{"id":"https://openalex.org/W7225658587","doi":"https://doi.org/10.3390/fermentation12110524","title":"Exploiting Ethanol to Improve Production of Glutathione by Saccharomyces cerevisiae","display_name":"Exploiting Ethanol to Improve Production of Glutathione by Saccharomyces cerevisiae","publication_year":2026,"publication_date":"2026-11-08","ids":{"openalex":"https://openalex.org/W7225658587","doi":"https://doi.org/10.3390/fermentation12110524"},"language":"en","primary_location":{"id":"doi:10.3390/fermentation12110524","doi":"https://doi.org/10.3390/fermentation12110524","is_oa":true,"landing_page_url":"https://doi.org/10.3390/fermentation12110524","pdf_url":null,"source":{"id":"https://openalex.org/S2739076822","display_name":"Fermentation","issn_l":"2311-5637","issn":["2311-5637"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Fermentation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/fermentation12110524","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086877915","display_name":"Mengxiong Xiang","orcid":"https://orcid.org/0009-0003-5259-2941","observed_orcids":["https://orcid.org/0009-0003-5259-2941"]},"institutions":[{"id":"https://openalex.org/I74525822","display_name":"Hubei University of Technology","ror":"https://ror.org/02d3fj342","country_code":"CN","type":"education","lineage":["https://openalex.org/I74525822"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mengxiong Xiang","raw_affiliation_strings":["Cooperative Innovation Center of Industrial Fermentation (Ministry of Education & Hubei Province), Hubei Key Laboratory of Industrial Microbiology, Hubei University of Technology, Wuhan 430068, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cooperative Innovation Center of Industrial Fermentation (Ministry of Education & Hubei Province), Hubei Key Laboratory of Industrial Microbiology, Hubei University of Technology, Wuhan 430068, China","institution_ids":["https://openalex.org/I74525822"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161325268","display_name":"Runmei Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74525822","display_name":"Hubei University of Technology","ror":"https://ror.org/02d3fj342","country_code":"CN","type":"education","lineage":["https://openalex.org/I74525822"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Runmei Zhang","raw_affiliation_strings":["Cooperative Innovation Center of Industrial Fermentation (Ministry of Education & Hubei Province), Hubei Key Laboratory of Industrial Microbiology, Hubei University of Technology, Wuhan 430068, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cooperative Innovation Center of Industrial Fermentation (Ministry of Education & Hubei Province), Hubei Key Laboratory of Industrial Microbiology, Hubei University of Technology, Wuhan 430068, China","institution_ids":["https://openalex.org/I74525822"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5137687310","display_name":"Zheng Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74525822","display_name":"Hubei University of Technology","ror":"https://ror.org/02d3fj342","country_code":"CN","type":"education","lineage":["https://openalex.org/I74525822"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zheng Wu","raw_affiliation_strings":["Cooperative Innovation Center of Industrial Fermentation (Ministry of Education & Hubei Province), Hubei Key Laboratory of Industrial Microbiology, Hubei University of Technology, Wuhan 430068, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cooperative Innovation Center of Industrial Fermentation (Ministry of Education & Hubei Province), Hubei Key Laboratory of Industrial Microbiology, Hubei University of Technology, Wuhan 430068, China","institution_ids":["https://openalex.org/I74525822"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111837757","display_name":"Jun Cai","orcid":"https://orcid.org/0000-0002-1702-7985","observed_orcids":["https://orcid.org/0000-0002-1702-7985"]},"institutions":[{"id":"https://openalex.org/I74525822","display_name":"Hubei University of Technology","ror":"https://ror.org/02d3fj342","country_code":"CN","type":"education","lineage":["https://openalex.org/I74525822"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jun Cai","raw_affiliation_strings":["Cooperative Innovation Center of Industrial Fermentation (Ministry of Education & Hubei Province), Hubei Key Laboratory of Industrial Microbiology, Hubei University of Technology, Wuhan 430068, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cooperative Innovation Center of Industrial Fermentation (Ministry of Education & Hubei Province), Hubei Key Laboratory of Industrial Microbiology, Hubei University of Technology, Wuhan 430068, China","institution_ids":["https://openalex.org/I74525822"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5111837757"],"corresponding_institution_ids":["https://openalex.org/I74525822"],"apc_list":{"value":2100,"currency":"CHF","value_usd":2534},"apc_paid":{"value":2100,"currency":"CHF","value_usd":2534},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"12","issue":"11","first_page":"524","last_page":"524"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.7886000275611877,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.7886000275611877,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.12070000171661377,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11481","display_name":"Sulfur Compounds in Biology","score":0.06480000168085098,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glutathione-synthesis","display_name":"glutathione synthesis","score":0.8859999775886536},{"id":"https://openalex.org/keywords/saccharomyces-cerevisiae","display_name":"Saccharomyces cerevisiae","score":0.996999979019165},{"id":"https://openalex.org/keywords/ethanol-supplementation","display_name":"ethanol supplementation","score":0.7760000228881836},{"id":"https://openalex.org/keywords/membrane-permeability","display_name":"membrane permeability","score":0.871999979019165},{"id":"https://openalex.org/keywords/fed-batch-fermentation","display_name":"fed-batch fermentation","score":0.7929999828338623},{"id":"https://openalex.org/keywords/fermentation-parameter-optimization","display_name":"fermentation parameter optimization","score":0.7929999828338623},{"id":"https://openalex.org/keywords/medium-composition-optimization","display_name":"medium composition optimization","score":0.6809999942779541},{"id":"https://openalex.org/keywords/feedback-inhibition","display_name":"product inhibition","score":0.4749999940395355}],"concepts":[{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.8730999827384949},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.7810999751091003},{"id":"https://openalex.org/C100544194","wikidata":"https://www.wikidata.org/wiki/Q41760","display_name":"Fermentation","level":2,"score":0.7062000036239624},{"id":"https://openalex.org/C2777576037","wikidata":"https://www.wikidata.org/wiki/Q719725","display_name":"Saccharomyces cerevisiae","level":3,"score":0.6916000247001648},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.6384999752044678},{"id":"https://openalex.org/C167392928","wikidata":"https://www.wikidata.org/wiki/Q4820777","display_name":"Tripeptide","level":3,"score":0.5745000243186951},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.5309000015258789},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.5005999803543091},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.47769999504089355},{"id":"https://openalex.org/C168170006","wikidata":"https://www.wikidata.org/wiki/Q864699","display_name":"Bioreactor","level":2,"score":0.428600013256073},{"id":"https://openalex.org/C65183824","wikidata":"https://www.wikidata.org/wiki/Q194361","display_name":"Ethanol fuel","level":3,"score":0.3702000081539154},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.35019999742507935},{"id":"https://openalex.org/C6350086","wikidata":"https://www.wikidata.org/wiki/Q6822347","display_name":"Metabolic engineering","level":3,"score":0.33880001306533813},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.321399986743927},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32120001316070557},{"id":"https://openalex.org/C2779222958","wikidata":"https://www.wikidata.org/wiki/Q45422","display_name":"Yeast","level":2,"score":0.25619998574256897},{"id":"https://openalex.org/C125111812","wikidata":"https://www.wikidata.org/wiki/Q902311","display_name":"Chemostat","level":3,"score":0.250900000333786}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3390/fermentation12110524","doi":"https://doi.org/10.3390/fermentation12110524","is_oa":true,"landing_page_url":"https://doi.org/10.3390/fermentation12110524","pdf_url":null,"source":{"id":"https://openalex.org/S2739076822","display_name":"Fermentation","issn_l":"2311-5637","issn":["2311-5637"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Fermentation","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.3390/fermentation12110524","doi":"https://doi.org/10.3390/fermentation12110524","is_oa":true,"landing_page_url":"https://doi.org/10.3390/fermentation12110524","pdf_url":null,"source":{"id":"https://openalex.org/S2739076822","display_name":"Fermentation","issn_l":"2311-5637","issn":["2311-5637"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Fermentation","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320330031","display_name":"Science and Technology Department of Hubei Province","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W1979379297","https://openalex.org/W1998766277","https://openalex.org/W2064164434","https://openalex.org/W2086229851","https://openalex.org/W2095482541","https://openalex.org/W2119350124","https://openalex.org/W2140485535","https://openalex.org/W2156888527","https://openalex.org/W2611457812","https://openalex.org/W2808758074","https://openalex.org/W2901211904","https://openalex.org/W2976027672","https://openalex.org/W3020280166","https://openalex.org/W3024809027","https://openalex.org/W4211242412","https://openalex.org/W4213245207","https://openalex.org/W4225390900","https://openalex.org/W4315471231","https://openalex.org/W4385430836","https://openalex.org/W4388214872","https://openalex.org/W4390014099","https://openalex.org/W4391450928","https://openalex.org/W4391597467","https://openalex.org/W4392851125","https://openalex.org/W4405257438","https://openalex.org/W4409446383","https://openalex.org/W4410615996"],"related_works":["https://openalex.org/W1998766277","https://openalex.org/W2138966605","https://openalex.org/W4213245207","https://openalex.org/W4414475556","https://openalex.org/W7118482469","https://openalex.org/W4416756541","https://openalex.org/W4400299612","https://openalex.org/W2279233283","https://openalex.org/W2370693765","https://openalex.org/W2015187176"],"abstract_inverted_index":{"Glutathione":[0],"(GSH)":[1,82],"is":[2,19],"a":[3,33,49,57,94,104,111,162,201],"crucial":[4],"antioxidant":[5],"tripeptide":[6],"with":[7],"extensive":[8],"applications":[9],"in":[10,84,110,114,125,161,165],"pharmaceuticals,":[11],"food,":[12],"and":[13,26,75,150,172,192,203],"cosmetics.":[14],"Nevertheless,":[15],"its":[16],"microbial":[17],"production":[18,66],"constrained":[20],"by":[21,67,154],"low":[22],"yields,":[23],"intracellular":[24],"accumulation,":[25],"feedback":[27],"inhibition.":[28],"While":[29],"Saccharomyces":[30,68],"cerevisiae":[31],"presents":[32],"promising":[34],"host":[35],"for":[36,206],"GSH":[37,43,65,115,120,153,167,178,209],"synthesis,":[38],"the":[39,45,79,100,118,126,134,141,148,176,180,188],"efficient":[40],"secretion":[41,151,195],"of":[42,72,136,144,152,175],"into":[44,179],"culture":[46,86,129],"medium":[47,76],"poses":[48],"significant":[50,112],"challenge.":[51],"In":[52],"this":[53],"study,":[54],"we":[55],"implemented":[56],"multi-stage":[58],"bioengineering":[59],"strategy":[60],"aimed":[61],"at":[62],"maximizing":[63],"extracellular":[64,80,119,181,208],"cerevisiae.":[69],"Statistical":[70],"optimization":[71],"fermentation":[73,101],"parameters":[74],"composition":[77],"enhanced":[78,146],"glutathione":[81],"yield":[83],"shake-flask":[85,128],"from":[87,122],"18.56":[88],"mg/L":[89,124],"to":[90,103,130],"63.60":[91],"mg/L,":[92],"representing":[93],"3.43-fold":[95],"increase.":[96],"Furthermore,":[97],"scaling":[98],"up":[99],"process":[102,199],"30-L":[105],"high-density":[106],"fed-batch":[107],"bioreactor":[108],"resulted":[109,160],"increase":[113,164],"production,":[116],"elevating":[117],"concentration":[121],"63.660":[123],"optimized":[127],"1033.33":[131],"mg/L.":[132],"Moreover,":[133],"addition":[135],"1%":[137],"(v/v)":[138],"ethanol":[139],"during":[140],"later":[142],"stages":[143],"cultivation":[145],"both":[147],"biosynthesis":[149],"increasing":[155],"membrane":[156],"permeability.":[157],"This":[158],"treatment":[159],"35.27%":[163],"total":[166,177],"content,":[168],"reaching":[169],"94.80":[170],"mg/g,":[171],"redirected":[173],"76.76%":[174],"fraction.":[182],"Collectively,":[183],"these":[184],"strategies":[185],"effectively":[186],"addressed":[187],"cell-membrane":[189],"transport":[190],"barrier":[191],"significantly":[193],"improved":[194],"efficiency.":[196],"The":[197],"integrated":[198],"offers":[200],"robust":[202],"scalable":[204],"platform":[205],"industrial-scale":[207],"production.":[210]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-10T00:00:00"}
