389/fcell.2026.1996111","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcell.2026.1996111","pdf_url":"https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2026.1996111/pdf","source":{"id":"https://openalex.org/S2596924766","display_name":"Frontiers in Cell and Developmental Biology","issn_l":"2296-634X","issn":["2296-634X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cell and Developmental Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2026.1996111/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034294477","display_name":"Yuqi Cao","orcid":"https://orcid.org/0009-0005-1982-2308","observed_orcids":["https://orcid.org/0009-0005-1982-2308"]},"institutions":[{"id":"https://openalex.org/I162868743","display_name":"Tianjin University","ror":"https://ror.org/012tb2g32","country_code":"CN","type":"education","lineage":["https://openalex.org/I162868743"]},{"id":"https://openalex.org/I4210150108","display_name":"Tianjin Chest Hospital","ror":"https://ror.org/05r9v1368","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210150108"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuqi Cao","raw_affiliation_strings":["Tianjin Chest Hospital, Tianjin University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tianjin Chest Hospital, Tianjin University","institution_ids":["https://openalex.org/I162868743","https://openalex.org/I4210150108"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161344290","display_name":"Feng Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I162868743","display_name":"Tianjin University","ror":"https://ror.org/012tb2g32","country_code":"CN","type":"education","lineage":["https://openalex.org/I162868743"]},{"id":"https://openalex.org/I4210150108","display_name":"Tianjin Chest Hospital","ror":"https://ror.org/05r9v1368","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210150108"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Feng Chen","raw_affiliation_strings":["Tianjin Chest Hospital, Tianjin University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tianjin Chest Hospital, Tianjin University","institution_ids":["https://openalex.org/I162868743","https://openalex.org/I4210150108"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161338061","display_name":"Hao Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I162868743","display_name":"Tianjin University","ror":"https://ror.org/012tb2g32","country_code":"CN","type":"education","lineage":["https://openalex.org/I162868743"]},{"id":"https://openalex.org/I2802573037","display_name":"Tianjin Medical University Cancer Institute and Hospital","ror":"https://ror.org/0152hn881","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802573037"]},{"id":"https://openalex.org/I4210150108","display_name":"Tianjin Chest Hospital","ror":"https://ror.org/05r9v1368","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210150108"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hao Zhang","raw_affiliation_strings":["Tianjin Chest Hospital, Tianjin University","Tianjin Medical University Cancer Institute and Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tianjin Chest Hospital, Tianjin University","institution_ids":["https://openalex.org/I162868743","https://openalex.org/I4210150108"]},{"raw_affiliation_string":"Tianjin Medical University Cancer Institute and Hospital","institution_ids":["https://openalex.org/I2802573037"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078862131","display_name":"Wenchao Xia","orcid":"https://orcid.org/0009-0002-2308-4318","observed_orcids":["https://orcid.org/0009-0002-2308-4318"]},"institutions":[{"id":"https://openalex.org/I162868743","display_name":"Tianjin University","ror":"https://ror.org/012tb2g32","country_code":"CN","type":"education","lineage":["https://openalex.org/I162868743"]},{"id":"https://openalex.org/I4210150108","display_name":"Tianjin Chest Hospital","ror":"https://ror.org/05r9v1368","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210150108"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenchao Xia","raw_affiliation_strings":["Tianjin Chest Hospital, Tianjin University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tianjin Chest Hospital, Tianjin University","institution_ids":["https://openalex.org/I162868743","https://openalex.org/I4210150108"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100354006","display_name":"Xin Li","orcid":"https://orcid.org/0000-0003-0469-5121","observed_orcids":["https://orcid.org/0000-0003-0469-5121"]},"institutions":[{"id":"https://openalex.org/I162868743","display_name":"Tianjin University","ror":"https://ror.org/012tb2g32","country_code":"CN","type":"education","lineage":["https://openalex.org/I162868743"]},{"id":"https://openalex.org/I4210150108","display_name":"Tianjin Chest Hospital","ror":"https://ror.org/05r9v1368","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210150108"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xin Li","raw_affiliation_strings":["Tianjin Chest Hospital, Tianjin University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tianjin Chest Hospital, Tianjin University","institution_ids":["https://openalex.org/I162868743","https://openalex.org/I4210150108"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161358790","display_name":"Han Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I162868743","display_name":"Tianjin University","ror":"https://ror.org/012tb2g32","country_code":"CN","type":"education","lineage":["https://openalex.org/I162868743"]},{"id":"https://openalex.org/I2802573037","display_name":"Tianjin Medical University Cancer Institute and Hospital","ror":"https://ror.org/0152hn881","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802573037"]},{"id":"https://openalex.org/I4210150108","display_name":"Tianjin Chest Hospital","ror":"https://ror.org/05r9v1368","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210150108"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Han Zhang","raw_affiliation_strings":["Tianjin Chest Hospital, Tianjin University","Tianjin Medical University Cancer Institute and Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tianjin Chest Hospital, Tianjin University","institution_ids":["https://openalex.org/I162868743","https://openalex.org/I4210150108"]},{"raw_affiliation_string":"Tianjin Medical University Cancer Institute and Hospital","institution_ids":["https://openalex.org/I2802573037"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100529360","display_name":"Yijun Xu","orcid":"https://orcid.org/0009-0008-6626-9439","observed_orcids":["https://orcid.org/0009-0008-6626-9439"]},"institutions":[{"id":"https://openalex.org/I162868743","display_name":"Tianjin University","ror":"https://ror.org/012tb2g32","country_code":"CN","type":"education","lineage":["https://openalex.org/I162868743"]},{"id":"https://openalex.org/I4210150108","display_name":"Tianjin Chest Hospital","ror":"https://ror.org/05r9v1368","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210150108"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yijun Xu","raw_affiliation_strings":["Tianjin Chest Hospital, Tianjin University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tianjin Chest Hospital, Tianjin University","institution_ids":["https://openalex.org/I162868743","https://openalex.org/I4210150108"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5100529360"],"corresponding_institution_ids":["https://openalex.org/I162868743","https://openalex.org/I4210150108"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"14","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.4494999945163727,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.4494999945163727,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.44530001282691956,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.01730000041425228,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oxeiptosis","display_name":"oxeiptosis","score":0.9629999995231628},{"id":"https://openalex.org/keywords/lung-adenocarcinoma","display_name":"lung adenocarcinoma","score":0.9919999837875366},{"id":"https://openalex.org/keywords/psmd2","display_name":"PSMD2","score":0.9409999847412109},{"id":"https://openalex.org/keywords/prognostic-gene-signature","display_name":"prognostic gene signature","score":0.8579999804496765},{"id":"https://openalex.org/keywords/transcriptional-heterogeneity","display_name":"transcriptional heterogeneity","score":0.824999988079071},{"id":"https://openalex.org/keywords/tumor-immune-infiltration","display_name":"tumor immune infiltration","score":0.7110000252723694},{"id":"https://openalex.org/keywords/drug-response-prediction","display_name":"drug response prediction","score":0.7649999856948853},{"id":"https://openalex.org/keywords/cell-migration-and-invasion","display_name":"cell migration and invasion","score":0.7860000133514404},{"id":"https://openalex.org/keywords/single-cell-gene-expression","display_name":"single-cell gene expression","score":0.4959999918937683},{"id":"https://openalex.org/keywords/hla-genes","display_name":"HLA genes","score":0.6159999966621399},{"id":"https://openalex.org/keywords/ribociclib","display_name":"ribociclib","score":0.7609999775886536},{"id":"https://openalex.org/keywords/bi-2536","display_name":"BI2536","score":0.9810000061988831}],"concepts":[{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.6503999829292297},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5342000126838684},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.5235999822616577},{"id":"https://openalex.org/C2779733811","wikidata":"https://www.wikidata.org/wiki/Q5531562","display_name":"Gene signature","level":4,"score":0.5027999877929688},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.4681999981403351},{"id":"https://openalex.org/C83546350","wikidata":"https://www.wikidata.org/wiki/Q1139051","display_name":"Regression","level":2,"score":0.46219998598098755},{"id":"https://openalex.org/C10515644","wikidata":"https://www.wikidata.org/wiki/Q543310","display_name":"Survival analysis","level":2,"score":0.45590001344680786},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.44929999113082886},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.42559999227523804},{"id":"https://openalex.org/C170964787","wikidata":"https://www.wikidata.org/wiki/Q7611170","display_name":"Stepwise regression","level":2,"score":0.4196999967098236},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.41839998960494995},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.38019999861717224},{"id":"https://openalex.org/C152877465","wikidata":"https://www.wikidata.org/wiki/Q208042","display_name":"Regression analysis","level":2,"score":0.3767000138759613},{"id":"https://openalex.org/C2777615720","wikidata":"https://www.wikidata.org/wiki/Q11888847","display_name":"Prioritization","level":2,"score":0.3571000099182129},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.35530000925064087},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3522000014781952},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.34150001406669617},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.33880001306533813},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.328900009393692},{"id":"https://openalex.org/C48921125","wikidata":"https://www.wikidata.org/wiki/Q10861030","display_name":"Linear regression","level":2,"score":0.3273000121116638},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.32199999690055847},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.31220000982284546},{"id":"https://openalex.org/C3019894029","wikidata":"https://www.wikidata.org/wiki/Q332823","display_name":"Overall survival","level":2,"score":0.30799999833106995},{"id":"https://openalex.org/C11783203","wikidata":"https://www.wikidata.org/wiki/Q5478027","display_name":"Framingham Risk Score","level":3,"score":0.30300000309944153},{"id":"https://openalex.org/C2986432223","wikidata":"https://www.wikidata.org/wiki/Q5449740","display_name":"Risk model","level":2,"score":0.2890999913215637},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.2858999967575073},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.28540000319480896},{"id":"https://openalex.org/C12174686","wikidata":"https://www.wikidata.org/wiki/Q1058438","display_name":"Risk assessment","level":2,"score":0.28519999980926514},{"id":"https://openalex.org/C65409693","wikidata":"https://www.wikidata.org/wiki/Q425265","display_name":"Statistical significance","level":2,"score":0.27399998903274536},{"id":"https://openalex.org/C63363279","wikidata":"https://www.wikidata.org/wiki/Q5133848","display_name":"Clinical significance","level":2,"score":0.26750001311302185},{"id":"https://openalex.org/C77350462","wikidata":"https://www.wikidata.org/wiki/Q1125472","display_name":"Confounding","level":2,"score":0.26429998874664307},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.2597000002861023}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3389/fcell.2026.1996111","doi":"https://doi.org/10.3389/fcell.2026.1996111","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcell.2026.1996111","pdf_url":"https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2026.1996111/pdf","source":{"id":"https://openalex.org/S2596924766","display_name":"Frontiers in Cell and Developmental Biology","issn_l":"2296-634X","issn":["2296-634X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cell and Developmental Biology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.3389/fcell.2026.1996111","doi":"https://doi.org/10.3389/fcell.2026.1996111","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcell.2026.1996111","pdf_url":"https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2026.1996111/pdf","source":{"id":"https://openalex.org/S2596924766","display_name":"Frontiers in Cell and Developmental Biology","issn_l":"2296-634X","issn":["2296-634X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cell and Developmental Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225658745.pdf","grobid_xml":"https://content.openalex.org/works/W7225658745.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W2123879591","https://openalex.org/W2130430382","https://openalex.org/W2616922646","https://openalex.org/W2984472267","https://openalex.org/W3182293965","https://openalex.org/W4210910593","https://openalex.org/W4214829272","https://openalex.org/W4307425304","https://openalex.org/W4308834549","https://openalex.org/W4323036511","https://openalex.org/W4324129788","https://openalex.org/W4324377408","https://openalex.org/W4361274957","https://openalex.org/W4365137707","https://openalex.org/W4365137743","https://openalex.org/W4378953806","https://openalex.org/W4379280261","https://openalex.org/W4379879135","https://openalex.org/W4386522627","https://openalex.org/W4387341707","https://openalex.org/W4387996162","https://openalex.org/W4390571246","https://openalex.org/W4396915845","https://openalex.org/W4401211263","https://openalex.org/W4403157733","https://openalex.org/W4403243250","https://openalex.org/W4404028988","https://openalex.org/W4407203128","https://openalex.org/W4407316118","https://openalex.org/W4410219182"],"related_works":["https://openalex.org/W4309458076","https://openalex.org/W4402734815","https://openalex.org/W3207931012","https://openalex.org/W7128548916","https://openalex.org/W4318592029","https://openalex.org/W4386573975","https://openalex.org/W7214575752","https://openalex.org/W4288037284","https://openalex.org/W4400190372","https://openalex.org/W2968165963"],"abstract_inverted_index":{"Background":[0],"It":[1],"remains":[2],"uncertain":[3],"whether":[4],"transcriptional":[5],"variation":[6],"related":[7],"to":[8,176,238,247,286],"oxeiptosis":[9],"carries":[10],"prognostic":[11,296],"information":[12],"in":[13,86,94,171,190,257,275],"lung":[14],"adenocarcinoma":[15],"(LUAD).":[16],"We":[17,62],"investigated":[18],"this":[19],"question":[20],"and":[21,39,44,55,67,96,103,123,157,164,192,214,240,259,268,273,291,300],"sought":[22],"a":[23,177],"model-derived":[24],"gene":[25,56],"whose":[26],"contribution":[27,297],"could":[28],"be":[29],"examined":[30,59,226],"experimentally.":[31],"Methods":[32],"Oxeiptosis-associated":[33],"candidates":[34],"were":[35,49,58],"identified":[36],"from":[37],"TCGA-LUAD":[38,111],"used":[40],"for":[41,161],"tumor":[42],"classification":[43],"survival":[45],"modeling.":[46],"Competing":[47],"models":[48],"evaluated":[50],"across":[51,81,139],"six":[52,141],"GEO":[53,194],"cohorts,":[54,195],"contributions":[57],"by":[60,100,131],"SHAP.":[61],"also":[63],"analyzed":[64],"immune-related":[65],"expression":[66,115,285],"estimated":[68],"drug":[69,293],"IC":[70],"50":[71],"values":[72],"with":[73,212,234,243],"oncoPredict.":[74],"The":[75,107,147,208,280,295],"distribution":[76],"of":[77,117,224,298,303,309],"the":[78,135,140,172,197,202,218,225,264,301],"model":[79,149,282],"signature":[80],"cell":[82,277],"populations":[83],"was":[84,91],"explored":[85],"GSE171145":[87],"using":[88],"AUCell.":[89],"PSMD2":[90,262,299],"then":[92],"silenced":[93],"A549":[95],"PC9":[97],"cells,":[98],"followed":[99,130],"qRT-PCR,":[101],"wound-healing,":[102],"Transwell":[104],"assays.":[105],"Results":[106],"45-gene":[108],"panel":[109],"separated":[110],"tumors":[112],"into":[113],"four":[114,193],"groups,":[116],"which":[118],"C3":[119],"contained":[120],"greater":[121,235,244],"immune":[122,289],"stromal":[124],"components.":[125],"Bidirectional":[126],"stepwise":[127],"Cox":[128],"regression":[129,133],"ridge":[132],"produced":[134],"best":[136],"overall":[137],"performance":[138],"evaluation":[142],"cohorts":[143],"(mean":[144],"C-index,":[145],"0.669).":[146],"resulting":[148],"comprised":[150],"PSMD2,":[151],"LSG1,":[152],"PTBP1,":[153],"ELAVL1,":[154],"ANP32B,":[155],"IMMT,":[156],"HSPD1.":[158],"After":[159],"adjustment":[160],"age,":[162],"sex,":[163],"pathological":[165],"stage,":[166],"each":[167],"standard":[168],"deviation":[169],"increase":[170],"risk":[173,180,233,242],"score":[174,209],"corresponded":[175],"higher":[178,241],"mortality":[179],"(HR,":[181],"1.62;":[182],"95%":[183],"CI,":[184],"1.41\u20131.85).":[185],"Survival":[186],"separation":[187],"reached":[188],"significance":[189],"TCGA":[191],"whereas":[196],"remaining":[198],"two":[199],"datasets":[200],"showed":[201],"same":[203],"direction":[204],"without":[205],"statistical":[206],"significance.":[207],"tracked":[210],"positively":[211],"cell-cycle":[213],"DNA-replication":[215],"activity,":[216],"while":[217],"high-risk":[219],"group":[220],"expressed":[221],"lower":[222,232],"levels":[223],"HLA":[227],"genes.":[228],"Drug-response":[229],"estimation":[230],"associated":[231],"predicted":[236,245,292],"sensitivity":[237,246],"ribociclib":[239],"BI-2536.":[248],"At":[249],"single-cell":[250],"resolution,":[251],"high":[252],"AUCell":[253],"scores":[254],"occurred":[255],"mainly":[256],"epithelial":[258],"myeloid":[260],"populations.":[261],"made":[263],"largest":[265],"SHAP":[266],"contribution,":[267],"its":[269,304,310],"silencing":[270],"impaired":[271],"migration":[272],"invasion":[274],"both":[276],"lines.":[278],"Conclusion":[279],"seven-gene":[281],"links":[283],"oxeiptosis-related":[284],"LUAD":[287],"prognosis,":[288],"features,":[290],"sensitivity.":[294],"effects":[302],"knockdown":[305],"support":[306],"further":[307],"investigation":[308],"function.":[311]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-10T00:00:00"}
